GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Mapk1 | increases expression | EXP | | 6480464 | CTD | leflunomide results in increased expression of MAPK1 mRNA | PMID:24136188 | Mapk1 | increases phosphorylation | ISO | MAPK1 (Homo sapiens) | 6480464 | CTD | leflunomide results in increased phosphorylation of MAPK1 protein | PMID:28988120 | Mapk1 | multiple interactions | ISO | MAPK1 (Homo sapiens) | 6480464 | CTD | 2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide inhibits the reaction [Leflunomide results in increased phosphorylation of MAPK1 protein]; MAPK1 protein affects the reaction [Leflunomide results in increased expression of ATF4 protein]; MAPK1 protein affects the reaction [Leflunomide results in increased expression of DDIT3 protein] | PMID:28988120 | |
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