GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Mapk1 | increases phosphorylation | EXP | | 6480464 | CTD | Tetrachlorodibenzodioxin results in increased phosphorylation of MAPK1 protein | PMID:30621213 | Mapk1 | multiple interactions | EXP | | 6480464 | CTD | AHR gene mutant form inhibits the reaction [Tetrachlorodibenzodioxin results in decreased phosphorylation of MAPK1 protein]; Tetrachlorodibenzodioxin inhibits the reaction [IGF1 protein results in increased phosphorylation of MAPK1 protein] | PMID:23639626 | Mapk1 | affects expression | ISO | Mapk1 (Mus musculus) | 6480464 | CTD | Tetrachlorodibenzodioxin affects the expression of MAPK1 mRNA | PMID:21570461 | Mapk1 | increases activity | ISO | MAPK1 (Homo sapiens) | 6480464 | CTD | Tetrachlorodibenzodioxin results in increased activity of MAPK1 protein | PMID:16051281 PMID:27117977 | Mapk1 | increases expression | ISO | Mapk1 (Mus musculus) | 6480464 | CTD | Tetrachlorodibenzodioxin results in increased expression of MAPK1 mRNA | PMID:16906519 | Mapk1 | increases phosphorylation | ISO | MAPK1 (Homo sapiens) | 6480464 | CTD | Tetrachlorodibenzodioxin results in increased phosphorylation of MAPK1 protein | PMID:15313166 PMID:19751709 PMID:23228475 PMID:24469321 PMID:26971374 | Mapk1 | increases phosphorylation | ISO | Mapk1 (Mus musculus) | 6480464 | CTD | Tetrachlorodibenzodioxin results in increased phosphorylation of MAPK1 protein | PMID:20181658 PMID:20450880 PMID:25194622 | Mapk1 | multiple interactions | ISO | MAPK1 (Homo sapiens) | 6480464 | CTD | 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of MAPK1 protein]; 3'-methoxy-4'-nitroflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of and results in increased activity of MAPK1 protein]; [AREG protein co-treated with EREG protein co-treated with TGFA protein] affects the reaction [Tetrachlorodibenzodioxin results in increased activity of MAPK1 protein]; [Tetrachlorodibenzodioxin co-treated with Oxygen deficiency] results in increased phosphorylation of MAPK1 protein; alpha-naphthoflavone inhibits the reaction [[Tetrachlorodibenzodioxin co-treated with Oxygen deficiency] results in increased phosphorylation of MAPK1 protein]; batimastat inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of MAPK1 protein]; EGFR protein promotes the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of and results in increased activity of MAPK1 protein]; KN 62 inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of MAPK1 protein]; RTKI cpd inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Tetrachlorodibenzodioxin inhibits the reaction [[CD40LG protein co-treated with IL2 protein co-treated with IL6 protein co-treated with IL10 protein] affects the activity of MAPK1 protein]; Tetrachlorodibenzodioxin results in increased phosphorylation of and results in increased activity of MAPK1 protein; Tetrachlorodibenzodioxin results in increased phosphorylation of and results in increased expression of MAPK1 protein | PMID:11309286 PMID:12668121 PMID:16051281 PMID:17223712 PMID:19578757 PMID:19962423 PMID:21807014 PMID:24469321 PMID:27117977 | Mapk1 | multiple interactions | ISO | Mapk1 (Mus musculus) | 6480464 | CTD | 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of and results in increased activity of MAPK1 protein]; 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of MAPK1 protein]; 3'-methoxy-4'-nitroflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of and results in increased activity of MAPK1 protein]; [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MAPK1 mRNA; Calcium deficiency inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of and results in increased activity of MAPK1 protein]; chelerythrine inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of and results in increased activity of MAPK1 protein]; CSK protein promotes the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of and results in increased activity of MAPK1 protein]; epigallocatechin gallate inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of MAPK1 protein]; MAPK1 protein promotes the reaction [Tetrachlorodibenzodioxin results in decreased expression of PPARG protein]; MAPK1 protein promotes the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]; MAPK1 protein promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein]; naringenin inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of MAPK1 protein]; Tetrachlorodibenzodioxin promotes the reaction [Dimethylnitrosamine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Tetrachlorodibenzodioxin results in increased phosphorylation of and results in increased activity of MAPK1 protein; Tetradecanoylphorbol Acetate promotes the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of and results in increased activity of MAPK1 protein]; TGFA gene mutant form inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of MAPK1 mRNA]; U 0126 inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of and results in increased activity of MAPK1 protein]; U 0126 inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of MAPK1 protein] | PMID:10037446 PMID:12213569 PMID:12758056 PMID:16906519 PMID:17942748 PMID:19555203 PMID:19782052 PMID:20450880 PMID:25194622 PMID:9664232 | | ||||||||||||||||||||||
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