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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:lidocaine pharmacodynamics pathway
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Accession:PW:0002538 term browser browse the term
Definition:The pathway of lidocaine-target interaction and of the biochemical or physiological responses to drug. Lidocaine is an important class 1b antiarrhythmic drug also used as a local anesthetic. Genetic variations can cause differences in the response of the organism to the drug.
Synonyms:related_synonym: SMP:00328;   SMP:00398


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lidocaine pharmacodynamics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc8 ATP binding cassette subfamily C member 8 ISO SMPDB SMP:00328 NCBI chr 1:105,734,992...105,816,272 JBrowse link
G Abcc9 ATP binding cassette subfamily C member 9 ISO SMPDB SMP:00328 NCBI chr 4:175,531,854...175,655,849 JBrowse link
G Adra1a adrenoceptor alpha 1A ISO SMPDB SMP:00398 NCBI chr15:40,830,125...40,935,902 JBrowse link
G Adrb1 adrenoceptor beta 1 ISO SMPDB SMP:00328 NCBI chr 1:265,777,103...265,780,114 JBrowse link
G Agtr1a angiotensin II receptor, type 1a ISO SMPDB SMP:00328 NCBI chr17:34,173,446...34,226,892 JBrowse link
G Atp1a1 ATPase Na+/K+ transporting subunit alpha 1 ISO SMPDB SMP:00328 SMP:00398 NCBI chr 2:189,020,722...189,048,826 JBrowse link
G Atp1a2 ATPase Na+/K+ transporting subunit alpha 2 ISO SMPDB SMP:00328 SMP:00398 NCBI chr13:84,729,597...84,754,544 JBrowse link
G Atp1a3 ATPase Na+/K+ transporting subunit alpha 3 ISO SMPDB SMP:00328 SMP:00398 NCBI chr 1:80,572,790...80,601,936 JBrowse link
G Atp1a4 ATPase Na+/K+ transporting subunit alpha 4 ISO SMPDB SMP:00328 SMP:00398 NCBI chr13:84,683,766...84,719,790 JBrowse link
G Atp1b1 ATPase Na+/K+ transporting subunit beta 1 ISO SMPDB SMP:00328 SMP:00398 NCBI chr13:76,786,580...76,807,096 JBrowse link
G Atp1b2 ATPase Na+/K+ transporting subunit beta 2 ISO SMPDB SMP:00328 SMP:00398 NCBI chr10:54,318,698...54,324,933 JBrowse link
G Atp1b3 ATPase Na+/K+ transporting subunit beta 3 ISO SMPDB SMP:00328 SMP:00398 NCBI chr 8:96,910,265...96,941,592 JBrowse link
G Atp1b4 ATPase Na+/K+ transporting family member beta 4 ISO SMPDB SMP:00328 SMP:00398 NCBI chr  X:117,087,284...117,108,023 JBrowse link
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 ISO SMPDB SMP:00328 NCBI chr12:34,072,710...34,122,142 JBrowse link
G Cacna1a calcium voltage-gated channel subunit alpha1 A ISO SMPDB SMP:00398 NCBI chr19:40,425,560...40,724,810 JBrowse link
G Cacna1c calcium voltage-gated channel subunit alpha1 C ISO SMPDB SMP:00328 NCBI chr 4:153,431,169...154,051,932 JBrowse link
G Cacna1g calcium voltage-gated channel subunit alpha1 G ISO SMPDB SMP:00328 NCBI chr10:79,354,998...79,422,960 JBrowse link
G Cacna1h calcium voltage-gated channel subunit alpha1 H ISO SMPDB SMP:00328 NCBI chr10:14,390,104...14,448,204 JBrowse link
G Cacna2d2 calcium voltage-gated channel auxiliary subunit alpha2delta 2 ISO SMPDB SMP:00328 SMP:00398 NCBI chr 8:108,072,208...108,203,516 JBrowse link
G Cacnb1 calcium voltage-gated channel auxiliary subunit beta 1 ISO SMPDB SMP:00328 SMP:00398 NCBI chr10:82,998,182...83,018,838 JBrowse link
G Calm1 calmodulin 1 ISO SMPDB SMP:00328 NCBI chr 6:119,487,691...119,495,759 JBrowse link
G Chrm2 cholinergic receptor, muscarinic 2 ISO SMPDB SMP:00328 NCBI chr 4:65,981,136...66,116,128 JBrowse link
