Enah (ENAH, actin regulator) - Rat Genome Database

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Gene: Enah (ENAH, actin regulator) Rattus norvegicus
Analyze
Symbol: Enah
Name: ENAH, actin regulator
RGD ID: 1307666
Description: Predicted to enable SH3 domain binding activity; WW domain binding activity; and profilin binding activity. Involved in postsynaptic cytoskeleton organization. Is active in GABA-ergic synapse and postsynapse. Human ortholog(s) of this gene implicated in stomach cancer. Orthologous to human ENAH (ENAH actin regulator); PARTICIPATES IN E-cadherin signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 3,3',4,4',5-pentachlorobiphenyl; cadmium dichloride.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: enabled homolog; enabled homolog (Drosophila); LOC360891
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81396,149,437 - 96,269,841 (-)NCBIGRCr8
mRatBN7.21393,617,747 - 93,738,119 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1393,626,944 - 93,740,955 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1396,123,053 - 96,243,421 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01397,522,946 - 97,643,298 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01394,705,126 - 94,825,478 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.013100,297,421 - 100,415,335 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl13100,300,054 - 100,414,226 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.013105,277,627 - 105,392,796 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41397,919,690 - 98,025,153 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11398,108,627 - 98,214,089 (-)NCBI
Celera1393,161,661 - 93,266,823 (-)NCBICelera
Cytogenetic Map13q26NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-fluorouracil  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (ISO)
bisphenol AF  (ISO)
bisphenol F  (ISO)
butanal  (ISO)
cadmium dichloride  (EXP,ISO)
calciol  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
cisplatin  (ISO)
cocaine  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP,ISO)
dorsomorphin  (ISO)
ethanol  (ISO)
fenvalerate  (EXP)
folic acid  (ISO)
FR900359  (ISO)
furan  (EXP)
gentamycin  (EXP)
inulin  (ISO)
ivermectin  (ISO)
L-methionine  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
methoxychlor  (EXP)
microcystin-LR  (EXP)
okadaic acid  (ISO)
oxaliplatin  (EXP)
oxybenzone  (ISO)
paracetamol  (EXP,ISO)
pentanal  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
potassium chromate  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
Soman  (EXP)
tetrachloromethane  (ISO)
thiram  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
trichostatin A  (ISO)
triptonide  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cell projection  (IEA)
cytoplasm  (IEA)
cytoskeleton  (IEA)
cytosol  (IEA,ISO)
filopodium  (ISO)
focal adhesion  (IBA,IEA,ISO)
GABA-ergic synapse  (IDA)
lamellipodium  (IEA,ISO)
neuron projection  (ISO)
plasma membrane  (IBA,IEA,ISO)
postsynapse  (IDA)
stress fiber  (ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. The state of the actin cytoskeleton determines its association with gephyrin: role of ena/VASP family members. Bausen M, etal., Mol Cell Neurosci. 2006 Feb;31(2):376-86. doi: 10.1016/j.mcn.2005.11.004. Epub 2006 Jan 11.
2. Molecular recognition of the Tes LIM2-3 domains by the actin-related protein Arp7A. Boeda B, etal., J Biol Chem. 2011 Apr 1;286(13):11543-54. doi: 10.1074/jbc.M110.171264. Epub 2011 Jan 29.
3. Enabled homolog (ENAH) regulated by RNA binding protein splicing factor 3b subunit 4 (SF3B4) exacerbates the proliferation, invasion and migration of hepatocellular carcinoma cells via Notch signaling pathway. Deng G, etal., Bioengineered. 2022 Feb;13(2):2194-2206. doi: 10.1080/21655979.2021.2023983.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
7. GOA pipeline RGD automated data pipeline
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. TES functions as a Mena-dependent tumor suppressor in gastric cancer carcinogenesis and metastasis. Wang DD, etal., Cancer Commun (Lond). 2019 Feb 6;39(1):3. doi: 10.1186/s40880-019-0347-y.
