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small cell lung carcinoma pathway - Ontology Report - Rat Genome Database

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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (https://rgd.mcw.edu/rgdweb/contact/contactus.html).
Term:small cell lung carcinoma pathway
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Accession:PW:0000704 term browser browse the term
Definition:Small cell lung cancer is an aggressive type of lung cancer. Several pathways appear to be deregulated and they include the intrinsic apoptotic pathway, PI3K-Akt signaling and changes in oncogene transcription factors such as Myc and p53.
Synonyms:exact_synonym: oat cell carcinoma of lung pathway;   small cell carcinoma of lung pathway;   small cell lung cancer pathway;   small cell neuroendocrine carcinoma of lung pathway
 related_synonym: KEGG:05222;   SCLC pathway;   small cell lung neoplasm pathway

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small cell lung carcinoma pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 IEA KEGG rno:05222 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Akt2 AKT serine/threonine kinase 2 IEA KEGG rno:05222 NCBI chr 1:92,004,705...92,061,420
Ensembl chr 1:82,883,547...82,933,817 		JBrowse link
G Akt3 AKT serine/threonine kinase 3 IEA KEGG rno:05222 NCBI chr13:91,475,839...91,758,060
Ensembl chr13:88,946,091...89,225,708 		JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 IEA KEGG rno:05222 NCBI chr 7:27,381,392...27,466,772
Ensembl chr 7:25,494,609...25,579,540 		JBrowse link
G Bcl2 BCL2, apoptosis regulator IEA KEGG rno:05222 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl2l1 Bcl2-like 1 IEA KEGG rno:05222 NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:141,253,523...141,303,479
Ensembl chr 1:141,253,523...141,303,479 		JBrowse link
G Birc2 baculoviral IAP repeat-containing 2 IEA KEGG rno:05222 NCBI chr 8:13,253,697...13,273,672
Ensembl chr 8:4,968,842...4,988,732 		JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 IEA KEGG rno:05222 NCBI chr 8:13,285,702...13,313,329
Ensembl chr 8:5,000,845...5,015,802 		JBrowse link
G Casp9 caspase 9 IEA KEGG rno:05222 Ensembl chr 5:154,109,046...154,126,626 JBrowse link
G Ccnd1 cyclin D1 IEA KEGG rno:05222 NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Ccne1 cyclin E1 IEA KEGG rno:05222 NCBI chr 1:99,918,672...99,927,986
Ensembl chr 1:90,781,949...90,791,101 		JBrowse link
G Ccne2 cyclin E2 IEA KEGG rno:05222 NCBI chr 5:29,082,169...29,094,879
Ensembl chr 5:24,284,922...24,297,632 		JBrowse link
G Cdk2 cyclin dependent kinase 2 IEA KEGG rno:05222 NCBI chr 7:1,714,392...1,721,964
Ensembl chr 7:1,129,811...1,137,403 		JBrowse link
G Cdk4 cyclin-dependent kinase 4 IEA KEGG rno:05222 NCBI chr 7:64,771,453...64,774,891
Ensembl chr 7:62,883,105...62,942,403 		JBrowse link
G Cdk6 cyclin-dependent kinase 6 IEA KEGG rno:05222 NCBI chr 4:31,592,384...31,784,732
Ensembl chr 4:30,646,460...30,829,634 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B IEA KEGG rno:05222 NCBI chr 4:169,491,273...169,496,500
Ensembl chr 4:167,760,181...167,764,982 		JBrowse link
G Cdkn2b cyclin-dependent kinase inhibitor 2B IEA KEGG rno:05222 NCBI chr 5:109,123,308...109,134,906
Ensembl chr 5:104,010,680...104,019,050 		JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex IEA KEGG rno:05222 NCBI chr 1:252,908,748...252,944,273
Ensembl chr 1:242,959,760...242,995,065 		JBrowse link
G Cks1b CDC28 protein kinase regulatory subunit 1B IEA KEGG rno:05222 NCBI chr 2:177,130,751...177,135,333
Ensembl chr 2:174,833,050...174,837,636 		JBrowse link
G Cks2 CDC28 protein kinase regulatory subunit 2 IEA KEGG rno:05222 NCBI chr17:13,722,360...13,727,519 JBrowse link
G Col4a1 collagen type IV alpha 1 chain IEA KEGG rno:05222 NCBI chr16:84,885,597...84,996,482
Ensembl chr16:78,183,533...78,294,412 		JBrowse link
G Col4a2 collagen type IV alpha 2 chain IEA KEGG rno:05222 NCBI chr16:84,749,672...84,885,520
