Prkdc (protein kinase, DNA activated, catalytic polypeptide) - Rat Genome Database

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Gene: Prkdc (protein kinase, DNA activated, catalytic polypeptide) Mus musculus
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Symbol: Prkdc
Name: protein kinase, DNA activated, catalytic polypeptide
RGD ID: 1319073
MGI Page MGI
Description: Enables DNA-dependent protein kinase activity; double-stranded DNA binding activity; and enzyme binding activity. Involved in several processes, including regulation of hematopoietic stem cell differentiation; regulation of hemopoiesis; and regulation of protein metabolic process. Acts upstream of or within several processes, including DNA metabolic process; ectopic germ cell programmed cell death; and hemopoiesis. Located in nucleus. Is expressed in several structures, including central nervous system; liver; neural retina; and thymus primordium. Used to study Duchenne muscular dystrophy; severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, Nk cell-positive; and type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in immunodeficiency 26. Orthologous to human PRKDC (protein kinase, DNA-activated, catalytic subunit).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AI326420; AU019811; DNA; DNA-; DNA-dependent protein kinase catalytic subunit; DNA-PK catalytic subunit; DNA-PKcs; DNAPDcs; DNAPK; DNPK1; DOX; DOXNPH; doxorubicin nephropathy; dxn; dxnph; HYRC1; p460; scid; severe combined immunodeficiency; slip; XRCC; XRCC7
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391615,455,698 - 15,660,103 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1615,455,730 - 15,660,099 (+)EnsemblGRCm39 Ensembl
GRCm381615,637,444 - 15,842,239 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1615,637,866 - 15,842,235 (+)EnsemblGRCm38mm10GRCm38
MGSCv371615,637,959 - 15,842,332 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361615,551,467 - 15,755,813 (+)NCBIMGSCv36mm8
Celera1616,214,291 - 16,413,213 (+)NCBICelera
Cytogenetic Map16A2NCBI
cM Map1610.09NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
(-)-alpha-phellandrene  (EXP)
(-)-demecolcine  (ISO)
(1->4)-beta-D-glucan  (EXP)
1,2-dimethylhydrazine  (EXP)
1-chloro-2,4-dinitrobenzene  (ISO)
1-nitropyrene  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4,6-tribromophenol  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-aminobenzamide  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-Nitrofluoranthene  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-amino-1,8-naphthalimide  (EXP)
4-hydroxynon-2-enal  (ISO)
4-nitrophenol  (EXP)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
7,12-dimethyltetraphene  (EXP)
acrolein  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (EXP)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
alpha-phellandrene  (EXP)
alpha-pinene  (ISO)
amphetamine  (ISO)
aphidicolin  (ISO)
arecoline  (ISO)
aristolochic acid A  (ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (ISO)
atrazine  (ISO)
benzene  (EXP,ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[e]pyrene  (ISO)
beta-lapachone  (ISO)
biphenyl-4-amine  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (EXP)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
bromoacetate  (ISO)
butanal  (ISO)
cadmium dichloride  (ISO)
caffeine  (EXP,ISO)
capsaicin  (ISO)
casticin  (ISO)
chlorpyrifos  (EXP)
chromium atom  (ISO)
cisplatin  (EXP,ISO)
clofibrate  (EXP)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
coumarin  (ISO)
coumestrol  (ISO)
curcumin  (ISO)
deguelin  (ISO)
dexamethasone  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
dichlorvos  (ISO)
dicrotophos  (ISO)
dioxygen  (EXP)
doxorubicin  (EXP,ISO)
endosulfan  (ISO)
Enterolactone  (ISO)
enzyme inhibitor  (ISO)
etoposide  (ISO)
folic acid  (EXP,ISO)
FR900359  (ISO)
fulvestrant  (ISO)
furan  (ISO)
gallic acid  (ISO)
glyphosate  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (EXP,ISO)
indometacin  (ISO)
irinotecan  (ISO)
ivermectin  (ISO)
josamycin  (ISO)
lead diacetate  (EXP)
lipopolysaccharide  (ISO)
lycopene  (ISO)
methapyrilene  (ISO)
monocrotaline  (EXP)
motexafin gadolinium  (ISO)
myristicin  (ISO)
N-acetyl-L-cysteine  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
ochratoxin A  (ISO)
ouabain  (ISO)
oxaliplatin  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (EXP)
phenol  (ISO)
phenytoin  (EXP)
phosphoramide mustard  (ISO)
pifithrin-?  (ISO)
pirinixic acid  (EXP)
quercetin  (EXP,ISO)
raloxifene  (ISO)
resveratrol  (ISO)
