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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70500
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk1
Name: mitogen activated protein kinase 1
Acc ID: CHEBI:15422
Term: ATP
Definition: An adenosine 5'-phosphate in which the 5'-phosphate is a triphosphate group. It is involved in the transportation of chemical energy during metabolic pathways.
Chemical ID: MESH:D000255
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk1increases activityEXP 6480464CTDAdenosine Triphosphate results in increased activity of MAPK1 proteinPMID:12513686
Mapk1increases activityISOMAPK1 (Homo sapiens)6480464CTDAdenosine Triphosphate results in increased activity of MAPK1 proteinPMID:24300283
Mapk1increases phosphorylationISOMAPK1 (Homo sapiens)6480464CTDAdenosine Triphosphate results in increased phosphorylation of MAPK1 proteinPMID:15034929 PMID:21503959 PMID:26104857 PMID:30502331
Mapk1increases phosphorylationISOMapk1 (Mus musculus)6480464CTDAdenosine Triphosphate results in increased phosphorylation of MAPK1 proteinPMID:26522449
Mapk1multiple interactionsISOMAPK1 (Homo sapiens)6480464CTD1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Adenosine Triphosphate results in increased phosphorylation of MAPK1 protein]; [Alcohols co-treated with Adenosine Triphosphate] results in increased activity of MAPK1 protein; Alcohols inhibits the reaction [Adenosine Triphosphate results in increased activity of MAPK1 protein]; AZ10606120 inhibits the reaction [Adenosine Triphosphate promotes the reaction [Cesium-137 results in increased phosphorylation of MAPK1 protein]]; sodium arsenite promotes the reaction [Adenosine Triphosphate results in increased phosphorylation of MAPK1 protein]PMID:15034929 PMID:24300283 PMID:26104857 PMID:32941855
Mapk1multiple interactionsISOMapk1 (Mus musculus)6480464CTD[Adenosine Triphosphate co-treated with HMGB1 protein] results in increased phosphorylation of MAPK1 protein; azetidine analog inhibits the reaction [Adenosine Triphosphate results in increased phosphorylation of MAPK1 protein]; sodium houttuyfonate inhibits the reaction [[Adenosine Triphosphate co-treated with HMGB1 protein] results in increased phosphorylation of MAPK1 protein]PMID:26522449 PMID:34405489
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