Tnnc2 (troponin C2, fast skeletal type)

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Gene: Tnnc2 (troponin C2, fast skeletal type) Rattus norvegicus

Analyze

Symbol:

Tnnc2

Name:

troponin C2, fast skeletal type

RGD ID:

1311973

Description:

Predicted to enable actin filament binding activity; calcium ion binding activity; and calcium-dependent protein binding activity. Predicted to contribute to actin binding activity. Predicted to be involved in regulation of muscle contraction and skeletal muscle contraction. Predicted to be part of troponin complex. Orthologous to human TNNC2 (troponin C2, fast skeletal type); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

LOC296369; skeletal troponin C; troponin C type 2 (fast); troponin C, skeletal muscle; troponin C2, fast

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	TNNC2 (troponin C2, fast skeletal type)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Tnnc2 (troponin C2, fast)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Tnnc2 (troponin C2, fast skeletal type)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	TNNC2 (troponin C2, fast skeletal type)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	TNNC2 (troponin C2, fast skeletal type)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Tnnc2 (troponin C2, fast skeletal type)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	TNNC2 (troponin C2, fast skeletal type)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	TNNC2 (troponin C2, fast skeletal type)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	TNNC2 (troponin C2, fast skeletal type)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Tnnc2 (troponin C2, fast)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	si:rp71-17i16.4	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	tnnc2 (troponin C type 2 (fast))	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	F43C9.2	Alliance	DIOPT (OrthoFinder\|PhylomeDB)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	3	153,513,272 - 153,516,033 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	153,513,271 - 153,516,029 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	157,321,952 - 157,324,670 (-)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	3	165,820,922 - 165,823,640 (-)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	3	163,564,699 - 163,567,417 (-)	NCBI	Rnor_WKY
Rnor_6.0	3	161,243,607 - 161,246,335 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	161,243,587 - 161,246,351 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	167,429,345 - 167,430,429 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	155,807,133 - 155,808,219 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	155,713,032 - 155,715,733 (-)	NCBI
Celera	3	152,121,028 - 152,123,756 (-)	NCBI		Celera
Cytogenetic Map	3	q42	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

visual epilepsy (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

17alpha-ethynylestradiol (ISO)

17beta-estradiol (EXP,ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,3,7,8-Tetrachlorodibenzofuran (EXP)

2-hydroxypropanoic acid (ISO)

3,3',5,5'-tetrabromobisphenol A (EXP)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4,4'-sulfonyldiphenol (ISO)

6-propyl-2-thiouracil (EXP)

acetamide (EXP)

acrylamide (EXP)

aristolochic acid A (ISO)

arsane (ISO)

arsenic atom (ISO)

benzo[a]pyrene (ISO)

benzo[e]pyrene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

bromobenzene (EXP)

carbamazepine (ISO)

carbon nanotube (ISO)

chlordecone (ISO)

chrysene (ISO)

cisplatin (ISO)

copper atom (EXP)

copper(0) (EXP)

copper(II) sulfate (ISO)

Cuprizon (EXP)

dexamethasone (ISO)

dextran sulfate (ISO)

diuron (EXP)

dorsomorphin (ISO)

entinostat (ISO)

genistein (ISO)

glycidol (EXP)

graphite (ISO)

indometacin (ISO)

ketamine (EXP)

Licochalcone B (ISO)

methapyrilene (ISO)

methylmercury chloride (ISO)

phenobarbital (ISO)

PhIP (EXP)

pioglitazone (ISO)

progesterone (ISO)

propanal (ISO)

rac-lactic acid (ISO)

resveratrol (ISO)

SB 431542 (ISO)

sodium arsenate (ISO)

Soman (EXP)

spermine (ISO)

tetrachloromethane (EXP)

thioacetamide (EXP)

titanium dioxide (ISO)

triazines (ISO)

triclosan (ISO)

triptonide (ISO)

tunicamycin (ISO)

urethane (ISO)

valproic acid (EXP,ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

regulation of muscle contraction (IBA)

skeletal muscle contraction (IBA,ISO)

Cellular Component

troponin complex (IBA,ISO)

