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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:triterpene
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Accession:CHEBI:35191 term browser browse the term
Definition:A C30 terpene.
Synonyms:related_synonym: Triterpen;   triterpenes;   triterpeno;   triterpenos


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(20R)-protopanaxadiol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions ISO protopanaxadiol inhibits the reaction [Scopolamine results in increased activity of ACHE protein] CTD PMID:29133030 NCBI chr12:19,407,359...19,413,713 JBrowse link
G Bcl2l1 Bcl2-like 1 increases expression ISO protopanaxadiol results in increased expression of BCL2L1 mRNA CTD PMID:31805304 NCBI chr 3:141,253,508...141,304,582 JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 affects expression ISO protopanaxadiol affects the expression of BIRC5 protein CTD PMID:31805304 NCBI chr10:103,072,530...103,081,382 JBrowse link
G Casp3 caspase 3 increases expression
affects cleavage
ISO protopanaxadiol results in increased expression of CASP3 mRNA
protopanaxadiol affects the cleavage of CASP3 protein
CTD PMID:31805304 NCBI chr16:45,662,910...45,681,171 JBrowse link
G Casp9 caspase 9 increases expression
affects expression
ISO protopanaxadiol results in increased expression of CASP9 mRNA
protopanaxadiol affects the expression of CASP9 protein
CTD PMID:31805304 NCBI chr 5:154,108,872...154,126,628 JBrowse link
G Ccna2 cyclin A2 increases expression ISO protopanaxadiol results in increased expression of CCNA2 mRNA CTD PMID:31805304 NCBI chr 2:119,427,239...119,433,645 JBrowse link
G Ccnb1 cyclin B1 increases expression ISO protopanaxadiol results in increased expression of CCNB1 mRNA CTD PMID:31805304 NCBI chr 2:31,912,190...31,921,163 JBrowse link
G Ccnd1 cyclin D1 increases expression ISO protopanaxadiol results in increased expression of CCND1 mRNA CTD PMID:31805304 NCBI chr 1:200,089,002...200,098,524 JBrowse link
G Cdc25a cell division cycle 25A multiple interactions
increases expression
ISO protopanaxadiol results in increased expression of and results in decreased phosphorylation of CDC25A protein
protopanaxadiol results in increased expression of CDC25A mRNA
CTD PMID:31805304 NCBI chr 8:109,864,356...109,882,734 JBrowse link
G Cdc25c cell division cycle 25C increases expression
multiple interactions
ISO protopanaxadiol results in increased expression of CDC25C mRNA
protopanaxadiol affects the expression of and affects the phosphorylation of CDC25C protein
CTD PMID:31805304 NCBI chr18:26,335,156...26,356,199 JBrowse link
G Cdk1 cyclin-dependent kinase 1 increases expression ISO protopanaxadiol results in increased expression of CDK1 mRNA CTD PMID:31805304 NCBI chr20:19,266,226...19,281,417 JBrowse link
G Cdk2 cyclin dependent kinase 2 increases expression ISO protopanaxadiol results in increased expression of CDK2 mRNA CTD PMID:31805304 NCBI chr 7:1,129,878...1,137,431 JBrowse link
G Cdk4 cyclin-dependent kinase 4 increases expression ISO protopanaxadiol results in increased expression of CDK4 mRNA; protopanaxadiol results in increased expression of CDK4 protein CTD PMID:31805304 NCBI chr 7:62,885,647...62,889,562 JBrowse link
G Chat choline O-acetyltransferase multiple interactions ISO protopanaxadiol inhibits the reaction [Scopolamine results in decreased activity of CHAT protein] CTD PMID:29133030 NCBI chr16:7,657,362...7,717,093 JBrowse link
G Egfr epidermal growth factor receptor multiple interactions
decreases activity
ISO protopanaxadiol results in decreased expression of and results in increased phosphorylation of EGFR protein
protopanaxadiol results in decreased activity of EGFR protein
CTD PMID:31805304 NCBI chr14:91,176,931...91,349,722 JBrowse link
G Egr1 early growth response 1 multiple interactions ISO protopanaxadiol inhibits the reaction [Scopolamine results in decreased expression of EGR1 protein] CTD PMID:29133030 NCBI chr18:26,463,333...26,465,531 JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO protopanaxadiol inhibits the reaction [Scopolamine results in decreased expression of FOS protein] CTD PMID:29133030 NCBI chr 6:105,121,170...105,124,036 JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO protopanaxadiol inhibits the reaction [Scopolamine results in decreased expression of JUN protein] CTD PMID:29133030 NCBI chr 5:109,894,175...109,897,268 JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 increases expression ISO protopanaxadiol results in increased expression of MAP2K1 mRNA CTD PMID:31805304 NCBI chr 8:64,683,449...64,754,900 JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation ISO protopanaxadiol results in decreased phosphorylation of MAPK1 protein CTD PMID:31805304 NCBI chr11:83,957,813...84,023,629 JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation ISO protopanaxadiol results in decreased phosphorylation of MAPK3 protein CTD PMID:31805304 NCBI chr 1:181,366,646...181,372,863 JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases expression ISO protopanaxadiol results in increased expression of PARP1 mRNA CTD PMID:31805304 NCBI chr13:92,307,593...92,339,406 JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase increases phosphorylation ISO protopanaxadiol results in increased phosphorylation of RAF1 protein CTD PMID:31805304 NCBI chr 4:148,679,534...148,740,265 JBrowse link
