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ONTOLOGY REPORT - ANNOTATIONS

Term:intrinsic apoptotic signaling pathway in response to DNA damage
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Accession:GO:0008630 term browser browse the term
Definition:The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the detection of DNA damage, and ends when the execution phase of apoptosis is triggered.
Synonyms:related_synonym: DNA damage response, signal transduction resulting in induction of apoptosis


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intrinsic apoptotic signaling pathway in response to DNA damage term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atad5 ATPase family, AAA domain containing 5 acts_upstream_of_or_within IGI (PMID:15983387) MGI PMID:15983387 NCBI chr11:79,980,205...80,026,623
Ensembl chr11:79,980,226...80,026,620 		JBrowse link
G Atm ataxia telangiectasia mutated acts_upstream_of_or_within
involved_in		 IMP
IGI
IBA		 (PMID:11040211), (PMID:16777961)
(PMID:17476307)		 MGI
GO_Central		 PMID:11040211 PMID:16777961 PMID:17476307 GO_REF:0000033 NCBI chr 9:53,348,422...53,448,125
Ensembl chr 9:53,350,449...53,448,040 		JBrowse link
G Bad BCL2-associated agonist of cell death acts_upstream_of_or_within IMP
IDA		 (PMID:12431371)
(PMID:15231831)		 MGI PMID:12431371 PMID:15231831 NCBI chr19:6,919,229...6,929,273
Ensembl chr19:6,919,229...6,929,267 		JBrowse link
G Bak1 BCL2-antagonist/killer 1 acts_upstream_of_or_within
involved_in		 IMP
IBA
IGI		 (PMID:15901672)
(PMID:15967824)		 MGI
GO_Central		 PMID:15901672 PMID:15967824 GO_REF:0000033 NCBI chr17:27,238,786...27,247,601
Ensembl chr17:27,238,784...27,247,983 		JBrowse link
G Bax BCL2-associated X protein acts_upstream_of_or_within
involved_in		 IMP
IGI
ISO
IBA		 (PMID:12952892)
(PMID:15901672)
(PMID:15967824)		 MGI
GO_Central		 PMID:12952892 PMID:15901672 PMID:15967824 GO_REF:0000033 GO_REF:0000119 NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322 		JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 acts_upstream_of_or_within
involved_in		 IGI
IBA		 (PMID:15983387) MGI
GO_Central		 PMID:15983387 GO_REF:0000033 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004 		JBrowse link
G Bcl2a1a B cell leukemia/lymphoma 2 related protein A1a involved_in IBA GO_Central GO_REF:0000033 NCBI chr 9:88,838,973...88,844,469
Ensembl chr 9:88,838,953...88,844,472 		JBrowse link
G Bcl2a1b B cell leukemia/lymphoma 2 related protein A1b involved_in IBA GO_Central GO_REF:0000033 NCBI chr 9:89,081,326...89,089,891
Ensembl chr 9:89,081,262...89,089,880 		JBrowse link
G Bcl2a1c B cell leukemia/lymphoma 2 related protein A1c involved_in IBA GO_Central GO_REF:0000033 NCBI chr 9:114,159,203...114,159,646
Ensembl chr 9:114,159,203...114,159,646 		JBrowse link
G Bcl2a1d B cell leukemia/lymphoma 2 related protein A1d involved_in IBA GO_Central GO_REF:0000033 NCBI chr 9:88,605,341...88,613,903
Ensembl chr 9:88,605,338...88,613,967 		JBrowse link
G Bcl2l1 BCL2-like 1 acts_upstream_of_or_within
involved_in		 IMP
IBA		 (PMID:14517295) MGI
GO_Central		 PMID:14517295 GO_REF:0000033 NCBI chr 2:152,600,652...152,673,632
Ensembl chr 2:152,622,588...152,673,648 		JBrowse link
G Bcl2l10 Bcl2-like 10 involved_in IBA GO_Central GO_REF:0000033 NCBI chr 9:75,255,040...75,258,922
Ensembl chr 9:75,255,040...75,258,931 		JBrowse link
G Bcl2l11 BCL2 like 11 acts_upstream_of_or_within ISO
IGI		 (PMID:11546872)
(PMID:15967824)		 MGI PMID:11546872 PMID:15967824 NCBI chr 2:127,967,958...128,004,467
Ensembl chr 2:127,967,958...128,004,467 		JBrowse link
G Bcl2l2 BCL2-like 2 involved_in IBA GO_Central GO_REF:0000033 NCBI chr14:55,120,900...55,125,691