Additional References at PubMed
PMID:8861907   PMID:9126384   PMID:10069337   PMID:12477932   PMID:12672821   PMID:12967995   PMID:15148305   PMID:15371503   PMID:17686488   PMID:20439489   PMID:21423176   PMID:24186093  
PMID:26221026  


Genomics

Comparative Map Data
Enah
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81396,149,437 - 96,269,841 (-)NCBIGRCr8
mRatBN7.21393,617,747 - 93,738,119 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1393,626,944 - 93,740,955 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1396,123,053 - 96,243,421 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01397,522,946 - 97,643,298 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01394,705,126 - 94,825,478 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.013100,297,421 - 100,415,335 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl13100,300,054 - 100,414,226 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.013105,277,627 - 105,392,796 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41397,919,690 - 98,025,153 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11398,108,627 - 98,214,089 (-)NCBI
Celera1393,161,661 - 93,266,823 (-)NCBICelera
Cytogenetic Map13q26NCBI
ENAH
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381225,486,829 - 225,653,878 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1225,486,765 - 225,653,142 (-)EnsemblGRCh38hg38GRCh38
GRCh371225,674,531 - 225,840,825 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361223,741,157 - 223,907,468 (-)NCBINCBI36Build 36hg18NCBI36
Build 341221,981,268 - 222,147,580NCBI
Celera1198,865,129 - 199,031,134 (-)NCBICelera
Cytogenetic Map1q42.12NCBI
HuRef1196,193,432 - 196,359,068 (-)NCBIHuRef
CHM1_11226,946,878 - 227,113,178 (-)NCBICHM1_1
T2T-CHM13v2.01224,675,098 - 224,841,848 (-)NCBIT2T-CHM13v2.0
Enah
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391181,723,949 - 181,848,132 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1181,723,949 - 181,847,555 (-)EnsemblGRCm39 Ensembl
GRCm381181,896,384 - 182,027,556 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1181,896,384 - 182,019,990 (-)EnsemblGRCm38mm10GRCm38
MGSCv371183,834,576 - 183,950,111 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361183,742,188 - 183,856,336 (-)NCBIMGSCv36mm8
Celera1188,957,160 - 189,017,504 (-)NCBICelera
Cytogenetic Map1H5NCBI
cM Map184.93NCBI
Enah
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955520308,070 - 371,922 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955520310,482 - 374,800 (+)NCBIChiLan1.0ChiLan1.0
ENAH
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2123,885,156 - 24,045,244 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1123,834,054 - 23,996,296 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01200,956,988 - 201,113,242 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11205,963,067 - 206,115,672 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1205,963,247 - 206,115,672 (-)Ensemblpanpan1.1panPan2
ENAH
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1739,105,024 - 39,250,126 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl739,105,039 - 39,247,595 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha738,587,078 - 38,732,144 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0738,938,972 - 39,084,406 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl738,938,017 - 39,084,402 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1738,778,555 - 38,923,489 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0738,786,801 - 38,932,026 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0739,056,619 - 39,201,943 (+)NCBIUU_Cfam_GSD_1.0
Enah
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934452,269,764 - 52,414,557 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365262,332,664 - 2,477,833 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365262,332,344 - 2,477,827 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ENAH
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1013,446,426 - 13,609,303 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11013,439,772 - 13,609,347 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21016,217,878 - 16,292,117 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ENAH
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1254,134,853 - 4,264,392 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl254,134,852 - 4,260,928 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660554,119,116 - 4,284,897 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Enah
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248356,292,808 - 6,442,349 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Enah
529 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:134
Count of miRNA genes:102
Interacting mature miRNAs:115
Transcripts:ENSRNOT00000039974
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1320605871101339738Rat