G Rps6ka1 ribosomal protein S6 kinase A1 increases expression ISO protopanaxadiol results in increased expression of RPS6KA1 mRNA CTD PMID:31805304 NCBI chr 5:146,079,018...146,118,272 JBrowse link
G Stat3 signal transducer and activator of transcription 3 affects expression ISO protopanaxadiol affects the expression of STAT3 protein CTD PMID:31805304 NCBI chr10:85,811,206...85,863,057 JBrowse link
G Tp53 tumor protein p53 increases expression ISO protopanaxadiol results in increased expression of TP53 mRNA; protopanaxadiol results in increased expression of TP53 protein CTD PMID:31805304 NCBI chr10:54,300,070...54,311,525 JBrowse link
(20S)-ginsenoside Rg3 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions
decreases expression
ISO XMU-MP-1 inhibits the reaction [ginsenoside Rg3 results in decreased expression of ABCG2 mRNA] CTD PMID:31916386 NCBI chr 4:87,676,241...87,802,757 JBrowse link
G Acp5 acid phosphatase 5, tartrate resistant multiple interactions EXP ginsenoside Rg3 inhibits the reaction [Dexamethasone results in increased activity of ACP5 protein] CTD PMID:27387537 NCBI chr 8:20,663,984...20,670,604 JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 multiple interactions
decreases activity
ISO XMU-MP-1 inhibits the reaction [ginsenoside Rg3 results in decreased activity of ALDH1 protein] CTD PMID:31916386 NCBI chr 1:218,000,470...218,152,962 JBrowse link
G Ar androgen receptor increases degradation
multiple interactions
ISO ginsenoside Rg3 results in increased degradation of AR protein
ginsenoside Rg3 inhibits the reaction [Testosterone results in increased expression of AR protein]
CTD PMID:22101440 NCBI chr  X:63,104,771...63,273,934 JBrowse link
G Areg amphiregulin decreases expression ISO ginsenoside Rg3 results in decreased expression of AREG mRNA CTD PMID:31916386 NCBI chr14:16,972,185...16,981,443 JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO ginsenoside Rg3 inhibits the reaction [cagA protein, Helicobacter pylori results in decreased expression of BAX protein] CTD PMID:26427350 NCBI chr 1:95,940,001...95,945,407 JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO ginsenoside Rg3 inhibits the reaction [cagA protein, Helicobacter pylori results in increased expression of BCL2 protein] CTD PMID:26427350 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions ISO [Plant Extracts co-treated with Terpenes co-treated with ginsenoside Rg3] inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased expression of BDNF protein]; [staurosporine aglycone binds to and results in decreased activity of NTRK2 protein] inhibits the reaction [[Plant Extracts co-treated with Terpenes co-treated with ginsenoside Rg3] inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased expression of BDNF protein]] CTD PMID:24394491 NCBI chr 3:96,165,042...96,215,621 JBrowse link
G Bglap bone gamma-carboxyglutamate protein multiple interactions EXP ginsenoside Rg3 inhibits the reaction [Dexamethasone results in decreased expression of BGLAP protein] CTD PMID:27387537 NCBI chr 2:173,838,518...173,839,495 JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 decreases expression ISO ginsenoside Rg3 results in decreased expression of BIRC5 mRNA; ginsenoside Rg3 results in decreased expression of BIRC5 protein CTD PMID:19778801 NCBI chr10:103,072,530...103,081,382 JBrowse link
G Bmp2 bone morphogenetic protein 2 multiple interactions EXP ginsenoside Rg3 inhibits the reaction [Dexamethasone inhibits the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid] results in increased expression of BMP2 protein]]; ginsenoside Rg3 inhibits the reaction [Dexamethasone results in decreased expression of BMP2 mRNA]; ginsenoside Rg3 inhibits the reaction [Dexamethasone results in decreased expression of BMP2 protein]; NOG protein inhibits the reaction [ginsenoside Rg3 inhibits the reaction [Dexamethasone inhibits the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid] results in increased expression of BMP2 protein]]] CTD PMID:27387537 NCBI chr 3:120,812,660...120,822,579 JBrowse link
G Bmpr1a bone morphogenetic protein receptor type 1A multiple interactions EXP ginsenoside Rg3 inhibits the reaction [Dexamethasone inhibits the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid] results in increased expression of BMPR1A protein]]; ginsenoside Rg3 inhibits the reaction [Dexamethasone results in decreased expression of BMPR1A mRNA]; ginsenoside Rg3 inhibits the reaction [Dexamethasone results in decreased expression of BMPR1A protein]; NOG protein inhibits the reaction [ginsenoside Rg3 inhibits the reaction [Dexamethasone inhibits the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid] results in increased expression of BMPR1A protein]]] CTD PMID:27387537 NCBI chr16:9,736,390...9,829,825 JBrowse link
