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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:E-cadherin signaling pathway
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Accession:PW:0000992 term browser browse the term
Definition:E-cadherin or the epithelial cadherin encoded by the Cdh1 gene, is a member of the classical cadherin family and among the best studied cadherin pathway. Deregulation of the pathway has been associated with several forms of cancer.
Synonyms:related_synonym: Cdh1 signaling pathway;   PID:200124;   PID:200147;   PID:200182


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E-cadherin signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abi1 abl-interactor 1 ISO PID PID:200124 PID:200182 NCBI chr17:85,098,837...85,179,829
Ensembl chr17:85,098,550...85,179,792 		JBrowse link
G Actn1 actinin, alpha 1 ISO PID PID:200182 NCBI chr 6:98,998,553...99,093,334
Ensembl chr 6:98,998,556...99,093,251 		JBrowse link
G Ajuba ajuba LIM protein ISO PID PID:200147 NCBI chr15:28,019,775...28,031,537
Ensembl chr15:28,019,778...28,030,021 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 ISO PID PID:200124 PID:200147 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Akt2 AKT serine/threonine kinase 2 ISO PID PID:200147 NCBI chr 1:82,877,228...82,933,828
Ensembl chr 1:82,883,547...82,933,817 		JBrowse link
G Ap1m1 adaptor related protein complex 1 subunit mu 1 ISO PID PID:200124 NCBI chr16:17,586,886...17,602,410
Ensembl chr16:17,584,730...17,602,403 		JBrowse link
G Aqp3 aquaporin 3 (Gill blood group) ISO PID PID:200182 NCBI chr 5:56,239,200...56,244,718
Ensembl chr 5:56,239,201...56,244,720 		JBrowse link
G Aqp5 aquaporin 5 ISO PID PID:200182 NCBI chr 7:130,722,675...130,726,207
Ensembl chr 7:130,721,748...130,726,209 		JBrowse link
G Arf6 ADP-ribosylation factor 6 ISO PID PID:200124 PID:200182 NCBI chr 6:87,853,742...87,854,890
Ensembl chr 6:87,840,142...87,874,114 		JBrowse link
G Camsap3 calmodulin regulated spectrin-associated protein family, member 3 ISO PID PID:200182 NCBI chr12:1,643,062...1,666,685
Ensembl chr12:1,643,251...1,666,685 		JBrowse link
G Casr calcium-sensing receptor ISO PID PID:200147 NCBI chr11:64,235,251...64,304,811
Ensembl chr11:64,235,251...64,304,811 		JBrowse link
G Ccnd1 cyclin D1 ISO PID PID:200124 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Cdc42 cell division cycle 42 ISO PID PID:200124 NCBI chr 5:149,555,069...149,593,239
Ensembl chr 5:149,553,724...149,593,111 		JBrowse link
G Cdh1 cadherin 1 ISO PID PID:200124 PID:200147 PID:200182 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775 		JBrowse link
G Crk CRK proto-oncogene, adaptor protein ISO PID PID:200124 NCBI chr10:60,530,469...60,556,703
Ensembl chr10:60,530,464...60,553,406 		JBrowse link
G Csnk2a1 casein kinase 2 alpha 1 ISO PID PID:200124 NCBI chr 3:140,709,984...140,756,757
Ensembl chr 3:140,709,991...140,756,696 		JBrowse link
G Csnk2a2 casein kinase 2 alpha 2 ISO PID PID:200124 NCBI chr19:9,556,443...9,596,080
Ensembl chr19:9,556,260...9,596,080 		JBrowse link
G Csnk2b casein kinase 2 beta ISO PID PID:200124 NCBI chr20:3,700,363...3,705,331
Ensembl chr20:3,698,733...3,707,133 		JBrowse link
G Ctnna1 catenin alpha 1 ISO PID PID:200124 PID:200147 PID:200182 NCBI chr18:26,728,246...26,860,911
Ensembl chr18:26,728,485...26,860,910 		JBrowse link
G Ctnnb1 catenin beta 1 ISO PID PID:200124 PID:200147 PID:200182 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G Ctnnd1 catenin delta 1 ISO PID PID:200124 PID:200147 PID:200182 NCBI chr 3:69,683,328...69,734,550
Ensembl chr 3:69,683,313...69,734,516 		JBrowse link
G Cttn cortactin ISO PID PID:200124 NCBI chr 1:199,599,710...199,635,254
Ensembl chr 1:199,599,710...199,635,164 		JBrowse link
G Cyfip2 cytoplasmic FMR1 interacting protein 2 ISO PID PID:200124 PID:200182 NCBI chr10:30,621,318...30,741,113
Ensembl chr10:30,621,318...30,741,113 		JBrowse link
G Diaph1 diaphanous-related formin 1 ISO PID PID:200182 NCBI chr18:29,669,659...29,769,070
