Prkdc (protein kinase, DNA activated, catalytic polypeptide) - Rat Genome Database

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Gene: Prkdc (protein kinase, DNA activated, catalytic polypeptide) Mus musculus
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Symbol: Prkdc
Name: protein kinase, DNA activated, catalytic polypeptide
RGD ID: 1319073
MGI Page MGI
Description: Enables DNA-dependent protein kinase activity; double-stranded DNA binding activity; and enzyme binding activity. Involved in several processes, including regulation of hematopoietic stem cell differentiation; regulation of hemopoiesis; and regulation of protein metabolic process. Acts upstream of or within several processes, including DNA metabolic process; ectopic germ cell programmed cell death; and hemopoiesis. Located in nucleus. Is expressed in several structures, including central nervous system; liver; neural retina; and thymus primordium. Used to study Duchenne muscular dystrophy; severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, Nk cell-positive; and type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in immunodeficiency 26. Orthologous to human PRKDC (protein kinase, DNA-activated, catalytic subunit).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AI326420; AU019811; DNA; DNA-; DNA-dependent protein kinase catalytic subunit; DNA-PK catalytic subunit; DNA-PKcs; DNAPDcs; DNAPK; DNPK1; DOX; DOXNPH; doxorubicin nephropathy; dxn; dxnph; HYRC1; p460; scid; severe combined immunodeficiency; slip; XRCC; XRCC7
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391615,455,698 - 15,660,103 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1615,455,730 - 15,660,099 (+)EnsemblGRCm39 Ensembl
GRCm381615,637,444 - 15,842,239 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1615,637,866 - 15,842,235 (+)EnsemblGRCm38mm10GRCm38
MGSCv371615,637,959 - 15,842,332 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361615,551,467 - 15,755,813 (+)NCBIMGSCv36mm8
Celera1616,214,291 - 16,413,213 (+)NCBICelera
Cytogenetic Map16A2NCBI
cM Map1610.09NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
(-)-alpha-phellandrene  (EXP)
(-)-demecolcine  (ISO)
(1->4)-beta-D-glucan  (EXP)
1,2-dimethylhydrazine  (EXP)
1-chloro-2,4-dinitrobenzene  (ISO)
1-nitropyrene  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4,6-tribromophenol  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-aminobenzamide  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-Nitrofluoranthene  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-amino-1,8-naphthalimide  (EXP)
4-hydroxynon-2-enal  (ISO)
4-nitrophenol  (EXP)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
7,12-dimethyltetraphene  (EXP)
acrolein  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (EXP)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
alpha-phellandrene  (EXP)
alpha-pinene  (ISO)
amphetamine  (ISO)
aphidicolin  (ISO)
arecoline  (ISO)
aristolochic acid A  (ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (ISO)
atrazine  (ISO)
benzene  (EXP,ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[e]pyrene  (ISO)
biphenyl-4-amine  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (EXP)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
bromoacetate  (ISO)
butanal  (ISO)
caffeine  (EXP,ISO)
capsaicin  (ISO)
casticin  (ISO)
chlorpyrifos  (EXP)
chromium atom  (ISO)
cisplatin  (EXP,ISO)
clofibrate  (EXP)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
coumarin  (ISO)
coumestrol  (ISO)
curcumin  (ISO)
deguelin  (ISO)
dexamethasone  (ISO)
dibutyl phthalate  (EXP,ISO)
dichlorvos  (ISO)
dicrotophos  (ISO)
dioxygen  (EXP)
doxorubicin  (EXP,ISO)
endosulfan  (ISO)
Enterolactone  (ISO)
enzyme inhibitor  (ISO)
etoposide  (ISO)
folic acid  (EXP,ISO)
FR900359  (ISO)
fulvestrant  (ISO)
furan  (ISO)
gallic acid  (ISO)
glyphosate  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (EXP,ISO)
indometacin  (ISO)
irinotecan  (ISO)
ivermectin  (ISO)
josamycin  (ISO)
lead diacetate  (EXP)
lipopolysaccharide  (ISO)
lycopene  (ISO)
methapyrilene  (ISO)
monocrotaline  (EXP)
motexafin gadolinium  (ISO)
myristicin  (ISO)
N-acetyl-L-cysteine  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
ochratoxin A  (ISO)
ouabain  (ISO)
oxaliplatin  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (EXP)
phenol  (ISO)
phenytoin  (EXP)
phosphoramide mustard  (ISO)
pirinixic acid  (EXP)
quercetin  (EXP,ISO)
raloxifene  (ISO)
resveratrol  (ISO)
rifampicin  (EXP)
SB 431542  (ISO)
serpentine asbestos  (EXP)
sodium arsenite  (EXP,ISO)
tamibarotene  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (ISO)
topotecan  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
trovafloxacin  (EXP)
tungsten  (EXP)
urethane  (ISO)
usnic acid  (ISO)
valproic acid  (ISO)
vinclozolin  (ISO)
vincristine  (ISO)
vorinostat  (ISO)
wortmannin  (EXP)
zinc acetate  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of innate immune response  (ISO)
B cell lineage commitment  (IMP)
brain development  (IGI)
cellular response to insulin stimulus  (ISO)
DNA damage response  (ISO)
DNA repair  (IEA)
double-strand break repair  (IBA,IMP,ISO)
double-strand break repair via nonhomologous end joining  (IMP,NAS)
ectopic germ cell programmed cell death  (IMP)
heart development  (IGI)
immature B cell differentiation  (IMP)
immune system process  (IEA)
immunoglobulin production  (ISO)
immunoglobulin V(D)J recombination  (IBA,IMP)
innate immune response  (IEA)
intrinsic apoptotic signaling pathway in response to DNA damage  (IBA,IMP)
lymphocyte differentiation  (IMP)
maturation of 5.8S rRNA  (ISO)
mitotic G1 DNA damage checkpoint signaling  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of cellular senescence  (ISO)
negative regulation of cGAS/STING signaling pathway  (ISO)
negative regulation of immunoglobulin production  (ISO)
negative regulation of protein phosphorylation  (IMP)
negative regulation of response to gamma radiation  (ISO)