rifampicin  (EXP)
SB 431542  (ISO)
serpentine asbestos  (EXP)
sodium arsenite  (EXP,ISO)
tamibarotene  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (ISO)
thiram  (ISO)
titanium dioxide  (EXP)
topotecan  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
trovafloxacin  (EXP)
tungsten  (EXP)
urethane  (ISO)
usnic acid  (ISO)
valproic acid  (ISO)
vinclozolin  (ISO)
vincristine  (ISO)
vorinostat  (ISO)
wortmannin  (EXP)
zinc acetate  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of innate immune response  (IEA,ISO)
B cell lineage commitment  (IMP)
brain development  (IGI)
cellular response to insulin stimulus  (IEA,ISO)
chromatin remodeling  (IEA)
DNA damage response  (ISO,ISS)
double-strand break repair  (IBA,IMP,ISO)
double-strand break repair via nonhomologous end joining  (IMP,NAS)
ectopic germ cell programmed cell death  (IMP)
heart development  (IGI)
immature B cell differentiation  (IMP)
immunoglobulin production  (ISO)
immunoglobulin V(D)J recombination  (IBA,IMP)
innate immune response  (IEA)
intrinsic apoptotic signaling pathway in response to DNA damage  (IBA,IMP)
lymphocyte differentiation  (IMP)
maturation of 5.8S rRNA  (ISO,ISS)
mitotic G1 DNA damage checkpoint signaling  (ISO,ISS)
negative regulation of apoptotic process  (IEA,ISO)
negative regulation of cellular senescence  (IEA,ISO)
negative regulation of cGAS/STING signaling pathway  (IEA,ISO)
negative regulation of immunoglobulin production  (IEA,ISO)
negative regulation of protein phosphorylation  (IMP)
negative regulation of response to gamma radiation  (IEA,ISO)
peptidyl-serine phosphorylation  (ISO,ISS)
peptidyl-threonine phosphorylation  (ISO,ISS)
positive regulation of apoptotic process  (IMP)
positive regulation of developmental growth  (IEA,ISO)
positive regulation of double-strand break repair via nonhomologous end joining  (ISO,ISS)
positive regulation of erythrocyte differentiation  (IMP)
positive regulation of fibroblast proliferation  (IEA,ISO)
positive regulation of immune system process  (ISO)
positive regulation of lymphocyte differentiation  (IMP)
positive regulation of platelet formation  (IMP)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
positive regulation of translation  (IMP)
pro-B cell differentiation  (IMP)
protein destabilization  (IDA)
protein phosphorylation  (ISO)
regulation of circadian rhythm  (IMP)
regulation of epithelial cell proliferation  (IEA,ISO)
regulation of hematopoietic stem cell differentiation  (IMP)
regulation of smooth muscle cell proliferation  (ISO,ISS)
response to activity  (IEA,ISO)
response to gamma radiation  (IMP)
response to ionizing radiation  (IMP)
rhythmic process  (IEA)
small-subunit processome assembly  (ISO,ISS)
somitogenesis  (IGI)
spleen development  (IEA,ISO)
T cell differentiation in thymus  (IMP)
T cell lineage commitment  (IMP)
T cell receptor V(D)J recombination  (IMP)
telomere capping  (IEA,ISO)
telomere maintenance  (IBA,IMP)
thymus development  (IEA,ISO)
V(D)J recombination  (IGI)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal B cell differentiation  (IAGP)
abnormal B cell physiology  (IEA)
abnormal brain morphology  (IAGP)
abnormal brainstem morphology  (IAGP)
abnormal CD4-positive T cell differentiation  (IEA)
abnormal CD4-positive, alpha beta T cell morphology  (IAGP)
abnormal CD8-positive, alpha beta T cell morphology  (IAGP)
abnormal CD8-positive, alpha-beta T cell differentiation  (IEA)
abnormal cerebellar cortex morphology  (IAGP)
abnormal cerebellum morphology  (IAGP)
abnormal chromosome morphology  (IAGP)
abnormal circulating protein level  (IAGP)
abnormal class switch recombination  (IAGP)
abnormal colon morphology  (IAGP)
abnormal complement pathway  (IAGP)
abnormal DNA repair  (IAGP)
abnormal double-positive T cell morphology  (IAGP)
abnormal glucose homeostasis  (IAGP)
abnormal granulocyte morphology  (IAGP)
abnormal hematopoietic stem cell physiology  (IAGP)
abnormal hematopoietic system morphology/development  (IAGP)
abnormal hippocampus morphology  (IAGP)
abnormal homeostasis  (IAGP)
abnormal humoral immune response  (IAGP)
abnormal immune system morphology  (IAGP)
abnormal immune system organ morphology  (IAGP)
abnormal immune system physiology  (IEA)
abnormal immunoglobulin heavy chain V(D)J recombination  (IAGP)
abnormal immunoglobulin light chain V-J recombination  (IAGP)
abnormal immunoglobulin V(D)J recombination  (IAGP)
abnormal intestinal epithelium morphology  (IAGP)
abnormal intromission  (IAGP)
abnormal kidney morphology  (IAGP)
abnormal large intestine crypts of Lieberkuhn morphology  (IAGP)
