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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70500
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk1
Name: mitogen activated protein kinase 1
Acc ID: CHEBI:47217
Term: arsane
Definition: An arsine that has formula 77.94542.
Chemical ID: MESH:D001151
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk1multiple interactionsEXP 6480464CTD[sodium arsenite results in increased abundance of Arsenic] which results in increased phosphorylation of MAPK1 protein; Arsenic results in increased phosphorylation of and results in increased activity of MAPK1 protein; O(2)-(2,4-dinitrophenyl) 1-((4-ethoxycarbonyl)piperazin-1-yl)diazen-1-ium-1,2-diolate promotes the reaction [Arsenic results in increased phosphorylation of and results in increased activity of MAPK1 protein]; O(2)-(2,4-dinitrophenyl) 1-(4-(N,N-diethylcarboxamido)piperazin-1-yl)diazen-1-ium 1,2-diolate promotes the reaction [Arsenic results in increased phosphorylation of and results in increased activity of MAPK1 protein]PMID:11756236 PMID:15210857 PMID:35307918
Mapk1affects methylationISOMAPK1 (Homo sapiens)6480464CTDArsenic affects the methylation of MAPK1 genePMID:25304211
Mapk1decreases activityISOMapk1 (Mus musculus)6480464CTDArsenic results in decreased activity of MAPK1 proteinPMID:21784148
Mapk1increases phosphorylationISOMAPK1 (Homo sapiens)6480464CTDArsenic analog results in increased phosphorylation of MAPK1 protein; Arsenic results in increased phosphorylation of MAPK1 proteinPMID:24582688 PMID:25273566
Mapk1multiple interactionsISOMAPK1 (Homo sapiens)6480464CTD[Arsenic results in increased abundance of Reactive Oxygen Species] which results in increased phosphorylation of and results in increased activity of MAPK1 protein; [sodium arsenite results in increased abundance of Arsenic] promotes the reaction [Benzo(a)pyrene results in increased phosphorylation of MAPK1 protein]; [sodium arsenite results in increased abundance of Arsenic] which results in increased phosphorylation of MAPK1 protein; Acetylcysteine inhibits the reaction [Arsenic analog results in increased phosphorylation of MAPK1 protein]; Arsenic results in increased phosphorylation of and results in increased activity of MAPK1 protein; bafilomycin A1 promotes the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased phosphorylation of MAPK1 protein]; Benzo(a)pyrene promotes the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased phosphorylation of MAPK1 protein]; CAT protein inhibits the reaction [[Arsenic results in increased abundance of Reactive Oxygen Species] which results in increased phosphorylation of and results in increased activity of MAPK1 protein]; CXCL8 protein promotes the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased phosphorylation of MAPK1 protein]; diphenyleneiodonium inhibits the reaction [[Arsenic results in increased abundance of Reactive Oxygen Species] which results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Genistein inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased phosphorylation of MAPK1 protein]; Iron promotes the reaction [Arsenic results in increased phosphorylation of and results in increased activity of MAPK1 protein]; KRAS affects the reaction [Arsenic results in increased phosphorylation of MAPK1 protein]; Lapatinib inhibits the reaction [CXCL8 protein promotes the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased phosphorylation of MAPK1 protein]]; reparixin inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased phosphorylation of MAPK1 protein]; SOCS3 protein inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] promotes the reaction [Benzo(a)pyrene results in increased phosphorylation of MAPK1 protein]]; SOCS3 protein inhibits the reaction [Benzo(a)pyrene promotes the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased phosphorylation of MAPK1 protein]]PMID:14633691 PMID:21687637 PMID:23100159 PMID:24582688 PMID:25273566 PMID:32062438 PMID:32645460 PMID:33396024
Mapk1multiple interactionsISOMapk1 (Mus musculus)6480464CTD[[sodium arsenite results in increased abundance of Arsenic] which co-treated with Benzo(a)pyrene] results in increased phosphorylation of MAPK1 protein; [sodium arsenite results in increased abundance of Arsenic] which results in increased phosphorylation of MAPK1 proteinPMID:30889423 PMID:32062438
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