G Casp3 caspase 3 increases cleavage
multiple interactions
ISO ginsenoside Rg3 results in increased cleavage of CASP3 protein
[ginsenoside Rg3 co-treated with osimertinib] results in increased cleavage of CASP3 protein; ginsenoside Rg3 inhibits the reaction [cagA protein, Helicobacter pylori results in decreased cleavage of CASP3 protein]
CTD PMID:22101440 PMID:26427350 PMID:31916386 NCBI chr16:45,662,910...45,681,171 JBrowse link
G Casp8 caspase 8 multiple interactions ISO ginsenoside Rg3 inhibits the reaction [cagA protein, Helicobacter pylori results in decreased cleavage of CASP8 protein] CTD PMID:26427350 NCBI chr 9:60,263,863...60,312,542 JBrowse link
G Casp9 caspase 9 multiple interactions ISO ginsenoside Rg3 inhibits the reaction [cagA protein, Helicobacter pylori results in decreased cleavage of CASP9 protein] CTD PMID:26427350 NCBI chr 5:154,108,872...154,126,628 JBrowse link
G Ccn1 cellular communication network factor 1 decreases expression ISO ginsenoside Rg3 results in decreased expression of CYR61 mRNA CTD PMID:31916386 NCBI chr 2:234,562,410...234,565,370 JBrowse link
G Ccn2 cellular communication network factor 2 decreases expression ISO ginsenoside Rg3 results in decreased expression of CCN2 mRNA CTD PMID:31916386 NCBI chr 1:20,802,199...20,805,315 JBrowse link
G Cdh1 cadherin 1 multiple interactions ISO ginsenoside Rg3 analog inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein] CTD PMID:24793912 NCBI chr19:34,492,371...34,561,775 JBrowse link
G Egf epidermal growth factor multiple interactions ISO EGF protein promotes the reaction [ginsenoside Rg3 affects the phosphorylation of EGFR protein]; ginsenoside Rg3 inhibits the reaction [EGF protein promotes the reaction [EGFR protein binds to EGFR protein]] CTD PMID:25824408 NCBI chr 2:218,219,408...218,302,370 JBrowse link
G Egfr epidermal growth factor receptor multiple interactions
affects phosphorylation
ISO EGF protein promotes the reaction [ginsenoside Rg3 affects the phosphorylation of EGFR protein]; ginsenoside Rg3 inhibits the reaction [EGF protein promotes the reaction [EGFR protein binds to EGFR protein]]; ginsenoside Rg3 results in decreased expression of and affects the localization of EGFR protein CTD PMID:25824408 NCBI chr14:91,176,931...91,349,722 JBrowse link
G Epcam epithelial cell adhesion molecule decreases expression ISO ginsenoside Rg3 results in decreased expression of EPCAM mRNA CTD PMID:31916386 NCBI chr 6:6,880,142...6,896,103 JBrowse link
G Fut4 fucosyltransferase 4 multiple interactions
decreases expression
ISO ginsenoside Rg3 inhibits the reaction [cagA protein, Helicobacter pylori results in increased expression of FUT4 protein]
ginsenoside Rg3 results in decreased expression of FUT4 protein
CTD PMID:26427350 NCBI chr 8:11,586,721...11,590,682 JBrowse link
G Hsf1 heat shock transcription factor 1 multiple interactions
decreases expression
ISO ginsenoside Rg3 inhibits the reaction [cagA protein, Helicobacter pylori results in increased expression of HSF1 protein]
ginsenoside Rg3 results in decreased expression of HSF1 protein
CTD PMID:26427350 NCBI chr 7:108,196,040...108,223,011 JBrowse link
G Il1b interleukin 1 beta increases expression EXP ginsenoside Rg3 results in increased expression of IL1B protein CTD PMID:14534150 NCBI chr 3:116,577,005...116,583,386 JBrowse link
G Il6 interleukin 6 multiple interactions ISO ginsenoside Rg3 inhibits the reaction [Galactose results in increased secretion of IL6 protein] CTD PMID:29412148 NCBI chr 4:5,214,602...5,219,178 JBrowse link
G Kit KIT proto-oncogene receptor tyrosine kinase decreases expression ISO ginsenoside Rg3 results in decreased expression of KIT mRNA CTD PMID:31916386 NCBI chr14:32,547,459...32,624,694 JBrowse link
G Klf4 Kruppel like factor 4 decreases expression ISO ginsenoside Rg3 results in decreased expression of KLF4 mRNA CTD PMID:31916386 NCBI chr 5:70,278,843...70,283,751 JBrowse link
G Lats1 large tumor suppressor kinase 1 increases expression ISO ginsenoside Rg3 results in increased expression of LATS1 mRNA CTD PMID:31916386 NCBI chr 1:2,160,411...2,193,640 JBrowse link
G Lats2 large tumor suppressor kinase 2 increases expression ISO ginsenoside Rg3 results in increased expression of LATS2 mRNA CTD PMID:31916386 NCBI chr15:31,825,068...31,877,193 JBrowse link
G Map2 microtubule-associated protein 2 increases expression ISO ginsenoside Rg3 results in increased expression of MAP2 mRNA CTD PMID:24599032 NCBI chr 9:67,723,422...67,981,886 JBrowse link