Ensembl chr14:55,120,834...55,125,691 		JBrowse link
G Bok BCL2-related ovarian killer involved_in IBA GO_Central GO_REF:0000033 NCBI chr 1:93,613,297...93,623,492
Ensembl chr 1:93,613,382...93,623,486 		JBrowse link
G Brca1 breast cancer 1, early onset acts_upstream_of_or_within ISO (PMID:14654789) MGI PMID:14654789 NCBI chr11:101,379,587...101,442,808
Ensembl chr11:101,379,590...101,442,781 		JBrowse link
G Brca2 breast cancer 2, early onset acts_upstream_of_or_within IGI (PMID:17476307) MGI PMID:17476307 NCBI chr 5:150,445,759...150,493,612
Ensembl chr 5:150,446,095...150,493,794 		JBrowse link
G Casp2 caspase 2 involved_in IBA GO_Central GO_REF:0000033 NCBI chr 6:42,241,942...42,259,442
Ensembl chr 6:42,241,919...42,259,442 		JBrowse link
G Casp9 caspase 9 involved_in IBA
ISO
ISS		 GO_Central
UniProt		 GO_REF:0000024 GO_REF:0000033 GO_REF:0000119 NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287 		JBrowse link
G Chek2 checkpoint kinase 2 involved_in ISO
ISS		 GO_Central
UniProt		 GO_REF:0000024 GO_REF:0000119 NCBI chr 5:110,987,668...111,022,006
Ensembl chr 5:110,987,845...111,022,011 		JBrowse link
G Crip1 cysteine-rich protein 1 involved_in IBA
ISO
ISS		 (PMID:20415737) GO_Central
UniProt		 PMID:20415737 GO_REF:0000033 GO_REF:0000119 NCBI chr12:113,115,632...113,117,499
Ensembl chr12:113,109,936...113,117,499 		JBrowse link
G E2f1 E2F transcription factor 1 involved_in ISO
IEA		 GO_Central
Ensembl		 GO_REF:0000107 GO_REF:0000119 NCBI chr 2:154,401,320...154,411,812
Ensembl chr 2:154,401,327...154,411,812 		JBrowse link
G Ei24 etoposide induced 2.4 mRNA acts_upstream_of_or_within IDA (PMID:10594026) MGI PMID:10594026 NCBI chr 9:36,690,449...36,708,630
Ensembl chr 9:36,690,455...36,708,689 		JBrowse link
G Epha2 Eph receptor A2 involved_in IEA
ISO		 Ensembl
GO_Central		 GO_REF:0000107 GO_REF:0000119 NCBI chr 4:141,028,532...141,056,695
Ensembl chr 4:141,028,551...141,056,695 		JBrowse link
G Ercc6 excision repair cross-complementing rodent repair deficiency, complementation group 6 acts_upstream_of_or_within IMP (PMID:11005836) MGI PMID:11005836 NCBI chr14:32,235,248...32,302,947
Ensembl chr14:32,235,478...32,302,947 		JBrowse link
G Fnip2 folliculin interacting protein 2 involved_in IMP (PMID:19137017) UniProt PMID:19137017 NCBI chr 3:79,363,556...79,475,458
Ensembl chr 3:79,363,281...79,475,103 		JBrowse link
G Hic1 hypermethylated in cancer 1 involved_in IDA
ISO		 (PMID:16269335) UniProt
GO_Central		 PMID:16269335 GO_REF:0000119 NCBI chr11:75,052,203...75,059,970
Ensembl chr11:75,055,391...75,060,345 		JBrowse link
G Hmox1 heme oxygenase 1 involved_in ISO RGD
GO_Central		 PMID:11854317 GO_REF:0000096 RGD:625692 NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217 		JBrowse link
G Htra2 HtrA serine peptidase 2 involved_in ISO
IEA		 GO_Central
Ensembl		 GO_REF:0000107 GO_REF:0000119 NCBI chr 6:83,028,247...83,031,552
Ensembl chr 6:83,028,247...83,032,254 		JBrowse link
G Ier3 immediate early response 3 acts_upstream_of_or_within IDA (PMID:11753682) MGI PMID:11753682 NCBI chr17:36,132,605...36,133,803
Ensembl chr17:36,132,576...36,133,815 		JBrowse link
G Ikbke inhibitor of kappaB kinase epsilon involved_in ISS
ISO		 UniProt
GO_Central		 GO_REF:0000024 GO_REF:0000119 NCBI chr 1:131,182,337...131,207,339
Ensembl chr 1:131,182,080...131,207,344 		JBrowse link
G Mael maelstrom spermatogenic transposon silencer acts_upstream_of_or_within IMP (PMID:18694567) MGI PMID:18694567 NCBI chr 1:166,028,954...166,066,313
Ensembl chr 1:166,028,770...166,066,316 		JBrowse link
G Mbd4 methyl-CpG binding domain protein 4 acts_upstream_of_or_within IMP (PMID:14562041) MGI PMID:14562041 NCBI chr 6:115,817,658...115,830,361
