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Gene: Myo6 (myosin VI) Rattus norvegicus
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Symbol: Myo6
Name: myosin VI
Description: Predicted to have several functions, including ADP binding activity; actin filament binding activity; and calmodulin binding activity. Involved in response to drug. Localizes to several cellular components, including the cytoplasm; microvillus; and ruffle membrane. Predicted to colocalize with the clathrin-coated endocytic vesicle. Used to study hypertension. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 22; autosomal recessive nonsyndromic deafness 37; ovarian cancer; and sensorineural hearing loss. Orthologous to human MYO6 (myosin VI); PARTICIPATES IN auditory mechanotransduction pathway; E-cadherin signaling pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: MODEL
Also known as: LOC315840; RGD1560646; similar to Myosin VI; unconventional myosin-VI
Orthologs:
Homo sapiens (human) : MYO6 (myosin VI)  HGNC  Alliance
Mus musculus (house mouse) : Myo6 (myosin VI)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Myo6 (myosin VI)
Pan paniscus (bonobo/pygmy chimpanzee) : MYO6 (myosin VI)
Canis lupus familiaris (dog) : MYO6 (myosin VI)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Myo6 (myosin VI)
Sus scrofa (pig) : MYO6 (myosin VI)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0887,583,649 - 87,731,271 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0887,121,910 - 87,268,900 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4885,203,987 - 85,368,026 (+)NCBIRGSC3.4rn4RGSC3.4
Celera880,810,746 - 80,962,891 (+)NCBICelera
Cytogenetic Map8q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 5.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
 
More on Myo6
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1560646
Created: 2006-02-09
Species: Rattus norvegicus
Last Modified: 2019-05-07
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.