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Actein - Ontology Report - Rat Genome Database

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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:Actein
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Accession:CHEBI:70241 term browser browse the term
Definition:A triterpenoid that has formula C37H56O11.
Synonyms:related_synonym: Formula=C37H56O11;   InChI=1S/C37H56O11/c1-17-12-37(29-34(7,47-29)30(42)48-37)46-20-13-32(5)22-9-8-21-31(3,4)23(45-28-27(41)26(40)19(39)15-43-28)10-11-35(21)16-36(22,35)14-24(44-18(2)38)33(32,6)25(17)20/h17,19-30,39-42H,8-16H2,1-7H3/t17-,19-,20+,21+,22+,23+,24-,25+,26+,27-,28+,29-,30+,32+,33-,34+,35-,36+,37-/m1/s1;   InChIKey=NEWMWGLPJQHSSQ-PSDKAYTQSA-N;   SMILES=[H][C@]1(OC[C@@H](O)[C@H](O)[C@H]1O)O[C@H]1CC[C@]23C[C@]22C[C@@H](OC(C)=O)[C@]4(C)[C@@]5([H])[C@H](C)C[C@]6(O[C@H](O)[C@@]7(C)O[C@@]67[H])O[C@@]5([H])C[C@@]4(C)[C@]2([H])CC[C@@]3([H])C1(C)C
 xref_mesh: MESH:C096064
 xref: PMID:21082802

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Actein term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2m alpha-2-macroglobulin increases expression EXP actein results in increased expression of A2M mRNA; actein results in increased expression of A2M protein CTD PMID:19527300 PMID:29969672 NCBI chr 4:156,570,163...156,619,870
Ensembl chr 4:154,897,877...154,947,786 		JBrowse link
G Acox1 acyl-CoA oxidase 1 decreases expression EXP actein results in decreased expression of ACOX1 mRNA CTD PMID:19527300 NCBI chr10:101,905,083...101,930,136
Ensembl chr10:101,406,197...101,431,232 		JBrowse link
G Acox2 acyl-CoA oxidase 2 increases expression EXP actein results in increased expression of ACOX2 protein CTD PMID:29969672 NCBI chr15:19,090,820...19,122,392
Ensembl chr15:16,660,272...16,692,160 		JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions ISO actein inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of AHR protein] CTD PMID:28836330 NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Ahrr aryl-hydrocarbon receptor repressor multiple interactions ISO actein inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of AHRR protein] CTD PMID:28836330 NCBI chr 1:30,822,219...30,917,251
Ensembl chr 1:28,993,634...29,088,673 		JBrowse link
G Alox15 arachidonate 15-lipoxygenase increases expression EXP actein results in increased expression of ALOX15 protein CTD PMID:29969672 NCBI chr10:55,559,060...55,567,535
Ensembl chr10:55,060,412...55,068,874 		JBrowse link
G Alpl alkaline phosphatase, biomineralization associated multiple interactions ISO actein inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of ALPL mRNA]; actein inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of ALPL protein] CTD PMID:28836330 NCBI chr 5:155,234,770...155,289,785
Ensembl chr 5:149,951,409...150,006,446 		JBrowse link
G Apcs amyloid P component, serum decreases expression EXP actein results in decreased expression of APCS mRNA CTD PMID:19527300 NCBI chr13:87,905,532...87,906,508
Ensembl chr13:85,373,220...85,374,298 		JBrowse link
G Ascl1 achaete-scute family bHLH transcription factor 1 decreases expression EXP actein results in decreased expression of ASCL1 protein CTD PMID:29969672 NCBI chr 7:23,790,642...23,793,509
Ensembl chr 7:21,903,126...21,905,993 		JBrowse link
G Atp5me ATP synthase membrane subunit e decreases expression EXP actein results in decreased expression of ATP5ME mRNA CTD PMID:19527300 NCBI chr14:1,464,788...1,465,989
Ensembl chr14:1,319,868...1,321,013 		JBrowse link
G C4bpa complement component 4 binding protein, alpha increases expression EXP actein results in increased expression of C4BPA mRNA CTD PMID:19527300 NCBI chr13:44,627,959...44,663,552
Ensembl chr13:42,075,717...42,111,205 		JBrowse link