Ensembl chr 6:115,817,658...115,830,332 		JBrowse link
G Mcl1 myeloid cell leukemia sequence 1 acts_upstream_of_or_within
involved_in		 IDA
IBA		 (PMID:15901672) MGI
GO_Central		 PMID:15901672 GO_REF:0000033 NCBI chr 3:95,564,017...95,583,553
Ensembl chr 3:95,566,099...95,570,487 		JBrowse link
G Mlh1 mutL homolog 1 acts_upstream_of_or_within IMP (PMID:14562041) MGI PMID:14562041 NCBI chr 9:111,057,296...111,100,854
Ensembl chr 9:111,057,296...111,100,859 		JBrowse link
G Moap1 modulator of apoptosis 1 involved_in ISO
IEA		 GO_Central
Ensembl		 GO_REF:0000107 GO_REF:0000119 NCBI chr12:102,706,089...102,709,920
Ensembl chr12:102,708,489...102,709,920 		JBrowse link
G Msh2 mutS homolog 2 acts_upstream_of_or_within IMP (PMID:10097137)
(PMID:14744764)		 MGI PMID:10097137 PMID:14744764 NCBI chr17:87,979,960...88,031,141
Ensembl chr17:87,979,758...88,031,141 		JBrowse link
G Msh6 mutS homolog 6 acts_upstream_of_or_within IMP (PMID:15324697) MGI PMID:15324697 NCBI chr17:88,282,478...88,298,320
Ensembl chr17:88,282,490...88,298,320 		JBrowse link
G Myc myelocytomatosis oncogene acts_upstream_of_or_within IMP
IDA		 (PMID:14517295) MGI PMID:14517295 NCBI chr15:61,857,190...61,862,210
Ensembl chr15:61,857,240...61,862,223 		JBrowse link
G Nfatc4 nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 4 acts_upstream_of_or_within IGI
IMP		 (PMID:17242187) MGI PMID:17242187 NCBI chr14:56,062,252...56,071,400
Ensembl chr14:56,060,601...56,071,400 		JBrowse link
G Pcbp4 poly(rC) binding protein 4 involved_in ISO (PMID:10891498) UniProt PMID:10891498 NCBI chr 9:106,330,181...106,341,211
Ensembl chr 9:106,330,490...106,341,211 		JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 acts_upstream_of_or_within IGI
IMP		 (PMID:17242187) MGI PMID:17242187 NCBI chr13:101,817,269...101,904,725
Ensembl chr13:101,817,071...101,904,725 		JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 acts_upstream_of_or_within IMP (PMID:12952892) MGI PMID:12952892 NCBI chr18:66,591,675...66,598,629
Ensembl chr18:66,591,604...66,598,636 		JBrowse link
G Pml promyelocytic leukemia acts_upstream_of_or_within
involved_in		 IMP
IBA
ISO		 (PMID:15626733)
(PMID:9806545)		 MGI
GO_Central		 PMID:9806545 PMID:15626733 GO_REF:0000033 GO_REF:0000119 NCBI chr 9:58,125,359...58,157,077
Ensembl chr 9:58,125,359...58,157,069 		JBrowse link
G Pnp purine-nucleoside phosphorylase acts_upstream_of_or_within IMP (PMID:10859343) MGI PMID:10859343 NCBI chr14:51,181,760...51,190,869
Ensembl chr14:51,168,539...51,190,869 		JBrowse link
G Polb polymerase (DNA directed), beta acts_upstream_of_or_within IMP (PMID:10197627) MGI PMID:10197627 NCBI chr 8:23,118,135...23,143,482
Ensembl chr 8:23,118,142...23,143,451 		JBrowse link
G Prkdc protein kinase, DNA activated, catalytic polypeptide involved_in
acts_upstream_of_or_within		 IBA
IMP		 (PMID:12604618) GO_Central
MGI		 PMID:12604618 GO_REF:0000033 NCBI chr16:15,455,698...15,660,103
Ensembl chr16:15,455,730...15,660,099 		JBrowse link
G Rad9a RAD9 checkpoint clamp component A acts_upstream_of IMP
IGI		 (PMID:15983387) MGI PMID:15983387 NCBI chr19:4,245,195...4,251,710
Ensembl chr19:4,245,195...4,251,661 		JBrowse link
G Sfn stratifin involved_in ISO
IEA		 GO_Central
Ensembl		 GO_REF:0000107 GO_REF:0000119 NCBI chr 4:133,327,867...133,329,163
Ensembl chr 4:133,327,867...133,329,479 		JBrowse link
G Sirt1 sirtuin 1 involved_in IDA (PMID:16269335) UniProt PMID:16269335 NCBI chr10:63,154,784...63,174,814
Ensembl chr10:63,154,784...63,217,483 		JBrowse link
G Skil SKI-like acts_upstream_of IMP (PMID:10811619) MGI PMID:10811619 NCBI chr 3:31,149,259...31,176,741
Ensembl chr 3:31,149,207...31,176,726 		JBrowse link
