Enah (ENAH, actin regulator) - Rat Genome Database

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Gene: Enah (ENAH, actin regulator) Rattus norvegicus
Analyze
Symbol: Enah
Name: ENAH, actin regulator
RGD ID: 1307666
Description: Predicted to enable SH3 domain binding activity; WW domain binding activity; and profilin binding activity. Involved in postsynaptic cytoskeleton organization. Is active in GABA-ergic synapse and postsynapse. Human ortholog(s) of this gene implicated in stomach cancer. Orthologous to human ENAH (ENAH actin regulator); PARTICIPATES IN E-cadherin signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 3,3',4,4',5-pentachlorobiphenyl; cadmium dichloride.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: enabled homolog; enabled homolog (Drosophila); LOC360891
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81396,149,437 - 96,269,841 (-)NCBIGRCr8
mRatBN7.21393,617,747 - 93,738,119 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1393,626,944 - 93,740,955 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1396,123,053 - 96,243,421 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01397,522,946 - 97,643,298 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01394,705,126 - 94,825,478 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.013100,297,421 - 100,415,335 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl13100,300,054 - 100,414,226 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.013105,277,627 - 105,392,796 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41397,919,690 - 98,025,153 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11398,108,627 - 98,214,089 (-)NCBI
Celera1393,161,661 - 93,266,823 (-)NCBICelera
Cytogenetic Map13q26NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
EnahRathepatocellular carcinoma disease_progressionISOENAH (Homo sapiens)155791678mRNA:increased expression:liver (human)RGD 
EnahRatstomach cancer disease_progressionISOENAH (Homo sapiens)597621672 RGD 
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
EnahRatgastrointestinal stromal tumor  ISOENAH (Homo sapiens)8554872ClinVar Annotator: match by term: Gastrointestinal stromal tumorClinVarPMID:28492532
EnahRatparathyroid carcinoma  ISOENAH (Homo sapiens)8554872ClinVar Annotator: match by term: Parathyroid carcinomaClinVarPMID:28492532
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
EnahRatacute myeloid leukemia  ISOENAH (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:26237430

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Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
EnahRat1,2-dimethylhydrazine increases expressionISOEnah (Mus musculus)64804641 and 2-Dimethylhydrazine results in increased expression of ENAH mRNACTDPMID:22206623
EnahRat17alpha-ethynylestradiol multiple interactionsISOEnah (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ENAH mRNACTDPMID:17942748
EnahRat17alpha-ethynylestradiol increases expressionEXP 6480464Ethinyl Estradiol results in increased expression of ENAH mRNACTDPMID:29097150
EnahRat17beta-estradiol affects expressionISOENAH (Homo sapiens)6480464Estradiol affects the expression of ENAH mRNACTDPMID:22574217
EnahRat17beta-estradiol multiple interactionsISOENAH (Homo sapiens)6480464Estradiol promotes the reaction [ENAH protein binds to ESR1 protein]CTDPMID:27156127
EnahRat17beta-estradiol increases expressionISOEnah (Mus musculus)6480464Estradiol results in increased expression of ENAH mRNACTDPMID:19484750
EnahRat2,3',4,4',5-Pentachlorobiphenyl increases expressionISOEnah (Mus musculus)64804642 more ...CTDPMID:31388691
EnahRat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISOEnah (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ENAH mRNACTDPMID:17942748
EnahRat2,3,7,8-tetrachlorodibenzodioxine increases expressionISOEnah (Mus musculus)6480464Tetrachlorodibenzodioxin results in increased expression of ENAH mRNACTDPMID:19770486
EnahRat2,4-dibromophenyl 2,4,5-tribromophenyl ether affects expressionISOEnah (Mus musculus)64804642 more ...CTDPMID:38648751
EnahRat3,3',4,4',5-pentachlorobiphenyl increases expressionEXP 64804643 more ...CTDPMID:23196670
EnahRat4,4'-diaminodiphenylmethane decreases expressionISOEnah (Mus musculus)64804644 and 4'-diaminodiphenylmethane results in decreased expression of ENAH mRNACTDPMID:18648102
EnahRat4-hydroxyphenyl retinamide increases expressionISOEnah (Mus musculus)6480464Fenretinide results in increased expression of ENAH mRNACTDPMID:28973697
EnahRat5-fluorouracil affects response to substanceISOENAH (Homo sapiens)6480464ENAH protein affects the susceptibility to FluorouracilCTDPMID:16217747
EnahRataflatoxin B1 decreases expressionISOEnah (Mus musculus)6480464Aflatoxin B1 results in decreased expression of ENAH mRNACTDPMID:19770486
EnahRataflatoxin B1 increases methylationISOENAH (Homo sapiens)6480464Aflatoxin B1 results in increased methylation of ENAH intronCTDPMID:30157460
EnahRatall-trans-retinoic acid decreases expressionISOENAH (Homo sapiens)6480464Tretinoin results in decreased expression of ENAH mRNACTDPMID:21934132 and PMID:33167477
EnahRataristolochic acid A decreases expressionISOENAH (Homo sapiens)6480464aristolochic acid I results in decreased expression of ENAH mRNACTDPMID:33212167
EnahRatarsenite(3-) multiple interactionsISOENAH (Homo sapiens)6480464arsenite inhibits the reaction [G3BP1 protein binds to ENAH mRNA]CTDPMID:32406909
EnahRatarsenous acid increases expressionISOENAH (Homo sapiens)6480464Arsenic Trioxide results in increased expression of ENAH mRNACTDPMID:22521957