abnormal level of surface class II molecules  (IAGP)
abnormal lymph node B cell domain morphology  (IAGP)
abnormal lymph node morphology  (IAGP)
abnormal lymphocyte morphology  (IEA)
abnormal motor learning  (IAGP)
abnormal neutrophil morphology  (IAGP)
abnormal NK cell physiology  (IAGP)
abnormal pancreatic islet morphology  (IAGP)
abnormal Peyer's patch morphology  (IAGP)
abnormal professional antigen presenting cell morphology  (IAGP)
abnormal response to transplant  (IAGP)
abnormal single-positive T cell number  (IAGP)
abnormal spermatid morphology  (IAGP)
abnormal spermatogenesis  (IAGP)
abnormal spleen morphology  (IAGP)
abnormal spleen white pulp morphology  (IAGP)
abnormal splenic cell ratio  (IAGP)
abnormal splenocyte morphology  (IAGP)
abnormal striatum morphology  (IAGP)
abnormal T cell differentiation  (IAGP)
abnormal T cell number  (IAGP)
abnormal T cell receptor alpha chain V-J recombination  (IAGP)
abnormal T cell receptor beta chain V(D)J recombination  (IAGP)
abnormal T cell receptor delta chain V(D)J recombination  (IAGP)
abnormal T cell receptor V(D)J recombination  (IAGP)
abnormal thymus corticomedullary boundary morphology  (IAGP)
abnormal thymus lobule morphology  (IAGP)
abnormal thymus morphology  (IAGP)
abnormal vertebral column morphology  (IAGP)
abnormal zygomatic bone morphology  (IAGP)
absent B cells  (IAGP)
absent CD4-positive, alpha-beta T cells  (IAGP)
absent CD8-positive, alpha-beta T cells  (IAGP)
absent lymphocyte  (IAGP)
absent mature B cells  (IAGP)
absent Peyer's patches  (IAGP)
absent pre-B cells  (IAGP)
absent seminal vesicle  (IAGP)
absent T cells  (IAGP)
absent thymus cortex  (IAGP)
absent thymus corticomedullary boundary  (IAGP)
arrested B cell differentiation  (IAGP)
arrested T cell differentiation  (IAGP)
broad head  (IAGP)
cecum inflammation  (IEA)
centrally nucleated skeletal muscle fibers  (IAGP)
colitis  (IEA)
decreased alpha-beta T cell number  (IEA)
decreased B cell number  (IAGP)
decreased B cell proliferation  (IAGP)
decreased B-1 B cell number  (IEA)
decreased B-1a cell number  (IEA)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased bone marrow cell number  (IAGP)
decreased CD4-positive, alpha-beta T cell number  (IAGP)
decreased CD8-positive, alpha-beta T cell number  (IAGP)
decreased CD8-positive, naive alpha-beta T cell number  (IEA)
decreased circulating follicle stimulating hormone level  (IAGP)
decreased circulating insulin level  (IAGP)
decreased circulating luteinizing hormone level  (IAGP)
decreased circulating testosterone level  (IAGP)
decreased double-negative T cell number  (IAGP)
decreased double-positive T cell number  (IAGP)
decreased effector memory CD4-positive, alpha-beta T cell number  (IEA)
decreased erythrocyte cell number  (IAGP)
decreased gamma-delta T cell number  (IAGP)
decreased granulocyte number  (IAGP)
decreased hematopoietic stem cell number  (IAGP)
decreased IgG level  (IAGP)
decreased IgM level  (IAGP)
decreased immature B cell number  (IAGP)
decreased immunoglobulin level  (IAGP)
decreased incidence of tumors by ionizing radiation induction  (IAGP)
decreased kidney weight  (IAGP)
decreased leukocyte cell number  (IAGP)
decreased level of surface class I molecules  (IAGP)
decreased liver weight  (IAGP)
decreased lymphocyte cell number  (IAGP)
decreased macrophage cell number  (IAGP)
decreased mature B cell number  (IAGP)
decreased mean corpuscular hemoglobin concentration  (IEA)
decreased mean corpuscular volume  (IAGP)
decreased mounting behavior  (IAGP)
decreased NK cell number  (IAGP)
decreased NK T cell number  (IEA)
decreased pancreatic beta cell number  (IAGP)
decreased pre-B cell number  (IAGP)
decreased retroperitoneal fat pad weight  (IAGP)
decreased single-positive T cell number  (IAGP)
decreased spleen B cell follicle number  (IAGP)
decreased spleen weight  (IAGP)
decreased spleen white pulp amount  (IAGP)
decreased splenocyte number  (IAGP)
decreased susceptibility to autoimmune diabetes  (IAGP)
decreased susceptibility to bacterial infection  (IAGP)
decreased susceptibility to graft versus host disease  (IAGP)
decreased T cell number  (IAGP)
decreased T cell proliferation  (IAGP)
decreased telomere length  (IAGP)
decreased testes secretion  (IAGP)
decreased thymocyte apoptosis  (IAGP)
decreased thymocyte number  (IAGP)
decreased transforming growth factor beta level  (IAGP)
decreased tumor incidence  (IAGP)
diarrhea  (IEA)
dilated renal tubule  (IAGP)
enhanced humoral immune response  (IEA)
enlarged mesenteric lymph nodes  (IEA)
enophthalmos  (IAGP)