G Sod2 superoxide dismutase 2, mitochondrial acts_upstream_of_or_within IMP (PMID:15642323) MGI PMID:15642323 NCBI chr17:13,226,726...13,237,006
Ensembl chr17:13,225,733...13,258,950 		JBrowse link
G Tnf tumor necrosis factor acts_upstream_of_or_within IDA (PMID:17242187) MGI PMID:17242187 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
G Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a acts_upstream_of_or_within IMP (PMID:17242187) MGI PMID:17242187 NCBI chr 6:125,326,686...125,339,446
Ensembl chr 6:125,326,325...125,339,447 		JBrowse link
G Tnfrsf1b tumor necrosis factor receptor superfamily, member 1b acts_upstream_of_or_within
involved_in		 IMP
IBA		 (PMID:17242187) MGI
GO_Central		 PMID:17242187 GO_REF:0000033 NCBI chr 4:144,938,938...144,973,453
Ensembl chr 4:144,940,033...144,973,440 		JBrowse link
G Topors topoisomerase I binding, arginine/serine-rich involved_in ISO
ISS		 GO_Central
UniProt		 GO_REF:0000024 GO_REF:0000119 NCBI chr 4:40,259,606...40,269,841
Ensembl chr 4:40,259,601...40,269,850 		JBrowse link
G Uaca uveal autoantigen with coiled-coil domains and ankyrin repeats acts_upstream_of_or_within
involved_in		 IMP
IBA		 (PMID:15271982) MGI
GO_Central		 PMID:15271982 GO_REF:0000033 NCBI chr 9:60,700,488...60,787,713
Ensembl chr 9:60,701,824...60,787,652 		JBrowse link
G Usp47 ubiquitin specific peptidase 47 acts_upstream_of IMP (PMID:19966869) MGI PMID:19966869 NCBI chr 7:111,622,692...111,710,591
Ensembl chr 7:111,622,711...111,710,868 		JBrowse link
G Xpa xeroderma pigmentosum, complementation group A acts_upstream_of_or_within IMP (PMID:11005836) MGI PMID:11005836 NCBI chr 4:46,175,222...46,196,317
Ensembl chr 4:46,155,347...46,196,311 		JBrowse link
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aen apoptosis enhancing nuclease involved_in ISO
ISS
IBA		 GO_Central
UniProt		 GO_REF:0000024 GO_REF:0000033 GO_REF:0000119 NCBI chr 7:78,545,675...78,560,957
Ensembl chr 7:78,545,602...78,560,957 		JBrowse link
G Atad5 ATPase family, AAA domain containing 5 acts_upstream_of_or_within IGI (PMID:15983387) MGI PMID:15983387 NCBI chr11:79,980,205...80,026,623
Ensembl chr11:79,980,226...80,026,620 		JBrowse link
G Bag6 BCL2-associated athanogene 6 involved_in ISS
ISO		 UniProt
GO_Central		 GO_REF:0000024 GO_REF:0000119 NCBI chr17:35,354,132...35,366,297
Ensembl chr17:35,354,154...35,366,298 		JBrowse link
G Bbc3 BCL2 binding component 3 acts_upstream_of_or_within IMP (PMID:16151013) MGI PMID:16151013 NCBI chr 7:16,042,307...16,052,130
Ensembl chr 7:16,042,318...16,052,130 		JBrowse link
G Bcl3 B cell leukemia/lymphoma 3 acts_upstream_of_or_within ISO MGI GO_REF:0000008 NCBI chr 7:19,542,387...19,556,691
Ensembl chr 7:19,542,387...19,556,695 		JBrowse link
G Brca2 breast cancer 2, early onset acts_upstream_of_or_within IGI
IMP		 (PMID:17476307)
(PMID:15735671)		 MGI PMID:15735671 PMID:17476307 NCBI chr 5:150,445,759...150,493,612
Ensembl chr 5:150,446,095...150,493,794 		JBrowse link
G Cdip1 cell death inducing Trp53 target 1 acts_upstream_of_or_within
involved_in		 ISO
IBA		 MGI
GO_Central		 GO_REF:0000008 GO_REF:0000033 NCBI chr16:4,583,325...4,608,156
Ensembl chr16:4,568,212...4,608,156 		JBrowse link
G Cdkn1a cyclin dependent kinase inhibitor 1A acts_upstream_of_or_within IMP (PMID:12952892) MGI PMID:12952892 NCBI chr17:29,309,953...29,319,696
Ensembl chr17:29,309,950...29,319,701 		JBrowse link
G Chek2 checkpoint kinase 2 acts_upstream_of_or_within IMP (PMID:10710310) MGI PMID:10710310 NCBI chr 5:110,987,668...111,022,006
Ensembl chr 5:110,987,845...111,022,011 		JBrowse link
G Ddit4 DNA-damage-inducible transcript 4 involved_in IMP (PMID:21896779) UniProt PMID:21896779 NCBI chr10:59,785,497...59,787,592
