Bok (BCL2-related ovarian killer) - Rat Genome Database

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Gene: Bok (BCL2-related ovarian killer) Mus musculus
Analyze
Symbol: Bok
Name: BCL2-related ovarian killer
RGD ID: 737139
MGI Page MGI
Description: Enables protein homodimerization activity; signaling receptor binding activity; and ubiquitin protein ligase binding activity. Involved in several processes, including negative regulation of mitochondrial depolarization; negative regulation of programmed cell death; and positive regulation of response to endoplasmic reticulum stress. Acts upstream of or within neuron apoptotic process. Located in several cellular components, including bounding membrane of organelle; mitochondrial membrane; and trans-Golgi network membrane. Is expressed in several structures, including central nervous system; embryo mesenchyme; gut; retina; and vibrissa dermal component. Orthologous to human BOK (BCL2 family apoptosis regulator BOK).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AI847676; apoptosis activator Mtd; AU021146; bcl-2-related ovarian killer protein; Bcl-2-related ovarian killer protein-like; mat; matador; mtd
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39193,613,297 - 93,623,492 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl193,613,382 - 93,623,486 (+)EnsemblGRCm39 Ensembl
GRCm38193,685,575 - 93,695,770 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl193,685,660 - 93,695,764 (+)EnsemblGRCm38mm10GRCm38
MGSCv37195,582,271 - 95,592,339 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36195,516,100 - 95,526,168 (+)NCBIMGSCv36mm8
Celera196,630,738 - 96,640,880 (+)NCBICelera
Cytogenetic Map1DNCBI
cM Map147.28NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-dexrazoxane  (EXP)
(S)-nicotine  (EXP)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2-dichloroethane  (EXP)
1,2-dimethylhydrazine  (EXP)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
1H-pyrazole  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2-(tert-butylimino)-5-phenyl-3-(propan-2-yl)-1,3,5-thiadiazinan-4-one  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxyphenyl retinamide  (EXP)
5-azacytidine  (ISO)
6-propyl-2-thiouracil  (ISO)
acetamide  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
ammonium chloride  (ISO)
amphetamine  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[e]pyrene  (ISO)
beta-naphthoflavone  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
buprofezin  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbamazepine  (ISO)
carbon nanotube  (EXP)
CGP 52608  (ISO)
chlorpyrifos  (EXP)
chromium(6+)  (EXP,ISO)
cisplatin  (ISO)
clobetasol  (EXP)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
dexamethasone  (EXP)
diazinon  (ISO)
dibenz[a,h]anthracene  (EXP)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
dichloroacetic acid  (EXP)
diepoxybutane  (ISO)
dimethylarsinic acid  (ISO)
diuron  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP)
endosulfan  (ISO)
entinostat  (ISO)
epichlorohydrin  (ISO)
ethanol  (EXP)
fenthion  (EXP)
ferroheme b  (EXP)
flavonoids  (ISO)
folic acid  (EXP,ISO)
furan  (ISO)
furosemide  (ISO)
glyphosate  (ISO)
heme b  (EXP)
hydrogen peroxide  (ISO)
isoprenaline  (EXP)
lipopolysaccharide  (ISO)
methapyrilene  (ISO)
methoxychlor  (EXP)
mono(2-ethylhexyl) phthalate  (EXP)
monobenzyl phthalate  (EXP)
monoethyl phthalate  (EXP)
morphine  (EXP)
Myrtucommulone A  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (ISO)
nickel dichloride  (ISO)
nicotine  (EXP)
ozone  (EXP)
p-menthan-3-ol  (ISO)
paracetamol  (EXP,ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (EXP)
propiconazole  (EXP)
propylparaben  (ISO)
resveratrol  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
sodium arsenite  (EXP)
sodium dichromate  (ISO)
Soman  (ISO)
thimerosal  (ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP)
trichloroethene  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
trovafloxacin  (EXP)
urethane  (ISO)
usnic acid  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