positive regulation of apoptotic process  (IMP)
positive regulation of developmental growth  (ISO)
positive regulation of double-strand break repair via nonhomologous end joining  (ISO)
positive regulation of erythrocyte differentiation  (IMP)
positive regulation of fibroblast proliferation  (ISO)
positive regulation of immune system process  (ISO)
positive regulation of lymphocyte differentiation  (IMP)
positive regulation of platelet formation  (IMP)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of translation  (IMP)
pro-B cell differentiation  (IMP)
protein destabilization  (IDA)
regulation of circadian rhythm  (IMP)
regulation of epithelial cell proliferation  (ISO)
regulation of hematopoietic stem cell differentiation  (IMP)
regulation of smooth muscle cell proliferation  (ISO)
response to activity  (ISO)
response to gamma radiation  (IMP)
response to ionizing radiation  (IMP)
rhythmic process  (IEA)
ribosome biogenesis  (IEA)
small-subunit processome assembly  (ISO)
somitogenesis  (IGI)
spleen development  (ISO)
T cell differentiation in thymus  (IMP)
T cell lineage commitment  (IMP)
T cell receptor V(D)J recombination  (IMP)
telomere capping  (ISO)
telomere maintenance  (IBA,IMP)
thymus development  (ISO)
V(D)J recombination  (IGI)

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal B cell differentiation  (IAGP)
abnormal B cell physiology  (IEA)
abnormal brain morphology  (IAGP)
abnormal brainstem morphology  (IAGP)
abnormal CD4-positive T cell differentiation  (IEA)
abnormal CD4-positive, alpha beta T cell morphology  (IAGP)
abnormal CD8-positive, alpha beta T cell morphology  (IAGP)
abnormal CD8-positive, alpha-beta T cell differentiation  (IEA)
abnormal cerebellar cortex morphology  (IAGP)
abnormal cerebellum morphology  (IAGP)
abnormal chromosome morphology  (IAGP)
abnormal circulating protein level  (IAGP)
abnormal class switch recombination  (IAGP)
abnormal colon morphology  (IAGP)
abnormal complement pathway  (IAGP)
abnormal DNA repair  (IAGP)
abnormal double-positive T cell morphology  (IAGP)
abnormal glucose homeostasis  (IAGP)
abnormal granulocyte morphology  (IAGP)
abnormal hematopoietic stem cell physiology  (IAGP)
abnormal hematopoietic system morphology/development  (IAGP)
abnormal hippocampus morphology  (IAGP)
abnormal homeostasis  (IAGP)
abnormal humoral immune response  (IAGP)
abnormal immune system morphology  (IAGP)
abnormal immune system organ morphology  (IAGP)
abnormal immune system physiology  (IEA)
abnormal immunoglobulin heavy chain V(D)J recombination  (IAGP)
abnormal immunoglobulin light chain V-J recombination  (IAGP)
abnormal immunoglobulin V(D)J recombination  (IAGP)
abnormal intestinal epithelium morphology  (IAGP)
abnormal kidney morphology  (IAGP)
abnormal large intestine crypts of Lieberkuhn morphology  (IAGP)
abnormal level of surface class II molecules  (IAGP)
abnormal lymph node B cell domain morphology  (IAGP)
abnormal lymph node morphology  (IAGP)
abnormal lymphocyte morphology  (IEA)
abnormal motor learning  (IAGP)
abnormal neutrophil morphology  (IAGP)
abnormal NK cell physiology  (IAGP)
abnormal pancreatic islet morphology  (IAGP)
abnormal Peyer's patch morphology  (IAGP)
abnormal professional antigen presenting cell morphology  (IAGP)
abnormal response to transplant  (IAGP)
abnormal single-positive T cell number  (IAGP)
abnormal spermatid morphology  (IAGP)
abnormal spermatogenesis  (IAGP)
abnormal spleen morphology  (IAGP)
abnormal spleen white pulp morphology  (IAGP)
abnormal splenic cell ratio  (IAGP)
abnormal splenocyte morphology  (IAGP)
abnormal striatum morphology  (IAGP)
abnormal T cell differentiation  (IAGP)
abnormal T cell number  (IAGP)
abnormal T cell receptor alpha chain V-J recombination  (IAGP)
abnormal T cell receptor beta chain V(D)J recombination  (IAGP)
abnormal T cell receptor delta chain V(D)J recombination  (IAGP)
abnormal T cell receptor V(D)J recombination  (IAGP)
abnormal thymus corticomedullary boundary morphology  (IAGP)
abnormal thymus lobule morphology  (IAGP)
abnormal thymus morphology  (IAGP)
abnormal vertebral column morphology  (IAGP)
abnormal zygomatic bone morphology  (IAGP)
absent B cells  (IAGP)
absent CD4-positive, alpha-beta T cells  (IAGP)
absent CD8-positive, alpha-beta T cells  (IAGP)
absent lymphocyte  (IAGP)
absent mature B cells  (IAGP)
absent Peyer's patches  (IAGP)
absent pre-B cells  (IAGP)
absent seminal vesicle  (IAGP)
absent T cells  (IAGP)
absent thymus cortex  (IAGP)
absent thymus corticomedullary boundary  (IAGP)
arrested B cell differentiation  (IAGP)
arrested T cell differentiation  (IAGP)
broad head  (IAGP)
cecum inflammation  (IEA)
centrally nucleated skeletal muscle fibers  (IAGP)
colitis  (IEA)
decreased alpha-beta T cell number  (IEA)
decreased B cell number  (IAGP)
decreased B cell proliferation  (IAGP)
decreased B-1 B cell number  (IEA)
decreased B-1a cell number  (IEA)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased bone marrow cell number  (IAGP)
decreased CD4-positive, alpha-beta T cell number  (IAGP)
decreased CD8-positive, alpha-beta T cell number  (IAGP)
decreased CD8-positive, naive alpha-beta T cell number  (IEA)
decreased circulating follicle stimulating hormone level  (IAGP)
decreased circulating insulin level  (IAGP)
decreased circulating luteinizing hormone level  (IAGP)
decreased circulating testosterone level  (IAGP)
decreased double-negative T cell number  (IAGP)
decreased double-positive T cell number  (IAGP)
decreased effector memory CD4-positive, alpha-beta T cell number  (IEA)
decreased erythrocyte cell number  (IAGP)
decreased gamma-delta T cell number  (IAGP)
decreased granulocyte number  (IAGP)
decreased hematopoietic stem cell number  (IAGP)
decreased IgG level  (IAGP)
decreased IgM level  (IAGP)
decreased immature B cell number  (IAGP)
decreased immunoglobulin level  (IAGP)
decreased incidence of tumors by ionizing radiation induction  (IAGP)
decreased kidney weight  (IAGP)