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Biological Process
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Cellular Component
1 to 20 of 24 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
EnahRatcell projection located_inIEAUniProtKB-KW:KW-09661600115GO_REF:0000043UniProtGO_REF:0000043
EnahRatcytoplasm located_inIEAARBA:ARBA000269711600115GO_REF:0000117UniProtGO_REF:0000117
EnahRatcytoplasm located_inIEAUniProtKB-KW:KW-09631600115GO_REF:0000043UniProtGO_REF:0000043
EnahRatcytoskeleton located_inIEAUniProtKB-KW:KW-02061600115GO_REF:0000043UniProtGO_REF:0000043
EnahRatcytoskeleton located_inIEAUniProtKB-SubCell:SL-00901600115GO_REF:0000044UniProtGO_REF:0000044
EnahRatcytosol located_inIEAUniProtKB:A0A4D6J698 and ensembl:ENSP000003558081600115GO_REF:0000107EnsemblGO_REF:0000107
EnahRatcytosol located_inISOENAH (Homo sapiens) more ...1624291 RGDGO_REF:0000052
EnahRatcytosol located_inIEAUniProtKB:Q8N8S7 and ensembl:ENSP000003558081600115GO_REF:0000107EnsemblGO_REF:0000107
EnahRatfilopodium located_inISOEnah (Mus musculus)1624291 PMID:10069337 and PMID:15148305RGDPMID:10069337 and PMID:15148305
EnahRatfocal adhesion is_active_inIBAMGI:108360 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
EnahRatfocal adhesion located_inIEAUniProtKB:A0A4D6J698 and ensembl:ENSP000003558081600115GO_REF:0000107EnsemblGO_REF:0000107
EnahRatfocal adhesion located_inIEAUniProtKB:Q8N8S7 and ensembl:ENSP000003558081600115GO_REF:0000107EnsemblGO_REF:0000107
EnahRatfocal adhesion located_inISOEnah (Mus musculus)1624291 PMID:8861907RGDPMID:8861907
EnahRatfocal adhesion located_inISOENAH (Homo sapiens) more ...1624291 RGDGO_REF:0000052
EnahRatGABA-ergic synapse is_active_inIDA 405650240PMID:16376568SynGO 
EnahRatlamellipodium located_inIEAUniProtKB-SubCell:SL-02911600115GO_REF:0000044UniProtGO_REF:0000044
EnahRatlamellipodium located_inISOEnah (Mus musculus)1624291 PMID:12672821 and PMID:15148305RGDPMID:12672821 and PMID:15148305
EnahRatneuron projection located_inISOEnah (Mus musculus)1624291 PMID:10069337RGDPMID:10069337
EnahRatplasma membrane located_inISOENAH (Homo sapiens) more ...1624291 RGDGO_REF:0000052
EnahRatplasma membrane located_inIEAUniProtKB:A0A4D6J698 and ensembl:ENSP000003558081600115GO_REF:0000107EnsemblGO_REF:0000107
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Molecular Function
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Imported Annotations - PID (archival)

