GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Mapk1 | decreases phosphorylation | EXP | | 6480464 | CTD | Oxygen deficiency results in decreased phosphorylation of MAPK1 protein | PMID:29139225 | Mapk1 | increases phosphorylation | EXP | | 6480464 | CTD | Oxygen deficiency results in increased phosphorylation of MAPK1 protein; Oxygen results in increased phosphorylation of MAPK1 protein | PMID:20812253 PMID:28478070 | Mapk1 | multiple interactions | EXP | | 6480464 | CTD | 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [Ursolic Acid inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased phosphorylation of MAPK1 protein]]; [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased susceptibility to SB 239063] which results in increased phosphorylation of MAPK1 protein; [Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased phosphorylation of MAPK1 protein; [Oxygen deficiency co-treated with Carbon Dioxide] results in decreased phosphorylation of MAPK1 protein; [Oxygen deficiency co-treated with Carbon Dioxide] results in increased expression of MAPK1 mRNA; [Oxygen deficiency co-treated with Carbon Dioxide] results in increased phosphorylation of MAPK1 protein; epigallocatechin gallate inhibits the reaction [Oxygen deficiency results in increased phosphorylation of MAPK1 protein]; ifenprodil inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in decreased phosphorylation of MAPK1 protein]; Lovastatin inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in decreased phosphorylation of MAPK1 protein]; MFN2 protein promotes the reaction [epigallocatechin gallate inhibits the reaction [Oxygen deficiency results in increased phosphorylation of MAPK1 protein]]; notoginsenoside R1 inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in increased expression of MAPK1 mRNA]; notoginsenoside R1 inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in increased phosphorylation of MAPK1 protein]; Ursolic Acid inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased phosphorylation of MAPK1 protein] | PMID:24718106 PMID:25004876 PMID:26116440 PMID:27274199 PMID:28478070 | Mapk1 | affects phosphorylation | ISO | Mapk1 (Mus musculus) | 6480464 | CTD | Oxygen deficiency affects the phosphorylation of MAPK1 protein | PMID:25448280 | Mapk1 | increases phosphorylation | ISO | MAPK1 (Homo sapiens) | 6480464 | CTD | Oxygen deficiency results in increased phosphorylation of MAPK1 protein | PMID:23728938 PMID:26906511 PMID:29630948 PMID:30266538 | Mapk1 | multiple interactions | ISO | MAPK1 (Homo sapiens) | 6480464 | CTD | [betulin co-treated with Oxygen deficiency] results in increased phosphorylation of MAPK1 protein; [Betulinic Acid co-treated with Oxygen deficiency] results in increased phosphorylation of MAPK1 protein; [Oxygen co-treated with Ozone co-treated with Cannabidiol] results in decreased expression of MAPK1 mRNA; [Oxygen co-treated with Ozone] results in decreased expression of MAPK1 mRNA; [Tetrachlorodibenzodioxin co-treated with Oxygen deficiency] results in increased phosphorylation of MAPK1 protein; alpha-naphthoflavone inhibits the reaction [[Tetrachlorodibenzodioxin co-treated with Oxygen deficiency] results in increased phosphorylation of MAPK1 protein]; dictamnine inhibits the reaction [Oxygen deficiency results in increased phosphorylation of MAPK1 protein]; Folic Acid inhibits the reaction [Oxygen deficiency results in increased phosphorylation of MAPK1 protein]; genipin inhibits the reaction [Oxygen deficiency results in increased phosphorylation of MAPK1 protein]; TXN protein promotes the reaction [Oxygen results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [Oxygen deficiency results in increased phosphorylation of MAPK1 protein] | PMID:19578757 PMID:20812253 PMID:26906511 PMID:29630948 PMID:30266538 PMID:32992648 PMID:33181113 | Mapk1 | multiple interactions | ISO | Mapk1 (Mus musculus) | 6480464 | CTD | [Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased phosphorylation of MAPK1 protein; [Oxygen deficiency co-treated with Glucose deficiency] results in increased phosphorylation of MAPK1 protein; epigallocatechin gallate inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased phosphorylation of MAPK1 protein]; Resveratrol inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased phosphorylation of MAPK1 protein]; SOD1 protein inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased phosphorylation of MAPK1 protein] | PMID:19228841 PMID:19303870 PMID:24682241 PMID:34740634 | | ||||||||||||||||||||||
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