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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70500
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk1
Name: mitogen activated protein kinase 1
Acc ID: CHEBI:46195
Term: paracetamol
Definition: A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
Chemical ID: MESH:D000082
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk1affects expressionEXP 6480464CTDAcetaminophen affects the expression of MAPK1 mRNAPMID:16701773
Mapk1increases expressionEXP 6480464CTDAcetaminophen results in increased expression of MAPK1 mRNAPMID:33387578
Mapk1multiple interactionsEXP 6480464CTDAcetaminophen results in increased phosphorylation of and results in increased activity of MAPK1 protein; N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide inhibits the reaction [Acetaminophen results in increased phosphorylation of and results in increased activity of MAPK1 protein]; U 0126 inhibits the reaction [Acetaminophen results in increased phosphorylation of and results in increased activity of MAPK1 protein]PMID:17088403
Mapk1increases phosphorylationISOMAPK1 (Homo sapiens)6480464CTDAcetaminophen results in increased phosphorylation of MAPK1 proteinPMID:27720869 PMID:29136249
Mapk1increases phosphorylationISOMapk1 (Mus musculus)6480464CTDAcetaminophen results in increased phosphorylation of MAPK1 proteinPMID:27720869 PMID:27866976 PMID:28209544 PMID:28286204 PMID:29689376 PMID:29873576
Mapk1multiple interactionsISOMAPK1 (Homo sapiens)6480464CTDAcetaminophen inhibits the reaction [Doxorubicin results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Acetaminophen results in decreased phosphorylation of and results in decreased activity of MAPK1 protein; caffeic acid inhibits the reaction [Acetaminophen results in increased phosphorylation of MAPK1 protein]; Chlorogenic Acid promotes the reaction [Acetaminophen results in increased phosphorylation of MAPK1 protein]PMID:17526808 PMID:27720869 PMID:29136249
Mapk1multiple interactionsISOMapk1 (Mus musculus)6480464CTD[Acetaminophen co-treated with Carbon Tetrachloride] results in increased phosphorylation of MAPK1 protein; caffeic acid inhibits the reaction [Acetaminophen results in increased phosphorylation of MAPK1 protein]; EGR1 protein affects the reaction [Acetaminophen results in increased phosphorylation of MAPK1 protein]; Rosiglitazone inhibits the reaction [Acetaminophen results in increased phosphorylation of MAPK1 protein]; SESN2 protein inhibits the reaction [Acetaminophen results in increased phosphorylation of MAPK1 protein]PMID:27720869 PMID:27866976 PMID:28209544 PMID:28286204 PMID:29873576
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