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
EnahRatE-cadherin signaling pathway  ISOENAH (Homo sapiens)6484113 PIDPID:200182
EnahRatE-cadherin signaling pathway  ISOENAH (Homo sapiens)6484113 PIDPID:200124

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#
Reference Title
Reference Citation
1. The state of the actin cytoskeleton determines its association with gephyrin: role of ena/VASP family members. Bausen M, etal., Mol Cell Neurosci. 2006 Feb;31(2):376-86. doi: 10.1016/j.mcn.2005.11.004. Epub 2006 Jan 11.
2. Molecular recognition of the Tes LIM2-3 domains by the actin-related protein Arp7A. Boeda B, etal., J Biol Chem. 2011 Apr 1;286(13):11543-54. doi: 10.1074/jbc.M110.171264. Epub 2011 Jan 29.
3. Enabled homolog (ENAH) regulated by RNA binding protein splicing factor 3b subunit 4 (SF3B4) exacerbates the proliferation, invasion and migration of hepatocellular carcinoma cells via Notch signaling pathway. Deng G, etal., Bioengineered. 2022 Feb;13(2):2194-2206. doi: 10.1080/21655979.2021.2023983.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
7. GOA pipeline RGD automated data pipeline
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. TES functions as a Mena-dependent tumor suppressor in gastric cancer carcinogenesis and metastasis. Wang DD, etal., Cancer Commun (Lond). 2019 Feb 6;39(1):3. doi: 10.1186/s40880-019-0347-y.
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PMID:8861907   PMID:9126384   PMID:10069337   PMID:12477932   PMID:12672821   PMID:12967995   PMID:15148305   PMID:15371503   PMID:17686488   PMID:20439489   PMID:21423176   PMID:24186093  
PMID:26221026  



Enah
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81396,149,437 - 96,269,841 (-)NCBIGRCr8
mRatBN7.21393,617,747 - 93,738,119 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1393,626,944 - 93,740,955 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1396,123,053 - 96,243,421 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01397,522,946 - 97,643,298 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01394,705,126 - 94,825,478 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.013100,297,421 - 100,415,335 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl13100,300,054 - 100,414,226 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.013105,277,627 - 105,392,796 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41397,919,690 - 98,025,153 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11398,108,627 - 98,214,089 (-)NCBI
Celera1393,161,661 - 93,266,823 (-)NCBICelera
Cytogenetic Map13q26NCBI
ENAH
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381225,486,829 - 225,653,878 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1225,486,765 - 225,653,142 (-)EnsemblGRCh38hg38GRCh38
GRCh371225,674,531 - 225,840,825 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361223,741,157 - 223,907,468 (-)NCBINCBI36Build 36hg18NCBI36
Build 341221,981,268 - 222,147,580NCBI
Celera1198,865,129 - 199,031,134 (-)NCBICelera
Cytogenetic Map1q42.12NCBI
HuRef1196,193,432 - 196,359,068 (-)NCBIHuRef
CHM1_11226,946,878 - 227,113,178 (-)NCBICHM1_1
T2T-CHM13v2.01224,675,098 - 224,841,848 (-)NCBIT2T-CHM13v2.0
Enah
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391181,723,949 - 181,848,132 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1181,723,949 - 181,847,555 (-)EnsemblGRCm39 Ensembl
GRCm381181,896,384 - 182,027,556 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1181,896,384 - 182,019,990 (-)EnsemblGRCm38mm10GRCm38
MGSCv371183,834,576 - 183,950,111 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361183,742,188 - 183,856,336 (-)NCBIMGSCv36mm8
Celera1188,957,160 - 189,017,504 (-)NCBICelera
Cytogenetic Map1H5NCBI
cM Map184.93NCBI
Enah
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955520308,070 - 371,922 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955520310,482 - 374,800 (+)NCBIChiLan1.0ChiLan1.0
ENAH
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2123,885,156 - 24,045,244 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1123,834,054 - 23,996,296 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01200,956,988 - 201,113,242 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11205,963,067 - 206,115,672 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1205,963,247 - 206,115,672 (-)Ensemblpanpan1.1panPan2
ENAH
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1739,105,024 - 39,250,126 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl739,105,039 - 39,247,595 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha738,587,078 - 38,732,144 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0738,938,972 - 39,084,406 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl738,938,017 - 39,084,402 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1738,778,555 - 38,923,489 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0738,786,801 - 38,932,026 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0739,056,619 - 39,201,943 (+)NCBIUU_Cfam_GSD_1.0
Enah
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934452,269,764 - 52,414,557 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365262,332,664 - 2,477,833 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365262,332,344 - 2,477,827 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ENAH
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1013,446,426 - 13,609,303 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11013,439,772 - 13,609,347 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21016,217,878 - 16,292,117 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ENAH
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1254,134,853 - 4,264,392 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl254,134,852 - 4,260,928 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660554,119,116 - 4,284,897 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Enah
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248356,292,808 - 6,442,349 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Enah
529 total Variants