7387280Uae43Urinary albumin excretion QTL 435.690.4174urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1366451204106807694Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1365103704106807694Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1330395351101056920Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1356056920101056920Rat
4889606Gluco63Glucose level QTL 632.860.003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1380753256106807694Rat
8655959Pur32Proteinuria QTL 328.4urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)137402391897213863Rat
1641901Alcrsp6Alcohol response QTL 6response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)135236217197362171Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1365103704106807694Rat
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1361825626106807694Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)138897350101631289Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131101056920Rat
2293341Glom15Glomerulus QTL 159.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1374862117101339893Rat

Markers in Region
RH134481  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21393,627,001 - 93,627,184 (+)MAPPERmRatBN7.2
Rnor_6.013100,300,112 - 100,300,294NCBIRnor6.0
Rnor_5.013105,280,318 - 105,280,500UniSTSRnor5.0
RGSC_v3.41397,919,760 - 97,919,942UniSTSRGSC3.4
Celera1393,161,731 - 93,161,913UniSTS
RH 3.4 Map13632.2UniSTS
Cytogenetic Map13q26UniSTS
BE112154  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21393,685,758 - 93,685,923 (+)MAPPERmRatBN7.2
Rnor_6.013100,358,853 - 100,359,017NCBIRnor6.0
Rnor_5.013105,339,147 - 105,339,311UniSTSRnor5.0
RGSC_v3.41397,978,672 - 97,978,836UniSTSRGSC3.4
Celera1393,220,263 - 93,220,427UniSTS
RH 3.4 Map13629.9UniSTS
Cytogenetic Map13q26UniSTS
BF410035  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21393,645,960 - 93,646,123 (+)MAPPERmRatBN7.2
Rnor_6.013100,319,074 - 100,319,236NCBIRnor6.0
Rnor_5.013105,299,084 - 105,299,246UniSTSRnor5.0
RGSC_v3.41397,938,932 - 97,939,094UniSTSRGSC3.4
Celera1393,180,652 - 93,180,814UniSTS
RH 3.4 Map13631.2UniSTS
Cytogenetic Map13q26UniSTS
BF405107  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21393,690,005 - 93,690,135 (+)MAPPERmRatBN7.2
Rnor_6.013100,363,100 - 100,363,229NCBIRnor6.0
Rnor_5.013105,343,394 - 105,343,523UniSTSRnor5.0
RGSC_v3.41397,982,919 - 97,983,048UniSTSRGSC3.4
Celera1393,224,510 - 93,224,639UniSTS
RH 3.4 Map13631.8UniSTS
Cytogenetic Map13q26UniSTS
AU047203  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21393,727,868 - 93,727,996 (+)MAPPERmRatBN7.2
Rnor_6.013100,400,877 - 100,401,004NCBIRnor6.0
Rnor_5.013105,381,171 - 105,381,298UniSTSRnor5.0
RGSC_v3.41398,020,691 - 98,020,818UniSTSRGSC3.4
Celera1393,262,361 - 93,262,488UniSTS
Cytogenetic Map13q26UniSTS
Enah  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21393,640,009 - 93,641,156 (+)MAPPERmRatBN7.2
Rnor_6.013100,313,117 - 100,314,263NCBIRnor6.0
Rnor_5.013105,293,000 - 105,294,146UniSTSRnor5.0
RGSC_v3.41397,933,114 - 97,934,260UniSTSRGSC3.4
Celera1393,174,705 - 93,175,851UniSTS
Cytogenetic Map13q26UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001012150 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001401377 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001415736 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017598853 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017598854 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017598855 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017598856 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017598857 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017598858 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017598859 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017598860 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017598861 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017598862 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090926 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090933 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272493 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272494 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272495 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272496 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272497 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272498 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272499 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272500 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272502 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272503 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272504 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272505 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272506 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC083927 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213757 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000013 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000039974   ⟹   ENSRNOP00000050866
