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Gene: Pias4 (protein inhibitor of activated STAT 4) Mus musculus
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Symbol: Pias4
Name: protein inhibitor of activated STAT 4
RGD ID: 1318688
Description: Exhibits several functions, including SUMO ligase activity; transcription corepressor activity; and ubiquitin protein ligase binding activity. Involved in several processes, including negative regulation of tumor necrosis factor-mediated signaling pathway; positive regulation of apoptotic process; and regulation of transcription, DNA-templated. Localizes to nuclear matrix; nucleoplasm; and transferase complex. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; heart; and limb. Orthologous to human PIAS4 (protein inhibitor of activated STAT 4); PARTICIPATES IN ataxia telangiectasia-mutated (ATM) signaling pathway; Jak-Stat signaling pathway; type II interferon signaling pathway; INTERACTS WITH 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine; aflatoxin B1.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: E3 SUMO-protein ligase PIAS4; P; Pias-gamma; Piasg; PIASY; protein inhibitor of activated STAT PIASy; protein inhibitor of activated STAT protein 4; protein inhibitor of activated STAT protein gamma; RING-type E3 ubiquitin transferase PIAS4
Orthologs:
Homo sapiens (human) : PIAS4 (protein inhibitor of activated STAT 4)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Pias4 (protein inhibitor of activated STAT, 4)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pias4 (protein inhibitor of activated STAT 4)
Pan paniscus (bonobo/pygmy chimpanzee) : PIAS4 (protein inhibitor of activated STAT 4)
Canis lupus familiaris (dog) : PIAS4 (protein inhibitor of activated STAT 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pias4 (protein inhibitor of activated STAT 4)
Sus scrofa (pig) : PIAS4 (protein inhibitor of activated STAT 4)
Chlorocebus sabaeus (African green monkey) : PIAS4 (protein inhibitor of activated STAT 4)
Heterocephalus glaber (naked mole-rat) : Pias4 (protein inhibitor of activated STAT 4)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391080,989,795 - 81,003,554 (-)NCBI
GRCm381081,153,961 - 81,167,720 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1081,153,266 - 81,167,923 (-)EnsemblGRCm38mm10GRCm38
MGSCv371080,616,706 - 80,630,465 (-)NCBIGRCm37mm9NCBIm37
MGSCv361080,557,090 - 80,571,052 (-)NCBImm8
Celera1082,174,317 - 82,188,076 (-)NCBICelera
Cytogenetic Map10C1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
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References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
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Additional Information

External Database Links
 
More on Pias4
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1318688
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2020-10-13
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.