decreased leukocyte cell number  (IAGP)
decreased level of surface class I molecules  (IAGP)
decreased liver weight  (IAGP)
decreased lymphocyte cell number  (IAGP)
decreased macrophage cell number  (IAGP)
decreased mature B cell number  (IAGP)
decreased mean corpuscular hemoglobin concentration  (IEA)
decreased mean corpuscular volume  (IAGP)
decreased NK cell number  (IAGP)
decreased NK T cell number  (IEA)
decreased pancreatic beta cell number  (IAGP)
decreased pre-B cell number  (IAGP)
decreased retroperitoneal fat pad weight  (IAGP)
decreased single-positive T cell number  (IAGP)
decreased spleen B cell follicle number  (IAGP)
decreased spleen weight  (IAGP)
decreased spleen white pulp amount  (IAGP)
decreased splenocyte number  (IAGP)
decreased susceptibility to autoimmune diabetes  (IAGP)
decreased susceptibility to bacterial infection  (IAGP)
decreased susceptibility to graft versus host disease  (IAGP)
decreased T cell number  (IAGP)
decreased T cell proliferation  (IAGP)
decreased telomere length  (IAGP)
decreased testes secretion  (IAGP)
decreased thymocyte apoptosis  (IAGP)
decreased thymocyte number  (IAGP)
decreased transforming growth factor beta level  (IAGP)
decreased tumor incidence  (IAGP)
diarrhea  (IEA)
dilated renal tubule  (IAGP)
enhanced humoral immune response  (IEA)
enlarged mesenteric lymph nodes  (IEA)
enophthalmos  (IAGP)
extended life span  (IAGP)
failure of copulatory plug deposition  (IAGP)
failure of ejaculation  (IAGP)
female infertility  (IAGP)
glomerulosclerosis  (IAGP)
hyperglycemia  (IAGP)
hyperpigmentation  (IAGP)
impaired complement classical pathway  (IAGP)
impaired coordination  (IAGP)
impaired exercise endurance  (IAGP)
impaired humoral immune response  (IEA)
impaired natural killer cell mediated cytotoxicity  (IAGP)
impaired skeletal muscle contractility  (IAGP)
increased alpha-beta T cell number  (IEA)
increased B cell number  (IEA)
increased B-1b cell number  (IEA)
increased body weight  (IEA)
increased bone marrow cell number  (IEA)
increased CD4-positive, alpha-beta T cell number  (IEA)
increased CD8-positive, alpha-beta T cell number  (IEA)
increased cellular sensitivity to alkylating agents  (IAGP)
increased cellular sensitivity to gamma-irradiation  (IAGP)
increased cellular sensitivity to ionizing radiation  (IAGP)
increased cellular sensitivity to ultraviolet irradiation  (IAGP)
increased cellular sensitivity to X-ray irradiation  (IAGP)
increased central memory CD4-positive, alpha-beta T cell number  (IEA)
increased central memory CD8 positive, alpha-beta T cell number  (IEA)
increased circulating glucose level  (IAGP)
increased circulating phosphate level  (IEA)
increased double-negative T cell number  (IAGP)
increased double-positive T cell number  (IAGP)
increased effector memory CD4-positive, alpha-beta T cell number  (IEA)
increased effector memory CD8-positive, alpha-beta T cell number  (IEA)
increased eosinophil cell number  (IAGP)
increased granulocyte number  (IAGP)
increased IgM level  (IEA)
increased incidence of tumors by ionizing radiation induction  (IAGP)
increased length of allograft survival  (IAGP)
increased liver iron level  (IAGP)
increased lung weight  (IAGP)
increased macrophage cell number  (IAGP)
increased mean corpuscular volume  (IAGP)
increased monocyte cell number  (IAGP)
increased mortality induced by gamma-irradiation  (IAGP)
increased mortality induced by ionizing radiation  (IAGP)
increased neutrophil cell number  (IAGP)
increased NK cell number  (IAGP)
increased physiological sensitivity to xenobiotic  (IAGP)
increased plasma cell number  (IEA)
increased plasmacytoid dendritic cell number  (IEA)
increased sensitivity to induced cell death  (IAGP)
increased skeletal muscle fiber diameter  (IAGP)
increased small intestinal crypt cell apoptosis  (IAGP)
increased susceptibility to autoimmune diabetes  (IAGP)
increased susceptibility to infection  (IAGP)
increased T cell derived lymphoma incidence  (IAGP)
increased T cell number  (IEA)
increased thymoma incidence  (IAGP)
increased urine glycosaminoglycan level  (IAGP)
increased urine protein level  (IAGP)
interstitial pneumonia  (IEA)
intestine polyps  (IAGP)
liver inflammation  (IEA)
lymph node hyperplasia  (IEA)
lymph node hypoplasia  (IAGP)
lymphoid hypoplasia  (IAGP)
male infertility  (IAGP)
myeloid hyperplasia  (IEA)
oligozoospermia  (IAGP)
pallor  (IAGP)
pancytopenia  (IAGP)
postnatal lethality, incomplete penetrance  (IAGP)
premature death  (IAGP)
preneoplasia  (IAGP)
pup cannibalization  (IAGP)
reduced fertility  (IAGP)
reduced male mating frequency  (IAGP)
rough coat  (IAGP)
salivary gland inflammation  (IAGP)
short snout  (IAGP)
skeletal muscle fiber degeneration  (IAGP)
skeletal muscle fibrosis  (IAGP)
slow postnatal weight gain  (IAGP)
small ears  (IAGP)
small lymph nodes  (IAGP)
small lymphoid organs  (IAGP)
small Peyer's patches  (IAGP)
small salivary gland  (IAGP)
small seminiferous tubules  (IAGP)
small spleen  (IAGP)
small thymus  (IAGP)
spleen hypoplasia  (IAGP)
stomach inflammation  (IAGP)
thrombocytopenia  (IAGP)
thymus cyst  (IAGP)
thymus hypoplasia  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Nonsense mutation at Tyr-4046 in the DNA-dependent protein kinase catalytic subunit of severe combined immune deficiency mice. Araki R, etal., Proc Natl Acad Sci U S A. 1997 Mar 18;94(6):2438-43.
2. Severe-combined immunodeficient rats can be used to generate a model of perinatal hypoxic-ischemic brain injury to facilitate studies of engrafted human neural stem cells. Beldick SR, etal., PLoS One. 2018 Nov 28;13(11):e0208105. doi: 10.1371/journal.pone.0208105. eCollection 2018.
3. The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway. Lieber MR Annu Rev Biochem. 2010;79:181-211. doi: 10.1146/annurev.biochem.052308.093131.
4. Generation and characterization of severe combined immunodeficiency rats. Mashimo T, etal., Cell Rep. 2012 Sep 27;2(3):685-94. doi: 10.1016/j.celrep.2012.08.009. Epub 2012 Sep 13.
