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Gene: Myo6 (myosin VI) Rattus norvegicus
Symbol: Myo6
Name: myosin VI
Description: Predicted to have several functions, including ADP binding activity; calmodulin binding activity; and nucleoside-triphosphatase activity. Involved in response to drug. Localizes to several cellular components, including endocytic vesicle; microvillus; and ruffle membrane. Predicted to colocalize with clathrin-coated endocytic vesicle. Used to study hypertension. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 22; autosomal recessive nonsyndromic deafness 37; ovarian cancer; and sensorineural hearing loss. Orthologous to human MYO6 (myosin VI); PARTICIPATES IN auditory mechanotransduction pathway; E-cadherin signaling pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: MODEL
Also known as: LOC315840; RGD1560646; similar to Myosin VI; unconventional myosin-VI
Homo sapiens (human) : MYO6 (myosin VI)  HGNC  Alliance
Mus musculus (house mouse) : Myo6 (myosin VI)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Myo6 (myosin VI)
Pan paniscus (bonobo/pygmy chimpanzee) : MYO6 (myosin VI)
Canis lupus familiaris (dog) : MYO6 (myosin VI)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Myo6 (myosin VI)
Sus scrofa (pig) : MYO6 (myosin VI)
Chlorocebus sabaeus (African green monkey) : MYO6 (myosin VI)
Heterocephalus glaber (naked mole-rat) : Myo6 (myosin VI)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0887,583,649 - 87,731,271 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl887,630,916 - 87,731,269 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0887,121,910 - 87,268,900 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4885,203,987 - 85,368,026 (+)NCBIRGSC3.4rn4RGSC3.4
Celera880,810,746 - 80,962,891 (+)NCBICelera
Cytogenetic Map8q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
More on Myo6
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1560646
Created: 2006-02-09
Species: Rattus norvegicus
Last Modified: 2020-07-28
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.