GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Mapk1 | decreases phosphorylation | EXP | | 6480464 | CTD | Streptozocin results in decreased phosphorylation of MAPK1 protein | PMID:23562514 PMID:29274332 | Mapk1 | increases activity | EXP | | 6480464 | CTD | Streptozocin results in increased activity of MAPK1 protein | PMID:12642375 | Mapk1 | increases expression | EXP | | 6480464 | CTD | Streptozocin results in increased expression of MAPK1 mRNA; Streptozocin results in increased expression of MAPK1 protein | PMID:12642375 PMID:17063547 | Mapk1 | increases phosphorylation | EXP | | 6480464 | CTD | Streptozocin results in increased phosphorylation of MAPK1 protein | PMID:19002579 PMID:19682444 PMID:20053369 PMID:21300041 PMID:30583000 PMID:33639173 PMID:34414639 | Mapk1 | multiple interactions | EXP | | 6480464 | CTD | 1,3-dimethoxy-5-methyl-2-(3-methyl-6-(1-methylethenyl)-2-cyclohexen-1-yl)benzene inhibits the reaction [4-(3-3,4-p-menthadien-(1,8)-yl)olivetol inhibits the reaction [Streptozocin results in decreased phosphorylation of MAPK1 protein]]; 4-(3-3,4-p-menthadien-(1,8)-yl)olivetol inhibits the reaction [Streptozocin results in decreased phosphorylation of MAPK1 protein]; arjunolic acid inhibits the reaction [Streptozocin results in increased phosphorylation of and results in increased activity of MAPK1 protein]; arjunolic acid inhibits the reaction [Streptozocin results in increased phosphorylation of MAPK1 protein]; baicalin inhibits the reaction [Streptozocin results in increased phosphorylation of MAPK1 protein]; Botulinum Toxins, Type A inhibits the reaction [Streptozocin results in increased phosphorylation of MAPK1 protein]; capsazepine inhibits the reaction [Streptozocin results in increased phosphorylation of MAPK1 protein]; diphenyldiselenide inhibits the reaction [Streptozocin results in increased phosphorylation of MAPK1 protein]; Donepezil inhibits the reaction [Streptozocin results in decreased phosphorylation of MAPK1 protein]; Memantine inhibits the reaction [Streptozocin results in decreased phosphorylation of MAPK1 protein]; Metformin inhibits the reaction [Streptozocin results in increased phosphorylation of MAPK1 protein]; Pioglitazone inhibits the reaction [Streptozocin results in increased expression of MAPK1 mRNA]; Pioglitazone inhibits the reaction [Streptozocin results in increased expression of MAPK1 protein]; Resveratrol inhibits the reaction [Streptozocin results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Resveratrol inhibits the reaction [Streptozocin results in increased phosphorylation of MAPK1 protein]; RN 1734 inhibits the reaction [Streptozocin results in increased phosphorylation of MAPK1 protein]; Streptozocin results in increased phosphorylation of and results in increased activity of MAPK1 protein; U 0126 inhibits the reaction [Streptozocin results in increased phosphorylation of MAPK1 protein]; xanthoceraside inhibits the reaction [Streptozocin results in decreased phosphorylation of MAPK1 protein] | PMID:17063547 PMID:19133311 PMID:19682444 PMID:20053369 PMID:20474069 PMID:21300041 PMID:23562514 PMID:29274332 PMID:30583000 PMID:33639173 PMID:34414639 | Mapk1 | increases phosphorylation | ISO | Mapk1 (Mus musculus) | 6480464 | CTD | Streptozocin results in increased phosphorylation of MAPK1 protein | PMID:30607903 PMID:33631230 | Mapk1 | multiple interactions | ISO | MAPK1 (Homo sapiens) | 6480464 | CTD | Streptozocin inhibits the reaction [AKR1B1 protein results in increased phosphorylation of MAPK1 protein] | PMID:25541468 | Mapk1 | multiple interactions | ISO | Mapk1 (Mus musculus) | 6480464 | CTD | 3-((6-(2-methoxyphenyl)pyrimidin-4-yl)amino)phenyl)methane sulfonamide inhibits the reaction [Streptozocin results in increased phosphorylation of MAPK1 protein]; [Streptozocin co-treated with Dietary Fats co-treated with Dietary Sugars] results in decreased expression of and results in decreased phosphorylation of MAPK1 protein; [Streptozocin co-treated with Dietary Fats co-treated with Dietary Sugars] results in decreased phosphorylation of MAPK1 protein; [Streptozocin co-treated with Dietary Fats] results in increased phosphorylation of MAPK1 protein; arachidonyl-2-chloroethylamide promotes the reaction [Streptozocin results in increased phosphorylation of MAPK1 protein]; Diethylhexyl Phthalate inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased phosphorylation of MAPK1 protein]; Diethylhexyl Phthalate promotes the reaction [[Streptozocin co-treated with Dietary Fats co-treated with Dietary Sugars] results in decreased expression of and results in decreased phosphorylation of MAPK1 protein]; Diethylhexyl Phthalate promotes the reaction [[Streptozocin co-treated with Dietary Fats co-treated with Dietary Sugars] results in decreased phosphorylation of MAPK1 protein]; Streptozocin promotes the reaction [NTN1 protein results in increased phosphorylation of MAPK1 protein] | PMID:29059224 PMID:30607903 PMID:32303808 PMID:33484791 PMID:33631230 | | ||||||||||||||||||||||
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