G C4bpb complement component 4 binding protein, beta increases expression EXP actein results in increased expression of C4BPB mRNA CTD PMID:19527300 NCBI chr13:44,673,064...44,683,781
Ensembl chr13:42,120,798...42,131,817 		JBrowse link
G C5 complement C5 increases expression EXP actein results in increased expression of C5 mRNA CTD PMID:19527300 NCBI chr 3:38,668,174...38,759,468
Ensembl chr 3:18,270,696...18,361,994 		JBrowse link
G Car3 carbonic anhydrase 3 increases expression EXP actein results in increased expression of CA3 protein CTD PMID:29969672 NCBI chr 2:88,491,666...88,501,299
Ensembl chr 2:86,770,420...86,784,280 		JBrowse link
G Ccnd1 cyclin D1 affects expression
decreases expression		 EXP
ISO		 actein affects the expression of CCND1 mRNA
actein results in decreased expression of CCND1 mRNA; actein results in decreased expression of CCND1 protein		 CTD PMID:14758092 PMID:19527300 PMID:29969672 NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Cd44 CD44 molecule increases expression EXP actein results in increased expression of CD44 mRNA CTD PMID:19527300 NCBI chr 3:109,610,824...109,699,776
Ensembl chr 3:89,157,058...89,244,620 		JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases expression ISO actein results in decreased expression of CDK4 protein CTD PMID:14758092 NCBI chr 7:64,771,453...64,774,891
Ensembl chr 7:62,883,105...62,942,403 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO actein results in increased expression of CDKN1A protein CTD PMID:14758092 NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Ces1d carboxylesterase 1D decreases expression EXP actein results in decreased expression of CES1 protein CTD PMID:29969672 NCBI chr19:30,046,494...30,085,039
Ensembl chr19:13,796,623...13,912,035 		JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 increases expression EXP actein results in increased expression of CXCL1 mRNA CTD PMID:19527300 NCBI chr14:17,477,542...17,479,321
Ensembl chr14:17,193,365...17,195,215 		JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 increases expression EXP actein results in increased expression of CXCL2 protein CTD PMID:29969672 NCBI chr14:17,465,210...17,467,255
Ensembl chr14:17,181,062...17,183,075 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO actein inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein] CTD PMID:28836330 NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp2c22 cytochrome P450, family 2, subfamily c, polypeptide 22 decreases expression EXP actein results in decreased expression of CYP2C22 mRNA CTD PMID:19527300 NCBI chr 1:248,941,143...248,980,767
Ensembl chr 1:238,991,610...239,021,738 		JBrowse link
G Cyp2j4 cytochrome P450, family 2, subfamily j, polypeptide 4 decreases expression EXP actein results in decreased expression of CYP2J9 protein CTD PMID:29969672 NCBI chr 5:116,295,691...116,323,219
Ensembl chr 5:111,178,703...111,244,794 		JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 increases expression EXP actein results in increased expression of CYP7A1 mRNA CTD PMID:19527300 NCBI chr 5:24,174,505...24,184,202
Ensembl chr 5:19,376,974...19,386,688 		JBrowse link
G Dipk1c divergent protein kinase domain 1C decreases expression EXP actein results in decreased expression of DIPK1C protein CTD PMID:29969672 NCBI chr18:78,087,972...78,109,910
Ensembl chr18:78,087,991...78,109,904 		JBrowse link
G Epo erythropoietin decreases expression EXP actein results in decreased expression of EPO mRNA CTD PMID:19527300 NCBI chr12:24,841,285...24,844,725
Ensembl chr12:19,204,508...19,207,946 		JBrowse link
G Fas Fas cell surface death receptor increases expression EXP actein results in increased expression of FAS mRNA CTD PMID:19527300 NCBI chr 1:241,212,155...241,245,774