5. MGDs mouse GO annotations MGD data from the GO Consortium
6. MGD IEA MGD IEA
7. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
8. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
9. Mouse MP Annotation Import Pipeline RGD automated import pipeline
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:1104226   PMID:1331523   PMID:1358814   PMID:1373084   PMID:1373493   PMID:1406659   PMID:1460420   PMID:1500852   PMID:1506683   PMID:1531270   PMID:1570153   PMID:1571284  
PMID:1580330   PMID:1639480   PMID:1639500   PMID:1661315   PMID:1733671   PMID:1804782   PMID:1818304   PMID:1830433   PMID:1996340   PMID:2412448   PMID:2908877   PMID:3093081  
PMID:3297105   PMID:3416632   PMID:3519770   PMID:3553324   PMID:4107291   PMID:6607948   PMID:6823332   PMID:7479885   PMID:7507860   PMID:7513537   PMID:7520728   PMID:7526201  
PMID:7535341   PMID:7535789   PMID:7547707   PMID:7559863   PMID:7561218   PMID:7578854   PMID:7586691   PMID:7589844   PMID:7590935   PMID:7600284   PMID:7600297   PMID:7600561  
PMID:7603011   PMID:7606793   PMID:7638222   PMID:7650476   PMID:7662981   PMID:7666867   PMID:7669664   PMID:7688088   PMID:7692193   PMID:7716261   PMID:7717446   PMID:7729614  
PMID:7732570   PMID:7751632   PMID:7769315   PMID:7770944   PMID:7775830   PMID:7790314   PMID:7796294   PMID:7797796   PMID:7835983   PMID:7850767   PMID:7855601   PMID:7860404  
PMID:7873382   PMID:7876540   PMID:7877992   PMID:7889411   PMID:7889575   PMID:7890426   PMID:7896825   PMID:7911241   PMID:7943168   PMID:7957574   PMID:7962563   PMID:7966017  
PMID:7971996   PMID:7981149   PMID:7983705   PMID:7983730   PMID:7989611   PMID:7995938   PMID:8004820   PMID:8029889   PMID:8047070   PMID:8057678   PMID:8073516   PMID:8075241  
PMID:8077678   PMID:8084602   PMID:8084613   PMID:8090783   PMID:8094405   PMID:8097186   PMID:8100803   PMID:8103346   PMID:8106771   PMID:8119666   PMID:8133891   PMID:8140728  
PMID:8161803   PMID:8196630   PMID:8212584   PMID:8245777   PMID:8256843   PMID:8258726   PMID:8261415   PMID:8263505   PMID:8267959   PMID:8270250   PMID:8281031   PMID:8299696  
PMID:8306262   PMID:8311119   PMID:8314017   PMID:8320956   PMID:8320959   PMID:8320961   PMID:8324894   PMID:8339285   PMID:8350042   PMID:8375494   PMID:8376791   PMID:8378344  
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PMID:10677503   PMID:10679090   PMID:10684864   PMID:10706709   PMID:10716994   PMID:10725249   PMID:10725718   PMID:10725754   PMID:10780672   PMID:10794053   PMID:10805749   PMID:10809058  
PMID:10839808   PMID:10841521   PMID:10878373   PMID:10878379   PMID:10886500   PMID:10899912   PMID:10910267   PMID:10922068   PMID:10950807   PMID:11042159   PMID:11067913   PMID:11076861  
PMID:11086102   PMID:11120869   PMID:11147678   PMID:11152110   PMID:11160136   PMID:11196687   PMID:11217851   PMID:11231155   PMID:11245929   PMID:11248063   PMID:11263788   PMID:11280730  
PMID:11298322   PMID:11319607   PMID:11326425   PMID:11340158   PMID:11390498   PMID:11426950   PMID:11427484   PMID:11439324   PMID:11452126   PMID:11522664   PMID:11532879   PMID:11560990  
PMID:11571274   PMID:11714766   PMID:11725048   PMID:11742099   PMID:11751629   PMID:11839092   PMID:11867233   PMID:11869679   PMID:11884426   PMID:11920579   PMID:11924817   PMID:11970883  
PMID:12065413   PMID:12077246   PMID:12119352   PMID:12133972   PMID:12186630   PMID:12194752   PMID:12225896   PMID:12361980   PMID:12370382   PMID:12384415   PMID:12406886   PMID:12426399  
PMID:12433363   PMID:12438215   PMID:12461083   PMID:12466851   PMID:12477932   PMID:12479823   PMID:12498815   PMID:12507776   PMID:12525697   PMID:12559174   PMID:12604618   PMID:12612906  
PMID:12626535   PMID:12626561   PMID:12646649   PMID:12689924   PMID:12716741   PMID:12727892   PMID:12750251   PMID:12750252   PMID:12794162   PMID:12857942   PMID:12897131   PMID:12960306  
PMID:14557749   PMID:14578206   PMID:14607957   PMID:14610273   PMID:14635033   PMID:14662857   PMID:14752107   PMID:14966265   PMID:15010310   PMID:15047613   PMID:15100310   PMID:15105825  
PMID:15153508   PMID:15177038   PMID:15194694   PMID:15226823   PMID:15236750   PMID:15262962   PMID:15265935   PMID:15300245   PMID:15308121   PMID:15339938   PMID:15356673   PMID:15383569  
PMID:15385481   PMID:15450426   PMID:15459109   PMID:15463679   PMID:15466391   PMID:15470030   PMID:15470055   PMID:15494484   PMID:15494496   PMID:15514013   PMID:15531925   PMID:15545322  
PMID:15557158   PMID:15578092   PMID:15583018   PMID:15585573   PMID:15592499   PMID:15647757   PMID:15664957   PMID:15678105   PMID:15688349   PMID:15694382   PMID:15699117   PMID:15699324  
PMID:15699352   PMID:15728239   PMID:15753207   PMID:15753354   PMID:15765149   PMID:15792956   PMID:15806156   PMID:15843544   PMID:15845457   PMID:15867147   PMID:15870287   PMID:15879151  
PMID:15900494   PMID:15920010   PMID:15983204   PMID:15998665   PMID:16081800   PMID:16081804   PMID:16111632   PMID:16135554   PMID:16141072   PMID:16141073   PMID:16166097   PMID:16169466  
PMID:16216017   PMID:16223725   PMID:16226703   PMID:16239571   PMID:16239576   PMID:16269452   PMID:16286021   PMID:16288010   PMID:16294221   PMID:16297152   PMID:16308571   PMID:16317068  
PMID:16365445   PMID:16393973   PMID:16400328   PMID:16404475   PMID:16413926   PMID:16428731   PMID:16429139   PMID:16456545   PMID:16548890   PMID:16549598   PMID:16585549   PMID:16606667  
PMID:16622013   PMID:16641981   PMID:16687486   PMID:16697736   PMID:16731819   PMID:16754748   PMID:16808805   PMID:16861655   PMID:16861670   PMID:16879257   PMID:16885376   PMID:16888083  
PMID:16890924   PMID:16895987   PMID:16919486   PMID:16936188   PMID:16968775   PMID:17001468   PMID:17008472   PMID:17010584   PMID:17010969   PMID:17015713   PMID:17021047   PMID:17030581  
PMID:17047059   PMID:17055754   PMID:17072335   PMID:17082624   PMID:17088411   PMID:17114442   PMID:17145779   PMID:17148676   PMID:17237807   PMID:17241822   PMID:17259968   PMID:17296939  
PMID:17307871   PMID:17312139   PMID:17336387   PMID:17376910   PMID:17392156   PMID:17397880   PMID:17404295   PMID:17420264   PMID:17437531   PMID:17438029   PMID:17457319   PMID:17478551  
PMID:17512212   PMID:17566079   PMID:17599403   PMID:17607359   PMID:17620361   PMID:17625067   PMID:17658952   PMID:17668421   PMID:17681665   PMID:17686847   PMID:17707375   PMID:17761671  
