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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70500
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk1
Name: mitogen activated protein kinase 1
Acc ID: CHEBI:32585
Term: 4-hydroxynon-2-enal
Definition: An enal consisting of non-2-ene having an oxo group at the 1-position and a hydroxy group at the 4-position.
Chemical ID: MESH:C027576
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk1increases phosphorylationEXP 6480464CTD4-hydroxy-2-nonenal results in increased phosphorylation of MAPK1 proteinPMID:24291486
Mapk1decreases activityISOMapk1 (Mus musculus)6480464CTD4-hydroxy-2-nonenal results in decreased activity of MAPK1 proteinPMID:17263905
Mapk1multiple interactionsISOMAPK1 (Homo sapiens)6480464CTD4-hydroxy-2-nonenal results in increased activity of and results in increased phosphorylation of MAPK1 proteinPMID:23845594
Mapk1multiple interactionsISOMapk1 (Mus musculus)6480464CTD4-hydroxy-2-nonenal results in decreased phosphorylation of and results in decreased activity of MAPK1 protein; 4-hydroxy-2-nonenal results in increased activity of [MAPK1 protein co-treated with MAPK3 protein]; 4-hydroxy-2-nonenal results in increased phosphorylation of and results in increased activity of MAPK1 protein; resveratrol inhibits the reaction [4-hydroxy-2-nonenal results in decreased phosphorylation of and results in decreased activity of MAPK1 protein]PMID:16322078 PMID:24423726
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