Ensembl chr18:29,669,659...29,769,172 		JBrowse link
G Dlg1 discs large MAGUK scaffold protein 1 ISO PID PID:200124 NCBI chr11:68,911,883...69,103,230
Ensembl chr11:68,911,883...69,102,689 		JBrowse link
G Efna1 ephrin A1 ISO PID PID:200182 NCBI chr 2:174,681,676...174,689,061
Ensembl chr 2:174,681,682...174,690,866 		JBrowse link
G Egf epidermal growth factor ISO PID PID:200182 NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064 		JBrowse link
G Egfr epidermal growth factor receptor ISO PID PID:200147 PID:200182 NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382 		JBrowse link
G Enah ENAH, actin regulator ISO PID PID:200124 PID:200182 NCBI chr13:93,617,747...93,738,119
Ensembl chr13:93,626,944...93,740,955 		JBrowse link
G Epha2 Eph receptor A2 ISO PID PID:200182 NCBI chr 5:153,605,644...153,634,115
Ensembl chr 5:153,605,644...153,634,117 		JBrowse link
G Exoc3 exocyst complex component 3 ISO PID PID:200182 NCBI chr 1:29,091,298...29,122,056
Ensembl chr 1:29,091,294...29,122,045 		JBrowse link
G Exoc4 exocyst complex component 4 ISO PID PID:200182 NCBI chr 4:61,807,706...62,584,316
Ensembl chr 4:61,807,761...62,585,723 		JBrowse link
G Fmn1 formin 1 ISO PID PID:200147 NCBI chr 3:100,101,103...100,485,652
Ensembl chr 3:100,134,549...100,479,220 		JBrowse link
G Fyn FYN proto-oncogene, Src family tyrosine kinase ISO PID PID:200147 NCBI chr20:42,767,733...42,960,903
Ensembl chr20:42,766,369...42,959,911 		JBrowse link
G Git1 GIT ArfGAP 1 ISO PID PID:200182 NCBI chr10:62,342,082...62,356,379
Ensembl chr10:62,342,299...62,356,373 		JBrowse link
G Hgf hepatocyte growth factor ISO PID PID:200182 NCBI chr 4:18,673,736...18,745,582
Ensembl chr 4:18,677,101...18,745,409 		JBrowse link
G Igf1 insulin-like growth factor 1 ISO PID PID:200182 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296 		JBrowse link
G Igf1r insulin-like growth factor 1 receptor ISO PID PID:200182 NCBI chr 1:121,549,831...121,838,548
Ensembl chr 1:121,550,743...121,831,777 		JBrowse link
G Iqgap1 IQ motif containing GTPase activating protein 1 ISO PID PID:200124 NCBI chr 1:134,679,581...134,769,776
Ensembl chr 1:134,679,586...134,769,755 		JBrowse link
G Itgae integrin subunit alpha E ISO PID PID:200124 NCBI chr10:57,704,813...57,764,093
Ensembl chr10:57,591,753...57,764,093
Ensembl chr10:57,591,753...57,764,093 		JBrowse link
G Itgb7 integrin subunit beta 7 ISO PID PID:200124 NCBI chr 7:133,347,927...133,364,955
Ensembl chr 7:133,347,960...133,364,876 		JBrowse link
G Jup junction plakoglobin ISO PID PID:200124 PID:200147 NCBI chr10:85,300,438...85,327,378
Ensembl chr10:85,300,440...85,327,057 		JBrowse link
G Kifc3 kinesin family member C3 ISO PID PID:200182 NCBI chr19:9,825,114...9,920,371
Ensembl chr19:9,886,693...9,920,451 		JBrowse link
G Klhl20 kelch-like family member 20 ISO PID PID:200124 NCBI chr13:73,363,451...73,408,293
Ensembl chr13:73,363,455...73,408,337 		JBrowse link
G Lima1 LIM domain and actin binding 1 ISO PID PID:200182 NCBI chr 7:130,901,717...131,001,512
Ensembl chr 7:130,901,717...131,001,473 		JBrowse link
G Lpp LIM domain containing preferred translocation partner in lipoma ISO PID PID:200182 NCBI chr11:75,787,326...76,426,646
Ensembl chr11:75,797,078...76,422,597 		JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase ISO PID PID:200182 NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876 		JBrowse link
G Mgat3 beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase ISO PID PID:200182 NCBI chr 7:111,708,353...111,761,825
Ensembl chr 7:111,675,730...111,762,026 		JBrowse link
G Myl2 myosin light chain 2 ISO PID PID:200182 NCBI chr12:34,454,223...34,468,554
Ensembl chr12:34,454,218...34,468,983 		JBrowse link
G Myo6 myosin VI ISO PID PID:200182 NCBI chr 8:81,087,157...81,242,022
Ensembl chr 8:81,087,139...81,239,292 		JBrowse link
G Nck1 NCK adaptor protein 1 ISO PID PID:200182 NCBI chr 8:101,018,610...101,079,237
Ensembl chr 8:101,018,702...101,079,300 		JBrowse link
