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Gene: Steap3 (STEAP family member 3) Mus musculus
Symbol: Steap3
Name: STEAP family member 3
Description: Exhibits cupric reductase activity; ferric-chelate reductase (NADPH) activity; and ferric-chelate reductase activity. Involved in several processes, including exosomal secretion; positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; and transition metal ion transport. Localizes to the endosome and plasma membrane. Is expressed in bone; ganglia; liver; placenta; and rib. Orthologous to human STEAP3 (STEAP3 metalloreductase); PARTICIPATES IN iron uptake pathway; p53 signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2-butoxyethanol; 4,4'-sulfonyldiphenol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 1010001D01Rik; dudulin 2; dudulin-2; metalloreductase STEAP3; pHyde; protein nm1054; six-transmembrane epithelial antigen of prostate 3; Tsap6; tumor suppressor-activated pathway protein 6
Homo sapiens (human) : STEAP3 (STEAP3 metalloreductase)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Steap3 (STEAP3 metalloreductase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Steap3 (STEAP3 metalloreductase)
Pan paniscus (bonobo/pygmy chimpanzee) : STEAP3 (STEAP3 metalloreductase)
Canis lupus familiaris (dog) : STEAP3 (STEAP3 metalloreductase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Steap3 (STEAP3 metalloreductase)
Sus scrofa (pig) : STEAP3 (STEAP3 metalloreductase)
Chlorocebus sabaeus (green monkey) : STEAP3 (STEAP3 metalloreductase)
Heterocephalus glaber (naked mole-rat) : Steap3 (STEAP3 metalloreductase)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl1120,190,757 - 120,272,705 (-)Ensembl
GRCm381120,226,414 - 120,271,082 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371122,122,993 - 122,167,659 (-)NCBIGRCm37mm9NCBIm37
MGSCv361122,054,752 - 122,092,804 (-)NCBImm8
Celera1122,886,890 - 122,931,707 (-)NCBICelera
Cytogenetic Map1E2.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Steap3
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1551194
Created: 2005-09-30
Species: Mus musculus
Last Modified: 2020-02-11
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.