G Chrna4 cholinergic receptor nicotinic alpha 4 subunit ISO SMPDB SMP:00398 NCBI chr 3:188,506,802...188,535,558 JBrowse link
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit ISO SMPDB SMP:00398 NCBI chr 2:177,479,091...177,487,306 JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 ISO SMPDB SMP:00328 SMP:00398 NCBI chr 8:58,075,367...58,082,255 JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 ISO SMPDB SMP:00328 SMP:00398 NCBI chr12:9,207,978...9,230,064 JBrowse link
G Dlg1 discs large MAGUK scaffold protein 1 ISO SMPDB SMP:00328 NCBI chr11:68,911,883...69,103,230 JBrowse link
G Drd1 dopamine receptor D1 ISO SMPDB SMP:00398 NCBI chr17:10,545,488...10,550,029 JBrowse link
G Fxyd2 FXYD domain-containing ion transport regulator 2 ISO SMPDB SMP:00328 SMP:00398 NCBI chr 8:45,712,901...45,720,032 JBrowse link
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 ISO SMPDB SMP:00398 NCBI chr 3:28,501,836...28,528,754 JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A ISO SMPDB SMP:00398 NCBI chr10:6,136,458...6,560,003 JBrowse link
G Grin3a glutamate ionotropic receptor NMDA type subunit 3A ISO SMPDB SMP:00398 NCBI chr 5:68,802,333...69,001,880 JBrowse link
G Hcn4 hyperpolarization activated cyclic nucleotide-gated potassium channel 4 ISO SMPDB SMP:00328 NCBI chr 8:59,222,206...59,259,626 JBrowse link
G Htr1a 5-hydroxytryptamine receptor 1A ISO SMPDB SMP:00398 NCBI chr 2:38,427,169...38,431,733 JBrowse link
G Itpr1 inositol 1,4,5-trisphosphate receptor, type 1 ISO SMPDB SMP:00328 NCBI chr 4:141,187,377...141,554,240 JBrowse link
G Kcna5 potassium voltage-gated channel subfamily A member 5 ISO SMPDB SMP:00328 NCBI chr 4:159,354,689...159,358,173 JBrowse link
G Kcnd2 potassium voltage-gated channel subfamily D member 2 ISO SMPDB SMP:00398 NCBI chr 4:49,775,812...50,277,746 JBrowse link
G Kcnd3 potassium voltage-gated channel subfamily D member 3 ISO SMPDB SMP:00328 NCBI chr 2:192,937,950...193,155,345 JBrowse link
G Kcne1 potassium voltage-gated channel subfamily E regulatory subunit 1 ISO SMPDB SMP:00328 NCBI chr11:31,580,951...31,594,116 JBrowse link
G Kcne2 potassium voltage-gated channel subfamily E regulatory subunit 2 ISO SMPDB SMP:00328 NCBI chr11:31,517,176...31,530,026 JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 ISO SMPDB SMP:00328 NCBI chr 4:10,826,834...10,859,009 JBrowse link
G Kcnip2 potassium voltage-gated channel interacting protein 2 ISO SMPDB SMP:00328 SMP:00398 NCBI chr 1:244,641,147...244,664,939 JBrowse link
G Kcnj11 potassium inwardly-rectifying channel, subfamily J, member 11 ISO SMPDB SMP:00328 NCBI chr 1:105,727,473...105,731,167 JBrowse link
G Kcnj2 potassium inwardly-rectifying channel, subfamily J, member 2 ISO SMPDB SMP:00328 NCBI chr10:96,060,834...96,071,397 JBrowse link
G Kcnj3 potassium inwardly-rectifying channel, subfamily J, member 3 ISO SMPDB SMP:00328 NCBI chr 3:39,944,896...40,106,646 JBrowse link
G Kcnj4 potassium inwardly-rectifying channel, subfamily J, member 4 ISO SMPDB SMP:00328 NCBI chr 7:111,047,097...111,074,151 JBrowse link
G Kcnj5 potassium inwardly-rectifying channel, subfamily J, member 5 ISO SMPDB SMP:00328 NCBI chr 8:30,724,923...30,753,083 JBrowse link
G Kcnj8 potassium inwardly-rectifying channel, subfamily J, member 8 ISO SMPDB SMP:00328 NCBI chr 4:175,508,908...175,515,829 JBrowse link
G Kcnk1 potassium two pore domain channel subfamily K member 1 ISO SMPDB SMP:00328 NCBI chr19:53,959,411...53,997,726 JBrowse link
G Kcnq1 potassium voltage-gated channel subfamily Q member 1 ISO SMPDB SMP:00328 NCBI chr 1:198,291,711...198,624,683 JBrowse link
