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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70500
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk1
Name: mitogen activated protein kinase 1
Acc ID: CHEBI:33217
Term: 3,3',5,5'-tetrabromobisphenol A
Definition: A bromobisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups and the phenyl rings are substituted by bromo groups at positions 2, 2', 6 and 6'. It is a brominated flame retardant.
Chemical ID: MESH:C020806
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk1increases phosphorylationEXP 6480464CTDtetrabromobisphenol A results in increased phosphorylation of MAPK1 proteinPMID:17205976
Mapk1multiple interactionsEXP 6480464CTDU 0126 inhibits the reaction [tetrabromobisphenol A results in increased phosphorylation of MAPK1 protein]PMID:17205976
Mapk1decreases expressionISOMAPK1 (Homo sapiens)6480464CTDtetrabromobisphenol A results in decreased expression of MAPK1 proteinPMID:31675489
Mapk1decreases phosphorylationISOMAPK1 (Homo sapiens)6480464CTDtetrabromobisphenol A results in decreased phosphorylation of MAPK1 proteinPMID:17254629
Mapk1increases phosphorylationISOMAPK1 (Homo sapiens)6480464CTDtetrabromobisphenol A results in increased phosphorylation of MAPK1 proteinPMID:15456914 PMID:17254629 PMID:25341744 PMID:30766661
Mapk1multiple interactionsISOMAPK1 (Homo sapiens)6480464CTDAcetylcysteine inhibits the reaction [tetrabromobisphenol A results in increased phosphorylation of MAPK1 protein]; diphenyleneiodonium inhibits the reaction [tetrabromobisphenol A results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [tetrabromobisphenol A results in increased phosphorylation of MAPK1 protein]; Verapamil inhibits the reaction [tetrabromobisphenol A results in increased phosphorylation of MAPK1 protein]PMID:15456914 PMID:17254629 PMID:30766661
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