Ensembl chr 1:231,798,960...231,832,591 		JBrowse link
G Fdps farnesyl diphosphate synthase increases expression EXP actein results in increased expression of FDPS mRNA CTD PMID:19527300 NCBI chr 2:176,795,192...176,804,816
Ensembl chr 2:174,486,665...174,507,776 		JBrowse link
G Flt1 Fms related receptor tyrosine kinase 1 increases expression EXP actein results in increased expression of FLT1 mRNA CTD PMID:19527300 NCBI chr12:12,333,050...12,504,750
Ensembl chr12:7,297,292...7,468,626 		JBrowse link
G Fmo1 flavin containing dimethylaniline monoxygenase 1 increases expression EXP actein results in increased expression of FMO1 protein CTD PMID:29969672 NCBI chr13:77,715,405...77,747,666
Ensembl chr13:75,182,176...75,214,647 		JBrowse link
G Gpd2 glycerol-3-phosphate dehydrogenase 2 decreases expression EXP actein results in decreased expression of GPD2 mRNA CTD PMID:19527300 NCBI chr 3:62,209,432...62,346,590
Ensembl chr 3:41,801,930...41,936,901 		JBrowse link
G Hamp hepcidin antimicrobial peptide decreases expression EXP actein results in decreased expression of HAMP protein CTD PMID:29969672 NCBI chr 1:95,298,332...95,300,271
Ensembl chr 1:86,170,901...86,172,891 		JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase affects expression EXP actein affects the expression of HMGCR mRNA CTD PMID:19527300 NCBI chr 2:29,732,163...29,754,276
Ensembl chr 2:27,997,525...28,019,703 		JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 affects expression
increases expression		 EXP actein affects the expression of HMGCS1 mRNA
actein results in increased expression of HMGCS1 mRNA		 CTD PMID:19527300 NCBI chr 2:53,379,457...53,399,807
Ensembl chr 2:51,649,497...51,667,100 		JBrowse link
G Hsd17b7 hydroxysteroid (17-beta) dehydrogenase 7 affects expression EXP actein affects the expression of HSD17B7 mRNA CTD PMID:19527300 NCBI chr13:84,702,875...84,722,810
Ensembl chr13:82,173,179...82,190,017 		JBrowse link
G Ibsp integrin-binding sialoprotein multiple interactions ISO actein inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of IBSP mRNA] CTD PMID:28836330 NCBI chr14:5,744,497...5,757,242
Ensembl chr14:5,439,829...5,452,693 		JBrowse link
G Id1 inhibitor of DNA binding 1 decreases expression EXP actein results in decreased expression of ID1 protein CTD PMID:29969672 NCBI chr 3:161,671,525...161,672,691
Ensembl chr 3:141,211,267...141,212,419 		JBrowse link
G Id3 inhibitor of DNA binding 3 affects expression EXP actein affects the expression of ID3 mRNA CTD PMID:19527300 NCBI chr 5:153,656,253...153,657,860
Ensembl chr 5:148,372,762...148,374,349 		JBrowse link
G Idi1 isopentenyl-diphosphate delta isomerase 1 increases expression EXP actein results in increased expression of IDI1 protein CTD PMID:29969672 NCBI chr17:66,539,761...66,547,524
Ensembl chr17:61,629,594...61,637,357 		JBrowse link
G Isg15 ISG15 ubiquitin-like modifier increases expression EXP actein results in increased expression of ISG15 protein CTD PMID:29969672 NCBI chr 5:172,066,369...172,067,656
Ensembl chr 5:166,784,148...166,785,435 		JBrowse link
G Lcn2 lipocalin 2 increases expression EXP actein results in increased expression of LCN2 protein CTD PMID:29969672 NCBI chr 3:36,078,432...36,081,851
Ensembl chr 3:15,680,687...15,684,095 		JBrowse link
G Lgalsl galectin-like decreases expression EXP actein results in decreased expression of LGALSL protein CTD PMID:29969672 NCBI chr14:99,198,340...99,205,846
Ensembl chr14:94,996,990...95,004,980 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO actein inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of MAPK3 mRNA] CTD PMID:28836330 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Me1 malic enzyme 1 decreases expression EXP actein results in decreased expression of ME1 mRNA CTD PMID:19527300 NCBI chr 8:96,429,057...96,540,244