extended life span  (IAGP)
failure of copulatory plug deposition  (IAGP)
failure of ejaculation  (IAGP)
female infertility  (IAGP)
glomerulosclerosis  (IAGP)
hyperglycemia  (IAGP)
hyperpigmentation  (IAGP)
impaired complement classical pathway  (IAGP)
impaired coordination  (IAGP)
impaired exercise endurance  (IAGP)
impaired humoral immune response  (IEA)
impaired natural killer cell mediated cytotoxicity  (IAGP)
impaired skeletal muscle contractility  (IAGP)
increased alpha-beta T cell number  (IEA)
increased B cell number  (IEA)
increased B-1b cell number  (IEA)
increased body weight  (IEA)
increased bone marrow cell number  (IEA)
increased CD4-positive, alpha-beta T cell number  (IEA)
increased CD8-positive, alpha-beta T cell number  (IEA)
increased cellular sensitivity to alkylating agents  (IAGP)
increased cellular sensitivity to gamma-irradiation  (IAGP)
increased cellular sensitivity to ionizing radiation  (IAGP)
increased cellular sensitivity to ultraviolet irradiation  (IAGP)
increased cellular sensitivity to X-ray irradiation  (IAGP)
increased central memory CD4-positive, alpha-beta T cell number  (IEA)
increased central memory CD8 positive, alpha-beta T cell number  (IEA)
increased circulating glucose level  (IAGP)
increased circulating phosphate level  (IEA)
increased double-negative T cell number  (IAGP)
increased double-positive T cell number  (IAGP)
increased effector memory CD4-positive, alpha-beta T cell number  (IEA)
increased effector memory CD8-positive, alpha-beta T cell number  (IEA)
increased eosinophil cell number  (IAGP)
increased granulocyte number  (IAGP)
increased IgM level  (IEA)
increased incidence of tumors by ionizing radiation induction  (IAGP)
increased length of allograft survival  (IAGP)
increased liver iron level  (IAGP)
increased lung weight  (IAGP)
increased macrophage cell number  (IAGP)
increased mean corpuscular volume  (IAGP)
increased monocyte cell number  (IAGP)
increased mortality induced by gamma-irradiation  (IAGP)
increased mortality induced by ionizing radiation  (IAGP)
increased neutrophil cell number  (IAGP)
increased NK cell number  (IAGP)
increased physiological sensitivity to xenobiotic  (IAGP)
increased plasma cell number  (IEA)
increased plasmacytoid dendritic cell number  (IEA)
increased sensitivity to induced cell death  (IAGP)
increased skeletal muscle fiber diameter  (IAGP)
increased small intestinal crypt cell apoptosis  (IAGP)
increased susceptibility to autoimmune diabetes  (IAGP)
increased susceptibility to infection  (IAGP)
increased T cell derived lymphoma incidence  (IAGP)
increased T cell number  (IEA)
increased thymoma incidence  (IAGP)
increased urine glycosaminoglycan level  (IAGP)
increased urine protein level  (IAGP)
interstitial pneumonia  (IEA)
intestine polyps  (IAGP)
liver inflammation  (IEA)
lymph node hyperplasia  (IEA)
lymph node hypoplasia  (IAGP)
lymphoid hypoplasia  (IAGP)
male infertility  (IAGP)
myeloid hyperplasia  (IEA)
oligozoospermia  (IAGP)
pallor  (IAGP)
pancytopenia  (IAGP)
postnatal lethality, incomplete penetrance  (IAGP)
premature death  (IAGP)
preneoplasia  (IAGP)
pup cannibalization  (IAGP)
reduced fertility  (IAGP)
rough coat  (IAGP)
salivary gland inflammation  (IAGP)
short snout  (IAGP)
skeletal muscle fiber degeneration  (IAGP)
skeletal muscle fibrosis  (IAGP)
slow postnatal weight gain  (IAGP)
small ears  (IAGP)
small lymph nodes  (IAGP)
small lymphoid organs  (IAGP)
small Peyer's patches  (IAGP)
small salivary gland  (IAGP)
small seminiferous tubules  (IAGP)
small spleen  (IAGP)
small thymus  (IAGP)
spleen hypoplasia  (IAGP)
stomach inflammation  (IAGP)
thrombocytopenia  (IAGP)
thymus cyst  (IAGP)
thymus hypoplasia  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Nonsense mutation at Tyr-4046 in the DNA-dependent protein kinase catalytic subunit of severe combined immune deficiency mice. Araki R, etal., Proc Natl Acad Sci U S A. 1997 Mar 18;94(6):2438-43.
2. Severe-combined immunodeficient rats can be used to generate a model of perinatal hypoxic-ischemic brain injury to facilitate studies of engrafted human neural stem cells. Beldick SR, etal., PLoS One. 2018 Nov 28;13(11):e0208105. doi: 10.1371/journal.pone.0208105. eCollection 2018.
3. The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway. Lieber MR Annu Rev Biochem. 2010;79:181-211. doi: 10.1146/annurev.biochem.052308.093131.
4. Generation and characterization of severe combined immunodeficiency rats. Mashimo T, etal., Cell Rep. 2012 Sep 27;2(3):685-94. doi: 10.1016/j.celrep.2012.08.009. Epub 2012 Sep 13.
