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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70500
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk1
Name: mitogen activated protein kinase 1
Acc ID: CHEBI:29073
Term: L-ascorbic acid
Definition: The L-enantiomer of ascorbic acid and conjugate acid of L-ascorbate.
Chemical ID: MESH:D001205
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk1multiple interactionsEXP 6480464CTDAscorbic Acid inhibits the reaction [Ethylene Chlorohydrin results in increased phosphorylation of MAPK1 protein]; Ascorbic Acid inhibits the reaction [lead acetate results in increased phosphorylation of MAPK1 protein]; Ascorbic Acid inhibits the reaction [Potassium Dichromate affects the localization of MAPK1 protein modified form]PMID:21262251 PMID:22728154 PMID:31585129
Mapk1increases phosphorylationISOMapk1 (Mus musculus)6480464CTDAscorbic Acid results in increased phosphorylation of MAPK1 proteinPMID:20530736
Mapk1multiple interactionsISOMAPK1 (Homo sapiens)6480464CTD[juglone co-treated with Ascorbic Acid] results in decreased phosphorylation of MAPK1 proteinPMID:29992683
Mapk1multiple interactionsISOMapk1 (Mus musculus)6480464CTDU 0126 inhibits the reaction [Ascorbic Acid results in increased phosphorylation of MAPK1 protein]PMID:20530736
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