apoptotic process  (ISO)
cellular component disassembly involved in execution phase of apoptosis  (IDA)
extrinsic apoptotic signaling pathway in absence of ligand  (IBA)
intrinsic apoptotic signaling pathway by p53 class mediator  (IEA,ISO)
intrinsic apoptotic signaling pathway in response to DNA damage  (IBA)
male gonad development  (IEA,ISO)
negative regulation of mitochondrial depolarization  (IMP)
negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway  (IMP)
negative regulation of necroptotic process  (IMP)
negative regulation of neuron apoptotic process  (IMP)
neuron apoptotic process  (IDA)
obsolete positive regulation of cysteine-type endopeptidase activity  (IMP,ISO,ISS)
oligodendrocyte differentiation  (IEA,ISO)
positive regulation of apoptotic process  (IBA,ISO)
positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway  (IDA,IMP)
positive regulation of execution phase of apoptosis  (ISO,ISS)
positive regulation of intrinsic apoptotic signaling pathway  (IDA)
positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway  (IDA)
positive regulation of PERK-mediated unfolded protein response  (IMP)
protein complex oligomerization  (IDA)
regulation of autophagy  (IEA,ISO)
regulation of chorionic trophoblast cell proliferation  (ISO,ISS)
regulation of cytosolic calcium ion concentration  (IMP)
regulation of granulosa cell apoptotic process  (ISO,ISS)
release of cytochrome c from mitochondria  (IBA,IEA,ISO)
response to cisplatin  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. The Bcl-2 apoptotic switch in cancer development and therapy. Adams JM and Cory S, Oncogene. 2007 Feb 26;26(9):1324-37.
2. Bok is a pro-apoptotic Bcl-2 protein with restricted expression in reproductive tissues and heterodimerizes with selective anti-apoptotic Bcl-2 family members. Hsu SY, etal., Proc Natl Acad Sci U S A 1997 Nov 11;94(23):12401-6.
3. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, etal., Development 2000 Apr;127(8):1737-49.
4. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
5. MGDs mouse GO annotations MGD data from the GO Consortium
6. Differential expression of stress response genes in the H-Tx rat model of congenital hydrocephalus. Morgan FW, etal., Brain Res Mol Brain Res. 2005 Aug 18;138(2):273-90.
7. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
8. A subtractive gene expression screen suggests a role of transcription factor AP-2 alpha in control of proliferation and differentiation. Pfisterer P, etal., J Biol Chem 2002 Feb 22;277(8):6637-44. Epub 2001 Dec 10.
9. Mouse MP Annotation Import Pipeline RGD automated import pipeline
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:9535847   PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12477932   PMID:15489334   PMID:16141072   PMID:16141073   PMID:16602821  
PMID:16772296   PMID:18799693   PMID:21873635   PMID:22185759   PMID:22281706   PMID:22357545   PMID:23429263   PMID:23744350   PMID:23884412   PMID:24990442   PMID:26015568   PMID:26949185  
PMID:27053113   PMID:27098698   PMID:27626380   PMID:28064468   PMID:29229991   PMID:29463805   PMID:29775594   PMID:30970248   PMID:30976095   PMID:31203423   PMID:31311867   PMID:31315048  
PMID:31787886   PMID:33691099   PMID:33807047   PMID:35091677   PMID:35393408   PMID:36060797   PMID:37813816   PMID:38355793   PMID:39181129  


Genomics

Comparative Map Data
Bok
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39193,613,297 - 93,623,492 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl193,613,382 - 93,623,486 (+)EnsemblGRCm39 Ensembl
GRCm38193,685,575 - 93,695,770 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl193,685,660 - 93,695,764 (+)EnsemblGRCm38mm10GRCm38
MGSCv37195,582,271 - 95,592,339 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36195,516,100 - 95,526,168 (+)NCBIMGSCv36mm8
Celera196,630,738 - 96,640,880 (+)NCBICelera
Cytogenetic Map1DNCBI
cM Map147.28NCBI
BOK
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382241,551,393 - 241,574,131 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2241,551,424 - 241,574,131 (+)EnsemblGRCh38hg38GRCh38
