Hic1 (hypermethylated in cancer 1) - Rat Genome Database
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Hic1 (hypermethylated in cancer 1) Mus musculus
Analyze
Symbol: Hic1
Name: hypermethylated in cancer 1
RGD ID: 1316775
MGI Page MGI
Description: Is expressed in several structures, including alimentary system; embryo mesenchyme; genitourinary system; immune system; and trophectoderm. Used to study Miller-Dieker lissencephaly syndrome. Orthologous to human HIC1 (HIC ZBTB transcriptional repressor 1); INTERACTS WITH 1,2-dichloroethane; 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AA408311; HIC-; HIC-1; hypermethylated in cancer 1 protein
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391175,052,203 - 75,061,081 (-)NCBIGRCm39mm39
GRCm39 Ensembl1175,055,391 - 75,060,345 (-)Ensembl
GRCm381175,161,377 - 75,170,255 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1175,164,565 - 75,169,519 (-)EnsemblGRCm38mm10GRCm38
MGSCv371174,978,067 - 74,983,757 (-)NCBIGRCm37mm9NCBIm37
MGSCv361174,980,763 - 74,985,714 (-)NCBImm8
Celera1182,671,336 - 82,677,017 (-)NCBICelera
Cytogenetic Map11B5NCBI
cM Map1145.76NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

References

Additional References at PubMed
PMID:8889548   PMID:9838134   PMID:10072440   PMID:10371200   PMID:10655551   PMID:10922068   PMID:11073960   PMID:11455436   PMID:11527402   PMID:12539045   PMID:12905154   PMID:15007385  
PMID:15488761   PMID:16141072   PMID:16269335   PMID:16724116   PMID:16844427   PMID:18287559   PMID:18347096   PMID:18751382   PMID:18799693   PMID:20154726   PMID:21297660   PMID:21309068  
PMID:21677750   PMID:21873635   PMID:22315224   PMID:23459939   PMID:24748541   PMID:25934696   PMID:28327618   PMID:28466555   PMID:29367758   PMID:29470558   PMID:30204129   PMID:30312658  
PMID:31108460   PMID:31809738  


Genomics

Comparative Map Data
Hic1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391175,052,203 - 75,061,081 (-)NCBIGRCm39mm39
GRCm39 Ensembl1175,055,391 - 75,060,345 (-)Ensembl
GRCm381175,161,377 - 75,170,255 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1175,164,565 - 75,169,519 (-)EnsemblGRCm38mm10GRCm38
MGSCv371174,978,067 - 74,983,757 (-)NCBIGRCm37mm9NCBIm37
MGSCv361174,980,763 - 74,985,714 (-)NCBImm8
Celera1182,671,336 - 82,677,017 (-)NCBICelera
Cytogenetic Map11B5NCBI
cM Map1145.76NCBI
HIC1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl172,054,154 - 2,063,241 (+)EnsemblGRCh38hg38GRCh38
GRCh38172,055,103 - 2,063,241 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37171,958,397 - 1,966,535 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36171,905,143 - 1,909,731 (+)NCBINCBI36hg18NCBI36
Build 34171,906,714 - 1,908,879NCBI
Celera171,974,408 - 1,978,996 (+)NCBI
Cytogenetic Map17p13.3NCBI
HuRef171,853,855 - 1,857,995 (+)NCBIHuRef
CHM1_1171,967,163 - 1,971,751 (+)NCBICHM1_1
Hic1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21060,014,520 - 60,019,475 (-)NCBI
Rnor_6.0 Ensembl1062,007,150 - 62,009,582 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01062,007,150 - 62,010,774 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01061,721,540 - 61,725,164 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41062,470,736 - 62,476,506 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11062,485,182 - 62,492,086 (-)NCBI
Celera1059,044,464 - 59,049,428 (-)NCBICelera
Cytogenetic Map10q24NCBI
Hic1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554811,179,015 - 1,181,825 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554811,179,015 - 1,182,936 (-)NCBIChiLan1.0ChiLan1.0
HIC1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1171,935,628 - 1,937,474 (+)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v0172,045,960 - 2,051,483 (+)NCBIMhudiblu_PPA_v0panPan3
HIC1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl946,159,136 - 46,162,004 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1946,156,909 - 46,162,849 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Hic1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365388,122,557 - 8,126,157 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HIC1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1248,168,766 - 48,171,635 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11248,167,861 - 48,172,540 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21250,021,109 - 50,025,558 (+)NCBISscrofa10.2Sscrofa10.2susScr3
HIC1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1161,687,560 - 1,697,888 (+)NCBI
ChlSab1.1 Ensembl161,694,341 - 1,697,023 (+)Ensembl
Hic1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247864,724,806 - 4,729,714 (+)NCBI

