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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70500
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk1
Name: mitogen activated protein kinase 1
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk1affects activityEXP 6480464CTDbisphenol A affects the activity of MAPK1 proteinPMID:19479018
Mapk1affects expressionEXP 6480464CTDbisphenol A affects the expression of MAPK1 mRNAPMID:25181051
Mapk1affects phosphorylationEXP 6480464CTDbisphenol A affects the phosphorylation of MAPK1 proteinPMID:32450286
Mapk1decreases expressionEXP 6480464CTDbisphenol A results in decreased expression of MAPK1 proteinPMID:32153214
Mapk1decreases phosphorylationEXP 6480464CTDbisphenol A analog results in decreased phosphorylation of MAPK1 protein; bisphenol A results in decreased phosphorylation of MAPK1 proteinPMID:30496632 PMID:32380187 PMID:35810996
Mapk1increases activityEXP 6480464CTDbisphenol A results in increased activity of MAPK1 proteinPMID:19497385
Mapk1increases expressionEXP 6480464CTDbisphenol A results in increased expression of MAPK1 mRNAPMID:24189132
Mapk1increases phosphorylationEXP 6480464CTDbisphenol A results in increased phosphorylation of MAPK1 proteinPMID:16123166 PMID:19463694 PMID:20096755 PMID:20219716 PMID:20921394 PMID:21574817 PMID:22230296 PMID:22446810 PMID:24189132 PMID:27025157 PMID:27743673 PMID:28689058 PMID:30677511
Mapk1multiple interactionsEXP 6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [bisphenol A results in increased phosphorylation of MAPK1 protein]; 4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline inhibits the reaction [bisphenol A results in increased phosphorylation of MAPK1 protein]; [bisphenol A co-treated with Glutamic Acid] results in increased phosphorylation of MAPK1 protein; afimoxifene inhibits the reaction [[bisphenol A co-treated with Glutamic Acid] results in increased phosphorylation of MAPK1 protein]; bisphenol A affects the reaction [Estradiol affects the phosphorylation of MAPK1 protein]; bisphenol A affects the reaction [Estriol affects the phosphorylation of MAPK1 protein]; bisphenol A affects the reaction [Estrone affects the phosphorylation of MAPK1 protein]; bisphenol A inhibits the reaction [[Dihydrotestosterone co-treated with Glutamic Acid] results in increased phosphorylation of MAPK1 protein]; bisphenol A inhibits the reaction [[Estradiol co-treated with Glutamic Acid] results in increased phosphorylation of MAPK1 protein]; bisphenol A inhibits the reaction [Estradiol results in increased phosphorylation of MAPK1 protein]; bisphenol A inhibits the reaction [NGF protein results in increased phosphorylation of MAPK1 protein]; bisphenol A results in decreased expression of and results in decreased phosphorylation of MAPK1 protein; bisphenol A results in increased expression of and results in increased phosphorylation of MAPK1 protein; crocin inhibits the reaction [bisphenol A results in increased phosphorylation of MAPK1 protein]; Flutamide inhibits the reaction [[bisphenol A co-treated with Glutamic Acid] results in increased phosphorylation of MAPK1 protein]; Fulvestrant inhibits the reaction [bisphenol A results in increased phosphorylation of MAPK1 protein]; Lycopene inhibits the reaction [bisphenol A results in decreased expression of MAPK1 protein]; NF023 inhibits the reaction [bisphenol A results in increased phosphorylation of MAPK1 protein]; Nystatin inhibits the reaction [bisphenol A results in increased phosphorylation of MAPK1 protein]; Pertussis Toxin inhibits the reaction [bisphenol A results in increased phosphorylation of MAPK1 protein]; Phytochemicals inhibits the reaction [bisphenol A results in increased phosphorylation of MAPK1 protein]PMID:16123166 PMID:17322771 PMID:20870566 PMID:21574817 PMID:21871873 PMID:22230296 PMID:22446810 PMID:26827910 PMID:26862991 PMID:27025157 PMID:28689058 PMID:30677511 PMID:30707916 PMID:32153214
Mapk1affects response to substanceISOMapk1 (Mus musculus)6480464CTDMAPK1 mRNA alternative form affects the susceptibility to bisphenol APMID:31020848
Mapk1decreases expressionISOMAPK1 (Homo sapiens)6480464CTDbisphenol A results in decreased expression of MAPK1 mRNA; bisphenol A results in decreased expression of MAPK1 proteinPMID:31675489 PMID:32963737
Mapk1decreases phosphorylationISOMAPK1 (Homo sapiens)6480464CTDbisphenol A results in decreased phosphorylation of MAPK1 proteinPMID:26133781
Mapk1decreases phosphorylationISOMapk1 (Mus musculus)6480464CTDbisphenol A results in decreased phosphorylation of MAPK1 proteinPMID:22484357 PMID:25637671 PMID:26779933 PMID:30015891