GRCh372242,498,160 - 242,513,546 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362242,146,865 - 242,162,226 (+)NCBINCBI36Build 36hg18NCBI36
Build 342242,218,181 - 242,233,541NCBI
Celera2236,166,128 - 236,181,243 (+)NCBICelera
Cytogenetic Map2q37.3NCBI
HuRef2234,252,352 - 234,267,504 (+)NCBIHuRef
CHM1_12242,504,201 - 242,519,152 (+)NCBICHM1_1
T2T-CHM13v2.02242,051,239 - 242,074,030 (+)NCBIT2T-CHM13v2.0
Bok
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr89101,670,729 - 101,681,834 (+)NCBIGRCr8
mRatBN7.2994,223,493 - 94,234,476 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl994,223,389 - 94,234,476 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx9102,659,055 - 102,669,960 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.09107,794,662 - 107,805,567 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.09106,150,763 - 106,161,668 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.09100,829,593 - 100,840,498 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl9100,829,552 - 100,840,504 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.09100,482,657 - 100,493,563 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4992,970,069 - 92,980,974 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1993,174,837 - 93,185,742 (+)NCBI
Celera991,758,055 - 91,768,960 (+)NCBICelera
Cytogenetic Map9q36NCBI
Bok
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955542224,471 - 232,428 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955542224,471 - 232,401 (-)NCBIChiLan1.0ChiLan1.0
BOK
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213144,264,085 - 144,279,627 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B144,278,982 - 144,294,524 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B128,832,458 - 128,847,918 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B247,626,494 - 247,640,238 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B247,626,494 - 247,640,238 (+)Ensemblpanpan1.1panPan2
BOK
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12551,449,700 - 51,450,967 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2551,662,160 - 51,671,783 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02551,642,280 - 51,651,918 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2551,641,083 - 51,651,905 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12551,491,666 - 51,501,244 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02551,231,578 - 51,241,142 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02551,507,856 - 51,517,459 (+)NCBIUU_Cfam_GSD_1.0
Bok
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303192,866,849 - 192,874,583 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936745345,635 - 351,749 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936745344,837 - 350,950 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BOK
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15140,171,143 - 140,184,121 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115140,171,134 - 140,184,126 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
BOK
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.110127,621,936 - 127,634,091 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl10127,622,149 - 127,635,833 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604071,688,317 - 71,701,116 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Bok
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248475,564,979 - 5,573,459 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248475,564,671 - 5,573,459 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Bok
591 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:302
Count of miRNA genes:231
Interacting mature miRNAs:263
Transcripts:ENSMUST00000027499
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
11039528Ccc3_mcolitis susceptibility in the Collaborative Cross 3 (mouse)13680142195051546Mouse
15039333Nmrs1_mNAFLD-associated magnetic resonance shift 1 (mouse)189786512123786512Mouse
10045976Tir6_mtrypanosome infection response 6 (mouse)Not determined193536855120529678Mouse