Molecular Function

actin binding (ISO)

actin filament binding (IBA)

calcium ion binding (IBA)

calcium-dependent protein binding (IBA)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

acebutolol pharmacodynamics pathway (ISO)

adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway (ISO)

amiodarone pharmacodynamics pathway (ISO)

amlodipine pharmacodynamics pathway (ISO)

atenolol pharmacodynamics pathway (ISO)

betaxolol pharmacodynamics pathway (ISO)

bisoprolol pharmacodynamics pathway (ISO)

bupranolol drug pathway (ISO)

bupranolol pharmacodynamics pathway (ISO)

calcium/calcium-mediated signaling pathway (IEA,ISO)

carvedilol pharmacodynamics pathway (ISO)

diltiazem pharmacodynamics pathway (ISO)

disopyramide pharmacodynamics pathway (ISO)

dobutamine pharmacodynamics pathway (ISO)

esmolol pharmacodynamics pathway (ISO)

flecainde pharmacodynamics pathway (ISO)

fosphenytoin pharmacodynamics pathway (ISO)

ibutilide pharmacodynamics pathway (ISO)

isoprenaline pharmacodynamics pathway (ISO)

isradipine pharmacodynamics pathway (ISO)

levobunolol pharmacodynamics pathway (ISO)

lidocaine pharmacodynamics pathway (ISO)

metoprolol pharmacodynamics pathway (ISO)

mexiletine pharmacodynamics pathway (ISO)

nadolol pharmacodynamics pathway (ISO)

nebivolol pharmacodynamics pathway (ISO)

nifedipine pharmacodynamics pathway (ISO)

nimodipine pharmacodynamics pathway (ISO)

nisoldipine pharmacodynamics pathway (ISO)

nitrendipine pharmacodynamics pathway (ISO)

penbutolol pharmacodynamics pathway (ISO)

phenytoin pharmacodynamics pathway (ISO)

pindolol pharmacodynamics pathway (ISO)

procainamide pharmacodynamics pathway (ISO)

propranolol pharmacodynamics pathway (ISO)

quinidine pharmacodynamics pathway (ISO)

sotalol pharmacodynamics pathway (ISO)

timolol pharmacodynamics pathway (ISO)

verapamil pharmacodynamics pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
4.	SMPDB Annotation Import Pipeline	Pipeline to import SMPDB annotations from SMPDB into RGD
5.	GOA pipeline	RGD automated data pipeline
6.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
7.	Calcium, troponin, calmodulin, S100 proteins: from myocardial basics to new therapeutic strategies.	Schaub MC and Heizmann CW, Biochem Biophys Res Commun. 2008 Apr 25;369(1):247-64. Epub 2007 Oct 25.

Additional References at PubMed

PMID:6179945	PMID:16839517	PMID:17194691	PMID:19182904

Genomics

Comparative Map Data

Tnnc2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	3	153,513,272 - 153,516,033 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	153,513,271 - 153,516,029 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	157,321,952 - 157,324,670 (-)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	3	165,820,922 - 165,823,640 (-)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	3	163,564,699 - 163,567,417 (-)	NCBI	Rnor_WKY
Rnor_6.0	3	161,243,607 - 161,246,335 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	161,243,587 - 161,246,351 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	167,429,345 - 167,430,429 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	155,807,133 - 155,808,219 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	155,713,032 - 155,715,733 (-)	NCBI
Celera	3	152,121,028 - 152,123,756 (-)	NCBI		Celera
Cytogenetic Map	3	q42	NCBI

TNNC2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	20	45,823,214 - 45,833,306 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	20	45,823,214 - 45,833,745 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	20	44,451,853 - 44,455,951 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	20	43,885,260 - 43,889,360 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	20	43,885,263 - 43,889,360	NCBI
Celera	20	41,162,347 - 41,166,448 (-)	NCBI		Celera
Cytogenetic Map	20	q13.12	NCBI
HuRef	20	41,193,614 - 41,197,713 (-)	NCBI		HuRef
CHM1_1	20	44,354,991 - 44,359,091 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	20	47,559,705 - 47,563,804 (-)	NCBI		T2T-CHM13v2.0

Tnnc2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	164,619,081 - 164,621,654 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	164,619,081 - 164,621,887 (-)	Ensembl		GRCm39 Ensembl
GRCm38	2	164,777,161 - 164,779,734 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	164,777,161 - 164,779,967 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	164,602,661 - 164,605,234 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	164,468,366 - 164,470,939 (-)	NCBI		MGSCv36	mm8
Celera	2	170,714,468 - 170,717,041 (-)	NCBI		Celera
Cytogenetic Map	2	H3	NCBI

Tnnc2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955445	11,466,579 - 11,469,123 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955445	11,466,579 - 11,469,123 (+)	NCBI	ChiLan1.0	ChiLan1.0

TNNC2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	20	43,249,725 - 43,260,984 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	20	43,249,725 - 43,254,134 (-)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	20	42,162,502 - 42,172,829 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3