PMID:17764815   PMID:17920451   PMID:17923115   PMID:17947634   PMID:17967861   PMID:17982083   PMID:17982459   PMID:17983440   PMID:18056341   PMID:18097035   PMID:18167537   PMID:18178819  
PMID:18292290   PMID:18316419   PMID:18322195   PMID:18332204   PMID:18371405   PMID:18402690   PMID:18408127   PMID:18424731   PMID:18439899   PMID:18453602   PMID:18453623   PMID:18467653  
PMID:18491294   PMID:18501428   PMID:18515407   PMID:18519557   PMID:18538732   PMID:18563383   PMID:18614044   PMID:18614704   PMID:18653525   PMID:18684934   PMID:18687751   PMID:18688847  
PMID:18691745   PMID:18752298   PMID:18755145   PMID:18757368   PMID:18785974   PMID:18799670   PMID:18799693   PMID:18802110   PMID:18936235   PMID:18945784   PMID:18984741   PMID:19000702  
PMID:19015239   PMID:19017790   PMID:19052619   PMID:19057578   PMID:19058849   PMID:19112095   PMID:19136475   PMID:19144640   PMID:19155490   PMID:19181665   PMID:19185848   PMID:19194513  
PMID:19249873   PMID:19254573   PMID:19254958   PMID:19276376   PMID:19279572   PMID:19303849   PMID:19324903   PMID:19349356   PMID:19349693   PMID:19362533   PMID:19369639   PMID:19421183  
PMID:19447681   PMID:19450527   PMID:19481135   PMID:19535452   PMID:19564926   PMID:19596237   PMID:19596993   PMID:19625622   PMID:19636062   PMID:19644014   PMID:19659776   PMID:19664609  
PMID:19670381   PMID:19797068   PMID:19802382   PMID:19805087   PMID:19808649   PMID:19898488   PMID:19901909   PMID:19948826   PMID:20016601   PMID:20033053   PMID:20052418   PMID:20068223  
PMID:20072130   PMID:20080755   PMID:20083664   PMID:20086180   PMID:20147609   PMID:20150414   PMID:20181889   PMID:20207228   PMID:20231360   PMID:20348415   PMID:20362541   PMID:20381385  
PMID:20382848   PMID:20395428   PMID:20395436   PMID:20404133   PMID:20423932   PMID:20430958   PMID:20439540   PMID:20448641   PMID:20472832   PMID:20478526   PMID:20484573   PMID:20485377  
PMID:20495069   PMID:20505160   PMID:20523894   PMID:20554971   PMID:20570944   PMID:20601939   PMID:20615947   PMID:20617180   PMID:20634377   PMID:20668064   PMID:20668220   PMID:20671122  
PMID:20671189   PMID:20686503   PMID:20688981   PMID:20691153   PMID:20713716   PMID:20729912   PMID:20739949   PMID:20805496   PMID:20818375   PMID:20823234   PMID:20924105   PMID:20956382  
PMID:20966071   PMID:20972425   PMID:20978358   PMID:20980458   PMID:21030983   PMID:21112563   PMID:21159645   PMID:21169553   PMID:21182079   PMID:21209895   PMID:21224054   PMID:21238430  
PMID:21245310   PMID:21245316   PMID:21265624   PMID:21266349   PMID:21266499   PMID:21266536   PMID:21267068   PMID:21298413   PMID:21300912   PMID:21308778   PMID:21340626   PMID:21362573  
PMID:21364666   PMID:21368761   PMID:21381033   PMID:21397859   PMID:21429805   PMID:21482716   PMID:21505262   PMID:21525235   PMID:21565611   PMID:21567299   PMID:21576322   PMID:21576342  
PMID:21602895   PMID:21613629   PMID:21715554   PMID:21724588   PMID:21750982   PMID:21813778   PMID:21825066   PMID:21833014   PMID:21849469   PMID:21854253   PMID:21873530   PMID:21873635  
PMID:21874051   PMID:21875955   PMID:21907924   PMID:21921286   PMID:21926352   PMID:21944754   PMID:21979916   PMID:21985373   PMID:22027841   PMID:22028197   PMID:22052192   PMID:22053215  
PMID:22065769   PMID:22072769   PMID:22084406   PMID:22096586   PMID:22099311   PMID:22135462   PMID:22147896   PMID:22172721   PMID:22174447   PMID:22210480   PMID:22239103   PMID:22246028  
PMID:22279057   PMID:22285186   PMID:22287717   PMID:22290877   PMID:22340590   PMID:22343031   PMID:22351938   PMID:22371883   PMID:22392992   PMID:22403066   PMID:22403295   PMID:22406538  
PMID:22407920   PMID:22427377   PMID:22430210   PMID:22464800   PMID:22465227   PMID:22490868   PMID:22516957   PMID:22542847   PMID:22547698   PMID:22558161   PMID:22566533   PMID:22586266  
PMID:22593616   PMID:22611244   PMID:22614020   PMID:22617213   PMID:22626807   PMID:22642909   PMID:22664870   PMID:22665378   PMID:22724066   PMID:22745333   PMID:22751694   PMID:22753496  
PMID:22761313   PMID:22768283   PMID:22771497   PMID:22773809   PMID:22791816   PMID:22865049   PMID:22890824   PMID:22897850   PMID:22902233   PMID:22937164   PMID:22960283   PMID:22972376  
PMID:22981535   PMID:22982065   PMID:23018460   PMID:23028636   PMID:23045614   PMID:23094018   PMID:23135917   PMID:23142821   PMID:23203926   PMID:23223360   PMID:23232394   PMID:23246483  
PMID:23251783   PMID:23290315   PMID:23293079   PMID:23300950   PMID:23332746   PMID:23345432   PMID:23348745   PMID:23349496   PMID:23376950   PMID:23378057   PMID:23426180   PMID:23430111  
PMID:23437231   PMID:23467088   PMID:23529621   PMID:23612011   PMID:23643966   PMID:23670188   PMID:23686485   PMID:23687340   PMID:23690475   PMID:23722536   PMID:23740949   PMID:23747725  
PMID:23765217   PMID:23772025   PMID:23776508   PMID:23791643   PMID:23792169   PMID:23825700   PMID:23833235   PMID:23836881   PMID:23853597   PMID:23869841   PMID:23896410   PMID:23897709  
PMID:23918367   PMID:23922938   PMID:23925295   PMID:23956433   PMID:23959857   PMID:23960238   PMID:23965627   PMID:23975863   PMID:23986435   PMID:24002064   PMID:24011591   PMID:24012878  
PMID:24043895   PMID:24085291   PMID:24096482   PMID:24098118   PMID:24101478   PMID:24143217   PMID:24158435   PMID:24194952   PMID:24198282   PMID:24209604   PMID:24227685   PMID:24253447  
PMID:24290754   PMID:24292709   PMID:24293628   PMID:24307589   PMID:24356421   PMID:24361497   PMID:24435807   PMID:24446517   PMID:24457600   PMID:24463278   PMID:24466051   PMID:24474774  
PMID:24477911   PMID:24516154   PMID:24531377   PMID:24591363   PMID:24618599   PMID:24657168   PMID:24662822   PMID:24715688   PMID:24736457   PMID:24740260   PMID:24793546   PMID:24794298  
PMID:24798995   PMID:24808370   PMID:24870234   PMID:24888589   PMID:24892805   PMID:24917593   PMID:24928388   PMID:24943270   PMID:24954133   PMID:24984783   PMID:24985346   PMID:25008178  
PMID:25017720   PMID:25030174   PMID:25078033   PMID:25078284   PMID:25087979   PMID:25189770   PMID:25210793   PMID:25264192   PMID:25264618   PMID:25329668   PMID:25362351   PMID:25391321  
PMID:25421435   PMID:25479751   PMID:25497973   PMID:25532725   PMID:25601207   PMID:25605905   PMID:25645357   PMID:25646432   PMID:25692509   PMID:25712342   PMID:25729921   PMID:25733518  
PMID:25754535   PMID:25794782   PMID:25818648   PMID:25834108   PMID:25849135   PMID:25884569   PMID:25902143   PMID:25908435   PMID:25910642   PMID:25915732   PMID:25939063   PMID:26022250  
