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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70500
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk1
Name: mitogen activated protein kinase 1
Acc ID: CHEBI:30740
Term: ethylene glycol bis(2-aminoethyl)tetraacetic acid
Definition: A diether that is ethylene glycol in which the hydrogens of the hydroxy groups have been replaced by 2-[bis(carboxymethyl)amino]ethyl group respectively.
Chemical ID: MESH:D004533
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk1multiple interactionsEXP 6480464CTDEgtazic Acid inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased activity of and results in increased phosphorylation of MAPK1 protein]; Egtazic Acid inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Egtazic Acid inhibits the reaction [Calcimycin results in increased activity of and results in increased phosphorylation of MAPK1 protein]; Egtazic Acid inhibits the reaction [Dinoprost results in increased phosphorylation of MAPK1 protein]; Egtazic Acid inhibits the reaction [Thapsigargin results in increased activity of MAPK1 protein]; Egtazic Acid promotes the reaction [Tetracaine results in increased phosphorylation of MAPK1 protein]PMID:11914123 PMID:11981161 PMID:21544200
Mapk1multiple interactionsISOMAPK1 (Homo sapiens)6480464CTDEgtazic Acid inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Egtazic Acid inhibits the reaction [PDGFB protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Egtazic Acid inhibits the reaction [Vehicle Emissions results in increased localization of MAPK1 protein modified form]PMID:19576918 PMID:21245013 PMID:21544200
Mapk1multiple interactionsISOMapk1 (Mus musculus)6480464CTDEgtazic Acid inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Egtazic Acid inhibits the reaction [cypermethrin results in increased phosphorylation of and results in increased activity of MAPK1 protein]PMID:21544200 PMID:29149324
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