TNNC2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	24	33,136,644 - 33,139,289 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	24	33,128,290 - 33,163,050 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	24	32,663,877 - 32,666,541 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	24	33,847,135 - 33,849,798 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	24	33,847,144 - 33,849,791 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	24	33,105,691 - 33,108,351 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	24	33,220,760 - 33,223,430 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	24	33,759,900 - 33,762,559 (-)	NCBI		UU_Cfam_GSD_1.0

Tnnc2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	191,742,934 - 191,745,960 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936514	7,196,536 - 7,199,649 (+)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936514	7,196,576 - 7,199,603 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TNNC2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	17	48,024,687 - 48,028,651 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	17	48,025,621 - 48,026,762 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	17	53,671,689 - 53,672,831 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

TNNC2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	2	18,051,708 - 18,063,108 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	2	18,061,492 - 18,062,971 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666050	66,691,630 - 66,703,067 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Variants

Variants in Tnnc2
3 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	81
Count of miRNA genes:	72
Interacting mature miRNAs:	74
Transcripts:	ENSRNOT00000020348
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
70216	Cm14	Cardiac mass QTL 14	2.1		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	3	31172320	163586636	Rat
2301970	Bw81	Body weight QTL 81	5.19		body mass (VT:0001259)	body weight (CMO:0000012)	3	41874578	155617519	Rat
2301971	Cm71	Cardiac mass QTL 71	4.63		heart left ventricle mass (VT:0007031)	heart left ventricle weight (CMO:0000776)	3	41874578	155617519	Rat
1559282	Emca5	Estrogen-induced mammary cancer QTL 5	3.9		mammary gland integrity trait (VT:0010552)	percentage of study population developing mammary tumors during a period of time (CMO:0000948)	3	43827364	169034231	Rat
1581568	Rf53	Renal function QTL 53			urine total protein amount (VT:0000032)	urine protein excretion rate to body weight ratio (CMO:0001099)	3	56395968	161299569	Rat
8662816	Vetf4	Vascular elastic tissue fragility QTL 4	4		renal artery integrity trait (VT:0010642)	number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)	3	59242096	157323038	Rat
631841	Niddm39	Non-insulin dependent diabetes mellitus QTL 39	3.36		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	3	94856903	159898684	Rat
2312659	Slep7	Serum leptin concentration QTL 7		0.001	blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	3	98535255	168026850	Rat
2312670	Bw94	Body weight QTL 94		0.01	inguinal fat pad mass (VT:0010424)	inguinal fat pad weight to body weight ratio (CMO:0001253)	3	98535255	168026850	Rat
2312673	Scl63	Serum cholesterol level QTL 63		0.001	blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	3	98535255	168026850	Rat
2302373	Gluco39	Glucose level QTL 39	5.01		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	3	98535386	161695835	Rat
1578754	Stresp16	Stress response QTL 16	4	0.001	blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	3	112681431	157681431	Rat
1576306	Schws3	Schwannoma susceptibility QTL 3		0.001	nervous system integrity trait (VT:0010566)	percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)	3	118839124	163839124	Rat
1598877	Bp285	Blood pressure QTL 285	1.5	0.03	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	120538241	165538241	Rat
1300159	Kidm4	Kidney mass QTL 4	3.83		kidney mass (VT:0002707)	right kidney wet weight to body weight ratio (CMO:0001953)	3	121056165	157309487	Rat
10755461	Coatc16	Coat color QTL 16			coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	3	122438700	167438700	Rat
631541	Bp81	Blood pressure QTL 81	4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	124122556	169034231	Rat
2303620	Vencon4	Ventilatory control QTL 4	3.9		respiration trait (VT:0001943)	tidal volume (CMO:0000222)	3	127162703	168026850	Rat
631673	Iddm13	Insulin dependent diabetes mellitus QTL 13	1.3	0.663	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	3	130193298	161695983	Rat
1578656	Vnigr2	Vascular neointimal growth QTL 2	4.2		artery morphology trait (VT:0002191)	lesioned artery residual lumen area (CMO:0001417)	3	130656562	169034231	Rat
1578653	Vnigr3	Vascular neointimal growth QTL 3	3.1		artery morphology trait (VT:0002191)	artery neointimal hyperplastic lesion area (CMO:0001414)	3	130656562	169034231	Rat
9589106	Insul23	Insulin level QTL 23	13.86	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	3	131635904	169034231	Rat
2298477	Eau4	Experimental allergic uveoretinitis QTL 4		0.0011	uvea integrity trait (VT:0010551)	experimental autoimmune uveitis score (CMO:0001504)	3	137398739	169034231	Rat
8552952	Pigfal13	Plasma insulin-like growth factor 1 level QTL 13			blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	3	138799500	169034231	Rat
1298068	Bp167	Blood pressure QTL 167		0.004	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	141074471	169034231	Rat
1331726	Bp208	Blood pressure QTL 208	3.129		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	141339013	162184794	Rat
61335	Bp20	Blood pressure QTL 20	3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	141339236	155617360	Rat
2317883	Alcrsp26	Alcohol response QTL 26	1.8	0.63	response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	3	145526770	169034231	Rat
12879871	Am7	Aortic mass QTL 7		0.001	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	3	145925360	166177555	Rat
12879872	Cm97	Cardiac mass QTL 97		0.001	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	3	145925360	166177555	Rat
12879873	Cm96	Cardiac mass QTL 96		0.001	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	3	145925360	166177555	Rat
12879874	Cm98	Cardiac mass QTL 98		0.005	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	3	145925360	166177555	Rat
12879875	Kidm64	Kidney mass QTL 64		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	3	145925360	166177555	Rat
12879876	Bw182	Body weight QTL 182		0.003	body mass (VT:0001259)	body weight (CMO:0000012)	3	145925360	166177555	Rat
2301411	Bp320	Blood pressure QTL 320		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	145925360	166177555	Rat
1300113	Bp176	Blood pressure QTL 176	3.9		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	145956084	157309487	Rat
1598854	Memor10	Memory QTL 10	2		exploratory behavior trait (VT:0010471)	average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)	3	145956084	161299569	Rat
8552791	Vie2	Viral induced encephalitis QTL 2	4.1		brain integrity trait (VT:0010579)	encephalitis incidence/prevalence measurement (CMO:0002361)	3	145956084	169034231	Rat
1578666	Vnigr1	Vascular neointimal growth QTL 1	4.6		artery morphology trait (VT:0002191)	artery lumen area (CMO:0001409)	3	149040888	168026850	Rat