Ensembl chr16:78,047,602...78,183,839 		JBrowse link
G Col4a5 collagen type IV alpha 5 chain IEA KEGG rno:05222 NCBI chr  X:109,907,251...110,111,214
Ensembl chr  X:105,118,820...105,322,692 		JBrowse link
G Cycs cytochrome c, somatic IEA KEGG rno:05222 NCBI chr 4:80,982,667...80,984,767
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054 		JBrowse link
G Cyct cytochrome c, testis IEA KEGG rno:05222 NCBI chr 3:61,290,090...61,297,158
Ensembl chr 3:60,913,562...61,297,158 		JBrowse link
G E2f1 E2F transcription factor 1 IEA KEGG rno:05222 NCBI chr 3:163,524,739...163,535,563
Ensembl chr 3:143,049,478...143,075,361 		JBrowse link
G E2f3 E2F transcription factor 3 IEA KEGG rno:05222 NCBI chr17:34,810,355...34,887,725
Ensembl chr17:34,601,830...34,676,253 		JBrowse link
G Fhit fragile histidine triad diadenosine triphosphatase IEA KEGG rno:05222 NCBI chr15:16,365,401...17,872,901
Ensembl chr15:13,934,995...15,442,340 		JBrowse link
G Fn1 fibronectin 1 IEA KEGG rno:05222 NCBI chr 9:80,645,507...80,714,200
Ensembl chr 9:73,196,044...73,264,678 		JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta IEA KEGG rno:05222 NCBI chr16:76,021,968...76,075,717
Ensembl chr16:69,319,554...69,373,250 		JBrowse link
G Ikbkg inhibitor of nuclear factor kappa B kinase regulatory subunit gamma IEA KEGG rno:05222 NCBI chr  X:157,358,279...157,397,563
Ensembl chr  X:152,216,596...152,239,499 		JBrowse link
G Itga2 integrin subunit alpha 2 IEA KEGG rno:05222 NCBI chr 2:48,253,412...48,354,509
Ensembl chr 2:46,523,948...46,621,481 		JBrowse link
G Itga2b integrin subunit alpha 2b IEA KEGG rno:05222 NCBI chr10:87,908,697...87,926,225
Ensembl chr10:87,408,536...87,426,168 		JBrowse link
G Itga6 integrin subunit alpha 6 IEA KEGG rno:05222 NCBI chr 3:77,012,168...77,097,076
Ensembl chr 3:56,617,268...56,689,428 		JBrowse link
G Itgb1 integrin subunit beta 1 IEA KEGG rno:05222 NCBI chr19:73,602,277...73,650,271
Ensembl chr19:56,705,171...56,753,195 		JBrowse link
G Lama1 laminin subunit alpha 1 IEA KEGG rno:05222 NCBI chr 9:115,139,548...115,263,620
Ensembl chr 9:107,692,770...107,817,478 		JBrowse link
G Lama2 laminin subunit alpha 2 IEA KEGG rno:05222 NCBI chr 1:19,492,126...20,140,056
Ensembl chr 1:17,672,536...18,320,530 		JBrowse link
G Lama5 laminin subunit alpha 5 IEA KEGG rno:05222 NCBI chr 3:187,647,904...187,695,974
Ensembl chr 3:167,270,296...167,318,451 		JBrowse link
G Lamb2 laminin subunit beta 2 IEA KEGG rno:05222 NCBI chr 8:118,056,899...118,069,090
Ensembl chr 8:109,178,409...109,190,549 		JBrowse link
G Lamb3 laminin subunit beta 3 IEA KEGG rno:05222 NCBI chr13:107,362,514...107,404,081
Ensembl chr13:104,833,873...104,875,405 		JBrowse link
G Lamc1 laminin subunit gamma 1 IEA KEGG rno:05222 NCBI chr13:67,924,872...68,051,986
Ensembl chr13:65,374,372...65,501,492 		JBrowse link
G Lamc2 laminin subunit gamma 2 IEA KEGG rno:05222 NCBI chr13:67,835,199...67,894,694
Ensembl chr13:65,284,664...65,344,200 		JBrowse link
G Lamc3 laminin subunit gamma 3 IEA KEGG rno:05222 NCBI chr 3:35,562,989...35,624,460
Ensembl chr 3:15,165,220...15,226,697 		JBrowse link
G Max MYC associated factor X IEA KEGG rno:05222 NCBI chr 6:101,369,989...101,395,333
Ensembl chr 6:95,636,858...95,662,137 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor IEA KEGG rno:05222 NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 IEA KEGG rno:05222 NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Nfkbia NFKB inhibitor alpha IEA KEGG rno:05222 NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Nos2 nitric oxide synthase 2 IEA KEGG rno:05222 NCBI chr10:64,313,335...64,349,221
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Pias1 protein inhibitor of activated STAT, 1 IEA KEGG rno:05222 NCBI chr 8:72,233,566...72,347,085
Ensembl chr 8:63,338,150...63,438,905 		JBrowse link
G Pias2 protein inhibitor of activated STAT, 2 IEA KEGG rno:05222 NCBI chr18:72,883,008...72,989,486
Ensembl chr18:70,607,665...70,710,033 		JBrowse link
