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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70500
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk1
Name: mitogen activated protein kinase 1
Acc ID: CHEBI:44616
Term: afimoxifene
Definition: A tertiary amino compound that is tamoxifen in which the phenyl group which is in a Z- relationship to the ethyl substituent is hydroxylated at the para- position. It is the active metabolite of tamoxifen.
Chemical ID: MESH:C016601
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk1multiple interactionsEXP 6480464CTDafimoxifene inhibits the reaction [[bisphenol A co-treated with Glutamic Acid] results in increased phosphorylation of MAPK1 protein]PMID:30707916
Mapk1decreases response to substanceISOMAPK1 (Homo sapiens)6480464CTDMAPK1 results in decreased susceptibility to afimoxifenePMID:21233418
Mapk1increases phosphorylationISOMAPK1 (Homo sapiens)6480464CTDafimoxifene results in increased phosphorylation of MAPK1 proteinPMID:19549922 PMID:23624423
Mapk1multiple interactionsISOMAPK1 (Homo sapiens)6480464CTD[BRAF protein co-treated with afimoxifene] results in increased phosphorylation of MAPK1 protein; afimoxifene inhibits the reaction [Estradiol results in increased phosphorylation of MAPK1 protein]; afimoxifene inhibits the reaction [Glyphosate results in increased phosphorylation of MAPK1 protein]PMID:25645941 PMID:29890199
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