Ensembl chr10:59,785,491...59,787,656 		JBrowse link
G Dyrk2 dual-specificity tyrosine phosphorylation regulated kinase 2 involved_in ISS
ISO		 UniProt
GO_Central		 GO_REF:0000024 GO_REF:0000119 NCBI chr10:118,691,507...118,725,144
Ensembl chr10:118,691,508...118,706,114 		JBrowse link
G Ell3 elongation factor RNA polymerase II-like 3 acts_upstream_of IMP (PMID:22768269) MGI PMID:22768269 NCBI chr 2:121,269,508...121,273,082
Ensembl chr 2:121,269,491...121,274,759 		JBrowse link
G Ep300 E1A binding protein p300 involved_in IEA
ISO		 Ensembl
GO_Central		 GO_REF:0000107 GO_REF:0000119 NCBI chr15:81,470,329...81,536,273
Ensembl chr15:81,469,552...81,536,278 		JBrowse link
G Hipk1 homeodomain interacting protein kinase 1 involved_in
acts_upstream_of_or_within		 IBA
IGI		 (PMID:16537918) GO_Central
MGI		 PMID:16537918 GO_REF:0000033 NCBI chr 3:103,647,131...103,699,210
Ensembl chr 3:103,647,131...103,698,879 		JBrowse link
G Hipk2 homeodomain interacting protein kinase 2 involved_in
acts_upstream_of_or_within		 IBA
IGI		 (PMID:16537918) GO_Central
MGI		 PMID:16537918 GO_REF:0000033 NCBI chr 6:38,664,447...38,853,236
Ensembl chr 6:38,671,325...38,853,099 		JBrowse link
G Ifi204 interferon activated gene 204 acts_upstream_of_or_within ISO (PMID:14654789) MGI PMID:14654789 NCBI chr 1:173,574,859...173,594,606
Ensembl chr 1:173,574,859...173,594,509 		JBrowse link
G Msh2 mutS homolog 2 acts_upstream_of_or_within IGI (PMID:10097137) MGI PMID:10097137 NCBI chr17:87,979,960...88,031,141
Ensembl chr17:87,979,758...88,031,141 		JBrowse link
G Nupr1 nuclear protein transcription regulator 1 acts_upstream_of_or_within IMP (PMID:11896600) MGI PMID:11896600 NCBI chr 7:126,222,418...126,224,642
Ensembl chr 7:126,222,421...126,230,033 		JBrowse link
G Phlda3 pleckstrin homology like domain, family A, member 3 involved_in IBA
ISO
ISS		 GO_Central
UniProt		 GO_REF:0000024 GO_REF:0000033 GO_REF:0000119 NCBI chr 1:135,693,823...135,696,872
Ensembl chr 1:135,693,857...135,696,874 		JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 acts_upstream_of_or_within IDA (PMID:10807576) MGI PMID:10807576 NCBI chr18:66,591,675...66,598,629
Ensembl chr18:66,591,604...66,598,636 		JBrowse link
G Pml promyelocytic leukemia involved_in IMP (PMID:15626733) UniProt PMID:15626733 NCBI chr 9:58,125,359...58,157,077
Ensembl chr 9:58,125,359...58,157,069 		JBrowse link
G Ppp2r5c protein phosphatase 2, regulatory subunit B', gamma involved_in ISO GO_Central GO_REF:0000119 NCBI chr12:110,413,532...110,549,509
Ensembl chr12:110,413,554...110,549,496 		JBrowse link
G Pycard PYD and CARD domain containing involved_in ISO
IEA		 GO_Central
Ensembl		 GO_REF:0000107 GO_REF:0000119 NCBI chr 7:127,590,545...127,593,039
Ensembl chr 7:127,588,880...127,593,039 		JBrowse link
G Rps27l ribosomal protein S27-like involved_in ISO GO_Central GO_REF:0000119 NCBI chr 9:66,851,906...66,856,804
Ensembl chr 9:66,853,368...66,856,798 		JBrowse link
G Shisa5 shisa family member 5 acts_upstream_of_or_within IDA (PMID:12135983) MGI PMID:12135983 NCBI chr 9:108,867,635...108,886,860
Ensembl chr 9:108,867,633...108,886,845 		JBrowse link
G Sirt1 sirtuin 1 involved_in ISO
ISS		 GO_Central
UniProt		 GO_REF:0000024 GO_REF:0000119 NCBI chr10:63,154,784...63,174,814
Ensembl chr10:63,154,784...63,217,483 		JBrowse link
G Snw1 SNW domain containing 1 involved_in ISO
ISS		 GO_Central
UniProt		 GO_REF:0000024 GO_REF:0000119 NCBI chr12:87,496,680...87,519,069
Ensembl chr12:87,495,845...87,519,044 		JBrowse link
G Tmem109 transmembrane protein 109 involved_in
acts_upstream_of_or_within		 IBA
IMP		 (PMID:20060811) GO_Central
MGI		 PMID:20060811 GO_REF:0000033 NCBI chr19:10,848,021...10,859,107