G Pias3 protein inhibitor of activated STAT, 3 IEA KEGG rno:05222 NCBI chr 2:186,921,384...186,930,292
Ensembl chr 2:184,232,571...184,241,480 		JBrowse link
G Pias4 protein inhibitor of activated STAT, 4 IEA KEGG rno:05222 NCBI chr 7:9,197,032...9,210,557
Ensembl chr 7:8,546,312...8,559,808 		JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha IEA KEGG rno:05222 NCBI chr 2:117,103,643...117,177,411
Ensembl chr 2:115,174,984...115,249,032 		JBrowse link
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta IEA KEGG rno:05222 NCBI chr 8:108,474,017...108,579,140
Ensembl chr 8:99,594,644...99,699,663 		JBrowse link
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta IEA KEGG rno:05222 NCBI chr 5:165,377,994...165,426,620
Ensembl chr 5:160,094,952...160,120,930 		JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 IEA KEGG rno:05222 NCBI chr 2:34,612,946...34,697,660
Ensembl chr 2:32,882,032...32,963,631 		JBrowse link
G Pik3r2 phosphoinositide-3-kinase regulatory subunit 2 IEA KEGG rno:05222 NCBI chr16:18,699,389...18,708,045
Ensembl chr16:18,665,457...18,674,065 		JBrowse link
G Pik3r3 phosphoinositide-3-kinase regulatory subunit 3 IEA KEGG rno:05222 NCBI chr 5:134,936,790...135,009,303
Ensembl chr 5:129,701,229...129,772,583 		JBrowse link
G Pik3r5 phosphoinositide-3-kinase, regulatory subunit 5 IEA KEGG rno:05222 NCBI chr10:53,631,469...53,699,550
Ensembl chr10:53,132,603...53,199,374 		JBrowse link
G Pten phosphatase and tensin homolog IEA KEGG rno:05222 NCBI chr 1:240,043,707...240,110,330
Ensembl chr 1:230,630,338...230,696,838 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 IEA KEGG rno:05222 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Ptk2 protein tyrosine kinase 2 IEA KEGG rno:05222 NCBI chr 7:107,015,730...107,220,865
Ensembl chr 7:105,126,728...105,331,783 		JBrowse link
G Rarb retinoic acid receptor, beta IEA KEGG rno:05222 NCBI chr15:10,837,252...11,482,037
Ensembl chr15:8,406,492...9,051,288 		JBrowse link
G Rb1 RB transcriptional corepressor 1 IEA KEGG rno:05222 NCBI chr15:54,780,858...54,911,989
Ensembl chr15:48,371,296...48,502,302 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit IEA KEGG rno:05222 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Rxra retinoid X receptor alpha IEA KEGG rno:05222 NCBI chr 3:31,387,892...31,474,415
Ensembl chr 3:10,989,832...11,073,712 		JBrowse link
G Rxrb retinoid X receptor beta IEA KEGG rno:05222 NCBI chr20:4,818,707...4,824,968
Ensembl chr20:4,816,815...4,828,773 		JBrowse link
G Rxrg retinoid X receptor gamma IEA KEGG rno:05222 NCBI chr13:82,276,330...82,318,097
Ensembl chr13:79,743,563...79,785,167 		JBrowse link
G Skp2 S-phase kinase associated protein 2 IEA KEGG rno:05222 NCBI chr 2:59,888,406...59,916,471
Ensembl chr 2:58,161,229...58,189,338 		JBrowse link
G Tp53 tumor protein p53 IEA KEGG rno:05222 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Traf2 Tnf receptor-associated factor 2 IEA KEGG rno:05222 NCBI chr 3:28,740,098...28,764,752
Ensembl chr 3:8,341,951...8,366,538 		JBrowse link
G Traf3 Tnf receptor-associated factor 3 IEA KEGG rno:05222 NCBI chr 6:136,025,097...136,128,363
Ensembl chr 6:130,206,484...130,305,481 		JBrowse link
G Traf4 Tnf receptor associated factor 4 IEA KEGG rno:05222 NCBI chr10:63,552,251...63,558,356
Ensembl chr10:63,054,181...63,060,284 		JBrowse link
G Traf6 TNF receptor associated factor 6 IEA KEGG rno:05222 NCBI chr 3:108,418,537...108,443,330
Ensembl chr 3:87,963,514...87,983,507 		JBrowse link
G Xiap X-linked inhibitor of apoptosis IEA KEGG rno:05222 NCBI chr  X:125,756,107...125,803,979
Ensembl chr  X:120,897,907...120,934,700 		JBrowse link
Term paths to the root
Path 1
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  pathway 6091
    disease pathway 1954
      cancer pathway 369
        thoracic cancer pathway 104
          respiratory tract cancer pathway 104
            lung cancer pathway 104
              small cell lung carcinoma pathway 75
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