G Mki67 marker of proliferation Ki-67 multiple interactions ISO [ginsenoside Rg3 co-treated with osimertinib] results in decreased expression of MKI67 protein CTD PMID:31916386 NCBI chr 1:190,496,319...190,522,983 JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO ginsenoside Rg3 analog inhibits the reaction [TGFB1 protein results in increased expression of and results in increased activity of MMP2 protein]; ginsenoside Rg3 analog inhibits the reaction [TGFB1 protein results in increased expression of MMP2 mRNA] CTD PMID:24793912 NCBI chr19:14,154,657...14,182,870 JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor decreases expression ISO ginsenoside Rg3 results in decreased expression of MYC mRNA CTD PMID:31916386 NCBI chr 7:93,593,705...93,598,633 JBrowse link
G Nanog Nanog homeobox decreases expression ISO ginsenoside Rg3 results in decreased expression of NANOG mRNA CTD PMID:31916386 NCBI chr 4:155,943,737...155,951,116 JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions
increases activity
EXP [ginsenoside Rg3 results in increased phosphorylation of and results in increased degradation of NFKBIA protein] which results in increased activity of NFKB1 protein
ginsenoside Rg3 results in increased activity of NFKB1 protein
CTD PMID:14534150 NCBI chr 2:224,016,214...224,132,135 JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions EXP [ginsenoside Rg3 results in increased phosphorylation of and results in increased degradation of NFKBIA protein] which results in increased activity of NFKB1 protein; [ginsenoside Rg3 results in increased phosphorylation of and results in increased degradation of NFKBIA protein] which results in increased activity of RELA protein CTD PMID:14534150 NCBI chr 6:72,858,713...72,861,941 JBrowse link
G Nog noggin multiple interactions EXP NOG protein inhibits the reaction [ginsenoside Rg3 inhibits the reaction [Dexamethasone inhibits the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid] results in increased expression of BMP2 protein]]]; NOG protein inhibits the reaction [ginsenoside Rg3 inhibits the reaction [Dexamethasone inhibits the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid] results in increased expression of BMPR1A protein]]]; NOG protein inhibits the reaction [ginsenoside Rg3 inhibits the reaction [Dexamethasone inhibits the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid] results in increased expression of RUNX2 protein]]]; NOG protein inhibits the reaction [ginsenoside Rg3 inhibits the reaction [Dexamethasone results in decreased expression of TNFRSF11B mRNA]]; NOG protein inhibits the reaction [ginsenoside Rg3 inhibits the reaction [Dexamethasone results in decreased expression of TNFRSF11B protein]]; NOG protein inhibits the reaction [ginsenoside Rg3 inhibits the reaction [Dexamethasone results in increased expression of TNFSF11 mRNA]]; NOG protein inhibits the reaction [ginsenoside Rg3 inhibits the reaction [Dexamethasone results in increased expression of TNFSF11 protein]] CTD PMID:27387537 NCBI chr10:74,128,712...74,130,339 JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
increases expression
EXP Staurosporine inhibits the reaction [ginsenoside Rg3 results in increased expression of NOS2 protein]; Tetradecanoylphorbol Acetate inhibits the reaction [ginsenoside Rg3 results in increased expression of NOS2 protein]
ginsenoside Rg3 results in increased expression of NOS2 mRNA
CTD PMID:14534150 NCBI chr10:63,815,308...63,851,208 JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 multiple interactions ISO [staurosporine aglycone binds to and results in decreased activity of NTRK2 protein] inhibits the reaction [[Plant Extracts co-treated with Terpenes co-treated with ginsenoside Rg3] inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased expression of BDNF protein]]; [staurosporine aglycone binds to and results in decreased activity of NTRK2 protein] inhibits the reaction [[Plant Extracts co-treated with Terpenes co-treated with ginsenoside Rg3] results in decreased susceptibility to Chlorodiphenyl (54% Chlorine)]; [staurosporine aglycone binds to and results in decreased activity of NTRK2 protein] results in decreased susceptibility to [Plant Extracts co-treated with Terpenes co-treated with ginsenoside Rg3]
[Plant Extracts co-treated with Terpenes co-treated with ginsenoside Rg3] inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased expression of NTRK2 protein modified form]; [staurosporine aglycone binds to and results in decreased activity of NTRK2 protein] inhibits the reaction [[Plant Extracts co-treated with Terpenes co-treated with ginsenoside Rg3] results in decreased susceptibility to Chlorodiphenyl (54% Chlorine)]; [staurosporine aglycone binds to and results in decreased activity of NTRK2 protein] results in decreased susceptibility to [Plant Extracts co-treated with Terpenes co-treated with ginsenoside Rg3]
CTD PMID:24394491 NCBI chr17:5,558,992...5,870,299 JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage
multiple interactions
