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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70500
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk1
Name: mitogen activated protein kinase 1
Acc ID: CHEBI:53444
Term: potassium dichromate
Definition: A potassium salt that is the dipotassium salt of dichromic acid.
Chemical ID: MESH:D011192
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk1affects localizationEXP 6480464CTDPotassium Dichromate affects the localization of MAPK1 protein modified formPMID:21262251
Mapk1increases phosphorylationEXP 6480464CTDPotassium Dichromate results in increased phosphorylation of MAPK1 proteinPMID:21262251
Mapk1multiple interactionsEXP 6480464CTD[alpha-Tocopherol affects the activity of MAPK1 protein] which results in decreased susceptibility to Potassium Dichromate; Ascorbic Acid inhibits the reaction [Potassium Dichromate affects the localization of MAPK1 protein modified form]; U 0126 inhibits the reaction [Potassium Dichromate results in increased phosphorylation of MAPK1 protein]PMID:19766176 PMID:21262251
Mapk1increases activityISOMAPK1 (Homo sapiens)6480464CTDPotassium Dichromate results in increased activity of MAPK1 proteinPMID:11678615
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