5. MGDs mouse GO annotations MGD data from the GO Consortium
6. MGD IEA MGD IEA
7. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
8. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
9. Mouse MP Annotation Import Pipeline RGD automated import pipeline
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:1104226   PMID:1331523   PMID:1358814   PMID:1373084   PMID:1373493   PMID:1406659   PMID:1460420   PMID:1500852   PMID:1506683   PMID:1531270   PMID:1570153   PMID:1571284  
PMID:1580330   PMID:1639480   PMID:1639500   PMID:1661315   PMID:1733671   PMID:1804782   PMID:1818304   PMID:1830433   PMID:1996340   PMID:2412448   PMID:2908877   PMID:3093081  
PMID:3297105   PMID:3416632   PMID:3519770   PMID:3553324   PMID:4107291   PMID:6607948   PMID:6823332   PMID:7479885   PMID:7507860   PMID:7513537   PMID:7520728   PMID:7526201  
PMID:7535341   PMID:7535789   PMID:7547707   PMID:7559863   PMID:7561218   PMID:7578854   PMID:7586691   PMID:7589844   PMID:7590935   PMID:7600284   PMID:7600297   PMID:7600561  
PMID:7603011   PMID:7606793   PMID:7638222   PMID:7650476   PMID:7662981   PMID:7666867   PMID:7669664   PMID:7688088   PMID:7692193   PMID:7716261   PMID:7717446   PMID:7729614  
PMID:7732570   PMID:7751632   PMID:7769315   PMID:7770944   PMID:7775830   PMID:7790314   PMID:7796294   PMID:7797796   PMID:7835983   PMID:7850767   PMID:7855601   PMID:7860404  
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PMID:32187555   PMID:32213588   PMID:32320679   PMID:32325033   PMID:32484502   PMID:32484802   PMID:32535027   PMID:32589703   PMID:32619407   PMID:32686190   PMID:32691428   PMID:32723479  
PMID:32730753   PMID:32735605   PMID:32763164   PMID:32768387   PMID:32814027   PMID:32814902   PMID:32870971   PMID:32884084   PMID:32890138   PMID:32914752   PMID:32938729   PMID:32938796  
PMID:32949466   PMID:32968282   PMID:33027513   PMID:33027668   PMID:33087935   PMID:33117338   PMID:33177175   PMID:33271070   PMID:33273464   PMID:33289702   PMID:33295943   PMID:33311516  
PMID:33359474   PMID:33373620   PMID:33428661   PMID:33579786   PMID:33761330   PMID:33778768   PMID:33839407   PMID:33857287   PMID:33951431   PMID:34015257   PMID:34113809   PMID:34192538  
PMID:34296202   PMID:34301760   PMID:34303658   PMID:34352206   PMID:34388391   PMID:34417259   PMID:34473953   PMID:34521752   PMID:34562454   PMID:34678150   PMID:34702956   PMID:34731608  
PMID:34752416   PMID:34793707   PMID:34795004   PMID:34813502   PMID:34847378   PMID:34848557   PMID:34961794   PMID:34963055   PMID:35089323   PMID:35121993   PMID:35150889   PMID:35167491  
PMID:35256767   PMID:35290083   PMID:35395188   PMID:35444206   PMID:35452600   PMID:35474871   PMID:35537038   PMID:35550508   PMID:35584694   PMID:35617958   PMID:35688159   PMID:35709757  
PMID:35760520   PMID:35767962   PMID:35924921   PMID:35959876   PMID:36045118   PMID:36211388   PMID:36215121   PMID:36352193   PMID:36373232   PMID:36384141   PMID:36441774   PMID:36476935  
PMID:36494354   PMID:36584066   PMID:36692963   PMID:36693372   PMID:36723072   PMID:36759517   PMID:36765626   PMID:36801998   PMID:36803553   PMID:36848231   PMID:36868194   PMID:36868208  
PMID:36923281   PMID:36924493   PMID:36924504   PMID:36944331   PMID:36961817   PMID:36976649   PMID:37018075   PMID:37057874   PMID:37084714   PMID:37149747   PMID:37172564   PMID:37185464  
PMID:37219526   PMID:37245991   PMID:37307443   PMID:37327334   PMID:37345534   PMID:37352357   PMID:37385251   PMID:37429951   PMID:37485636   PMID:37508502   PMID:37541213   PMID:37626903  
PMID:37651888   PMID:37652013   PMID:37712758   PMID:37715782   PMID:37729060   PMID:37730988   PMID:37799325   PMID:37802054   PMID:37802055   PMID:37865088   PMID:37868957   PMID:37877672  
PMID:37909039   PMID:37914731   PMID:37924979   PMID:37936122   PMID:37966111   PMID:37992684   PMID:38041810   PMID:38060328   PMID:38191884   PMID:38286241   PMID:38327776   PMID:38336745  
PMID:38355793   PMID:38363680   PMID:38389837   PMID:38413714   PMID:38426910   PMID:38428396   PMID:38433905   PMID:38438561   PMID:38461214   PMID:38518774   PMID:38530240   PMID:38538608  
PMID:38569552   PMID:38579682   PMID:38591006   PMID:38625797   PMID:38670091   PMID:38691454   PMID:38713510   PMID:38741708   PMID:38753486   PMID:38760896   PMID:38788720   PMID:38816579  
PMID:38833371   PMID:39047119   PMID:39088319   PMID:39137728   PMID:39181131   PMID:39262774   PMID:39303667   PMID:39321266   PMID:39332489   PMID:39346922  


Genomics

Comparative Map Data
Prkdc
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391615,455,698 - 15,660,103 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1615,455,730 - 15,660,099 (+)EnsemblGRCm39 Ensembl
GRCm381615,637,444 - 15,842,239 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1615,637,866 - 15,842,235 (+)EnsemblGRCm38mm10GRCm38