Assembly: Rnor_6.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain Variant Page
13 100316596 100316597 G A snv MNS/Gib (RGD) View more Information

Predicted Target Of
Summary Value
Count of predictions:134
Count of miRNA genes:102
Interacting mature miRNAs:115
Transcripts:ENSRNOT00000039974
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 13 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1320605871101339738Rat
7387280Uae43Urinary albumin excretion QTL 435.690.4174urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1366451204106807694Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1365103704106807694Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1330395351101056920Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1356056920101056920Rat
4889606Gluco63Glucose level QTL 632.860.003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1380753256106807694Rat
8655959Pur32Proteinuria QTL 328.4urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)137402391897213863Rat
1641901Alcrsp6Alcohol response QTL 6response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)135236217197362171Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1365103704106807694Rat
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1361825626106807694Rat

1 to 10 of 13 rows
RH134481  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21393,627,001 - 93,627,184 (+)MAPPERmRatBN7.2
Rnor_6.013100,300,112 - 100,300,294NCBIRnor6.0
Rnor_5.013105,280,318 - 105,280,500UniSTSRnor5.0
RGSC_v3.41397,919,760 - 97,919,942UniSTSRGSC3.4
Celera1393,161,731 - 93,161,913UniSTS
RH 3.4 Map13632.2UniSTS
Cytogenetic Map13q26UniSTS
BE112154  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21393,685,758 - 93,685,923 (+)MAPPERmRatBN7.2
Rnor_6.013100,358,853 - 100,359,017NCBIRnor6.0
Rnor_5.013105,339,147 - 105,339,311UniSTSRnor5.0
RGSC_v3.41397,978,672 - 97,978,836UniSTSRGSC3.4
Celera1393,220,263 - 93,220,427UniSTS
RH 3.4 Map13629.9UniSTS
Cytogenetic Map13q26UniSTS
BF410035  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21393,645,960 - 93,646,123 (+)MAPPERmRatBN7.2
Rnor_6.013100,319,074 - 100,319,236NCBIRnor6.0
Rnor_5.013105,299,084 - 105,299,246UniSTSRnor5.0
RGSC_v3.41397,938,932 - 97,939,094UniSTSRGSC3.4
Celera1393,180,652 - 93,180,814UniSTS
RH 3.4 Map13631.2UniSTS
Cytogenetic Map13q26UniSTS
BF405107  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21393,690,005 - 93,690,135 (+)MAPPERmRatBN7.2
Rnor_6.013100,363,100 - 100,363,229NCBIRnor6.0
Rnor_5.013105,343,394 - 105,343,523UniSTSRnor5.0
RGSC_v3.41397,982,919 - 97,983,048UniSTSRGSC3.4
Celera1393,224,510 - 93,224,639UniSTS
RH 3.4 Map13631.8UniSTS
Cytogenetic Map13q26UniSTS
AU047203  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21393,727,868 - 93,727,996 (+)MAPPERmRatBN7.2
Rnor_6.013100,400,877 - 100,401,004NCBIRnor6.0
Rnor_5.013105,381,171 - 105,381,298UniSTSRnor5.0
RGSC_v3.41398,020,691 - 98,020,818UniSTSRGSC3.4
Celera1393,262,361 - 93,262,488UniSTS
Cytogenetic Map13q26UniSTS
Enah  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21393,640,009 - 93,641,156 (+)MAPPERmRatBN7.2
Rnor_6.013100,313,117 - 100,314,263NCBIRnor6.0
Rnor_5.013105,293,000 - 105,294,146UniSTSRnor5.0
RGSC_v3.41397,933,114 - 97,934,260UniSTSRGSC3.4
Celera1393,174,705 - 93,175,851UniSTS
Cytogenetic Map13q26UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31