Position Markers
RH126523  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381175,164,636 - 75,164,764UniSTSGRCm38
MGSCv371174,978,138 - 74,978,266UniSTSGRCm37
Celera1182,671,407 - 82,671,535UniSTS
Cytogenetic Map11B5UniSTS
cM Map1147.65UniSTS
Whitehead/MRC_RH11930.26UniSTS
RH124699  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381175,164,569 - 75,164,713UniSTSGRCm38
MGSCv371174,978,071 - 74,978,215UniSTSGRCm37
Celera1182,671,340 - 82,671,484UniSTS
Cytogenetic Map11B5UniSTS
cM Map1147.65UniSTS
Hic1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381175,165,063 - 75,165,161UniSTSGRCm38
MGSCv371174,978,565 - 74,978,663UniSTSGRCm37
Celera1182,674,049 - 82,674,299UniSTS
Cytogenetic Map11B5UniSTS
cM Map1147.65UniSTS
G54864  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381175,167,263 - 75,167,455UniSTSGRCm38
MGSCv371174,980,765 - 74,980,957UniSTSGRCm37
Celera1182,674,034 - 82,674,226UniSTS
Cytogenetic Map11B5UniSTS
cM Map1147.65UniSTS
G54872  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381175,165,576 - 75,165,823UniSTSGRCm38
MGSCv371174,979,078 - 74,979,325UniSTSGRCm37
Celera1182,672,347 - 82,672,594UniSTS
Cytogenetic Map11B5UniSTS
cM Map1147.65UniSTS
Hic1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381175,167,278 - 75,167,528UniSTSGRCm38
MGSCv371174,980,780 - 74,981,030UniSTSGRCm37
Celera1182,674,049 - 82,674,299UniSTS
Cytogenetic Map11B5UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
13208559Wght10_mweight 10 (mouse)11400000089000000Mouse
13208558Lgth12_mbody length 12 (mouse)11400000095000000Mouse
1300905Scc6_mcolon tumor susceptibility 6 (mouse)Not determined11693027789128908Mouse
1357859Lvrq7_mliver weight QTL 7 (mouse)Not determined1112318637118131898Mouse
39128214Lwq20_mliver weight QTL 20 (mouse)1112318637118131898Mouse
4141894Nidd6k_mNidd6 on KK-A (mouse)Not determined1917420497007000Mouse
10412246Dfs2_mdental fluorosis suseptibility 2 (mouse)Not determined112185736495990405Mouse
13208569Bmiq10_mbody mass index QTL 10 (mouse)113600000085000000Mouse
1301328Mol4_mmodifier of LPS-response 4 (mouse)Not determined113639175083590530Mouse
11532698Sluc36a_msusceptibility to lung cancer 36a (mouse)114236579176365904Mouse
11532699Sluc36b_msusceptibility to lung cancer 36b (mouse)114236579176365904Mouse
4142300Ctrq3_mC. trachomatis resistance QTL 3 (mouse)Not determined114473921176963931Mouse
4141367Inf1_macute ozone induced inflammation (mouse)Not determined44739211113167183Mouse
4141000Nidd3_mnon-insulin-dependent diabetes mellitus 3 (mouse)Not determined4515120179151308Mouse
1302021Nidd1n_mnon-insulin-dependent diabetes mellitus 1 in NSY (mouse)Not determined114527504680087498Mouse
1357878Mastr_mmodifier of astrocytoma (mouse)Not determined114581775489927907Mouse
1300765Bbaa4_mB.burgdorferi-associated arthritis 4 (mouse)Not determined114629434180294436Mouse
1301988Bmd11_mbone mineral density 11 (mouse)Not determined114642858180428696Mouse
1301830Ssta4_msusceptibility to Salmonella typhimurium antigens 4 (mouse)Not determined115018736584187585Mouse
13524840Ppiq9a_mprepulse inhibition QTL 9a (mouse)115260355986603559Mouse
1300774Pgia7_mproteoglycan induced arthritis 7 (mouse)Not determined115349976287499911Mouse
4141830Pregq1_mpregnancy QTL 1 (mouse)Not determined115423592683842826Mouse
4142121Tmc1m2_mTmc1 modifier 2 (mouse)Not determined1156973201114267131Mouse
1300664Etohcta9_methanol conditioned taste aversion 9 (mouse)Not determined115786383491863932Mouse
1300924Ity2_mimmunity to S. typhimurium 2 (mouse)Not determined15861720487804412Mouse
4141982Skts-fp2_mskin tumor susceptibility in FVB and PWK 2 (mouse)Not determined5882844085175703Mouse
1301987Pid3_mprior incubation determinant 3 (mouse)Not determined116179599488808902Mouse
1301319Dautb4_mdopamine uptake transporter binding 4 (mouse)Not determined116226517996265327Mouse
27226730Tibmd1_mtibia midshaft diameter 1, 5 week (mouse)1162700000109500000Mouse
1301999Lmr15_mleishmaniasis resistance 15 (mouse)Not determined116342858181939647Mouse
10044004Stzid3_mstreptozotocin induced diabetes susceptibility 3 (mouse)Not determined116342858194173092Mouse
11039501Ltpr6a_mLeishmania tropica response 6a (mouse)116493951098939647Mouse
11039502Ltpr6b_mLeishmania tropica response 6b (mouse)116493951098939647Mouse
11039515Ltpr6_mLeishmania tropica response 6 (mouse)116493951098939647Mouse
1301546Pcir2_mperiosteal circumference 2 (mouse)Not determined1166842594100842826Mouse
1357766Si5lq6_mserum IGFBP-5 level QTL 6 (mouse)Not determined1166842594100842826Mouse
4141012Femwf6_mfemur work to failure 6 (mouse)Not determined66842594100842826Mouse
1301833Tbbmd5_mtotal body bone mineral density 5 (mouse)Not determined1166842594100842826Mouse
1300784Prdt3_mprion disease incubation time 3 (mouse)Not determined1166842594100842826Mouse
1300628Lgth6_mbody length 6 (mouse)Not determined1166842594100842826Mouse
4142316Ity2b_mimmunity to S. typhimurium 2b (mouse)Not determined116718736579923086Mouse
27226783Tibl5_mtibia length 5, 5 week (mouse)1168300000102000000Mouse
1300651Pcyts3_mplasmacytoma susceptibility 3 (mouse)Not determined1170800372104800540Mouse
1301681Sle13_msystematic lupus erythematosus susceptibility 13 (mouse)Not determined1170800372104800540Mouse
1558812Rafar_mretinoic acid induced forelimb autopod reduction (mouse)Not determined1170800372104800540Mouse
4141339Nilac2_mnicotine induced locomotor activity 2 (mouse)Not determined1170800372104800540Mouse
1301404Sbmd4_mspinal bone mineral density 4 (mouse)Not determined1172128823106128908Mouse
1301078Alcp2_malcohol preference locus 2 (mouse)Not determined117231897084840636Mouse
1301310Tmevd5_mTheiler's murine encephalomyelitis virus induced demyelinating disease susceptibility 5 (mouse)Not determined1172835299106835463Mouse
4142348Pstc2_mperiosteal circumference 2 (mouse)Not determined1172927789106927907Mouse
10043866Adip19_madiposity 19 (mouse)Not determined1172927789106927907Mouse
12903994Opfaq3_mopen field activity QTL 3 (mouse)117384671582178599Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:583
Count of miRNA genes:429
Interacting mature miRNAs:477
Transcripts:ENSMUST00000055619, ENSMUST00000131720
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000055619   ⟹   ENSMUSP00000053483
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1175,164,565 - 75,169,519 (-)Ensembl
RefSeq Acc Id: ENSMUST00000131720
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1175,167,153 - 75,168,146 (-)Ensembl
RefSeq Acc Id: NM_001098203   ⟹   NP_001091673
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391175,055,391 - 75,058,978 (-)NCBI
GRCm381175,164,565 - 75,168,152 (-)NCBI
MGSCv371174,978,067 - 74,983,757 (-)RGD
Celera1182,671,336 - 82,677,017 (-)RGD
cM Map11 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_010430   ⟹   NP_034560
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391175,055,391 - 75,061,081 (-)NCBI
GRCm381175,164,565 - 75,170,255 (-)ENTREZGENE
MGSCv371174,978,067 - 74,983,757 (-)RGD
Celera1182,671,336 - 82,677,017 (-)RGD
cM Map11 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006532275   ⟹   XP_006532338
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391175,052,203 - 75,059,535 (-)NCBI
GRCm381175,161,377 - 75,168,646 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_034560   ⟸   NM_010430
- Peptide Label: isoform 1
- UniProtKB: Z4YJP0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001091673   ⟸   NM_001098203
- Peptide Label: isoform 2
- UniProtKB: Q9R1Y5 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006532338   ⟸   XM_006532275
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSMUSP00000053483   ⟸   ENSMUST00000055619
Protein Domains
BTB   C2H2-type