Markers in Region

Tncs

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	153,513,814 - 153,514,468 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	161,244,150 - 161,244,803	NCBI	Rnor6.0
Rnor_5.0	3	167,429,748 - 167,430,401	UniSTS	Rnor5.0
RGSC_v3.4	3	155,807,536 - 155,808,189	UniSTS	RGSC3.4
Celera	3	152,121,571 - 152,122,224	UniSTS
Cytogenetic Map	3	q42	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High							8	11					8
Medium		1	9	6	3	6			13		13	7
Low	3	24	34	21	16	21			34	32	25	4
Below cutoff		18	14	14		14			25	3	3

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001037351	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_005501830	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC105815	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474005	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	DQ273679	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ215069	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ216531	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ216856	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ216869	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ216875	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ216940	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ216956	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ217047	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ217054	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ217106	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ217137	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ217169	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ217172	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ217195	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ217236	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ217299	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ217371	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ217378	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ217706	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ217788	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ217811	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ217840	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ217842	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ217896	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ217902	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ217974	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ217984	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ218010	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ218048	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ218061	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ223543	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ223572	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ223583	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ223607	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ223623	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ223636	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ223643	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ223690	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ223692	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ223711	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ223713	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ223719	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ223773	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ223816	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ223825	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ223832	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ223835	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ223976	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ223986	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ224079	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ224114	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ224128	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ224223	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ224258	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ224340	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ224376	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ224378	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ224387	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ224450	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ224462	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ224501	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ224599	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ224648	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ224672	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ224735	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ224749	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ224755	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ224795	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ224811	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ224822	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ224827	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	J00793	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000120	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000020348 ⟹ ENSRNOP00000020348

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	3	153,513,276 - 153,516,029 (-)	Ensembl
Rnor_6.0 Ensembl	3	161,243,587 - 161,246,351 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000098001 ⟹ ENSRNOP00000084039

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	3	153,513,271 - 153,514,652 (-)	Ensembl

RefSeq Acc Id:

NM_001037351 ⟹ NP_001032428

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	3	153,513,272 - 153,516,000 (-)	NCBI
Rnor_6.0	3	161,243,607 - 161,246,335 (-)	NCBI
Rnor_5.0	3	167,429,345 - 167,430,429 (-)	NCBI
RGSC_v3.4	3	155,807,133 - 155,808,219 (-)	RGD
Celera	3	152,121,028 - 152,123,756 (-)	NCBI

