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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70500
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk1
Name: mitogen activated protein kinase 1
Acc ID: CHEBI:34631
Term: chlorpyrifos
Definition: An organic thiophosphate that is O,O-diethyl hydrogen phosphorothioate in which the hydrogen of the hydroxy group has been replaced by a 3,5,6-trichloropyridin-2-yl group.
Chemical ID: MESH:D004390
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk1decreases phosphorylationEXP 6480464CTDChlorpyrifos results in decreased phosphorylation of MAPK1 proteinPMID:30621213
Mapk1increases phosphorylationEXP 6480464CTDChlorpyrifos results in increased phosphorylation of MAPK1 proteinPMID:22714038 PMID:35137321
Mapk1multiple interactionsEXP 6480464CTDChlorpyrifos inhibits the reaction [3,5-dihydroxyphenylglycine results in increased phosphorylation of MAPK1 protein]PMID:35137321
Mapk1decreases phosphorylationISOMAPK1 (Homo sapiens)6480464CTDChlorpyrifos results in decreased phosphorylation of MAPK1 proteinPMID:23994500
Mapk1increases activityISOMAPK1 (Homo sapiens)6480464CTDChlorpyrifos results in increased activity of MAPK1 proteinPMID:24793810
Mapk1increases expressionISOMAPK1 (Homo sapiens)6480464CTDChlorpyrifos results in increased expression of MAPK1 proteinPMID:16790487
Mapk1increases phosphorylationISOMAPK1 (Homo sapiens)6480464CTDChlorpyrifos results in increased phosphorylation of MAPK1 proteinPMID:26514924 PMID:28112198
Mapk1multiple interactionsISOMAPK1 (Homo sapiens)6480464CTDRosiglitazone promotes the reaction [Chlorpyrifos results in increased activity of MAPK1 protein]; U 0126 inhibits the reaction [Chlorpyrifos results in increased phosphorylation of MAPK1 protein]PMID:24793810 PMID:28112198
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