Ensembl chr 8:87,549,043...87,660,304 		JBrowse link
G Mx1 MX dynamin like GTPase 1 increases expression EXP actein results in increased expression of MX1 protein CTD PMID:29969672 NCBI chr11:50,269,056...50,294,699
Ensembl chr11:36,799,660...36,823,507 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO actein inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of NFKB1 mRNA] CTD PMID:28836330 NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Noct nocturnin decreases expression EXP actein results in decreased expression of NOCT protein CTD PMID:29969672 NCBI chr 2:137,422,074...137,442,282
Ensembl chr 2:135,271,189...135,291,400 		JBrowse link
G Npas2 neuronal PAS domain protein 2 decreases expression EXP actein results in decreased expression of NPAS2 protein CTD PMID:29969672 NCBI chr 9:48,959,225...49,138,036
Ensembl chr 9:41,463,830...41,642,320 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 affects expression
increases expression		 EXP actein affects the expression of NQO1 mRNA
actein results in increased expression of NQO1 mRNA		 CTD PMID:19527300 NCBI chr19:52,205,374...52,220,267
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 decreases expression EXP actein results in decreased expression of NR0B2 protein CTD PMID:29969672 NCBI chr 5:151,063,160...151,066,475
Ensembl chr 5:145,779,294...145,782,609 		JBrowse link
G Oas1a 2'-5' oligoadenylate synthetase 1A increases expression EXP actein results in increased expression of OAS1 protein CTD PMID:29969672 NCBI chr12:41,330,423...41,341,130
Ensembl chr12:35,669,801...35,680,517 		JBrowse link
G Oasl 2'-5'-oligoadenylate synthetase-like increases expression EXP actein results in increased expression of OASL protein CTD PMID:29969672 NCBI chr12:47,343,551...47,356,509
Ensembl chr12:41,682,900...41,695,641 		JBrowse link
G Pcsk9 proprotein convertase subtilisin/kexin type 9 increases expression EXP actein results in increased expression of PCSK9 protein CTD PMID:29969672 NCBI chr 5:126,440,102...126,462,507
Ensembl chr 5:121,211,278...121,233,688 		JBrowse link
G Psmb10 proteasome 20S subunit beta 10 increases expression EXP actein results in increased expression of PSMB10 mRNA CTD PMID:19527300 NCBI chr19:50,740,808...50,743,292
Ensembl chr19:33,827,229...33,833,626 		JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases expression ISO actein results in decreased expression of RB1 protein CTD PMID:14758092 NCBI chr15:54,780,858...54,911,989
Ensembl chr15:48,371,296...48,502,302 		JBrowse link
G Rgs5 regulator of G-protein signaling 5 increases expression EXP actein results in increased expression of RGS5 protein CTD PMID:29969672 NCBI chr13:84,381,077...84,417,875
Ensembl chr13:81,836,304...81,885,518 		JBrowse link
G S100a8 S100 calcium binding protein A8 increases expression EXP actein results in increased expression of S100A8 protein CTD PMID:29969672 NCBI chr 2:178,464,095...178,465,223
Ensembl chr 2:176,167,124...176,167,643 		JBrowse link
G S100a9 S100 calcium binding protein A9 increases expression
affects expression		 EXP actein results in increased expression of S100A9 mRNA; actein results in increased expression of S100A9 protein
actein affects the expression of S100A9 mRNA		 CTD PMID:19527300 PMID:29969672 NCBI chr 2:178,487,941...178,490,622
Ensembl chr 2:176,190,361...176,193,230 		JBrowse link
G Scd stearoyl-CoA desaturase decreases expression EXP actein results in decreased expression of SCD protein; actein results in decreased expression of SCD1 mRNA CTD PMID:19527300 PMID:29969672 NCBI chr 1:253,218,968...253,232,101
Ensembl chr 1:243,269,747...243,282,562 		JBrowse link