Ensembl chr19:10,848,024...10,859,365 		JBrowse link
G Topors topoisomerase I binding, arginine/serine-rich acts_upstream_of_or_within IDA (PMID:15735665) MGI PMID:15735665 NCBI chr 4:40,259,606...40,269,841
Ensembl chr 4:40,259,601...40,269,850 		JBrowse link
G Trp53 transformation related protein 53 acts_upstream_of_or_within
involved_in		 IMP
IDA
ISO
IGI		 (PMID:12135983)
(PMID:16213212)
(PMID:20818388)
(PMID:15983387)
(PMID:14654789)
(PMID:16286009)
(PMID:16777961)
(PMID:12952892)
(PMID:17476307)		 MGI
CAFA
GO_Central
BHF-UCL		 PMID:12135983 PMID:12952892 PMID:14654789 PMID:15983387 PMID:16213212 More... GO_REF:0000008 GO_REF:0000119 NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699 		JBrowse link
G Trp63 transformation related protein 63 acts_upstream_of_or_within IMP (PMID:17122775) MGI PMID:17122775 NCBI chr16:25,502,513...25,710,842
Ensembl chr16:25,502,513...25,710,852 		JBrowse link
G Trp73 transformation related protein 73 acts_upstream_of
involved_in		 IGI
ISO
ISS		 (PMID:15983387) MGI
GO_Central
UniProt		 PMID:15983387 GO_REF:0000024 GO_REF:0000119 NCBI chr 4:154,140,706...154,224,332
Ensembl chr 4:154,140,706...154,224,665 		JBrowse link
G Uri1 URI1, prefoldin-like chaperone involved_in IBA GO_Central GO_REF:0000033 NCBI chr 7:37,659,417...37,722,989
Ensembl chr 7:37,659,417...37,722,976 		JBrowse link
G Usp28 ubiquitin specific peptidase 28 involved_in ISS
ISO		 UniProt
GO_Central		 GO_REF:0000024 GO_REF:0000119 NCBI chr 9:48,896,577...48,953,817
Ensembl chr 9:48,896,675...48,953,817 		JBrowse link
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ackr3 atypical chemokine receptor 3 involved_in IEA
ISO		 Ensembl
GO_Central		 GO_REF:0000107 GO_REF:0000119 NCBI chr 1:90,131,702...90,143,446
Ensembl chr 1:90,131,702...90,144,473 		JBrowse link
G Atad5 ATPase family, AAA domain containing 5 acts_upstream_of_or_within IMP (PMID:15983387) MGI PMID:15983387 NCBI chr11:79,980,205...80,026,623
Ensembl chr11:79,980,226...80,026,620 		JBrowse link
G Bcl2l1 BCL2-like 1 involved_in ISO
IEA		 GO_Central
Ensembl		 GO_REF:0000107 GO_REF:0000119 NCBI chr 2:152,600,652...152,673,632
Ensembl chr 2:152,622,588...152,673,648 		JBrowse link
G Bid BH3 interacting domain death agonist acts_upstream_of_or_within IMP (PMID:26219591) MGI PMID:26219591 NCBI chr 6:120,870,080...120,894,074
Ensembl chr 6:120,868,891...120,893,814 		JBrowse link
G Ccar2 cell cycle activator and apoptosis regulator 2 involved_in ISS
ISO		 UniProt
GO_Central		 GO_REF:0000024 GO_REF:0000119 NCBI chr14:70,375,617...70,391,272
Ensembl chr14:70,375,613...70,391,260 		JBrowse link
G Cdkn2d cyclin dependent kinase inhibitor 2D involved_in IEA
ISO		 Ensembl
GO_Central		 GO_REF:0000107 GO_REF:0000119 NCBI chr 9:21,199,759...21,202,553
Ensembl chr 9:21,199,706...21,202,703 		JBrowse link
G Clu clusterin involved_in ISS
ISO		 UniProt
GO_Central		 GO_REF:0000024 GO_REF:0000119 NCBI chr14:66,206,093...66,218,992
Ensembl chr14:66,205,932...66,218,996 		JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 involved_in ISO GO_Central GO_REF:0000119 NCBI chr 6:117,145,496...117,158,329
Ensembl chr 6:117,145,496...117,158,328 		JBrowse link
G Ddias DNA damage-induced apoptosis suppressor involved_in ISO
IEA		 GO_Central
InterPro		 GO_REF:0000002 GO_REF:0000119 NCBI chr 7:92,506,734...92,523,455
Ensembl chr 7:92,506,733...92,523,455 		JBrowse link
G Sfrp2 secreted frizzled-related protein 2 involved_in ISO (PMID:14561758) BHF-UCL PMID:14561758 NCBI chr 3:83,673,628...83,681,621
Ensembl chr 3:83,673,628...83,681,623 		JBrowse link
G Snai1 snail family zinc finger 1 involved_in ISO
IEA		 GO_Central
Ensembl		 GO_REF:0000107 GO_REF:0000119 NCBI chr 2:167,380,115...167,384,734