PMID:26107252   PMID:26148229   PMID:26168294   PMID:26175416   PMID:26181057   PMID:26286024   PMID:26316789   PMID:26403887   PMID:26403969   PMID:26424750   PMID:26429886   PMID:26439188  
PMID:26544941   PMID:26546606   PMID:26569593   PMID:26590968   PMID:26603207   PMID:26616856   PMID:26644351   PMID:26690701   PMID:26702062   PMID:26785948   PMID:26796361   PMID:26809508  
PMID:26824076   PMID:26831077   PMID:26831100   PMID:26849055   PMID:26851521   PMID:26863197   PMID:26876593   PMID:26879149   PMID:26886799   PMID:26910463   PMID:26961115   PMID:26990302  
PMID:27109869   PMID:27136939   PMID:27160905   PMID:27173733   PMID:27197203   PMID:27197263   PMID:27270894   PMID:27292632   PMID:27300437   PMID:27301070   PMID:27373157   PMID:27513301  
PMID:27622331   PMID:27634757   PMID:27671674   PMID:27698445   PMID:27699249   PMID:27703030   PMID:27777971   PMID:27783956   PMID:27872496   PMID:27920091   PMID:27941793   PMID:27960088  
PMID:27989802   PMID:28087712   PMID:28089909   PMID:28108611   PMID:28115719   PMID:28123024   PMID:28238547   PMID:28253324   PMID:28258056   PMID:28377452   PMID:28450160   PMID:28467930  
PMID:28529307   PMID:28579392   PMID:28591638   PMID:28617827   PMID:28665271   PMID:28686579   PMID:28715505   PMID:28727820   PMID:28759779   PMID:28783664   PMID:28814715   PMID:28827518  
PMID:28832631   PMID:28874533   PMID:28959975   PMID:28960205   PMID:28973896   PMID:28981157   PMID:29031931   PMID:29061767   PMID:29146734   PMID:29151581   PMID:29153842   PMID:29168692  
PMID:29180744   PMID:29233917   PMID:29242210   PMID:29259102   PMID:29286001   PMID:29290617   PMID:29298866   PMID:29334357   PMID:29336888   PMID:29344644   PMID:29361613   PMID:29387068  
PMID:29396429   PMID:29431745   PMID:29446074   PMID:29452640   PMID:29474906   PMID:29533781   PMID:29549333   PMID:29551267   PMID:29588349   PMID:29594927   PMID:29628393   PMID:29661828  
PMID:29681511   PMID:29708512   PMID:29742392   PMID:29894694   PMID:29910151   PMID:29915428   PMID:29920276   PMID:29928062   PMID:29946151   PMID:29976923   PMID:30010942   PMID:30049704  
PMID:30072430   PMID:30111869   PMID:30127089   PMID:30174304   PMID:30220458   PMID:30258450   PMID:30333137   PMID:30352856   PMID:30355480   PMID:30409670   PMID:30428360   PMID:30433869  
PMID:30487575   PMID:30540841   PMID:30579708   PMID:30606609   PMID:30679796   PMID:30778347   PMID:30883740   PMID:30905671   PMID:30943405   PMID:31091443   PMID:31101667   PMID:31112530  
PMID:31127091   PMID:31171792   PMID:31185213   PMID:31185214   PMID:31189537   PMID:31230747   PMID:31371796   PMID:31464599   PMID:31509739   PMID:31603250   PMID:31740923   PMID:31745215  
PMID:31758089   PMID:31772172   PMID:31795137   PMID:31811168   PMID:31852888   PMID:31913286   PMID:31915293   PMID:31919590   PMID:31932854   PMID:31950264   PMID:32005704   PMID:32103174  
PMID:32144163   PMID:32187554   PMID:32213588   PMID:32325033   PMID:32484802   PMID:32535027   PMID:32686190   PMID:32691428   PMID:32723479   PMID:32730753   PMID:32735605   PMID:32763164  
PMID:32768387   PMID:32814902   PMID:32884084   PMID:32890138   PMID:32938729   PMID:32938796   PMID:32949466   PMID:32968282   PMID:33027513   PMID:33027668   PMID:33087935   PMID:33177175  
PMID:33273464   PMID:33289702   PMID:33295943   PMID:33359474   PMID:33373620   PMID:33428661   PMID:33761330   PMID:33839407   PMID:33951431   PMID:34192538   PMID:34301760   PMID:34303658  
PMID:34388391   PMID:34521752   PMID:34562454   PMID:34678150   PMID:34752416   PMID:34813502   PMID:34847378   PMID:34848557   PMID:34961794   PMID:35089323   PMID:35121993   PMID:35167491  
PMID:35290083   PMID:35444206   PMID:35550508   PMID:35709757   PMID:35760520   PMID:35924921   PMID:35959876   PMID:36045118   PMID:36211388   PMID:36352193   PMID:36373232   PMID:36384141  
PMID:36441774   PMID:36476935   PMID:36494354   PMID:36584066   PMID:36693372   PMID:36759517   PMID:36868194   PMID:36868208   PMID:37149747   PMID:37185464   PMID:37245991   PMID:37307443  
PMID:37345534   PMID:37485636   PMID:37541213   PMID:37651888   PMID:37715782   PMID:37729060   PMID:37802055   PMID:37865088   PMID:37877672   PMID:37914731   PMID:38286241   PMID:38363680  
PMID:38389837   PMID:38428396  


Genomics

Comparative Map Data
Prkdc
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391615,455,698 - 15,660,103 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1615,455,730 - 15,660,099 (+)EnsemblGRCm39 Ensembl
GRCm381615,637,444 - 15,842,239 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1615,637,866 - 15,842,235 (+)EnsemblGRCm38mm10GRCm38
MGSCv371615,637,959 - 15,842,332 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361615,551,467 - 15,755,813 (+)NCBIMGSCv36mm8
Celera1616,214,291 - 16,413,213 (+)NCBICelera
Cytogenetic Map16A2NCBI
cM Map1610.09NCBI
PRKDC
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38847,773,111 - 47,960,136 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl847,773,111 - 47,960,178 (-)EnsemblGRCh38hg38GRCh38
GRCh37848,685,672 - 48,872,696 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36848,848,222 - 49,035,296 (-)NCBINCBI36Build 36hg18NCBI36
Build 34848,848,221 - 49,035,296NCBI
Celera844,671,051 - 44,858,151 (-)NCBICelera
Cytogenetic Map8q11.21NCBI
HuRef844,148,581 - 44,335,706 (-)NCBIHuRef
CHM1_1848,738,053 - 48,925,105 (-)NCBICHM1_1
T2T-CHM13v2.0848,149,356 - 48,336,384 (-)NCBIT2T-CHM13v2.0
Prkdc
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81198,544,952 - 98,762,499 (-)NCBIGRCr8
mRatBN7.21185,040,790 - 85,258,357 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1185,040,792 - 85,257,952 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1193,767,902 - 93,984,974 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01186,429,067 - 86,646,132 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01185,482,663 - 85,699,739 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01189,293,547 - 89,510,948 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1189,293,696 - 89,510,871 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01192,347,175 - 92,565,022 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41186,951,420 - 87,169,229 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11186,992,362 - 87,209,825 (-)NCBI
Celera1183,781,535 - 83,998,574 (-)NCBICelera
