GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Mapk1 | decreases expression | EXP | | 6480464 | CTD | Nicotine results in decreased expression of MAPK1 protein | PMID:20050989 | Mapk1 | increases phosphorylation | EXP | | 6480464 | CTD | Nicotine results in increased phosphorylation of MAPK1 protein | PMID:20050989 PMID:29486207 | Mapk1 | multiple interactions | EXP | | 6480464 | CTD | Melatonin inhibits the reaction [Nicotine results in decreased expression of MAPK1 protein]; Melatonin inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; Nicotine results in increased phosphorylation of and results in increased activity of MAPK1 protein | PMID:15983034 PMID:18204935 PMID:20050989 | Mapk1 | increases activity | ISO | MAPK1 (Homo sapiens) | 6480464 | CTD | Nicotine results in increased activity of MAPK1 protein | PMID:12421819 PMID:17459420 | Mapk1 | increases expression | ISO | MAPK1 (Homo sapiens) | 6480464 | CTD | Nicotine results in increased expression of MAPK1 protein modified form | PMID:18676776 | Mapk1 | increases phosphorylation | ISO | MAPK1 (Homo sapiens) | 6480464 | CTD | Nicotine results in increased phosphorylation of MAPK1 protein | PMID:17003101 PMID:18448488 PMID:20727180 PMID:22119045 PMID:22261521 PMID:29486207 PMID:34890707 | Mapk1 | increases phosphorylation | ISO | Mapk1 (Mus musculus) | 6480464 | CTD | Nicotine results in increased phosphorylation of MAPK1 protein | PMID:12460746 | Mapk1 | multiple interactions | ISO | MAPK1 (Homo sapiens) | 6480464 | CTD | 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; 2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluoro-5-bromobenzamide inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; [Atenolol binds to and results in decreased activity of ADRB1 protein] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; [Camptothecin co-treated with Nicotine] results in increased phosphorylation of MAPK1 protein; [ICI 118551 binds to and results in decreased activity of ADRB2 protein] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; [Lobeline binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; [methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; [Nicotine co-treated with 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] results in increased phosphorylation of MAPK1 protein; [Nicotine co-treated with Ethanol] results in increased phosphorylation of MAPK1 protein; [U 0126 results in decreased activity of [MAPK1 protein co-treated with MAPK3 protein]] inhibits the reaction [Nicotine results in increased expression of FOS protein]; [U 0126 results in decreased activity of [MAPK1 protein co-treated with MAPK3 protein]] inhibits the reaction [Nicotine results in increased expression of JUN protein]; [U 0126 results in decreased activity of [MAPK1 protein co-treated with MAPK3 protein]] inhibits the reaction [Nicotine results in increased expression of PTGS2]; [U 0126 results in decreased activity of [MAPK1 protein co-treated with MAPK3 protein]] which results in decreased susceptibility to Nicotine; Acetylcysteine inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [Nicotine results in decreased activity of MAPK1 protein]; Curcumin inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; diphenyleneiodonium inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; Hexamethonium inhibits the reaction [Nicotine results in decreased phosphorylation of MAPK1 protein]; Hexamethonium inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; Lobeline inhibits the reaction [Nicotine results in decreased phosphorylation of MAPK1 protein]; Nicotine inhibits the reaction [Cisplatin results in increased activity of MAPK1 protein]; Nicotine inhibits the reaction [Fluorouracil results in increased phosphorylation of MAPK1 protein]; Nicotine inhibits the reaction [Paclitaxel results in increased activity of MAPK1 protein]; Nicotine results in decreased phosphorylation of and results in decreased activity of MAPK1 protein; Nicotine results in increased phosphorylation of and results in increased activity of MAPK1 protein; Propranolol inhibits the reaction [Nicotine results in decreased phosphorylation of MAPK1 protein]; Propranolol inhibits the reaction [Nicotine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Propranolol inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; Staurosporine inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; TP53 protein affects the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; Tubocurarine inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; Vecuronium Bromide inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein] | PMID:17003101 PMID:18448488 PMID:19903766 PMID:20106947 PMID:20727180 PMID:22119045 PMID:24095863 PMID:24201001 PMID:29486207 PMID:30259641 PMID:34890707 | Mapk1 | multiple interactions | ISO | Mapk1 (Mus musculus) | 6480464 | CTD | [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of MAPK1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of MAPK1 mRNA] | PMID:20230807 | | ||||||||||||||||||||||
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