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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70500
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk1
Name: mitogen activated protein kinase 1
Acc ID: CHEBI:34202
Term: 2,2',4,4',5,5'-hexachlorobiphenyl
Definition: A hexachlorobiphenyl that has formula C12H4Cl6.
Chemical ID: MESH:C014024
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk1increases phosphorylationEXP 6480464CTD2,4,5,2',4',5'-hexachlorobiphenyl results in increased phosphorylation of MAPK1 proteinPMID:24726520 PMID:27318803
Mapk1multiple interactionsEXP 6480464CTD2,4,5,2',4',5'-hexachlorobiphenyl promotes the reaction [MAPK1 protein results in increased phosphorylation of GJA1 protein]PMID:18832185
Mapk1decreases phosphorylationISOMAPK1 (Homo sapiens)6480464CTD2,4,5,2',4',5'-hexachlorobiphenyl results in decreased phosphorylation of MAPK1 proteinPMID:19751709
Mapk1multiple interactionsISOMAPK1 (Homo sapiens)6480464CTD2,4,5,2',4',5'-hexachlorobiphenyl binds to and results in increased activity of MAPK1 protein; 2,4,5,2',4',5'-hexachlorobiphenyl inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of MAPK1 protein]; 2,4,5,2',4',5'-hexachlorobiphenyl inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein]PMID:16293362 PMID:20840854 PMID:29329451
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