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Gene: Bok (BCL2-related ovarian killer) Mus musculus
Symbol: Bok
Name: BCL2-related ovarian killer
Description: Exhibits protein homodimerization activity; signaling receptor binding activity; and ubiquitin protein ligase binding activity. Involved in several processes, including ion homeostasis; positive regulation of PERK-mediated unfolded protein response; and regulation of programmed cell death. Localizes to the bounding membrane of organelle; endoplasmic reticulum membrane; and mitochondrial membrane. Is expressed in several structures, including central nervous system; embryo mesenchyme; gut; retina; and vibrissa dermal component. Orthologous to human BOK (BCL2 family apoptosis regulator BOK); PARTICIPATES IN intrinsic apoptotic pathway; INTERACTS WITH (+)-dexrazoxane; (S)-nicotine; 1,2-dichloroethane.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AI847676; apoptosis activator Mtd; AU021146; bcl-2-related ovarian killer protein; Bcl-2-related ovarian killer protein-like; matador; mtd
Homo sapiens (human) : BOK (BCL2 family apoptosis regulator BOK)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Bok (BCL2 family apoptosis regulator BOK)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Bok (BCL2 family apoptosis regulator BOK)
Pan paniscus (bonobo/pygmy chimpanzee) : BOK (BCL2 family apoptosis regulator BOK)
Canis lupus familiaris (dog) : BOK (BCL2 family apoptosis regulator BOK)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Bok (BCL2 family apoptosis regulator BOK)
Sus scrofa (pig) : BOK (BCL2 family apoptosis regulator BOK)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl193,685,660 - 93,695,764 (+)Ensembl
GRCm38193,685,575 - 93,695,770 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37195,582,271 - 95,592,339 (+)NCBIGRCm37mm9NCBIm37
MGSCv36195,516,100 - 95,526,168 (+)NCBImm8
Celera196,630,738 - 96,640,880 (+)NCBICelera
Cytogenetic Map1 DNCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
Nomenclature History
More on Bok
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 737139
Created: 2004-02-06
Species: Mus musculus
Last Modified: 2019-11-27
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.