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Gene: PRKDC (protein kinase, DNA-activated, catalytic subunit) Homo sapiens
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Symbol: PRKDC
Name: protein kinase, DNA-activated, catalytic subunit
Description: Exhibits several functions, including DNA-dependent protein kinase activity; double-stranded DNA binding activity; and transcription factor binding activity. Involved in several processes, including DNA metabolic process; positive regulation of nucleobase-containing compound metabolic process; and signal transduction involved in mitotic G1 DNA damage checkpoint. Localizes to the nucleus; protein-DNA complex; and transcription factor complex. Implicated in primary immunodeficiency disease.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: DNA-dependent protein kinase catalytic subunit; DNA-PK catalytic subunit; DNA-PKC; DNA-PKcs; DNAPK; DNAPKc; DNPK1; hyper-radiosensitivity of murine scid mutation, complementing 1; HYRC; HYRC1; IMD26; p350; p460; XRCC7
Orthologs:
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl847,773,111 - 47,960,178 (-)Ensembl
GRCh38 Ensembl847,773,108 - 47,960,183 (-)Ensembl
GRCh38847,773,111 - 47,960,136 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37848,685,669 - 48,872,743 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36848,848,222 - 49,035,296 (-)NCBINCBI36hg18NCBI36
Build 34848,848,221 - 49,035,296NCBI
Celera844,671,051 - 44,858,151 (-)NCBI
Cytogenetic Map8q11.21NCBI
HuRef844,148,581 - 44,335,706 (-)NCBIHuRef
CHM1_1848,738,053 - 48,925,105 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
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References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on PRKDC
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1319072
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-02-11
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.