Ensembl chr 2:167,380,115...167,384,734 		JBrowse link
G Snai2 snail family zinc finger 2 involved_in IEA
ISO		 Ensembl
GO_Central		 GO_REF:0000107 GO_REF:0000119 NCBI chr16:14,523,716...14,527,259
Ensembl chr16:14,523,716...14,527,249 		JBrowse link
G Tmem161a transmembrane protein 161A involved_in IEA
ISO		 Ensembl
GO_Central		 GO_REF:0000107 GO_REF:0000119 NCBI chr 8:70,624,979...70,636,331
Ensembl chr 8:70,625,006...70,636,331 		JBrowse link
G Tpt1 tumor protein, translationally-controlled 1 acts_upstream_of_or_within ISO MGI GO_REF:0000008 NCBI chr14:76,082,771...76,085,743
Ensembl chr14:76,082,533...76,085,965 		JBrowse link
G Trim32 tripartite motif-containing 32 involved_in ISS
ISO		 BHF-UCL
GO_Central		 GO_REF:0000024 GO_REF:0000119 NCBI chr 4:65,523,223...65,534,477
Ensembl chr 4:65,523,223...65,534,475 		JBrowse link
G Usp47 ubiquitin specific peptidase 47 acts_upstream_of_or_within IMP (PMID:19966869) MGI PMID:19966869 NCBI chr 7:111,622,692...111,710,591
Ensembl chr 7:111,622,711...111,710,868 		JBrowse link
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atad5 ATPase family, AAA domain containing 5 involved_in IMP (PMID:15983387) UniProt PMID:15983387 NCBI chr11:79,980,205...80,026,623
Ensembl chr11:79,980,226...80,026,620 		JBrowse link
G Bcl2l12 BCL2 like 12 acts_upstream_of_or_within IDA (PMID:20837658) MGI PMID:20837658 NCBI chr 7:44,640,646...44,647,011
Ensembl chr 7:44,640,646...44,648,136 		JBrowse link
G Cd44 CD44 antigen involved_in ISO
IMP		 (PMID:17045821) GO_Central
BHF-UCL		 PMID:17045821 GO_REF:0000119 NCBI chr 2:102,641,486...102,732,014
Ensembl chr 2:102,641,486...102,732,010 		JBrowse link
G Cd74 CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) involved_in IMP
IBA
ISO		 (PMID:17045821) BHF-UCL
GO_Central		 PMID:17045821 GO_REF:0000033 GO_REF:0000119 NCBI chr18:60,936,921...60,945,724
Ensembl chr18:60,936,920...60,945,724 		JBrowse link
G Ell3 elongation factor RNA polymerase II-like 3 acts_upstream_of_or_within IMP (PMID:22768269) MGI PMID:22768269 NCBI chr 2:121,269,508...121,273,082
Ensembl chr 2:121,269,491...121,274,759 		JBrowse link
G Kdm1a lysine (K)-specific demethylase 1A involved_in ISO
IEA		 GO_Central
Ensembl		 GO_REF:0000107 GO_REF:0000119 NCBI chr 4:136,277,844...136,330,127
Ensembl chr 4:136,277,851...136,330,034 		JBrowse link
G Marchf7 membrane associated ring-CH-type finger 7 involved_in ISO
ISS		 GO_Central
UniProt		 GO_REF:0000024 GO_REF:0000119 NCBI chr 2:60,040,086...60,079,555
Ensembl chr 2:60,040,231...60,081,020 		JBrowse link
G Mif macrophage migration inhibitory factor (glycosylation-inhibiting factor) involved_in ISO
IEA		 GO_Central
Ensembl		 GO_REF:0000107 GO_REF:0000119 NCBI chr10:75,695,187...75,696,111
Ensembl chr10:75,695,187...75,696,074 		JBrowse link
G Muc1 mucin 1, transmembrane involved_in ISO GO_Central GO_REF:0000119 NCBI chr 3:89,136,363...89,140,688
Ensembl chr 3:89,136,364...89,140,688 		JBrowse link
G Sirt1 sirtuin 1 involved_in IMP (PMID:11672522) BHF-UCL PMID:11672522 NCBI chr10:63,154,784...63,174,814
Ensembl chr10:63,154,784...63,217,483 		JBrowse link
G Triap1 TP53 regulated inhibitor of apoptosis 1 involved_in ISO
ISS		 GO_Central
HGNC		 GO_REF:0000024 GO_REF:0000119 NCBI chr 5:115,479,290...115,481,612
Ensembl chr 5:115,479,284...115,481,628 		JBrowse link
G Zfp385a zinc finger protein 385A involved_in ISS
ISO		 UniProt
GO_Central		 GO_REF:0000024 GO_REF:0000119 NCBI chr15:103,222,322...103,248,537
Ensembl chr15:103,222,322...103,248,520 		JBrowse link
positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fbh1 F-box DNA helicase 1 acts_upstream_of_or_within ISO MGI GO_REF:0000008 NCBI chr 2:11,747,384...11,782,396