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1393,626,944 - 93,732,335 (-)Ensembl
Rnor_6.0 Ensembl13100,300,054 - 100,405,339 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000085188   ⟹   ENSRNOP00000073827
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1393,626,944 - 93,732,335 (-)Ensembl
Rnor_6.0 Ensembl13100,300,199 - 100,414,226 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000097600   ⟹   ENSRNOP00000081404
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1393,626,944 - 93,740,955 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000098544   ⟹   ENSRNOP00000081655
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1393,626,944 - 93,740,955 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000109962   ⟹   ENSRNOP00000076584
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1393,626,944 - 93,740,955 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000114419   ⟹   ENSRNOP00000079564
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1393,626,944 - 93,681,785 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000114860   ⟹   ENSRNOP00000097849
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1393,626,944 - 93,740,955 (-)Ensembl
RefSeq Acc Id: NM_001012150   ⟹   NP_001012150
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81396,149,437 - 96,264,080 (-)NCBI
mRatBN7.21393,617,747 - 93,732,403 (-)NCBI
Rnor_6.013100,300,042 - 100,405,339 (-)NCBI
Rnor_5.013105,277,627 - 105,392,796 (-)NCBI
RGSC_v3.41397,919,690 - 98,025,153 (-)RGD
Celera1393,161,661 - 93,266,823 (-)RGD
Sequence:
RefSeq Acc Id: NM_001401377   ⟹   NP_001388306
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81396,149,437 - 96,269,796 (-)NCBI
mRatBN7.21393,617,747 - 93,738,119 (-)NCBI
RefSeq Acc Id: NM_001415736   ⟹   NP_001402665
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81396,149,437 - 96,269,796 (-)NCBI
mRatBN7.21393,617,747 - 93,738,119 (-)NCBI
RefSeq Acc Id: XM_039090926   ⟹   XP_038946854
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81396,149,441 - 96,269,127 (-)NCBI
mRatBN7.21393,617,751 - 93,732,334 (-)NCBI
RefSeq Acc Id: XM_039090933   ⟹   XP_038946861
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81396,149,441 - 96,180,340 (-)NCBI
mRatBN7.21393,617,751 - 93,648,652 (-)NCBI
RefSeq Acc Id: XM_063272493   ⟹   XP_063128563
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81396,149,441 - 96,269,127 (-)NCBI
RefSeq Acc Id: XM_063272494   ⟹   XP_063128564
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81396,149,441 - 96,269,841 (-)NCBI
RefSeq Acc Id: XM_063272495   ⟹   XP_063128565
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81396,149,441 - 96,182,942 (-)NCBI
RefSeq Acc Id: XM_063272496   ⟹   XP_063128566
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81396,149,441 - 96,269,127 (-)NCBI
RefSeq Acc Id: XM_063272497   ⟹   XP_063128567
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81396,149,441 - 96,269,841 (-)NCBI
RefSeq Acc Id: XM_063272498   ⟹   XP_063128568
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81396,149,441 - 96,269,127 (-)NCBI
RefSeq Acc Id: XM_063272499   ⟹   XP_063128569
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81396,149,441 - 96,269,127 (-)NCBI
RefSeq Acc Id: XM_063272500   ⟹   XP_063128570
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81396,149,441 - 96,269,841 (-)NCBI
RefSeq Acc Id: XM_063272502   ⟹   XP_063128572
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81396,149,441 - 96,269,841 (-)NCBI
RefSeq Acc Id: XM_063272503   ⟹   XP_063128573
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81396,149,441 - 96,269,841 (-)NCBI
RefSeq Acc Id: XM_063272504   ⟹   XP_063128574
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81396,149,441 - 96,180,339 (-)NCBI
RefSeq Acc Id: XM_063272505   ⟹   XP_063128575
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81396,149,441 - 96,180,352 (-)NCBI
RefSeq Acc Id: XM_063272506   ⟹   XP_063128576
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81396,149,441 - 96,269,127 (-)NCBI
RefSeq Acc Id: NP_001012150   ⟸   NM_001012150
- Peptide Label: isoform 2
- UniProtKB: Q5XHX3 (UniProtKB/TrEMBL),   A6JGK5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000073827   ⟸   ENSRNOT00000085188
Ensembl Acc Id: ENSRNOP00000050866   ⟸   ENSRNOT00000039974
RefSeq Acc Id: XP_038946854   ⟸   XM_039090926
- Peptide Label: isoform X3
- UniProtKB: A0A8I6G5W6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038946861   ⟸   XM_039090933
- Peptide Label: isoform X12
Ensembl Acc Id: ENSRNOP00000079564   ⟸   ENSRNOT00000114419
Ensembl Acc Id: ENSRNOP00000081655   ⟸   ENSRNOT00000098544
Ensembl Acc Id: ENSRNOP00000076584   ⟸   ENSRNOT00000109962
Ensembl Acc Id: ENSRNOP00000097849   ⟸   ENSRNOT00000114860
Ensembl Acc Id: ENSRNOP00000081404   ⟸   ENSRNOT00000097600
RefSeq Acc Id: NP_001402665   ⟸   NM_001415736