Sequence:

show sequence

AAATCCTGAAGGCTAGAGAGATCTGGGGCACCTTTGGGTGGTGGAGTGCGGAGGAGAGGACCCA
CAGCAGAGGAGTCCCAGTCACCAGCAACCATGACGGACCAACAGGCTGAGGCCAGGTCCTACCT
CAGCGAGGAGATGATCGCTGAGTTCAAGGCTGCCTTTGACATGTTTGATGCTGATGGTGGTGGG
GACATCAGCGTTAAAGAGCTGGGTACCGTGATGAGGATGCTAGGGCAGACACCCACCAAAGAGG
AACTGGACGCCATCATCGAGGAGGTGGACGAGGATGGCAGCGGTACCATCGACTTTGAAGAGTT
CTTGGTCATGATGGTGCGCCAGATGAAAGAGGATGCGAAAGGGAAGAGCGAAGAGGAACTGGCT
GAGTGTTTCCGCATCTTTGACAGGAACGCAGACGGTTACATTGATGCCGAGGAGCTGGCTGAGA
TTTTCCGGGCTTCTGGGGAGCATGTGACAGACGAGGAGATCGAATCCCTGATGAAGGATGGTGA
TAAGAACAACGATGGCCGCATTGACTTCGACGAGTTTCTGAAGATGATGGAGGGCGTTCAGTAA
GGAGCTGGTCTTCGTGTTCATCCAGACTGCAGGTCCCCTGGGCGTGGGCAACTCCATCCTTGCC
TCCTTGCCCTACCAGGGAAAGGCTGCTCCTTTGGGCTCTGTGGCTGGAAGGAATAAAAGCAGAC
AATGTAAAGCTGAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XR_005501830

RefSeq Status:

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	3	153,513,272 - 153,516,033 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001032428	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	ABB51540	(Get FASTA)	NCBI Sequence Viewer
	EDL96496	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:	NP_001032428 ⟸ NM_001037351
- UniProtKB:	Q304F3 (UniProtKB/TrEMBL), F2Z3S8 (UniProtKB/TrEMBL)
- Sequence:	show sequence MTDQQAEARSYLSEEMIAEFKAAFDMFDADGGGDISVKELGTVMRMLGQTPTKEELDAIIEEVD EDGSGTIDFEEFLVMMVRQMKEDAKGKSEEELAECFRIFDRNADGYIDAEELAEIFRASGEHVT DEEIESLMKDGDKNNDGRIDFDEFLKMMEGVQ hide sequence

RefSeq Acc Id:

ENSRNOP00000020348 ⟸ ENSRNOT00000020348

RefSeq Acc Id:

ENSRNOP00000084039 ⟸ ENSRNOT00000098001

Protein Domains

EF-hand

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q304F3-F1-model_v2	AlphaFold	Q304F3	1-160	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13692665

Promoter ID:

EPDNEW_R3189

Type:

multiple initiation site

Name:

Tnnc2_1

Description:

troponin C2, fast skeletal type

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	3	161,246,306 - 161,246,366	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1311973	AgrOrtholog
BioCyc Gene	G2FUF-46829	BioCyc
Ensembl Genes	ENSRNOG00000015155	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000020348	ENTREZGENE
	ENSRNOP00000020348.5	UniProtKB/TrEMBL
	ENSRNOP00000084039.1	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000020348	ENTREZGENE
	ENSRNOT00000020348.7	UniProtKB/TrEMBL
	ENSRNOT00000098001.1	UniProtKB/TrEMBL
InterPro	EF-hand-like_dom	UniProtKB/TrEMBL
	EF_Hand_1_Ca_BS	UniProtKB/TrEMBL
	EF_hand_Ca-bd	UniProtKB/TrEMBL
KEGG Report	rno:296369	UniProtKB/TrEMBL
NCBI Gene	296369	ENTREZGENE
Pfam	EF_hand_5	UniProtKB/TrEMBL
PhenoGen	Tnnc2	PhenoGen
PROSITE	EF_HAND_1	UniProtKB/TrEMBL
	EF_HAND_2	UniProtKB/TrEMBL
SMART	EFh	UniProtKB/TrEMBL
Superfamily-SCOP	SSF47473	UniProtKB/TrEMBL
UniProt	F2Z3S8	ENTREZGENE
	Q304F3	ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary	F2Z3S8	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-02-24	Tnnc2	troponin C2, fast skeletal type	Tnnc2	troponin C type 2 (fast)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-10-23	Tnnc2	troponin C type 2 (fast)	Tnnc2	troponin C2, fast	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-03-07	Tnnc2	troponin C2, fast	Tnnc2	troponin C type 2 (fast)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-03-30	Tnnc2	troponin C type 2 (fast)		troponin C2, fast	Name updated	1299863	APPROVED
2005-12-06	Tnnc2	troponin C2, fast	Tnnc2_predicted	troponin C2, fast (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-12	Tnnc2_predicted	troponin C2, fast (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

RGD Manual Annotations

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

RGD Manual Annotations

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)