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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70500
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk1
Name: mitogen activated protein kinase 1
Acc ID: CHEBI:28499
Term: kaempferol
Definition: A tetrahydroxyflavone in which the four hydroxy groups are located at positions 3, 5, 7 and 4'. Acting as an antioxidant by reducing oxidative stress, it is currently under consideration as a possible cancer treatment.
Chemical ID: MESH:C006552
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk1increases activityEXP 6480464CTDkaempferol results in increased activity of MAPK1 proteinPMID:19265714
Mapk1multiple interactionsEXP 6480464CTDkaempferol inhibits the reaction [Doxorubicin results in increased phosphorylation of MAPK1 protein]PMID:22155320
Mapk1increases phosphorylationISOMAPK1 (Homo sapiens)6480464CTDkaempferol results in increased phosphorylation of MAPK1 proteinPMID:16014620 PMID:18346843 PMID:30499162
Mapk1multiple interactionsISOMAPK1 (Homo sapiens)6480464CTD3',4'-dihydroxyflavone analog inhibits the reaction [kaempferol results in increased phosphorylation of MAPK1 protein]; kaempferol inhibits the reaction [IL1B protein results in increased phosphorylation of MAPK1 protein]; kaempferol inhibits the reaction [Paraquat results in increased phosphorylation of MAPK1 protein]PMID:16014620 PMID:19367675 PMID:25177032
Mapk1multiple interactionsISOMapk1 (Mus musculus)6480464CTDkaempferol inhibits the reaction [Lipopolysaccharides results in increased expression of MAPK1 protein modified form]; kaempferol inhibits the reaction [propacetamol results in increased phosphorylation of MAPK1 protein]PMID:15832817 PMID:29574133
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