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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70500
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk1
Name: mitogen activated protein kinase 1
Acc ID: CHEBI:5300
Term: Geniposide pentaacetate
Definition: A terpene glycoside that has formula C27H34O15.
Chemical ID: MESH:C074968
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk1increases phosphorylationEXP 6480464CTDpentaacetyl geniposide results in increased phosphorylation of MAPK1 proteinPMID:17651887
Mapk1multiple interactionsEXP 6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [pentaacetyl geniposide results in increased phosphorylation of MAPK1 protein]; pentaacetyl geniposide results in decreased phosphorylation of and results in decreased activity of MAPK1 proteinPMID:17651887 PMID:19464279
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