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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70500
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk1
Name: mitogen activated protein kinase 1
Acc ID: CHEBI:22977
Term: cadmium atom
Definition: A zinc group element atom that has formula Cd.
Chemical ID: MESH:D002104
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk1decreases phosphorylationEXP 6480464CTDCadmium results in decreased phosphorylation of MAPK1 proteinPMID:25981801
Mapk1increases activityEXP 6480464CTDCadmium results in increased activity of MAPK1 proteinPMID:18573614
Mapk1increases phosphorylationEXP 6480464CTDCadmium results in increased phosphorylation of MAPK1 proteinPMID:16568437 PMID:18541302 PMID:23577223 PMID:25643798
Mapk1multiple interactionsEXP 6480464CTD[Cadmium Chloride results in increased abundance of Cadmium] which results in increased phosphorylation of MAPK1 protein; Acetylcysteine affects the reaction [Cadmium results in increased phosphorylation of MAPK1 protein]PMID:23577223 PMID:34510229
Mapk1affects activityISOMAPK1 (Homo sapiens)6480464CTDCadmium affects the activity of MAPK1 proteinPMID:10874022 PMID:21425301
Mapk1decreases phosphorylationISOMapk1 (Mus musculus)6480464CTDCadmium results in decreased phosphorylation of MAPK1 proteinPMID:28666365
Mapk1increases activityISOMAPK1 (Homo sapiens)6480464CTDCadmium results in increased activity of MAPK1 proteinPMID:19524565 PMID:20153348 PMID:25069788 PMID:25343777
Mapk1increases activityISOMapk1 (Mus musculus)6480464CTDCadmium results in increased activity of MAPK1 proteinPMID:15254339 PMID:16445087 PMID:19182378
Mapk1increases phosphorylationISOMAPK1 (Homo sapiens)6480464CTDCadmium results in increased phosphorylation of MAPK1 proteinPMID:14499349 PMID:16959797 PMID:17055454 PMID:17125913 PMID:20232314 PMID:20868229 PMID:21787653 PMID:23966319 PMID:26006730 PMID:26514923 PMID:31437537
Mapk1increases phosphorylationISOMapk1 (Mus musculus)6480464CTDCadmium results in increased phosphorylation of MAPK1 proteinPMID:15212812 PMID:19609071 PMID:19786089 PMID:22356713 PMID:24614234
Mapk1multiple interactionsISOMAPK1 (Homo sapiens)6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased phosphorylation of MAPK1 protein]; 2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluoro-5-bromobenzamide inhibits the reaction [Cadmium results in increased phosphorylation of MAPK1 protein]; 4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased phosphorylation of MAPK1 protein]; [[Cadmium Chloride results in increased abundance of Cadmium] which co-treated with fenvalerate] results in increased phosphorylation of MAPK1 protein; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of MAPK1 mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased phosphorylation of MAPK1 protein; [SLC39A8 protein polymorphism affects the uptake of Cadmium] which affects the phosphorylation of MAPK1 protein; acetovanillone inhibits the reaction [Cadmium results in increased phosphorylation of MAPK1 protein]; Acetylcysteine affects the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [Cadmium results in increased phosphorylation of MAPK1 protein]; Buthionine Sulfoximine promotes the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased phosphorylation of MAPK1 protein]; Cadmium inhibits the reaction [CNTF protein results in increased phosphorylation of MAPK1 protein]; Cadmium promotes the reaction [EGF protein results in increased phosphorylation of MAPK1 protein]; Cadmium results in increased phosphorylation of and results in increased activity of MAPK1 protein; diacetyldichlorofluorescein inhibits the reaction [Cadmium results in increased phosphorylation of MAPK1 protein]; diphenyleneiodonium inhibits the reaction [Cadmium results in increased phosphorylation of MAPK1 protein]; EGF protein promotes the reaction [Cadmium results in increased phosphorylation of MAPK1 protein]; EGFR mutant form inhibits the reaction [Cadmium results in increased phosphorylation of MAPK1 protein]; ESR1 mutant form inhibits the reaction [Cadmium results in increased phosphorylation of MAPK1 protein]; Fulvestrant inhibits the reaction [Cadmium results in increased phosphorylation of MAPK1 protein]; GPER1 mutant form inhibits the reaction [Cadmium results in increased activity of MAPK1 protein]; GPER1 protein affects the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased phosphorylation of MAPK1 protein]; GSTP1 protein inhibits the reaction [Cadmium results in increased phosphorylation of MAPK1 protein]; Manganese inhibits the reaction [Cadmium results in increased phosphorylation of MAPK1 protein]; RTKI cpd inhibits the reaction [Cadmium results in increased activity of MAPK1 protein]; RTKI cpd inhibits the reaction [Cadmium results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [Cadmium results in increased phosphorylation of MAPK1 protein]PMID:16843830 PMID:16959797 PMID:17055454 PMID:17125913 PMID:20153348 PMID:20232314 PMID:20868229 PMID:21787653 PMID:24824807 PMID:25343777 PMID:26006730 PMID:26102734 PMID:26514923 PMID:28949029 PMID:31468104 PMID:31860779 PMID:33818655 PMID:34510229 PMID:35301059
Mapk1multiple interactionsISOMapk1 (Mus musculus)6480464CTD[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of MAPK1 mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased phosphorylation of MAPK1 protein; Acetylcysteine inhibits the reaction [Cadmium results in increased activity of MAPK1 protein]; Cadmium results in increased phosphorylation of and results in increased activity of MAPK1 protein; calphostin C inhibits the reaction [Cadmium results in increased phosphorylation of MAPK1 protein]; hwanggunchungyitang inhibits the reaction [Cadmium results in increased activity of MAPK1 protein]; Silymarin inhibits the reaction [Cadmium results in increased phosphorylation of and results in increased activity of MAPK1 protein]PMID:15212812 PMID:16445087 PMID:16728380 PMID:19182378 PMID:37261864 PMID:37325564
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