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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70500
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk1
Name: mitogen activated protein kinase 1
Acc ID: CHEBI:78373
Term: chelerythrine
Definition: A benzophenanthridine alkaloid isolated from the root of Zanthoxylum simulans, Chelidonium majus L., and other Papaveraceae.
Chemical ID: MESH:C016299
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk1multiple interactionsEXP 6480464CTDchelerythrine inhibits the reaction [Estradiol results in increased activity of MAPK1 protein]PMID:16713447
Mapk1multiple interactionsISOMAPK1 (Homo sapiens)6480464CTDchelerythrine inhibits the reaction [CXCL8 protein results in increased phosphorylation of MAPK1 protein]PMID:15831558
Mapk1multiple interactionsISOMapk1 (Mus musculus)6480464CTDchelerythrine inhibits the reaction [evodiamine results in increased phosphorylation of MAPK1 protein]; chelerythrine inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of and results in increased activity of MAPK1 protein]; chelerythrine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of and results in increased activity of MAPK1 protein]; chelerythrine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK1 protein]PMID:10037446 PMID:14511371 PMID:19854188
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