MGSCv371615,637,959 - 15,842,332 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361615,551,467 - 15,755,813 (+)NCBIMGSCv36mm8
Celera1616,214,291 - 16,413,213 (+)NCBICelera
Cytogenetic Map16A2NCBI
cM Map1610.09NCBI
PRKDC
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38847,773,111 - 47,960,136 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl847,773,111 - 47,960,178 (-)EnsemblGRCh38hg38GRCh38
GRCh37848,685,672 - 48,872,696 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36848,848,222 - 49,035,296 (-)NCBINCBI36Build 36hg18NCBI36
Build 34848,848,221 - 49,035,296NCBI
Celera844,671,051 - 44,858,151 (-)NCBICelera
Cytogenetic Map8q11.21NCBI
HuRef844,148,581 - 44,335,706 (-)NCBIHuRef
CHM1_1848,738,053 - 48,925,105 (-)NCBICHM1_1
T2T-CHM13v2.0848,149,356 - 48,336,384 (-)NCBIT2T-CHM13v2.0
Prkdc
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81198,544,952 - 98,762,499 (-)NCBIGRCr8
mRatBN7.21185,040,790 - 85,258,357 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1185,040,792 - 85,257,952 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1193,767,902 - 93,984,974 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01186,429,067 - 86,646,132 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01185,482,663 - 85,699,739 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01189,293,547 - 89,510,948 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1189,293,696 - 89,510,871 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01192,347,175 - 92,565,022 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41186,951,420 - 87,169,229 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11186,992,362 - 87,209,825 (-)NCBI
Celera1183,781,535 - 83,998,574 (-)NCBICelera
Cytogenetic Map11q23NCBI
Prkdc
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554547,733,978 - 7,890,867 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554547,733,697 - 7,890,896 (-)NCBIChiLan1.0ChiLan1.0
PRKDC
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2763,407,112 - 63,593,508 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1839,100,871 - 39,287,251 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0844,201,391 - 44,386,803 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1841,593,022 - 41,778,299 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl841,593,029 - 41,778,299 (-)Ensemblpanpan1.1panPan2
PRKDC
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12924,904 - 243,926 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2935,007 - 243,895 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha29449,958 - 669,362 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02920,665 - 241,975 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2922,025 - 241,944 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12920,944 - 240,298 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.029218,160 - 435,150 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.029285,564 - 503,393 (-)NCBIUU_Cfam_GSD_1.0
Prkdc
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530379,533,069 - 79,697,823 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365904,722,873 - 4,890,156 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365904,722,914 - 4,887,615 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PRKDC
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl479,687,375 - 79,846,656 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1479,687,375 - 79,850,146 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2487,185,946 - 87,343,690 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PRKDC
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1843,915,226 - 44,119,547 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl843,914,636 - 44,119,541 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603997,968,963 - 98,158,648 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Prkdc
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247357,534,506 - 7,700,305 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247357,534,483 - 7,702,079 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Prkdc
5957 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:111
Count of miRNA genes:90
Interacting mature miRNAs:105
Transcripts:ENSMUST00000023352, ENSMUST00000182134
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301970Heal11_mwound healing/regeneration 11 (mouse)Not determined16124263853Mouse
26884376Skwq4_mskull length QTL 4, 5 week (mouse)16841786490896888Mouse
1301841Lrnx9_mlearning-contextual 9 (mouse)Not determined161222536046225471Mouse
4142460Nilac10_mnicotine induced locomotor activity 10 (mouse)Not determined16713690629225471Mouse
38501069Tip4_mtuberculosis immunophenotype 4, IFN-g level (mouse)16431786444520363Mouse
1302106Rapop1_mradiation-induced apoptosis 1 (mouse)Not determined16378077915731053Mouse