Promoters
RGD ID:6848588
Promoter ID:MM_TRO:1608
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lung
Transcripts:MTR042930.11.1621.2
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361174,978,536 - 74,979,036 (-)MPROMDB
RGD ID:6821056
Promoter ID:MM_KWN:8485
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   Lung
Transcripts:NM_010430
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361174,982,586 - 74,983,837 (-)MPROMDB
RGD ID:8675518
Promoter ID:EPDNEW_M15790
Type:single initiation site
Name:Hic1_1
Description:Mus musculus hypermethylated in cancer 1 , transcript variant1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381175,168,153 - 75,168,213EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1338010 AgrOrtholog
Ensembl Genes ENSMUSG00000043099 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000053483 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000055619 ENTREZGENE, UniProtKB/TrEMBL
InterPro BTB/POZ_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HIC1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SKP1/BTB/POZ_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_C2H2_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_C2H2_type UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:15248 UniProtKB/Swiss-Prot
MGD MGI:1338010 ENTREZGENE
NCBI Gene 15248 ENTREZGENE
PANTHER PTHR24390:SF145 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam BTB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  zf-C2H2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Hic1 PhenoGen
PROSITE BTB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART BTB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZnF_C2H2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF54695 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57667 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt HIC1_MOUSE UniProtKB/Swiss-Prot
  Q6KDN9_MOUSE UniProtKB/TrEMBL
  Q9R1Y5 ENTREZGENE
  Z4YJP0 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary B1ARH0 UniProtKB/Swiss-Prot
  Q9R1Y6 UniProtKB/Swiss-Prot
  Q9R2B0 UniProtKB/Swiss-Prot