1357847Jckm2_mjuvenile cystic kidney modifier 2 (mouse)Not determined174991977133290937Mouse
4141627Bwq7_mbody weight, QTL 7 (mouse)Not determined192940909124497796Mouse
4142394Mssq1_mmandible size and shape QTL 1 (mouse)Not determined73615692107615830Mouse
10412185Hcs9_mhepatocarcinogenesis susceptibility 9 (mouse)Not determined163854690189303617Mouse
1558928Mord2_mmodifier of retinal degeneration 2 (mouse)Not determined177123115110536075Mouse
12879491Hfnq1_mhair follicle number QTL 1 (mouse)193310310123636759Mouse
1301722Cia9_mcollagen induced arthritis QTL 9 (mouse)Not determined145783900189303617Mouse
13824984Twq5_mtestis weight QTL 5 (mouse)13069992184732197Mouse
14697706Stsl3a_mSalmonella typhimurium susceptibility locus 3a (mouse)17747663795827725Mouse
12790991Aath1_maortic arch atherosclerosis 1 (mouse)186483929120483929Mouse
1357721Sle17_msystematic lupus erythematosus susceptibility 17 (mouse)Not determined139132808126445310Mouse
10412238Alpq5_malcohol preference QTL 5 (mouse)Not determined182832635116832635Mouse
1302146Cocrb1_mcocaine related behavior 1 (mouse)Not determined170133533104139557Mouse
1357760Synch3_msynechia 3 (mouse)Not determined192901442126901550Mouse
1558860W10q7_mweight 10 weeks QTL 7 (mouse)Not determined134760138150193871Mouse
4141347Reb1_mrepetitive behavior 1 (mouse)Not determined91468266100413667Mouse
12791004Aath7_maortic arch atherosclerosis 7 (mouse)182832635116832635Mouse
4141725Wbcq4_mwhite blood cell quantitative locus 4 (mouse)Not determined179858683113858791Mouse
12050069Nabq1_mnasal bone morphology QTL 1 (mouse)179858683113858791Mouse
1300976Bmd19_mbone mineral density 19 (mouse)Not determined173266214108838414Mouse
1357488Splq3_mspleen weight QTL 3 (mouse)Not determined134760138150193871Mouse
4141914Gcsfis_mG-CSF induced splenomegaly (mouse)Not determined74516235148715579Mouse
27095928Pglq6_mpelvic girdle length QTL 6, 10 week (mouse)175976637148775742Mouse
27095931Pglq1_mpelvic girdle length QTL 1, 5 week (mouse)175976637128527737Mouse
13452395Leusq2_mleucocytosis susceptibility QTL 2 (mouse)180245593126386517Mouse
1301748Abbp1_mA/J and C57BL/6 blood pressure 1 (mouse)Not determined162946755120529678Mouse
1301304Hrq3_mheart rate quantitative locus 3 (mouse)Not determined173615692107615830Mouse
1357439Popoa_mpremature ovulation and primary oocyte arrest (mouse)Not determined182643189135615379Mouse
4142291Aec2_mautoimmune exocrinopathy 2 (mouse)Not determined52457737182250592Mouse
1357753Kidq2_mkidney weight QTL 2 (mouse)Not determined134760138150193871Mouse
1300989Lrdg1_mlight induced retinal degeneration 1 (mouse)Not determined173755175147125370Mouse
4141329Mleu1_mmyeloid leukemia survival 1 (mouse)Not determined89786512123786512Mouse
11667074Led2_mlate embryonic death 2 (mouse)185696027117195081Mouse
27095918Ulnl1_mulna length 1, 5 week (mouse)167339159129727737Mouse
1301350Nidd4k_mNidd4 on KK-A (mouse)Not determined782291982147125370Mouse
1300841Ssial1_msusceptibility to sialadenitis 1 (mouse)Not determined163920002153557562Mouse
26884448Sklq1_mskull length QTL 1, 5 week (mouse)175976637181327565Mouse

Markers in Region
RH136451  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38193,695,532 - 93,695,731UniSTSGRCm38
MGSCv37195,592,109 - 95,592,308UniSTSGRCm37
Celera196,640,650 - 96,640,849UniSTS
Cytogenetic Map1DUniSTS
AI847676  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38193,695,145 - 93,695,255UniSTSGRCm38
MGSCv37195,591,722 - 95,591,832UniSTSGRCm37
Celera196,640,263 - 96,640,373UniSTS
Cytogenetic Map1DUniSTS
Whitehead/MRC_RH11317.93UniSTS
D1S2869  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38193,688,356 - 93,689,529UniSTSGRCm38
GRCm38X164,153,557 - 164,154,374UniSTSGRCm38
MGSCv37195,584,933 - 95,586,106UniSTSGRCm37
MGSCv37X160,591,489 - 160,592,306UniSTSGRCm37
CeleraX147,367,932 - 147,368,749UniSTS
Celera196,633,400 - 96,634,573UniSTS
Cytogenetic MapXF5UniSTS
Cytogenetic Map1DUniSTS
cM MapX70.5UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000027499   ⟹   ENSMUSP00000027499