26884432Zlq7_mzygomatic length QTL 7, 10 week (mouse)16381786464620363Mouse
1300632Loca2_mlocomotor activity 2 (mouse)Not determined16122500574Mouse
1301086Lprm5_mlymphoproliferation modifier 5 (mouse)Not determined161184882445848923Mouse
27226768Tibl9_mtibia length 9, 5 week (mouse)16331786451420363Mouse
1301443Mopkd2_mmodifier of polycystic kidney disease progression 2 (mouse)Not determined16464631438646414Mouse
10043978Obq35_mobesity QTL 35 (mouse)Not determined16988163143881631Mouse
1301575Tanidd3_mtally ho associated non-insulin dependednt diabetes mellitus 3 (mouse)Not determined16122897739Mouse
15092082Igly9_mIgG glycosylation 9, GP17b (mouse)161477522320103513Mouse
1357763Lp1_mlymphocyte proliferation 1 (mouse)Not determined16654297965466552Mouse
1301384Dice1_mdetermination of interleukin 4 commitment 1 (mouse)Not determined16128434358Mouse
1300943Skts9_mskin tumor susceptibility 9 (mouse)Not determined16577525239775440Mouse
10402497Lmr23_mleishmaniasis resistance 23 (mouse)Not determined16129674200Mouse
10412289Ppsl_mplasma P-selectin levels (mouse)Not determined16130814572Mouse
4141468Nhdlq10_mnon-HDL QTL 10 (mouse)Not determined16124263853Mouse
1300656Bgeq15_mbody growth early QTL 15 (mouse)Not determined16577525239775440Mouse
4142236Pstc4_mperiosteal circumference 4 (mouse)Not determined161552290949523112Mouse
1301559Bbaa19_mB.burgdorferi-associated arthritis 19 (mouse)Not determined16130066977Mouse
11251724Ewc6_methanol withdrawal and consumption 6 (mouse)16822605242226052Mouse
1300987Skull23_mskull morphology 23 (mouse)Not determined16577525239775440Mouse
1301945Skl7_mskeletal size (tail length) 7 (mouse)Not determined16577525239775440Mouse
4141010Bbq1_mbrain and behavior QTL 1 (mouse)Not determined16647700935021216Mouse
10045614Rapop6_mradiation-induced apoptosis 6 (mouse)Not determined161480292148803032Mouse
27095908Scvln7_msacral vertebrae length 2, 5 week (mouse)16331786439820362Mouse
4141060Pbwg19_mpostnatal body weight growth 19 (mouse)Not determined16120780888Mouse
10043879Adip25_madiposity 25 (mouse)Not determined16122520318Mouse
27226785Feml12_mfemur length 12, 5 week (mouse)16331786464620363Mouse

Markers in Region
RH136293  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381615,841,895 - 15,842,093UniSTSGRCm38
MGSCv371615,841,988 - 15,842,186UniSTSGRCm37
Celera1616,412,869 - 16,413,067UniSTS
Cytogenetic Map16B1UniSTS
RH136614  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381074,863,278 - 74,863,478UniSTSGRCm38
GRCm381615,736,447 - 15,736,646UniSTSGRCm38
MGSCv371074,326,023 - 74,326,223UniSTSGRCm37
MGSCv371615,736,540 - 15,736,739UniSTSGRCm37
Celera1616,314,791 - 16,314,990UniSTS
Celera1075,913,613 - 75,913,813UniSTS
Cytogenetic Map10B5.3UniSTS
Cytogenetic Map16B1UniSTS
Cytogenetic Map10C2UniSTS
cM Map1039.0UniSTS
RH131824  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381615,841,994 - 15,842,176UniSTSGRCm38
MGSCv371615,842,087 - 15,842,269UniSTSGRCm37
Celera1616,412,968 - 16,413,150UniSTS
Cytogenetic Map16B1UniSTS
AI326420  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381615,841,932 - 15,842,023UniSTSGRCm38
MGSCv371615,842,025 - 15,842,116UniSTSGRCm37
Celera1616,412,906 - 16,412,997UniSTS
Cytogenetic Map16B1UniSTS
Whitehead/MRC_RH16123.99UniSTS
06.MMHAP95FRB9.seq  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381615,699,438 - 15,699,589UniSTSGRCm38
MGSCv371615,699,531 - 15,699,682UniSTSGRCm37
Celera1616,277,768 - 16,277,919UniSTS
Cytogenetic Map16B1UniSTS
Whitehead_YAC16 UniSTS
D87521  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381615,842,071 - 15,842,176UniSTSGRCm38
MGSCv371615,842,164 - 15,842,269UniSTSGRCm37
Celera1616,413,045 - 16,413,150UniSTS
Cytogenetic Map16B1UniSTS
Whitehead/MRC_RH16122.18UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_011159 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006521861 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017316892 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB000629 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB007544 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB011543 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB030754 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC111103 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC154586 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ315658 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ315659 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ315660 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ315661 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK084827 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK088981 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK137732 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AU019811 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC028664 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466521 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CT010522 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CT030649 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D83786 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D87521 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ235257 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ235258 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U78157 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U78158 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000023352   ⟹   ENSMUSP00000023352
