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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70500
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk1
Name: mitogen activated protein kinase 1
Acc ID: CHEBI:3385
Term: carbachol
Definition: An ammonium salt that has formula C6H15N2O2.Cl.
Chemical ID: MESH:D002217
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk1decreases phosphorylationEXP 6480464CTDCarbachol results in decreased phosphorylation of MAPK1 proteinPMID:17008368
Mapk1multiple interactionsEXP 6480464CTDCalcium deficiency inhibits the reaction [Carbachol results in increased phosphorylation of and results in increased activity of MAPK1 protein]; calphostin C inhibits the reaction [Carbachol results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Carbachol results in increased phosphorylation of and results in increased activity of MAPK1 protein; PTK2B protein affects the reaction [Carbachol results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Ro 31-8220 inhibits the reaction [Carbachol results in increased phosphorylation of and results in increased activity of MAPK1 protein]; SRC protein affects the reaction [Carbachol results in increased phosphorylation of and results in increased activity of MAPK1 protein]PMID:16877402
Mapk1increases activityISOMAPK1 (Homo sapiens)6480464CTDCarbachol results in increased activity of MAPK1 proteinPMID:19017493 PMID:9121362
Mapk1increases activityISOMapk1 (Mus musculus)6480464CTDCarbachol results in increased activity of MAPK1 proteinPMID:19002953 PMID:19200344
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