ISO ginsenoside Rg3 results in increased cleavage of PARP1 protein
[ginsenoside Rg3 co-treated with osimertinib] results in increased cleavage of PARP1 protein; ginsenoside Rg3 analog inhibits the reaction [TGFB1 protein results in increased cleavage of PARP1 protein]; ginsenoside Rg3 inhibits the reaction [cagA protein, Helicobacter pylori results in decreased cleavage of PARP1 protein]
CTD PMID:22101440 PMID:24793912 PMID:26427350 PMID:31916386 NCBI chr13:92,307,593...92,339,406 JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 increases expression EXP ginsenoside Rg3 results in increased expression of PCK1 mRNA CTD PMID:30144466 NCBI chr 3:161,930,256...161,936,205 JBrowse link
G Pou5f1 POU class 5 homeobox 1 decreases expression ISO ginsenoside Rg3 results in decreased expression of POU5F1 mRNA CTD PMID:31916386 NCBI chr20:3,223,128...3,227,891 JBrowse link
G Ppargc1a PPARG coactivator 1 alpha increases expression EXP ginsenoside Rg3 results in increased expression of PPARGC1A mRNA CTD PMID:30144466 NCBI chr14:58,860,752...59,516,525 JBrowse link
G Prom1 prominin 1 decreases expression
multiple interactions
ISO ginsenoside Rg3 results in decreased expression of PROM1 mRNA
XMU-MP-1 inhibits the reaction [ginsenoside Rg3 results in decreased expression of PROM1 mRNA]
CTD PMID:31916386 NCBI chr14:66,989,545...67,094,534 JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP [ginsenoside Rg3 results in increased phosphorylation of and results in increased degradation of NFKBIA protein] which results in increased activity of RELA protein; ginsenoside Rg3 affects the localization of and results in increased activity of RELA protein CTD PMID:14534150 NCBI chr 1:202,925,001...202,935,484 JBrowse link
G Runx2 RUNX family transcription factor 2 multiple interactions EXP ginsenoside Rg3 inhibits the reaction [Dexamethasone inhibits the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid] results in increased expression of RUNX2 protein]]; ginsenoside Rg3 inhibits the reaction [Dexamethasone results in decreased expression of RUNX2 mRNA]; ginsenoside Rg3 inhibits the reaction [Dexamethasone results in decreased expression of RUNX2 protein]; NOG protein inhibits the reaction [ginsenoside Rg3 inhibits the reaction [Dexamethasone inhibits the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid] results in increased expression of RUNX2 protein]]] CTD PMID:27387537 NCBI chr 9:16,167,504...16,492,826 JBrowse link
G Sall4 spalt-like transcription factor 4 decreases expression ISO ginsenoside Rg3 results in decreased expression of SALL4 mRNA CTD PMID:31916386 NCBI chr 3:157,474,067...157,491,055 JBrowse link
G Sirt1 sirtuin 1 increases activity EXP ginsenoside Rg3 results in increased activity of SIRT1 protein CTD PMID:30144466 NCBI chr20:25,307,143...25,329,260 JBrowse link
G Slc6a2 solute carrier family 6 member 2 multiple interactions ISO [Plant Extracts co-treated with Terpenes co-treated with ginsenoside Rg3] inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased expression of SLC6A2 protein] CTD PMID:24394491 NCBI chr19:14,010,292...14,055,317 JBrowse link
G Slc6a3 solute carrier family 6 member 3 multiple interactions ISO [Plant Extracts co-treated with Terpenes co-treated with ginsenoside Rg3] inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased expression of SLC6A3 protein] CTD PMID:24394491 NCBI chr 1:29,709,443...29,750,413 JBrowse link
G Smad2 SMAD family member 2 multiple interactions ISO ginsenoside Rg3 analog inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD2 protein] CTD PMID:24793912 NCBI chr18:69,849,884...69,918,926 JBrowse link
G Snai1 snail family transcriptional repressor 1 multiple interactions ISO ginsenoside Rg3 analog inhibits the reaction [TGFB1 protein results in increased expression of SNAI1 mRNA]; ginsenoside Rg3 analog inhibits the reaction [TGFB1 protein results in increased expression of SNAI1 protein] CTD PMID:24793912 NCBI chr 3:156,248,479...156,252,969 JBrowse link
G Sox2 SRY-box transcription factor 2 decreases expression ISO ginsenoside Rg3 results in decreased expression of SOX2 mRNA CTD PMID:31916386 NCBI chr 2:117,536,929...117,539,338 JBrowse link
G Sp1 Sp1 transcription factor multiple interactions ISO ginsenoside Rg3 inhibits the reaction [cagA protein, Helicobacter pylori results in decreased expression of SP1 protein] CTD PMID:26427350 NCBI chr 7:133,541,302...133,571,961 JBrowse link
G Stk3 serine/threonine kinase 3 increases expression ISO ginsenoside Rg3 results in increased expression of STK3 mRNA CTD PMID:31916386 NCBI chr 7:66,053,209...66,323,292 JBrowse link