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl193,613,382 - 93,623,486 (+)Ensembl
GRCm38.p6 Ensembl193,685,660 - 93,695,764 (+)Ensembl
Ensembl Acc Id: ENSMUST00000185685
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl193,621,539 - 93,623,177 (+)Ensembl
GRCm38.p6 Ensembl193,693,817 - 93,695,455 (+)Ensembl
Ensembl Acc Id: ENSMUST00000188394   ⟹   ENSMUSP00000140412
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl193,613,985 - 93,621,792 (+)Ensembl
GRCm38.p6 Ensembl193,686,263 - 93,694,070 (+)Ensembl
Ensembl Acc Id: ENSMUST00000200888   ⟹   ENSMUSP00000144146
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl193,616,930 - 93,623,191 (+)Ensembl
GRCm38.p6 Ensembl193,689,208 - 93,695,469 (+)Ensembl
Ensembl Acc Id: ENSMUST00000201863   ⟹   ENSMUSP00000144347
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl193,613,424 - 93,622,932 (+)Ensembl
GRCm38.p6 Ensembl193,685,702 - 93,695,210 (+)Ensembl
RefSeq Acc Id: NM_016778   ⟹   NP_058058
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39193,613,297 - 93,623,492 (+)NCBI
GRCm38193,685,575 - 93,695,770 (+)NCBI
MGSCv37195,582,271 - 95,592,339 (+)RGD
Celera196,630,738 - 96,640,880 (+)RGD
cM Map1 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_058058   ⟸   NM_016778
- UniProtKB: O35425 (UniProtKB/Swiss-Prot),   Q3TH93 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000027499   ⟸   ENSMUST00000027499
Ensembl Acc Id: ENSMUSP00000140412   ⟸   ENSMUST00000188394
Ensembl Acc Id: ENSMUSP00000144347   ⟸   ENSMUST00000201863
Ensembl Acc Id: ENSMUSP00000144146   ⟸   ENSMUST00000200888
Protein Domains
Bcl-2 Bcl-2 homology region 1-3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O35425-F1-model_v2 AlphaFold O35425 1-213 view protein structure

Promoters
RGD ID:6874562
Promoter ID:EPDNEW_M732
Type:initiation region
Name:Bok_1
Description:Mus musculus BCL2-related ovarian killer , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38193,685,666 - 93,685,726EPDNEW
RGD ID:6817434
Promoter ID:MM_KWN:1702
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:ES_Cell,   Kidney,   MEF_B6
Transcripts:NM_016778
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36195,581,901 - 95,582,401 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1858494 AgrOrtholog
Ensembl Genes ENSMUSG00000026278 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000027499 ENTREZGENE
  ENSMUST00000027499.13 UniProtKB/Swiss-Prot
  ENSMUST00000188394.2 UniProtKB/TrEMBL
  ENSMUST00000200888.2 UniProtKB/TrEMBL
  ENSMUST00000201863.4 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.437.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Bcl-2_BH1-3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Bcl2-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Blc2-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Blc2_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:51800 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1858494 ENTREZGENE
NCBI Gene Bok ENTREZGENE
PANTHER PTHR11256 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11256:SF48 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Bcl-2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Bok PhenoGen
PRINTS BCL2FAMILY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE BCL2_FAMILY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART BCL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56854 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A087WR00_MOUSE UniProtKB/TrEMBL
  A0A0J9YUF0_MOUSE UniProtKB/TrEMBL
  BOK_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q3TH93 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2024-08-26 Bok  BCL2-related ovarian killer  Bokl-pending  Bcl-2-related ovarian killer protein-like-pending  Symbol and/or name updated 27372883 PROVISIONAL
2024-08-21 Bokl-pending  Bcl-2-related ovarian killer protein-like-pending  Bok  BCL2-related ovarian killer  Symbol and/or name change 5135510 APPROVED
2014-07-01 Bok  BCL2-related ovarian killer    BCL2-related ovarian killer protein  Symbol and/or name change 5135510 APPROVED