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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70500
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk1
Name: mitogen activated protein kinase 1
Acc ID: CHEBI:15343
Term: acetaldehyde
Definition: The aldehyde formed from acetic acid by reduction of the carboxy group. It is the most abundant carcinogen in tobacco smoke.
Chemical ID: MESH:D000079
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk1multiple interactionsEXP 6480464CTDAcetaldehyde results in increased phosphorylation of and results in increased activity of MAPK1 protein; Acetylcysteine inhibits the reaction [Acetaldehyde results in increased phosphorylation of and results in increased activity of MAPK1 protein]PMID:12065697
Mapk1increases phosphorylationISOMAPK1 (Homo sapiens)6480464CTDAcetaldehyde results in increased phosphorylation of MAPK1 proteinPMID:11343241
Mapk1multiple interactionsISOMAPK1 (Homo sapiens)6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Acetaldehyde results in increased phosphorylation of and results in increased activity of MAPK1 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Acetaldehyde results in increased phosphorylation of MAPK1 protein]; 4-hydroxymercuribenzoate inhibits the reaction [Acetaldehyde results in increased phosphorylation of MAPK1 protein]; Acetaldehyde results in increased phosphorylation of and results in increased activity of MAPK1 protein; calphostin C inhibits the reaction [Acetaldehyde results in increased phosphorylation of MAPK1 protein]; Imatinib Mesylate inhibits the reaction [Acetaldehyde results in increased phosphorylation of and results in increased activity of MAPK1 protein]; MAPK1 protein promotes the reaction [Acetaldehyde results in increased expression of COL1A1 protein]; rottlerin inhibits the reaction [Acetaldehyde results in increased phosphorylation of and results in increased activity of MAPK1 protein]PMID:11343241 PMID:14722101 PMID:17030193
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