Cytogenetic Map11q23NCBI
Prkdc
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554547,733,978 - 7,890,867 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554547,733,697 - 7,890,896 (-)NCBIChiLan1.0ChiLan1.0
PRKDC
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2763,407,112 - 63,593,508 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1839,100,871 - 39,287,251 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0844,201,391 - 44,386,803 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1841,593,022 - 41,778,299 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl841,593,029 - 41,778,299 (-)Ensemblpanpan1.1panPan2
PRKDC
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12924,904 - 243,926 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2935,007 - 243,895 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha29449,958 - 669,362 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02920,665 - 241,975 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2922,025 - 241,944 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12920,944 - 240,298 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.029218,160 - 435,150 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.029285,564 - 503,393 (-)NCBIUU_Cfam_GSD_1.0
Prkdc
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530379,533,069 - 79,697,823 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365904,722,873 - 4,890,156 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365904,722,914 - 4,887,615 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PRKDC
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl479,687,375 - 79,846,656 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1479,687,375 - 79,850,146 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2487,185,946 - 87,343,690 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PRKDC
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1843,915,226 - 44,119,547 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl843,914,636 - 44,119,541 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603997,968,963 - 98,158,648 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Prkdc
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247357,534,506 - 7,700,305 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247357,534,483 - 7,702,079 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Prkdc
5957 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:111
Count of miRNA genes:90
Interacting mature miRNAs:105
Transcripts:ENSMUST00000023352, ENSMUST00000182134
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4141060Pbwg19_mpostnatal body weight growth 19 (mouse)Not determined16120780888Mouse
1300632Loca2_mlocomotor activity 2 (mouse)Not determined16122500574Mouse
10043879Adip25_madiposity 25 (mouse)Not determined16122520318Mouse
1301575Tanidd3_mtally ho associated non-insulin dependednt diabetes mellitus 3 (mouse)Not determined16122897739Mouse
4141468Nhdlq10_mnon-HDL QTL 10 (mouse)Not determined16124263853Mouse
1301970Heal11_mwound healing/regeneration 11 (mouse)Not determined16124263853Mouse
1301384Dice1_mdetermination of interleukin 4 commitment 1 (mouse)Not determined16128434358Mouse
10402497Lmr23_mleishmaniasis resistance 23 (mouse)Not determined16129674200Mouse
1301559Bbaa19_mB.burgdorferi-associated arthritis 19 (mouse)Not determined16130066977Mouse
10412289Ppsl_mplasma P-selectin levels (mouse)Not determined16130814572Mouse
27095908Scvln7_msacral vertebrae length 2, 5 week (mouse)16331786439820362Mouse
27226768Tibl9_mtibia length 9, 5 week (mouse)16331786451420363Mouse
27226785Feml12_mfemur length 12, 5 week (mouse)16331786464620363Mouse
1302106Rapop1_mradiation-induced apoptosis 1 (mouse)Not determined16378077915731053Mouse
26884432Zlq7_mzygomatic length QTL 7, 10 week (mouse)16381786464620363Mouse
38501069Tip4_mtuberculosis immunophenotype 4, IFN-g level (mouse)16431786444520363Mouse
1301443Mopkd2_mmodifier of polycystic kidney disease progression 2 (mouse)Not determined16464631438646414Mouse
1300656Bgeq15_mbody growth early QTL 15 (mouse)Not determined16577525239775440Mouse
1301945Skl7_mskeletal size (tail length) 7 (mouse)Not determined16577525239775440Mouse
1300943Skts9_mskin tumor susceptibility 9 (mouse)Not determined16577525239775440Mouse
1300987Skull23_mskull morphology 23 (mouse)Not determined16577525239775440Mouse
4141010Bbq1_mbrain and behavior QTL 1 (mouse)Not determined16647700935021216Mouse
1357763Lp1_mlymphocyte proliferation 1 (mouse)Not determined16654297965466552Mouse
4142460Nilac10_mnicotine induced locomotor activity 10 (mouse)Not determined16713690629225471Mouse
11251724Ewc6_methanol withdrawal and consumption 6 (mouse)16822605242226052Mouse
26884376Skwq4_mskull length QTL 4, 5 week (mouse)16841786490896888Mouse
10043978Obq35_mobesity QTL 35 (mouse)Not determined16988163143881631Mouse
1301086Lprm5_mlymphoproliferation modifier 5 (mouse)Not determined161184882445848923Mouse
1301841Lrnx9_mlearning-contextual 9 (mouse)Not determined161222536046225471Mouse
15092082Igly9_mIgG glycosylation 9, GP17b (mouse)161477522320103513Mouse
10045614Rapop6_mradiation-induced apoptosis 6 (mouse)Not determined161480292148803032Mouse
4142236Pstc4_mperiosteal circumference 4 (mouse)Not determined161552290949523112Mouse

Markers in Region
RH136293  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381615,841,895 - 15,842,093UniSTSGRCm38
MGSCv371615,841,988 - 15,842,186UniSTSGRCm37
Celera1616,412,869 - 16,413,067UniSTS
Cytogenetic Map16B1UniSTS
RH136614  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381074,863,278 - 74,863,478UniSTSGRCm38
GRCm381615,736,447 - 15,736,646UniSTSGRCm38
MGSCv371074,326,023 - 74,326,223UniSTSGRCm37
MGSCv371615,736,540 - 15,736,739UniSTSGRCm37
Celera1616,314,791 - 16,314,990UniSTS
Celera1075,913,613 - 75,913,813UniSTS
Cytogenetic Map10B5.3UniSTS
Cytogenetic Map16B1UniSTS
Cytogenetic Map10C2UniSTS
cM Map1039.0UniSTS
RH131824  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381615,841,994 - 15,842,176UniSTSGRCm38
MGSCv371615,842,087 - 15,842,269UniSTSGRCm37
Celera1616,412,968 - 16,413,150UniSTS
Cytogenetic Map16B1UniSTS
AI326420  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381615,841,932 - 15,842,023UniSTSGRCm38
MGSCv371615,842,025 - 15,842,116UniSTSGRCm37
Celera1616,412,906 - 16,412,997UniSTS
Cytogenetic Map16B1UniSTS
Whitehead/MRC_RH16123.99UniSTS
