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Gene: Steap3 (STEAP family member 3) Mus musculus
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Symbol: Steap3
Name: STEAP family member 3
Description: Exhibits cupric reductase activity; ferric-chelate reductase (NADPH) activity; and ferric-chelate reductase activity. Involved in several processes, including exosomal secretion; positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; and transition metal ion transport. Localizes to the endosome and plasma membrane. Is expressed in bone; ganglia; liver; placenta; and rib. Orthologous to human STEAP3 (STEAP3 metalloreductase); PARTICIPATES IN iron uptake pathway; p53 signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2-butoxyethanol; 4,4'-sulfonyldiphenol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 1010001D01Rik; dudulin 2; dudulin-2; metalloreductase STEAP3; pHyde; protein nm1054; six-transmembrane epithelial antigen of prostate 3; Tsap6; tumor suppressor-activated pathway protein 6
Orthologs:
Homo sapiens (human) : STEAP3 (STEAP3 metalloreductase)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Steap3 (STEAP3 metalloreductase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Steap3 (STEAP3 metalloreductase)
Pan paniscus (bonobo/pygmy chimpanzee) : STEAP3 (STEAP3 metalloreductase)
Canis lupus familiaris (dog) : STEAP3 (STEAP3 metalloreductase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Steap3 (STEAP3 metalloreductase)
Sus scrofa (pig) : STEAP3 (STEAP3 metalloreductase)
Chlorocebus sabaeus (green monkey) : STEAP3 (STEAP3 metalloreductase)
Heterocephalus glaber (naked mole-rat) : Steap3 (STEAP3 metalloreductase)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl1120,190,757 - 120,272,705 (-)Ensembl
GRCm381120,226,414 - 120,271,082 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371122,122,993 - 122,167,659 (-)NCBIGRCm37mm9NCBIm37
MGSCv361122,054,752 - 122,092,804 (-)NCBImm8
Celera1122,886,890 - 122,931,707 (-)NCBICelera
Cytogenetic Map1E2.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Steap3
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1551194
Created: 2005-09-30
Species: Mus musculus
Last Modified: 2020-02-11
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.