G Sdf2l1 stromal cell-derived factor 2-like 1 increases expression EXP actein results in increased expression of SDF2L1 protein CTD PMID:29969672 NCBI chr11:97,376,878...97,379,120
Ensembl chr11:83,872,659...83,874,902 		JBrowse link
G Slc25a30 solute carrier family 25, member 30 decreases expression EXP actein results in decreased expression of SLC25A30 protein CTD PMID:29969672 NCBI chr15:57,486,346...57,508,981
Ensembl chr15:51,077,002...51,099,613 		JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions ISO actein inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of SOD2 mRNA] CTD PMID:28836330 NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Sod3 superoxide dismutase 3 multiple interactions ISO actein inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of SOD3 mRNA] CTD PMID:28836330 NCBI chr14:62,822,865...62,828,602
Ensembl chr14:58,609,958...58,615,990 		JBrowse link
G Sp7 Sp7 transcription factor multiple interactions ISO actein inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of SP7 mRNA] CTD PMID:28836330 NCBI chr 7:135,363,193...135,373,376
Ensembl chr 7:133,484,609...133,494,847 		JBrowse link
G Sqle squalene epoxidase increases expression EXP actein results in increased expression of SQLE protein CTD PMID:29969672 NCBI chr 7:92,758,175...92,773,049
Ensembl chr 7:90,868,011...90,883,618 		JBrowse link
G Tfrc transferrin receptor increases expression EXP actein results in increased expression of TFRC mRNA CTD PMID:19527300 NCBI chr11:81,668,478...81,690,318
Ensembl chr11:68,163,413...68,185,257 		JBrowse link
G Tsku tsukushi, small leucine rich proteoglycan decreases expression EXP actein results in decreased expression of TSKU protein CTD PMID:29969672 NCBI chr 1:162,071,459...162,082,972
Ensembl chr 1:152,656,693...152,672,588 		JBrowse link
G Tspo translocator protein increases expression EXP actein results in increased expression of TSPO mRNA CTD PMID:19527300 NCBI chr 7:116,600,214...116,610,461
Ensembl chr 7:114,720,188...114,730,450 		JBrowse link
G Usp18 ubiquitin specific peptidase 18 increases expression EXP actein results in increased expression of USP18 protein CTD PMID:29969672 NCBI chr 4:156,143,770...156,171,292
Ensembl chr 4:154,471,592...154,499,144 		JBrowse link
G Usp2 ubiquitin specific peptidase 2 decreases expression EXP actein results in decreased expression of USP2 protein CTD PMID:29969672 NCBI chr 8:53,308,264...53,336,800
Ensembl chr 8:44,411,607...44,438,331 		JBrowse link
G Zfp354a zinc finger protein 354A decreases expression EXP actein results in decreased expression of ZNF354A protein CTD PMID:29969672 NCBI chr10:35,897,217...35,909,063
Ensembl chr10:35,396,231...35,408,068 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19887
    role 19858
      biological role 19856
        biochemical role 19566
          metabolite 19554
            Actein 72
Path 2
Term Annotations click to browse term
  CHEBI ontology 19887
    subatomic particle 19885
      composite particle 19885
        hadron 19885
          baryon 19885
            nucleon 19885
              atomic nucleus 19885
                atom 19885
                  main group element atom 19824
                    main group molecular entity 19824
                      s-block molecular entity 19658
                        hydrogen molecular entity 19640
                          hydrides 19145
                            organic hydride 18698
                              organic fundamental parent 18698
                                hydrocarbon 18446
                                  terpene 14074
                                    triterpene 1268
                                      triterpenoid 1264
                                        Actein 72
paths to the root