- Peptide Label: isoform 3
- UniProtKB: A0A8I6G5W6 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001388306   ⟸   NM_001401377
- Peptide Label: isoform 1
- UniProtKB: A0A8I5ZT50 (UniProtKB/TrEMBL),   A6JGK6 (UniProtKB/TrEMBL),   A0A8I6G5W6 (UniProtKB/TrEMBL),   A0A8I6GMP8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063128573   ⟸   XM_063272503
- Peptide Label: isoform X11
- UniProtKB: A6JGK5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063128572   ⟸   XM_063272502
- Peptide Label: isoform X10
- UniProtKB: A0A8I5ZND4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063128570   ⟸   XM_063272500
- Peptide Label: isoform X9
- UniProtKB: A6JGK5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063128567   ⟸   XM_063272497
- Peptide Label: isoform X6
- UniProtKB: A0A8I5ZND4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063128564   ⟸   XM_063272494
- Peptide Label: isoform X2
- UniProtKB: A0A8I5Y4S4 (UniProtKB/TrEMBL),   A0A8I6G5W6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063128569   ⟸   XM_063272499
- Peptide Label: isoform X8
- UniProtKB: A0A8I5ZND4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063128568   ⟸   XM_063272498
- Peptide Label: isoform X7
- UniProtKB: A0A0G2K6I4 (UniProtKB/TrEMBL),   A6JGK5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063128566   ⟸   XM_063272496
- Peptide Label: isoform X5
- UniProtKB: A0A8I5ZND4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063128563   ⟸   XM_063272493
- Peptide Label: isoform X1
- UniProtKB: A0A8I6G5W6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063128576   ⟸   XM_063272506
- Peptide Label: isoform X15
- UniProtKB: A0A8I6G5W6 (UniProtKB/TrEMBL),   A0A8I6GMP8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063128565   ⟸   XM_063272495
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063128575   ⟸   XM_063272505
- Peptide Label: isoform X14
RefSeq Acc Id: XP_063128574   ⟸   XM_063272504
- Peptide Label: isoform X13
Protein Domains
WH1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K6I4-F1-model_v2 AlphaFold A0A0G2K6I4 1-564 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699073
Promoter ID:EPDNEW_R9598
Type:initiation region
Name:Enah_1
Description:ENAH, actin regulator
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R9599  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.013100,405,407 - 100,405,467EPDNEW
RGD ID:13699090
Promoter ID:EPDNEW_R9599
Type:single initiation site
Name:Enah_2
Description:ENAH, actin regulator
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R9598  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.013100,414,312 - 100,414,372EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307666 AgrOrtholog
BioCyc Gene G2FUF-17088 BioCyc
Ensembl Genes ENSRNOG00000031934 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000039974.6 UniProtKB/TrEMBL
  ENSRNOT00000085188 ENTREZGENE
  ENSRNOT00000085188.2 UniProtKB/TrEMBL
  ENSRNOT00000097600 ENTREZGENE
  ENSRNOT00000097600.1 UniProtKB/TrEMBL
  ENSRNOT00000098544 ENTREZGENE
  ENSRNOT00000098544.1 UniProtKB/TrEMBL
  ENSRNOT00000109962 ENTREZGENE
  ENSRNOT00000109962.1 UniProtKB/TrEMBL
  ENSRNOT00000114419.1 UniProtKB/TrEMBL
  ENSRNOT00000114860.1 UniProtKB/TrEMBL
  ENSRNOT00000153721 ENTREZGENE
  ENSRNOT00000171057 ENTREZGENE
Gene3D-CATH 2.30.29.30 UniProtKB/TrEMBL
  Vasodilator-stimulated phosphoprotein UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7135538 IMAGE-MGC_LOAD
InterPro EVH1 UniProtKB/TrEMBL
  PH_type UniProtKB/TrEMBL
  VASP_sf UniProtKB/TrEMBL
  VASP_tetra UniProtKB/TrEMBL
KEGG Report rno:360891 UniProtKB/TrEMBL
MGC_CLONE MGC:95334 IMAGE-MGC_LOAD
NCBI Gene 360891 ENTREZGENE
PANTHER PROTEIN ENABLED HOMOLOG UniProtKB/TrEMBL
  SPROUTY-RELATED, EVH1 DOMAIN-CONTAINING PROTEIN FAMILY MEMBER UniProtKB/TrEMBL
Pfam VASP_tetra UniProtKB/TrEMBL
  WH1 UniProtKB/TrEMBL
PhenoGen Enah PhenoGen
PRINTS PRICHEXTENSN UniProtKB/TrEMBL
PROSITE WH1 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000031934 RatGTEx
SMART WH1 UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/TrEMBL
  SSF118370 UniProtKB/TrEMBL
UniProt A0A0G2K6I4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5Y4S4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZND4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZT50 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6G5W6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GMP8 ENTREZGENE, UniProtKB/TrEMBL
  A6JGK5 ENTREZGENE, UniProtKB/TrEMBL
  A6JGK6 ENTREZGENE, UniProtKB/TrEMBL
  Q5XHX3 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-06-12 Enah  ENAH, actin regulator  Enah  enabled homolog (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Enah  enabled homolog (Drosophila)  Enah_predicted  enabled homolog (Drosophila) (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Enah_predicted  enabled homolog (Drosophila) (predicted)      Symbol and Name status set to approved 70820 APPROVED