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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70500
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk1
Name: mitogen activated protein kinase 1
Acc ID: CHEBI:35455
Term: 1-naphthyl isothiocyanate
Definition: An isothiocyanate that has formula C11H7NS.
Chemical ID: MESH:D015058
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk1increases phosphorylationEXP 6480464CTD1-Naphthylisothiocyanate results in increased phosphorylation of MAPK1 proteinPMID:27702592
Mapk1multiple interactionsEXP 6480464CTDU 0126 inhibits the reaction [1-Naphthylisothiocyanate results in increased phosphorylation of MAPK1 protein]PMID:27702592
Mapk1increases phosphorylationISOMapk1 (Mus musculus)6480464CTD1-Naphthylisothiocyanate results in increased phosphorylation of MAPK1 proteinPMID:32976922 PMID:33400020
Mapk1multiple interactionsISOMapk1 (Mus musculus)6480464CTDChenodeoxycholic Acid inhibits the reaction [1-Naphthylisothiocyanate results in increased phosphorylation of MAPK1 protein]; picroside II inhibits the reaction [1-Naphthylisothiocyanate results in increased phosphorylation of MAPK1 protein]; SEW2871 inhibits the reaction [1-Naphthylisothiocyanate results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [1-Naphthylisothiocyanate results in increased phosphorylation of MAPK1 protein]; U 0126 promotes the reaction [picroside II inhibits the reaction [1-Naphthylisothiocyanate results in increased phosphorylation of MAPK1 protein]]PMID:32976922 PMID:33400020
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