G Mylk myosin light chain kinase ISO SMPDB SMP:00328 NCBI chr11:65,783,008...66,030,239 JBrowse link
G Oprm1 opioid receptor, mu 1 ISO SMPDB SMP:00398 NCBI chr 1:43,160,057...43,413,409 JBrowse link
G Pcsk2 proprotein convertase subtilisin/kexin type 2 ISO SMPDB SMP:00398 NCBI chr 3:130,880,422...131,183,127 JBrowse link
G Plcb1 phospholipase C beta 1 ISO SMPDB SMP:00328 NCBI chr 3:122,059,988...122,772,896 JBrowse link
G Pln phospholamban ISO SMPDB SMP:00328 NCBI chr20:32,629,537...32,639,559 JBrowse link
G Pomc proopiomelanocortin ISO SMPDB SMP:00398 NCBI chr 6:32,659,137...32,665,175 JBrowse link
G Prkaca protein kinase cAMP-activated catalytic subunit alpha ISO SMPDB SMP:00328 NCBI chr19:24,155,081...24,178,430 JBrowse link
G Prkar1a protein kinase cAMP-dependent type I regulatory subunit alpha ISO SMPDB SMP:00328 NCBI chr10:94,621,042...94,639,534 JBrowse link
G Ryr2 ryanodine receptor 2 ISO SMPDB SMP:00328 NCBI chr17:58,389,925...58,975,641 JBrowse link
G Scn10a sodium voltage-gated channel alpha subunit 10 ISO SMPDB SMP:00398 NCBI chr 8:119,350,723...119,462,882 JBrowse link
G Scn1b sodium voltage-gated channel beta subunit 1 ISO SMPDB SMP:00398 NCBI chr 1:86,353,917...86,363,820 JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 ISO SMPDB SMP:00328 NCBI chr 8:119,220,905...119,318,816 JBrowse link
G Slc6a2 solute carrier family 6 member 2 ISO SMPDB SMP:00398 NCBI chr19:14,010,292...14,055,317 JBrowse link
G Slc6a3 solute carrier family 6 member 3 ISO SMPDB SMP:00398 NCBI chr 1:29,709,443...29,750,413 JBrowse link
G Slc6a4 solute carrier family 6 member 4 ISO SMPDB SMP:00398 NCBI chr10:62,322,688...62,357,060 JBrowse link
G Slc8a1 solute carrier family 8 member A1 ISO SMPDB SMP:00328 NCBI chr 6:13,194,609...13,547,369 JBrowse link
G Snta1 syntrophin, alpha 1 ISO SMPDB SMP:00328 NCBI chr 3:142,876,285...142,906,737 JBrowse link
G Sntb1 syntrophin, beta 1 ISO SMPDB SMP:00328 NCBI chr 7:87,060,926...87,329,315 JBrowse link
G Sntb2 syntrophin, beta 2 ISO SMPDB SMP:00328 NCBI chr19:34,831,657...34,922,325 JBrowse link
G Tnnc1 troponin C1, slow skeletal and cardiac type ISO SMPDB SMP:00328 NCBI chr16:6,400,801...6,405,634 JBrowse link
G Tnnc2 troponin C2, fast skeletal type ISO SMPDB SMP:00328 NCBI chr 3:153,513,272...153,516,033 JBrowse link
G Tnni1 troponin I1, slow skeletal type ISO SMPDB SMP:00328 NCBI chr13:47,229,217...47,241,640 JBrowse link
G Tnni2 troponin I2, fast skeletal type ISO SMPDB SMP:00328 NCBI chr 1:197,595,012...197,597,554 JBrowse link
G Tnni3 troponin I3, cardiac type ISO SMPDB SMP:00328 NCBI chr 1:69,299,900...69,303,582 JBrowse link
G Tnnt1 troponin T1, slow skeletal type ISO SMPDB SMP:00328 NCBI chr 1:69,306,362...69,316,721 JBrowse link
G Tnnt2 troponin T2, cardiac type ISO SMPDB SMP:00328 NCBI chr13:47,267,325...47,285,390 JBrowse link
G Tnnt3 troponin T3, fast skeletal type ISO SMPDB SMP:00328 NCBI chr 1:197,652,535...197,669,736 JBrowse link
G Tpm1 tropomyosin 1 ISO SMPDB SMP:00328 NCBI chr 8:67,635,479...67,662,330 JBrowse link
G Tpm2 tropomyosin 2 ISO SMPDB SMP:00328 NCBI chr 5:57,770,919...57,780,278 JBrowse link
Term paths to the root
Path 1
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  pathway 6091
    drug pathway 397
      cardiovascular system drug pathway 184
        antiarrhythmic drug pathway 98
          lidocaine drug pathway 79
            lidocaine pharmacodynamics pathway 79
paths to the root