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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70500
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk1
Name: mitogen activated protein kinase 1
Acc ID: CHEBI:49575
Term: diazepam
Definition: A 1,4-benzodiazepinone that is 1,3-dihydro-2H-1,4-benzodiazepin-2-one substituted by a chloro group at position 7, a methyl group at position 1 and a phenyl group at position 5.
Chemical ID: MESH:D003975
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk1multiple interactionsEXP 6480464CTD[asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman results in increased phosphorylation of MAPK1 protein]PMID:21971501
Mapk1increases activityISOMapk1 (Mus musculus)6480464CTDDiazepam results in increased activity of MAPK1 proteinPMID:18585439
Mapk1multiple interactionsISOMapk1 (Mus musculus)6480464CTDPlant Extracts inhibits the reaction [Diazepam results in increased activity of MAPK1 protein]PMID:18585439
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