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1615,455,753 - 15,660,099 (+)Ensembl
GRCm38.p6 Ensembl1615,637,889 - 15,842,235 (+)Ensembl
Ensembl Acc Id: ENSMUST00000182134
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1615,455,730 - 15,502,613 (+)Ensembl
GRCm38.p6 Ensembl1615,637,866 - 15,684,749 (+)Ensembl
RefSeq Acc Id: NM_011159   ⟹   NP_035289
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391615,455,730 - 15,660,103 (+)NCBI
GRCm381615,637,866 - 15,842,239 (+)NCBI
MGSCv371615,637,959 - 15,842,332 (+)RGD
Celera1616,214,291 - 16,413,213 (+)RGD
cM Map16 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006521861   ⟹   XP_006521924
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391615,455,698 - 15,627,532 (+)NCBI
GRCm381615,637,444 - 15,809,668 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017316892   ⟹   XP_017172381
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391615,455,698 - 15,625,889 (+)NCBI
GRCm381615,637,444 - 15,808,027 (+)NCBI
Sequence:
RefSeq Acc Id: NP_035289   ⟸   NM_011159
- UniProtKB: Q8C2A7 (UniProtKB/Swiss-Prot),   Q3V2W8 (UniProtKB/Swiss-Prot),   Q307W9 (UniProtKB/Swiss-Prot),   P97928 (UniProtKB/Swiss-Prot),   O88187 (UniProtKB/Swiss-Prot),   E9QN15 (UniProtKB/Swiss-Prot),   Q9Z341 (UniProtKB/Swiss-Prot),   P97313 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006521924   ⟸   XM_006521861
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_017172381   ⟸   XM_017316892
- Peptide Label: isoform X2
- Sequence:
Ensembl Acc Id: ENSMUSP00000023352   ⟸   ENSMUST00000023352
Protein Domains
FAT   FATC   PI3K/PI4K catalytic

Promoters
RGD ID:6827382
Promoter ID:MM_KWN:20228
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:NM_008565,   NM_011159,   UC007YHS.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361615,637,301 - 15,638,067 (+)MPROMDB
RGD ID:8685536
Promoter ID:EPDNEW_M20799
Type:multiple initiation site
Name:Prkdc_1
Description:Mus musculus protein kinase, DNA activated, catalytic polypeptide, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381615,637,866 - 15,637,926EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:104779 AgrOrtholog
Ensembl Genes ENSMUSG00000022672 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000023352 ENTREZGENE
  ENSMUST00000023352.9 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.1070.11 UniProtKB/Swiss-Prot
InterPro ARM-type_fold UniProtKB/Swiss-Prot
  DDR_Repair_Kinase UniProtKB/Swiss-Prot
  DNA-PK_dom UniProtKB/Swiss-Prot
  DNA-PKcs_N UniProtKB/Swiss-Prot
  DNAPKcs_CC1-2 UniProtKB/Swiss-Prot
  DNAPKcs_CC5 UniProtKB/Swiss-Prot
  FATC_dom UniProtKB/Swiss-Prot
  Kinase-like_dom_sf UniProtKB/Swiss-Prot
  NUC194 UniProtKB/Swiss-Prot
  PI3/4_kinase_cat_dom UniProtKB/Swiss-Prot
  PI3/4_kinase_cat_sf UniProtKB/Swiss-Prot
  PI3/4_kinase_CS UniProtKB/Swiss-Prot
  PIK-rel_kinase_FAT UniProtKB/Swiss-Prot
  PIK_FAT UniProtKB/Swiss-Prot
KEGG Report mmu:19090 UniProtKB/Swiss-Prot
MGD MGI:104779 ENTREZGENE
NCBI Gene 19090 ENTREZGENE
PANTHER ATAXIA TELANGIECTASIA MUTATED ATM -RELATED UniProtKB/Swiss-Prot
  DNA-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT UniProtKB/Swiss-Prot
Pfam DNA-PKcs_N UniProtKB/Swiss-Prot
  DNAPKcs_CC1-2 UniProtKB/Swiss-Prot
  DNAPKcs_CC5 UniProtKB/Swiss-Prot
  FAT UniProtKB/Swiss-Prot
  FATC UniProtKB/Swiss-Prot
  NUC194 UniProtKB/Swiss-Prot
  PI3_PI4_kinase UniProtKB/Swiss-Prot
PhenoGen Prkdc PhenoGen
PROSITE FAT UniProtKB/Swiss-Prot
  FATC UniProtKB/Swiss-Prot
  PI3_4_KINASE_1 UniProtKB/Swiss-Prot
  PI3_4_KINASE_2 UniProtKB/Swiss-Prot
  PI3_4_KINASE_3 UniProtKB/Swiss-Prot
SMART FATC UniProtKB/Swiss-Prot
  NUC194 UniProtKB/Swiss-Prot
  PI3Kc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48371 UniProtKB/Swiss-Prot
  SSF56112 UniProtKB/Swiss-Prot
UniProt E9QN15 ENTREZGENE
  O88187 ENTREZGENE
  P97313 ENTREZGENE
  P97928 ENTREZGENE
  PRKDC_MOUSE UniProtKB/Swiss-Prot
  Q307W9 ENTREZGENE
  Q3V2W8 ENTREZGENE
  Q8C2A7 ENTREZGENE
  Q91UZ3_MOUSE UniProtKB/TrEMBL
  Q91VE8_MOUSE UniProtKB/TrEMBL
  Q9Z341 ENTREZGENE
UniProt Secondary E9QN15 UniProtKB/Swiss-Prot
  O88187 UniProtKB/Swiss-Prot
  P97928 UniProtKB/Swiss-Prot
  Q307W9 UniProtKB/Swiss-Prot
  Q3V2W8 UniProtKB/Swiss-Prot
  Q8C2A7 UniProtKB/Swiss-Prot
  Q9Z341 UniProtKB/Swiss-Prot