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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70500
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk1
Name: mitogen activated protein kinase 1
Acc ID: CHEBI:17833
Term: gentamycin
Definition: Any of a group of aminoglycoside antibiotics produced by fermentation of some Micromonospora spp.
Chemical ID: MESH:D005839
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk1increases expressionEXP 6480464CTDGentamicins results in increased expression of MAPK1 mRNAPMID:22061828
Mapk1increases phosphorylationEXP 6480464CTDGentamicins results in increased phosphorylation of MAPK1 proteinPMID:34350654
Mapk1multiple interactionsISOMAPK1 (Homo sapiens)6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Gentamicins results in increased phosphorylation of and results in increased activity of MAPK1 protein]; CASR protein promotes the reaction [Gentamicins results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Gentamicins results in increased phosphorylation of and results in increased activity of MAPK1 proteinPMID:17537980
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