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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70500
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk1
Name: mitogen activated protein kinase 1
Acc ID: CHEBI:4031
Term: cyclosporin A
Definition: A cyclic nonribosomal peptide of eleven amino acids; an immunosuppressant drug widely used in post-allogeneic organ transplant to reduce the activity of the patient's immune system, and therefore the risk of organ rejection. Also causes reversible inhibition of immunocompetent lymphocytes in the G0- and G1-phase of the cell cycle.
Chemical ID: MESH:D016572
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk1increases phosphorylationEXP 6480464CTDCyclosporine results in increased phosphorylation of MAPK1 proteinPMID:25299210 PMID:25772258
Mapk1multiple interactionsEXP 6480464CTDCyclosporine inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein]PMID:16513848
Mapk1decreases phosphorylationISOMapk1 (Mus musculus)6480464CTDCyclosporine results in decreased phosphorylation of MAPK1 proteinPMID:15207740
Mapk1increases phosphorylationISOMAPK1 (Homo sapiens)6480464CTDCyclosporine results in increased phosphorylation of MAPK1 proteinPMID:22147139
Mapk1increases phosphorylationISOMapk1 (Mus musculus)6480464CTDCyclosporine results in increased phosphorylation of MAPK1 proteinPMID:22155090 PMID:32866465
Mapk1multiple interactionsISOMAPK1 (Homo sapiens)6480464CTD[U 0126 results in decreased phosphorylation of and results in decreased activity of [MAPK1 protein co-treated with MAPK3 protein]] inhibits the reaction [Cyclosporine results in increased abundance of Reactive Oxygen Species]; [U 0126 results in decreased phosphorylation of and results in decreased activity of [MAPK1 protein co-treated with MAPK3 protein]] which results in decreased susceptibility to Cyclosporine; U 0126 inhibits the reaction [Cyclosporine results in increased phosphorylation of MAPK1 protein]PMID:22147139
Mapk1multiple interactionsISOMapk1 (Mus musculus)6480464CTDCycloheximide inhibits the reaction [Cyclosporine results in increased phosphorylation of MAPK1 protein]; polyethylene glycol-superoxide dismutase inhibits the reaction [Cyclosporine results in increased phosphorylation of MAPK1 protein]; salubrinal inhibits the reaction [Cyclosporine results in increased phosphorylation of MAPK1 protein]PMID:22155090 PMID:32866465
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