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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70500
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk1
Name: mitogen activated protein kinase 1
Acc ID: CHEBI:17303
Term: morphine
Definition: A morphinane alkaloid that is a highly potent opiate analgesic psychoactive drug. Morphine acts directly on the central nervous system (CNS) to relieve pain but has a high potential for addiction, with tolerance and both physical and psychological dependence developing rapidly. Morphine is the most abundant opiate found in Papaver somniferum (the opium poppy).
Chemical ID: MESH:D009020
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk1increases phosphorylationEXP 6480464CTDMorphine deficiency results in increased phosphorylation of MAPK1 protein; Morphine results in increased phosphorylation of MAPK1 proteinPMID:21600884 PMID:24398105 PMID:32319158
Mapk1multiple interactionsEXP 6480464CTD[CP 154526 binds to and results in decreased activity of CRHR1 protein] inhibits the reaction [Morphine deficiency results in increased phosphorylation of MAPK1 protein]; ARL6IP5 mutant form inhibits the reaction [Morphine results in increased phosphorylation of MAPK1 protein]; bilobalide inhibits the reaction [Oxaliplatin promotes the reaction [Morphine results in increased phosphorylation of MAPK1 protein]]; Oxaliplatin promotes the reaction [Morphine results in increased phosphorylation of MAPK1 protein]PMID:21600884 PMID:24398105 PMID:32319158
Mapk1increases expressionISOMapk1 (Mus musculus)6480464CTDMorphine results in increased expression of MAPK1 protein modified formPMID:20359526
Mapk1increases phosphorylationISOMAPK1 (Homo sapiens)6480464CTDMorphine results in increased phosphorylation of MAPK1 proteinPMID:23965172
Mapk1increases phosphorylationISOMapk1 (Mus musculus)6480464CTDMorphine results in increased phosphorylation of MAPK1 proteinPMID:20519536 PMID:21235400 PMID:27461790 PMID:33609567
Mapk1multiple interactionsISOMAPK1 (Homo sapiens)6480464CTDARL6IP5 mutant form inhibits the reaction [Morphine results in increased phosphorylation of MAPK1 protein]; Morphine results in increased phosphorylation of and results in increased activity of MAPK1 protein; Naloxone promotes the reaction [Morphine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; OPRD1 mutant form inhibits the reaction [Morphine results in increased phosphorylation of MAPK1 protein]PMID:21483469 PMID:21600884
Mapk1multiple interactionsISOMapk1 (Mus musculus)6480464CTD[Morphine co-treated with Dehydroepiandrosterone Sulfate] results in decreased phosphorylation of MAPK1 protein; AM 251 inhibits the reaction [Morphine results in increased phosphorylation of MAPK1 protein]; HINT1 affects the reaction [Morphine promotes the reaction [OPRM1 protein binds to MAPK1 protein]]; MMP9 protein affects the reaction [Morphine results in increased phosphorylation of MAPK1 protein]; Morphine promotes the reaction [OPRM1 protein binds to MAPK1 protein]; suvorexant inhibits the reaction [Morphine results in increased phosphorylation of MAPK1 protein]PMID:15196791 PMID:20519536 PMID:21235400 PMID:27461790 PMID:33609567
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