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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70500
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk1
Name: mitogen activated protein kinase 1
Acc ID: CHEBI:490095
Term: esculetin
Definition: A hydroxycoumarin that is umbelliferone in which the hydrogen at position 6 is substituted by a hydroxy group. It is used in filters for absorption of ultraviolet light.
Chemical ID: MESH:C007628
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk1increases phosphorylationEXP 6480464CTDesculetin results in increased phosphorylation of MAPK1 proteinPMID:21600278
Mapk1multiple interactionsEXP 6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [esculetin results in increased phosphorylation of MAPK1 protein]; SB 203580 inhibits the reaction [esculetin results in increased phosphorylation of MAPK1 protein]PMID:21600278
Mapk1increases phosphorylationISOMAPK1 (Homo sapiens)6480464CTDesculetin results in increased phosphorylation of MAPK1 proteinPMID:24995577
Mapk1multiple interactionsISOMAPK1 (Homo sapiens)6480464CTD[esculetin co-treated with Paclitaxel] results in decreased expression of MAPK1 protein; esculetin results in decreased phosphorylation of and results in decreased activity of MAPK1 proteinPMID:16051289
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