1 to 30 of 31 rows
RefSeq Transcripts NM_001012150 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001401377 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001415736 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017598853 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017598854 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017598855 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017598856 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017598857 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017598858 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017598859 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017598860 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017598861 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017598862 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090926 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090933 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272493 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272494 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272495 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272496 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272497 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272498 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272499 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272500 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272502 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272503 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272504 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272505 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272506 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC083927 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213757 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
1 to 30 of 31 rows

Ensembl Acc Id: ENSRNOT00000039974   ⟹   ENSRNOP00000050866
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1393,626,944 - 93,732,335 (-)Ensembl
Rnor_6.0 Ensembl13100,300,054 - 100,405,339 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000085188   ⟹   ENSRNOP00000073827
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1393,626,944 - 93,732,335 (-)Ensembl
Rnor_6.0 Ensembl13100,300,199 - 100,414,226 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000097600   ⟹   ENSRNOP00000081404
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1393,626,944 - 93,740,955 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000098544   ⟹   ENSRNOP00000081655
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1393,626,944 - 93,740,955 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000109962   ⟹   ENSRNOP00000076584
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1393,626,944 - 93,740,955 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000114419   ⟹   ENSRNOP00000079564
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1393,626,944 - 93,681,785 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000114860   ⟹   ENSRNOP00000097849
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1393,626,944 - 93,740,955 (-)Ensembl
RefSeq Acc Id: NM_001012150   ⟹   NP_001012150
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81396,149,437 - 96,264,080 (-)NCBI
mRatBN7.21393,617,747 - 93,732,403 (-)NCBI
Rnor_6.013100,300,042 - 100,405,339 (-)NCBI
Rnor_5.013105,277,627 - 105,392,796 (-)NCBI
RGSC_v3.41397,919,690 - 98,025,153 (-)RGD
Celera1393,161,661 - 93,266,823 (-)RGD
Sequence:
RefSeq Acc Id: NM_001401377   ⟹   NP_001388306
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81396,149,437 - 96,269,796 (-)NCBI
mRatBN7.21393,617,747 - 93,738,119 (-)NCBI
RefSeq Acc Id: NM_001415736   ⟹   NP_001402665
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81396,149,437 - 96,269,796 (-)NCBI
mRatBN7.21393,617,747 - 93,738,119 (-)NCBI
RefSeq Acc Id: XM_039090926   ⟹   XP_038946854
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81396,149,441 - 96,269,127 (-)NCBI
mRatBN7.21393,617,751 - 93,732,334 (-)NCBI
RefSeq Acc Id: XM_039090933   ⟹   XP_038946861
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81396,149,441 - 96,180,340 (-)NCBI
mRatBN7.21393,617,751 - 93,648,652 (-)NCBI
RefSeq Acc Id: XM_063272493   ⟹   XP_063128563
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81396,149,441 - 96,269,127 (-)NCBI
RefSeq Acc Id: XM_063272494   ⟹   XP_063128564
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81396,149,441 - 96,269,841 (-)NCBI
RefSeq Acc Id: XM_063272495   ⟹   XP_063128565
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81396,149,441 - 96,182,942 (-)NCBI
RefSeq Acc Id: XM_063272496   ⟹   XP_063128566
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81396,149,441 - 96,269,127 (-)NCBI
RefSeq Acc Id: XM_063272497   ⟹   XP_063128567
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81396,149,441 - 96,269,841 (-)NCBI
RefSeq Acc Id: XM_063272498   ⟹   XP_063128568
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81396,149,441 - 96,269,127 (-)NCBI
RefSeq Acc Id: XM_063272499   ⟹   XP_063128569
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81396,149,441 - 96,269,127 (-)NCBI
RefSeq Acc Id: XM_063272500   ⟹   XP_063128570
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81396,149,441 - 96,269,841 (-)NCBI
RefSeq Acc Id: XM_063272502   ⟹   XP_063128572
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81396,149,441 - 96,269,841 (-)NCBI
RefSeq Acc Id: XM_063272503   ⟹   XP_063128573
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81396,149,441 - 96,269,841 (-)NCBI
RefSeq Acc Id: XM_063272504   ⟹   XP_063128574
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81396,149,441 - 96,180,339 (-)NCBI
RefSeq Acc Id: XM_063272505   ⟹   XP_063128575
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81396,149,441 - 96,180,352 (-)NCBI
RefSeq Acc Id: XM_063272506   ⟹   XP_063128576
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81396,149,441 - 96,269,127 (-)NCBI
1 to 5 of 25 rows
1 to 5 of 25 rows
RefSeq Acc Id: NP_001012150   ⟸   NM_001012150
- Peptide Label: isoform 2
- UniProtKB: Q5XHX3 (UniProtKB/TrEMBL),   A6JGK5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000073827   ⟸   ENSRNOT00000085188
Ensembl Acc Id: ENSRNOP00000050866   ⟸   ENSRNOT00000039974
RefSeq Acc Id: XP_038946854   ⟸   XM_039090926
- Peptide Label: isoform X3
- UniProtKB: A0A8I6G5W6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038946861   ⟸   XM_039090933
- Peptide Label: isoform X12
WH1

Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K6I4-F1-model_v2 AlphaFold A0A0G2K6I4 1-564 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13699073
Promoter ID:EPDNEW_R9598
Type:initiation region
Name:Enah_1
Description:ENAH, actin regulator
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R9599  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.013100,405,407 - 100,405,467EPDNEW
RGD ID:13699090
Promoter ID:EPDNEW_R9599
Type:single initiation site
Name:Enah_2
Description:ENAH, actin regulator
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R9598  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.013100,414,312 - 100,414,372EPDNEW


1 to 40 of 45 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-17088 BioCyc
Ensembl Genes ENSRNOG00000031934 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000039974.6 UniProtKB/TrEMBL
  ENSRNOT00000085188 ENTREZGENE
  ENSRNOT00000085188.2 UniProtKB/TrEMBL
  ENSRNOT00000097600 ENTREZGENE
  ENSRNOT00000097600.1 UniProtKB/TrEMBL
  ENSRNOT00000098544 ENTREZGENE
  ENSRNOT00000098544.1 UniProtKB/TrEMBL
  ENSRNOT00000109962 ENTREZGENE
  ENSRNOT00000109962.1 UniProtKB/TrEMBL
  ENSRNOT00000114419.1 UniProtKB/TrEMBL
  ENSRNOT00000114860.1 UniProtKB/TrEMBL
  ENSRNOT00000153721 ENTREZGENE
  ENSRNOT00000171057 ENTREZGENE
Gene3D-CATH 2.30.29.30 UniProtKB/TrEMBL
  Vasodilator-stimulated phosphoprotein UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7135538 IMAGE-MGC_LOAD
InterPro EVH1 UniProtKB/TrEMBL
  PH_type UniProtKB/TrEMBL
  VASP_sf UniProtKB/TrEMBL
  VASP_tetra UniProtKB/TrEMBL
KEGG Report rno:360891 UniProtKB/TrEMBL
MGC_CLONE MGC:95334 IMAGE-MGC_LOAD
NCBI Gene 360891 ENTREZGENE
PANTHER PROTEIN ENABLED HOMOLOG UniProtKB/TrEMBL
  SPROUTY-RELATED, EVH1 DOMAIN-CONTAINING PROTEIN FAMILY MEMBER UniProtKB/TrEMBL
Pfam VASP_tetra UniProtKB/TrEMBL
  WH1 UniProtKB/TrEMBL
PhenoGen Enah PhenoGen
PRINTS PRICHEXTENSN UniProtKB/TrEMBL
PROSITE WH1 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000031934 RatGTEx
SMART WH1 UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/TrEMBL
  SSF118370 UniProtKB/TrEMBL
UniProt A0A0G2K6I4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5Y4S4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZND4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZT50 ENTREZGENE, UniProtKB/TrEMBL
1 to 40 of 45 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-06-12 Enah  ENAH, actin regulator  Enah  enabled homolog (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Enah  enabled homolog (Drosophila)  Enah_predicted  enabled homolog (Drosophila) (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Enah_predicted  enabled homolog (Drosophila) (predicted)      Symbol and Name status set to approved 70820 APPROVED