06.MMHAP95FRB9.seq  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381615,699,438 - 15,699,589UniSTSGRCm38
MGSCv371615,699,531 - 15,699,682UniSTSGRCm37
Celera1616,277,768 - 16,277,919UniSTS
Cytogenetic Map16B1UniSTS
Whitehead_YAC16 UniSTS
D87521  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381615,842,071 - 15,842,176UniSTSGRCm38
MGSCv371615,842,164 - 15,842,269UniSTSGRCm37
Celera1616,413,045 - 16,413,150UniSTS
Cytogenetic Map16B1UniSTS
Whitehead/MRC_RH16122.18UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_011159 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006521861 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017316892 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB000629 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB007544 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB011543 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB030754 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC111103 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC154586 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ315658 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ315659 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ315660 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ315661 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK084827 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK088981 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK137732 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AU019811 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC028664 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466521 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CT010522 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CT030649 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D83786 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D87521 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ235257 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ235258 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U78157 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U78158 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSMUST00000023352   ⟹   ENSMUSP00000023352
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1615,455,753 - 15,660,099 (+)Ensembl
GRCm38.p6 Ensembl1615,637,889 - 15,842,235 (+)Ensembl
RefSeq Acc Id: ENSMUST00000182134
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1615,455,730 - 15,502,613 (+)Ensembl
GRCm38.p6 Ensembl1615,637,866 - 15,684,749 (+)Ensembl
RefSeq Acc Id: NM_011159   ⟹   NP_035289
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391615,455,730 - 15,660,103 (+)NCBI
GRCm381615,637,866 - 15,842,239 (+)NCBI
MGSCv371615,637,959 - 15,842,332 (+)RGD
Celera1616,214,291 - 16,413,213 (+)RGD
cM Map16 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006521861   ⟹   XP_006521924
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391615,455,698 - 15,627,532 (+)NCBI
GRCm381615,637,444 - 15,809,668 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017316892   ⟹   XP_017172381
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391615,455,698 - 15,625,889 (+)NCBI
GRCm381615,637,444 - 15,808,027 (+)NCBI
Sequence:
RefSeq Acc Id: NP_035289   ⟸   NM_011159
- UniProtKB: Q8C2A7 (UniProtKB/Swiss-Prot),   Q3V2W8 (UniProtKB/Swiss-Prot),   Q307W9 (UniProtKB/Swiss-Prot),   P97928 (UniProtKB/Swiss-Prot),   O88187 (UniProtKB/Swiss-Prot),   E9QN15 (UniProtKB/Swiss-Prot),   Q9Z341 (UniProtKB/Swiss-Prot),   P97313 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006521924   ⟸   XM_006521861
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_017172381   ⟸   XM_017316892
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSMUSP00000023352   ⟸   ENSMUST00000023352
Protein Domains
FAT   FATC   PI3K/PI4K catalytic

Promoters
RGD ID:6827382
Promoter ID:MM_KWN:20228
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:NM_008565,   NM_011159,   UC007YHS.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361615,637,301 - 15,638,067 (+)MPROMDB
RGD ID:8685536
Promoter ID:EPDNEW_M20799
Type:multiple initiation site
Name:Prkdc_1
Description:Mus musculus protein kinase, DNA activated, catalytic polypeptide, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381615,637,866 - 15,637,926EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:104779 AgrOrtholog
Ensembl Genes ENSMUSG00000022672 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000023352 ENTREZGENE
  ENSMUST00000023352.9 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.1070.11 UniProtKB/Swiss-Prot
InterPro ARM-type_fold UniProtKB/Swiss-Prot
  DNA-PK_dom UniProtKB/Swiss-Prot
  DNA-PKcs_N UniProtKB/Swiss-Prot
  DNAPKcs_CC1-2 UniProtKB/Swiss-Prot
  DNAPKcs_CC5 UniProtKB/Swiss-Prot
  FATC_dom UniProtKB/Swiss-Prot
  Kinase-like_dom_sf UniProtKB/Swiss-Prot
  NUC194 UniProtKB/Swiss-Prot
  PI3/4_kinase_cat_dom UniProtKB/Swiss-Prot
  PI3/4_kinase_cat_sf UniProtKB/Swiss-Prot
  PI3/4_kinase_CS UniProtKB/Swiss-Prot
  PIK-rel_kinase_FAT UniProtKB/Swiss-Prot
  PIK_FAT UniProtKB/Swiss-Prot
KEGG Report mmu:19090 UniProtKB/Swiss-Prot
MGD MGI:104779 ENTREZGENE
NCBI Gene 19090 ENTREZGENE
PANTHER ATAXIA TELANGIECTASIA MUTATED ATM -RELATED UniProtKB/Swiss-Prot
  DNA-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT UniProtKB/Swiss-Prot
Pfam DNA-PKcs_N UniProtKB/Swiss-Prot
  DNAPKcs_CC1-2 UniProtKB/Swiss-Prot
  DNAPKcs_CC5 UniProtKB/Swiss-Prot
  FAT UniProtKB/Swiss-Prot
  FATC UniProtKB/Swiss-Prot
  NUC194 UniProtKB/Swiss-Prot
  PI3_PI4_kinase UniProtKB/Swiss-Prot
PhenoGen Prkdc PhenoGen
PROSITE FAT UniProtKB/Swiss-Prot
  FATC UniProtKB/Swiss-Prot
  PI3_4_KINASE_1 UniProtKB/Swiss-Prot
  PI3_4_KINASE_2 UniProtKB/Swiss-Prot
  PI3_4_KINASE_3 UniProtKB/Swiss-Prot
SMART FATC UniProtKB/Swiss-Prot
  NUC194 UniProtKB/Swiss-Prot
  PI3Kc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48371 UniProtKB/Swiss-Prot
  SSF56112 UniProtKB/Swiss-Prot
UniProt E9QN15 ENTREZGENE
  O88187 ENTREZGENE
  P97313 ENTREZGENE
  P97928 ENTREZGENE
  PRKDC_MOUSE UniProtKB/Swiss-Prot
  Q307W9 ENTREZGENE
  Q3V2W8 ENTREZGENE
  Q8C2A7 ENTREZGENE
  Q91UZ3_MOUSE UniProtKB/TrEMBL
  Q91VE8_MOUSE UniProtKB/TrEMBL
  Q9Z341 ENTREZGENE
UniProt Secondary E9QN15 UniProtKB/Swiss-Prot
  O88187 UniProtKB/Swiss-Prot
  P97928 UniProtKB/Swiss-Prot
  Q307W9 UniProtKB/Swiss-Prot
  Q3V2W8 UniProtKB/Swiss-Prot
  Q8C2A7 UniProtKB/Swiss-Prot
  Q9Z341 UniProtKB/Swiss-Prot