G Nckap1 NCK-associated protein 1 ISO PID PID:200124 PID:200182 NCBI chr 3:65,417,450...65,491,769
Ensembl chr 3:65,417,453...65,492,217 		JBrowse link
G Nectin2 nectin cell adhesion molecule 2 ISO PID PID:200182 NCBI chr 1:79,372,123...79,407,379
Ensembl chr 1:79,372,119...79,407,360 		JBrowse link
G Nme1 NME/NM23 nucleoside diphosphate kinase 1 ISO PID PID:200124 NCBI chr10:78,907,036...78,929,659
Ensembl chr10:78,906,083...78,916,408 		JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha ISO PID PID:200124 PID:200147 NCBI chr 2:115,175,275...115,249,034
Ensembl chr 2:115,174,984...115,249,032 		JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 ISO PID PID:200124 PID:200147 NCBI chr 2:32,878,942...32,963,668
Ensembl chr 2:32,882,032...32,963,631 		JBrowse link
G Pip5k1a phosphatidylinositol-4-phosphate 5-kinase, type 1, alpha ISO PID PID:200147 NCBI chr 2:182,628,299...182,671,584
Ensembl chr 2:182,628,300...182,671,598 		JBrowse link
G Pip5k1c phosphatidylinositol-4-phosphate 5-kinase type 1 gamma ISO PID PID:200124 PID:200182 NCBI chr 7:8,397,406...8,426,030
Ensembl chr 7:8,397,406...8,425,988 		JBrowse link
G Plcg1 phospholipase C, gamma 1 ISO PID PID:200147 NCBI chr 3:149,385,587...149,416,330
Ensembl chr 3:149,385,587...149,416,330 		JBrowse link
G Plekha7 pleckstrin homology domain containing A7 ISO PID PID:200182 NCBI chr 1:170,364,524...170,547,843
Ensembl chr 1:170,365,135...170,547,775 		JBrowse link
G Rac1 Rac family small GTPase 1 ISO PID PID:200124 PID:200147 NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251 		JBrowse link
G Rap1a RAP1A, member of RAS oncogene family ISO PID PID:200124 NCBI chr 2:193,208,631...193,286,513
Ensembl chr 2:193,208,635...193,286,501 		JBrowse link
G Rap1b RAP1B, member of RAS oncogene family ISO PID PID:200124 NCBI chr 7:53,423,039...53,456,349
Ensembl chr 7:53,423,130...53,456,370 		JBrowse link
G Rapgef1 Rap guanine nucleotide exchange factor 1 ISO PID PID:200124 NCBI chr 3:12,898,349...13,016,234
Ensembl chr 3:12,898,266...13,013,984 		JBrowse link
G Rhoa ras homolog family member A ISO PID PID:200124 PID:200147 PID:200182 NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746 		JBrowse link
G Rock1 Rho-associated coiled-coil containing protein kinase 1 ISO PID PID:200182 NCBI chr18:1,114,532...1,236,345
Ensembl chr18:1,115,905...1,235,571 		JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase ISO PID PID:200124 PID:200147 NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476 		JBrowse link
G Stx4 syntaxin 4 ISO PID PID:200182 NCBI chr 1:182,451,108...182,459,701
Ensembl chr 1:182,451,117...182,459,979 		JBrowse link
G Tiam1 TIAM Rac1 associated GEF 1 ISO PID PID:200124 NCBI chr11:29,031,347...29,380,153
Ensembl chr11:29,031,348...29,159,901 		JBrowse link
G Tjp1 tight junction protein 1 ISO PID PID:200124 NCBI chr 1:118,849,838...119,094,492
Ensembl chr 1:118,849,838...119,094,432 		JBrowse link
G Vasp vasodilator-stimulated phosphoprotein ISO PID PID:200147 PID:200182 NCBI chr 1:78,910,009...78,925,791
Ensembl chr 1:78,910,011...78,925,061 		JBrowse link
G Vav2 vav guanine nucleotide exchange factor 2 ISO PID PID:200124 NCBI chr 3:10,584,688...10,754,128
Ensembl chr 3:10,584,688...10,754,052 		JBrowse link
G Vcl vinculin ISO PID PID:200182 NCBI chr15:3,265,776...3,355,586
Ensembl chr15:3,265,815...3,355,606 		JBrowse link
G Wasf2 WASP family member 2 ISO PID PID:200124 NCBI chr 5:145,336,817...145,402,041
Ensembl chr 5:145,336,842...145,399,242 		JBrowse link
G Zyx zyxin ISO PID PID:200147 PID:200182 NCBI chr 4:71,236,767...71,246,553
Ensembl chr 4:71,237,451...71,246,553 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6091
    signaling pathway 2634
      cell adhesion signaling pathway 413
        cell-cell signaling pathway 253
          cadherin mediated signaling pathway 97
            classical cadherin signaling pathway 97
              E-cadherin signaling pathway 75
                altered E-cadherin signaling pathway 0
paths to the root