G Stk4 serine/threonine kinase 4 increases expression ISO ginsenoside Rg3 results in increased expression of STK4 mRNA CTD PMID:31916386 NCBI chr 3:152,745,958...152,827,747 JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO ginsenoside Rg3 analog inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein]; ginsenoside Rg3 analog inhibits the reaction [TGFB1 protein results in increased cleavage of PARP1 protein]; ginsenoside Rg3 analog inhibits the reaction [TGFB1 protein results in increased expression of and results in increased activity of MMP2 protein]; ginsenoside Rg3 analog inhibits the reaction [TGFB1 protein results in increased expression of MMP2 mRNA]; ginsenoside Rg3 analog inhibits the reaction [TGFB1 protein results in increased expression of SNAI1 mRNA]; ginsenoside Rg3 analog inhibits the reaction [TGFB1 protein results in increased expression of SNAI1 protein]; ginsenoside Rg3 analog inhibits the reaction [TGFB1 protein results in increased expression of VIM protein]; ginsenoside Rg3 analog inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD2 protein] CTD PMID:24793912 NCBI chr 1:81,196,532...81,212,848 JBrowse link
G Thy1 Thy-1 cell surface antigen decreases expression ISO ginsenoside Rg3 results in decreased expression of THY1 mRNA CTD PMID:31916386 NCBI chr 8:44,389,495...44,394,688 JBrowse link
G Tnf tumor necrosis factor increases expression EXP ginsenoside Rg3 results in increased expression of TNF protein CTD PMID:14534150 NCBI chr20:3,622,011...3,624,629 JBrowse link
G Tnfrsf11b TNF receptor superfamily member 11B multiple interactions EXP ginsenoside Rg3 inhibits the reaction [Dexamethasone results in decreased expression of TNFRSF11B mRNA]; ginsenoside Rg3 inhibits the reaction [Dexamethasone results in decreased expression of TNFRSF11B protein]; NOG protein inhibits the reaction [ginsenoside Rg3 inhibits the reaction [Dexamethasone results in decreased expression of TNFRSF11B mRNA]]; NOG protein inhibits the reaction [ginsenoside Rg3 inhibits the reaction [Dexamethasone results in decreased expression of TNFRSF11B protein]] CTD PMID:27387537 NCBI chr 7:85,566,520...85,594,526 JBrowse link
G Tnfsf11 TNF superfamily member 11 multiple interactions EXP ginsenoside Rg3 inhibits the reaction [Dexamethasone results in increased expression of TNFSF11 mRNA]; ginsenoside Rg3 inhibits the reaction [Dexamethasone results in increased expression of TNFSF11 protein]; NOG protein inhibits the reaction [ginsenoside Rg3 inhibits the reaction [Dexamethasone results in increased expression of TNFSF11 mRNA]]; NOG protein inhibits the reaction [ginsenoside Rg3 inhibits the reaction [Dexamethasone results in increased expression of TNFSF11 protein]] CTD PMID:27387537 NCBI chr15:53,674,990...53,705,171 JBrowse link
G Vim vimentin multiple interactions ISO ginsenoside Rg3 analog inhibits the reaction [TGFB1 protein results in increased expression of VIM protein] CTD PMID:24793912 NCBI chr17:76,668,701...76,677,186 JBrowse link
G Wwtr1 WW domain containing transcription regulator 1 decreases expression ISO ginsenoside Rg3 results in decreased expression of WWTR1 mRNA CTD PMID:31916386 NCBI chr 2:141,651,159...141,766,919 JBrowse link
G Yap1 Yes1 associated transcriptional regulator decreases expression ISO ginsenoside Rg3 results in decreased expression of YAP1 mRNA CTD PMID:31916386 NCBI chr 8:5,095,705...5,166,808 JBrowse link
(20S)-ginsenoside Rh1 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression ISO ginsenoside Rh1 results in increased expression of FOS mRNA CTD PMID:16204943 NCBI chr 6:105,121,170...105,124,036 JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO ginsenoside Rh1 inhibits the reaction [TNF protein results in increased expression of ICAM1 protein] CTD PMID:21875580 NCBI chr 8:19,553,063...19,565,438 JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO ginsenoside Rh1 inhibits the reaction [Oxazolone results in increased expression of IL1B mRNA]; ginsenoside Rh1 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL1B mRNA] CTD PMID:16557482 NCBI chr 3:116,577,005...116,583,386 JBrowse link
G Il4 interleukin 4 decreases expression ISO ginsenoside Rh1 results in decreased expression of IL4 CTD PMID:22855946 NCBI chr10:37,771,203...37,776,750 JBrowse link
G Il6 interleukin 6 multiple interactions ISO ginsenoside Rh1 inhibits the reaction [Galactose results in increased secretion of IL6 protein] CTD PMID:29412148 NCBI chr 4:5,214,602...5,219,178 JBrowse link
G Itga4 integrin subunit alpha 4 multiple interactions ISO ginsenoside Rh1 inhibits the reaction [TNF protein results in increased expression of [ITGA4 protein binds to ITGB1 protein]] CTD PMID:21875580 NCBI chr 3:64,162,764...64,235,010 JBrowse link
G Itgal integrin subunit alpha L multiple interactions ISO ginsenoside Rh1 inhibits the reaction [TNF protein results in increased expression of [ITGAL protein binds to ITGB2 protein]] CTD PMID:21875580 NCBI chr 1:181,918,183...181,955,735 JBrowse link
G Itgb1 integrin subunit beta 1 multiple interactions ISO ginsenoside Rh1 inhibits the reaction [TNF protein results in increased expression of [ITGA4 protein binds to ITGB1 protein]] CTD PMID:21875580 NCBI chr19:56,705,123...56,753,199 JBrowse link