Mapk1increases activityISOMAPK1 (Homo sapiens)6480464CTDbisphenol A results in increased activity of MAPK1 proteinPMID:27038254
Mapk1increases activityISOMapk1 (Mus musculus)6480464CTDbisphenol A results in increased activity of MAPK1 proteinPMID:24495410
Mapk1increases expressionISOMAPK1 (Homo sapiens)6480464CTDbisphenol A results in increased expression of MAPK1 proteinPMID:34186270 PMID:37567409
Mapk1increases expressionISOMapk1 (Mus musculus)6480464CTDbisphenol A results in increased expression of MAPK1 mRNA alternative formPMID:31020848
Mapk1increases methylationISOMAPK1 (Homo sapiens)6480464CTDbisphenol A results in increased methylation of MAPK1 genePMID:31601247
Mapk1increases phosphorylationISOMAPK1 (Homo sapiens)6480464CTDbisphenol A results in increased phosphorylation of MAPK1 proteinPMID:18246544 PMID:18544561 PMID:18854640 PMID:20678512 PMID:20875696 PMID:22343039 PMID:22552965 PMID:25312822 PMID:26363213 PMID:28426875 PMID:28709031 PMID:28736254 PMID:29192164 PMID:29228121 PMID:29330934 PMID:29383186 PMID:29964091 PMID:30615907 PMID:30677511 PMID:31016847 PMID:31075703 PMID:31143956 PMID:31714645 PMID:32325111 PMID:33469997 PMID:34439521 PMID:34743013 PMID:34910997 PMID:35429799
Mapk1increases phosphorylationISOMapk1 (Mus musculus)6480464CTDbisphenol A results in increased phosphorylation of MAPK1 proteinPMID:18521933 PMID:20950447 PMID:22269103 PMID:23274518 PMID:24905940 PMID:25047101 PMID:27022677 PMID:28446726 PMID:28849599 PMID:30609183 PMID:30892605 PMID:32353937 PMID:32575098
Mapk1multiple interactionsISOMAPK1 (Homo sapiens)6480464CTD1,3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole inhibits the reaction [bisphenol A results in increased phosphorylation of MAPK1 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [bisphenol A results in increased phosphorylation of MAPK1 protein]; 2-chloro-5-nitrobenzanilide inhibits the reaction [bisphenol A results in increased phosphorylation of MAPK1 protein]; 4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline inhibits the reaction [bisphenol A results in increased phosphorylation of MAPK1 protein]; [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in decreased activity of [MAPK1 protein co-treated with MAPK3 protein]] inhibits the reaction [[bisphenol A co-treated with LEP protein] results in decreased activity of CASP3 protein]; [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in decreased activity of [MAPK1 protein co-treated with MAPK3 protein]] inhibits the reaction [[LEP protein co-treated with bisphenol A] results in decreased expression of CASP3 protein]; [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in decreased activity of [MAPK1 protein co-treated with MAPK3 protein]] inhibits the reaction [bisphenol A results in decreased activity of CASP3 protein]; [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in decreased activity of [MAPK1 protein co-treated with MAPK3 protein]] inhibits the reaction [bisphenol A results in decreased expression of CASP3 protein]; [bisphenol A co-treated with Dibutyl Phthalate] results in decreased phosphorylation of MAPK1 protein; [bisphenol A co-treated with Diethylhexyl Phthalate] results in decreased phosphorylation of MAPK1 protein; [bisphenol A co-treated with LIF protein] results in increased phosphorylation of MAPK1 protein; [bisphenol A co-treated with mono-(2-ethylhexyl)phthalate] results in increased phosphorylation of MAPK1 protein; [GPER1 protein co-treated with bisphenol A] results in increased phosphorylation of MAPK1 protein; [GPER1 protein results in increased susceptibility to bisphenol A] which results in increased phosphorylation of MAPK1 protein; [mono-(2-ethylhexyl)phthalate co-treated with bisphenol A] inhibits the reaction [HDAC6 protein affects the phosphorylation of MAPK1 protein]; [Tetradecanoylphorbol Acetate co-treated with bisphenol A] results in increased phosphorylation of MAPK1 protein; Acetylcysteine inhibits the reaction [bisphenol A results in increased phosphorylation of MAPK1 protein]; astaxanthine inhibits the reaction [bisphenol A results in increased phosphorylation of MAPK1 protein]; bicalutamide inhibits the reaction [bisphenol A results in increased phosphorylation of MAPK1 protein]; bisphenol A inhibits the reaction [HDAC6 protein affects the phosphorylation of MAPK1 protein]; bisphenol A inhibits the reaction [INS1 protein results in increased phosphorylation of MAPK1 protein]; bisphenol A promotes the reaction [BRAF protein mutant form results in increased phosphorylation of MAPK1 protein]; bisphenol A results in increased phosphorylation of and results in increased activity of MAPK1 protein; ESR1 protein affects the reaction [bisphenol A results in increased phosphorylation of MAPK1 protein]; Fulvestrant inhibits the reaction [[bisphenol A co-treated with Dibutyl Phthalate] results in decreased phosphorylation of MAPK1 protein]; Fulvestrant inhibits the reaction [[bisphenol A co-treated with Diethylhexyl Phthalate] results in decreased phosphorylation of MAPK1 protein]; Fulvestrant inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with bisphenol A] results in increased phosphorylation of MAPK1 protein]; Fulvestrant inhibits the reaction [bisphenol A results in decreased phosphorylation of MAPK1 protein]; Fulvestrant inhibits the reaction [bisphenol A results in increased phosphorylation of MAPK1 protein]; Gefitinib inhibits the reaction [bisphenol A results in increased phosphorylation of MAPK1 protein]; GPER1 mRNA affects the reaction [bisphenol A results in increased phosphorylation of MAPK1 protein]; GPER1 protein promotes the reaction [bisphenol A results in increased phosphorylation of MAPK1 protein]; Melatonin inhibits the reaction [bisphenol A results in increased phosphorylation of MAPK1 protein]; Phytochemicals inhibits the reaction [bisphenol A results in increased phosphorylation of MAPK1 protein]; pyrazolanthrone inhibits the reaction [bisphenol A inhibits the reaction [INS1 protein results in increased phosphorylation of MAPK1 protein]]; RTKI cpd inhibits the reaction [bisphenol A results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [bisphenol A results in increased phosphorylation of MAPK1 protein]PMID:14975756 PMID:18246544 PMID:18544561 PMID:20875696 PMID:22552965 PMID:23850738 PMID:24349194 PMID:25128825 PMID:25312822 PMID:26133781 PMID:28736254 PMID:29192164 PMID:29330934 PMID:29383186 PMID:30615907 PMID:31075703 PMID:33469997 PMID:34329126 PMID:34439521 PMID:34910997 PMID:35429799 PMID:37372083
Mapk1multiple interactionsISOMapk1 (Mus musculus)6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [bisphenol A results in increased phosphorylation of MAPK1 protein]; [bisphenol A co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] results in increased expression of MAPK1 mRNA; [bisphenol A co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] results in increased phosphorylation of MAPK1 protein; [bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with diethyl phthalate co-treated with di-n-octyl phthalate co-treated with diisodecyl phthalate co-treated with diisononyl phthalate] results in increased expression of MAPK1 protein; [bisphenol A co-treated with Diethylhexyl Phthalate co-treated with diethyl phthalate co-treated with diisononyl phthalate co-treated with di-n-octyl phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with diisodecyl phthalate] results in increased phosphorylation of MAPK1 protein; [bisphenol A results in increased phosphorylation of and results in increased activity of MAPK1 protein] which results in increased expression of NR4A1 mRNA; bisphenol A inhibits the reaction [Estradiol results in increased phosphorylation of MAPK1 protein]; bisphenol A inhibits the reaction [Estriol results in increased phosphorylation of MAPK1 protein]; bisphenol A inhibits the reaction [Estrone results in increased phosphorylation of MAPK1 protein]; bisphenol A inhibits the reaction [TNFSF11 protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; bisphenol A results in increased expression of and affects the phosphorylation of MAPK1 protein; bisphenol A results in increased phosphorylation of and results in increased activity of MAPK1 protein; FOS protein affects the reaction [bisphenol A results in increased phosphorylation of MAPK1 protein]; Fulvestrant inhibits the reaction [bisphenol A results in increased activity of MAPK1 protein]; Fulvestrant inhibits the reaction [bisphenol A results in increased phosphorylation of MAPK1 protein]; Fulvestrant promotes the reaction [bisphenol A results in increased phosphorylation of MAPK1 protein]; Ginsenosides inhibits the reaction [bisphenol A results in increased phosphorylation of MAPK1 protein]; GPER1 protein affects the reaction [bisphenol A results in increased phosphorylation of MAPK1 protein]; RTKI cpd inhibits the reaction [bisphenol A results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [bisphenol A results in increased phosphorylation of MAPK1 protein]; W 7 inhibits the reaction [bisphenol A results in increased phosphorylation of MAPK1 protein]PMID:12021184 PMID:20950447 PMID:22269103 PMID:23274518 PMID:23900028 PMID:24333847 PMID:24495410 PMID:24905940 PMID:28446726 PMID:28849599 PMID:30665118 PMID:31011801 PMID:35739755 PMID:37364641
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