Ensembl chr 2:11,747,384...11,782,393 		JBrowse link
G Mtch2 mitochondrial carrier 2 acts_upstream_of_or_within IMP (PMID:26219591) MGI PMID:26219591 NCBI chr 2:90,677,434...90,697,154
Ensembl chr 2:90,677,499...90,697,154 		JBrowse link
G Nacc2 nucleus accumbens associated 2, BEN and BTB (POZ) domain containing involved_in IEA
ISO		 Ensembl
GO_Central		 GO_REF:0000107 GO_REF:0000119 NCBI chr 2:25,945,547...26,012,823
Ensembl chr 2:25,945,547...26,013,232 		JBrowse link
G Pias4 protein inhibitor of activated STAT 4 acts_upstream_of_or_within IDA (PMID:16816390) MGI PMID:16816390 NCBI chr10:80,989,795...81,003,554
Ensembl chr10:80,989,100...81,003,757 		JBrowse link
G Plscr1 phospholipid scramblase 1 acts_upstream_of_or_within IDA (PMID:12509439) MGI PMID:12509439 NCBI chr 9:92,132,265...92,154,034
Ensembl chr 9:92,131,803...92,154,331 		JBrowse link
G Rad9a RAD9 checkpoint clamp component A acts_upstream_of_or_within IGI
IMP		 (PMID:15983387) MGI PMID:15983387 NCBI chr19:4,245,195...4,251,710
Ensembl chr19:4,245,195...4,251,661 		JBrowse link
G Rps3 ribosomal protein S3 involved_in ISO GO_Central GO_REF:0000119 NCBI chr 7:99,127,103...99,132,916
Ensembl chr 7:99,127,103...99,132,945 		JBrowse link
G Skil SKI-like acts_upstream_of_or_within IMP (PMID:10811619) MGI PMID:10811619 NCBI chr 3:31,149,259...31,176,741
Ensembl chr 3:31,149,207...31,176,726 		JBrowse link
positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rpl26 ribosomal protein L26 involved_in IMP
ISO		 (PMID:16213212) CAFA
GO_Central		 PMID:16213212 GO_REF:0000119 NCBI chr11:68,792,392...68,795,360
Ensembl chr11:68,792,409...68,797,815 		JBrowse link
G Steap3 STEAP family member 3 acts_upstream_of_or_within IMP (PMID:18617898) MGI PMID:18617898 NCBI chr 1:120,154,137...120,198,810
Ensembl chr 1:120,118,487...120,200,435 		JBrowse link
G Trp73 transformation related protein 73 acts_upstream_of_or_within IGI (PMID:15983387) MGI PMID:15983387 NCBI chr 4:154,140,706...154,224,332
Ensembl chr 4:154,140,706...154,224,665 		JBrowse link
regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hnrnpk heterogeneous nuclear ribonucleoprotein K acts_upstream_of_or_within IMP (PMID:20673990) MGI PMID:20673990 NCBI chr13:58,538,946...58,551,157
Ensembl chr13:58,538,956...58,551,157 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 28635
    response to stimulus 10961
      response to stress 4565
        cellular response to stress 2107
          DNA damage response 920
            intrinsic apoptotic signaling pathway in response to DNA damage 116
              intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator + 46
              negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage + 27
              positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage + 11
              regulation of intrinsic apoptotic signaling pathway in response to DNA damage + 39
Path 2
Term Annotations click to browse term
  biological_process 28635
    biological regulation 13440
      regulation of biological process 13004
        regulation of cellular process 12619
          signal transduction 6912
            apoptotic signaling pathway 709
              intrinsic apoptotic signaling pathway 368
                intrinsic apoptotic signaling pathway in response to DNA damage 116
                  intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator + 46
                  negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage + 27
                  positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage + 11
                  regulation of intrinsic apoptotic signaling pathway in response to DNA damage + 39
paths to the root