G Itgb2 integrin subunit beta 2 multiple interactions ISO ginsenoside Rh1 inhibits the reaction [TNF protein results in increased expression of [ITGAL protein binds to ITGB2 protein]] CTD PMID:21875580 NCBI chr20:11,061,394...11,097,656 JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit decreases activity ISO ginsenoside Rh1 results in decreased activity of JUN protein CTD PMID:22855946 NCBI chr 5:109,894,175...109,897,268 JBrowse link
G Lpl lipoprotein lipase increases secretion ISO ginsenoside Rh1 results in increased secretion of LPL protein CTD PMID:8988629 NCBI chr16:20,830,055...20,853,855 JBrowse link
G Pgr progesterone receptor increases expression ISO ginsenoside Rh1 results in increased expression of PGR protein CTD PMID:16204943 NCBI chr 8:6,073,216...6,131,552 JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO ginsenoside Rh1 inhibits the reaction [bisphenol A results in increased expression of PPARG mRNA]; ginsenoside Rh1 inhibits the reaction [bisphenol A results in increased expression of PPARG protein] CTD PMID:32623698 NCBI chr 4:148,423,102...148,548,471 JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO ginsenoside Rh1 inhibits the reaction [Oxazolone results in increased expression of PTGS2 mRNA]; ginsenoside Rh1 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 mRNA] CTD PMID:16557482 NCBI chr13:62,164,080...62,169,770 JBrowse link
G Sele selectin E multiple interactions ISO ginsenoside Rh1 inhibits the reaction [TNF protein results in increased expression of SELE protein] CTD PMID:21875580 NCBI chr13:76,402,841...76,412,741 JBrowse link
G Tff1 trefoil factor 1 increases expression ISO ginsenoside Rh1 results in increased expression of TFF1 mRNA CTD PMID:16204943 NCBI chr20:9,235,736...9,239,597 JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases expression
decreases response to substance
ISO ginsenoside Rh1 inhibits the reaction [TNF protein results in increased expression of [ITGA4 protein binds to ITGB1 protein]]; ginsenoside Rh1 inhibits the reaction [TNF protein results in increased expression of [ITGAL protein binds to ITGB2 protein]]; ginsenoside Rh1 inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; ginsenoside Rh1 inhibits the reaction [TNF protein results in increased expression of SELE protein]; ginsenoside Rh1 inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]
ginsenoside Rh1 inhibits the reaction [Oxazolone results in increased expression of TNF mRNA]; ginsenoside Rh1 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of TNF mRNA]
ginsenoside Rh1 results in decreased expression of TNF
ginsenoside Rh1 results in decreased susceptibility to TNF protein
CTD PMID:16557482 PMID:21875580 PMID:22855946 NCBI chr20:3,622,011...3,624,629 JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO ginsenoside Rh1 inhibits the reaction [TNF protein results in increased expression of VCAM1 protein] CTD PMID:21875580 NCBI chr 2:204,038,120...204,057,852 JBrowse link
(20S)-ginsenoside Rh2 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator increases expression ISO ginsenoside Rh2 results in increased expression of BAX protein CTD PMID:26482938 NCBI chr 1:95,940,001...95,945,407 JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO ginsenoside Rh2 results in decreased expression of BCL2 protein CTD PMID:26482938 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Casp3 caspase 3 increases cleavage ISO ginsenoside Rh2 results in increased cleavage of CASP3 protein CTD PMID:26482938 NCBI chr16:45,662,910...45,681,171 JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO ginsenoside Rh2 results in decreased expression of CCND1 protein CTD PMID:26482938 NCBI chr 1:200,089,002...200,098,524 JBrowse link
G Hdac1 histone deacetylase 1 decreases expression ISO ginsenoside Rh2 results in decreased expression of HDAC1 protein CTD PMID:26482938 NCBI chr 5:141,853,992...141,881,057 JBrowse link
G Hdac2 histone deacetylase 2 decreases expression ISO ginsenoside Rh2 results in decreased expression of HDAC2 protein CTD PMID:26482938 NCBI chr20:40,548,250...40,571,609 JBrowse link
G Hdac6 histone deacetylase 6 decreases expression ISO ginsenoside Rh2 results in decreased expression of HDAC6 protein CTD PMID:26482938 NCBI chr  X:14,550,645...14,572,445 JBrowse link
G Il6 interleukin 6 multiple interactions ISO ginsenoside Rh2 inhibits the reaction [Galactose results in increased secretion of IL6 protein] CTD PMID:29412148 NCBI chr 4:5,214,602...5,219,178 JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation ISO ginsenoside Rh2 results in decreased phosphorylation of MAPK1 protein CTD PMID:26482938 NCBI chr11:83,957,813...84,023,629 JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation ISO ginsenoside Rh2 results in decreased phosphorylation of MAPK3 protein CTD PMID:26482938 NCBI chr 1:181,366,646...181,372,863 JBrowse link
