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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70500
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk1
Name: mitogen activated protein kinase 1
Acc ID: CHEBI:33007
Term: chromium(6+)
Definition: A monoatomic hexacation that has formula Cr.
Chemical ID: MESH:C074702
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk1decreases phosphorylationEXP 6480464CTDchromium hexavalent ion results in decreased phosphorylation of MAPK1 proteinPMID:24530425
Mapk1increases activityEXP 6480464CTDchromium hexavalent ion results in increased activity of MAPK1 proteinPMID:8616849
Mapk1multiple interactionsEXP 6480464CTD[chromium hexavalent ion results in increased activity of MAPK1 protein] which results in increased abundance of Peroxides; Acetylcysteine inhibits the reaction [chromium hexavalent ion results in increased activity of MAPK1 protein]; Buthionine Sulfoximine promotes the reaction [chromium hexavalent ion results in increased activity of MAPK1 protein]PMID:8616849
Mapk1increases phosphorylationISOMAPK1 (Homo sapiens)6480464CTDchromium hexavalent ion results in increased phosphorylation of MAPK1 proteinPMID:17045426 PMID:23748240 PMID:25448439
Mapk1increases phosphorylationISOMapk1 (Mus musculus)6480464CTDchromium hexavalent ion results in increased phosphorylation of MAPK1 proteinPMID:19654923 PMID:19895865
Mapk1multiple interactionsISOMAPK1 (Homo sapiens)6480464CTDchromium hexavalent ion inhibits the reaction [Nickel results in increased phosphorylation of MAPK1 protein]; Luteolin inhibits the reaction [chromium hexavalent ion results in increased phosphorylation of MAPK1 protein]PMID:19403854 PMID:25448439
Mapk1multiple interactionsISOMapk1 (Mus musculus)6480464CTD[Arsenates co-treated with chromium hexavalent ion] results in increased phosphorylation of MAPK1 protein; [sodium chromate(VI) results in increased abundance of chromium hexavalent ion] which results in increased phosphorylation of MAPK1 protein; Melatonin inhibits the reaction [[sodium chromate(VI) results in increased abundance of chromium hexavalent ion] which results in increased phosphorylation of MAPK1 protein]PMID:19895865 PMID:35643323
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