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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70500
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk1
Name: mitogen activated protein kinase 1
Acc ID: CHEBI:1367
Term: 3,3',4,4'-tetrachlorobiphenyl
Definition: A tetrachlorobiphenyl that is biphenyl in which the hydrogens at position 3 and 4 on each phenyl group are replaced by chlorines.
Chemical ID: MESH:C028451
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk1increases phosphorylationISOMapk1 (Mus musculus)6480464CTD3,4,3',4'-tetrachlorobiphenyl results in increased phosphorylation of MAPK1 proteinPMID:20406653
Mapk1multiple interactionsISOMapk1 (Mus musculus)6480464CTDCAV1 mutant form inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl results in increased phosphorylation of and results in increased activity of MAPK1 protein]PMID:20406653
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