14-demethyllanosterol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Msmo1 methylsterol monooxygenase 1 decreases abundance ISO MSMO1 protein results in decreased abundance of 4,4-dimethyl-5-alpha-cholesta-(8,24)-dien-3-beta-ol CTD PMID:23125191 NCBI chr16:24,980,680...24,997,927 JBrowse link
23-epi-26-deoxyactein term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Creb1 cAMP responsive element binding protein 1 multiple interactions ISO 23-epi-26-deoxyactein inhibits the reaction [Antimycin A results in decreased phosphorylation of CREB1 protein] CTD PMID:22180388 NCBI chr 9:65,903,511...65,972,562 JBrowse link
G Il6 interleukin 6 multiple interactions ISO 23-epi-26-deoxyactein inhibits the reaction [Antimycin A results in increased expression of IL6 protein] CTD PMID:21910134 NCBI chr 4:5,214,602...5,219,178 JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO 23-epi-26-deoxyactein inhibits the reaction [Antimycin A results in increased expression of TNF protein] CTD PMID:21910134 NCBI chr20:3,622,011...3,624,629 JBrowse link
G Tnfsf11 TNF superfamily member 11 multiple interactions ISO 23-epi-26-deoxyactein inhibits the reaction [Antimycin A results in increased expression of TNFSF11 protein] CTD PMID:21910134 NCBI chr15:53,674,990...53,705,171 JBrowse link
24,25-dihydrolanosterol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp51 cytochrome P450, family 51 decreases abundance ISO CYP51A1 mRNA results in decreased abundance of lanostenol CTD PMID:23125191 NCBI chr 4:30,036,956...30,055,410 JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase decreases activity ISO lanostenol results in decreased activity of HMGCR protein CTD PMID:18024962 NCBI chr 2:27,997,523...28,018,983 JBrowse link
28-deoxonimbolide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 increases activity ISO 28-deoxonimbolide results in increased activity of CASP3 protein CTD PMID:21381696 NCBI chr16:45,662,910...45,681,171 JBrowse link
G Casp8 caspase 8 increases activity ISO 28-deoxonimbolide results in increased activity of CASP8 protein CTD PMID:21381696 NCBI chr 9:60,263,863...60,312,542 JBrowse link
G Casp9 caspase 9 increases activity ISO 28-deoxonimbolide results in increased activity of CASP9 protein CTD PMID:21381696 NCBI chr 5:154,108,872...154,126,628 JBrowse link
3beta-hydroxylanost-8-en-32-al term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase decreases activity ISO lanosten-3-ol-32-al results in decreased activity of HMGCR protein CTD PMID:12617470 NCBI chr 2:27,997,523...28,018,983 JBrowse link
8'-apo-beta,psi-caroten-8'-al term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acadm acyl-CoA dehydrogenase medium chain increases expression ISO apocarotenal results in increased expression of ACADM mRNA CTD PMID:17034753 NCBI chr 2:242,858,865...242,883,036 JBrowse link
G Adh5 alcohol dehydrogenase 5 (class III), chi polypeptide increases expression ISO apocarotenal results in increased expression of ADH5 mRNA CTD PMID:17034753 NCBI chr 2:226,975,184...226,987,591 JBrowse link
G Aldh1b1 aldehyde dehydrogenase 1 family, member B1 decreases expression ISO apocarotenal results in decreased expression of ALDH1B1 mRNA CTD PMID:17034753 NCBI chr 5:60,063,370...60,068,378 JBrowse link
G Aldh3b1 aldehyde dehydrogenase 3 family, member B1 decreases expression ISO apocarotenal results in decreased expression of ALDH3B1 mRNA CTD PMID:17034753 NCBI chr 1:201,145,309...201,162,675 JBrowse link
G Aldh4a1 aldehyde dehydrogenase 4 family, member A1 decreases expression ISO apocarotenal results in decreased expression of ALDH4A1 mRNA CTD PMID:17034753 NCBI chr 5:151,880,002...151,905,491 JBrowse link
G Ank2 ankyrin 2 increases expression ISO apocarotenal results in increased expression of ANK2 mRNA CTD PMID:17034753 NCBI chr 2:215,378,028...215,954,015 JBrowse link
G Ank3 ankyrin 3 increases expression ISO apocarotenal results in increased expression of ANK3 mRNA CTD PMID:17034753 NCBI chr20:18,602,267...19,225,831 JBrowse link
G Asah1 N-acylsphingosine amidohydrolase 1 increases expression ISO apocarotenal results in increased expression of ASAH1 mRNA CTD PMID:17034753 NCBI chr16:50,966,404...50,997,827 JBrowse link
G Asb1 ankyrin repeat and SOCS box-containing 1 increases expression ISO apocarotenal results in increased expression of ASB1 mRNA CTD PMID:17034753 NCBI chr 9:92,120,332...92,140,790 JBrowse link
G Asb9 ankyrin repeat and SOCS box-containing 9 increases expression ISO apocarotenal results in increased expression of ASB9 mRNA CTD PMID:17034753 NCBI chr  X:29,956,576...30,001,436 JBrowse link
G Bax BCL2 associated X, apoptosis regulator decreases expression ISO apocarotenal results in decreased expression of BAX mRNA CTD PMID:17034753 NCBI chr 1:95,940,001...95,945,407 JBrowse link
G Bco2 beta-carotene oxygenase 2 multiple interactions ISO [BCO2 protein results in increased metabolism of beta Carotene] which results in increased chemical synthesis of apocarotenal; [BCO2 protein results in increased metabolism of Cryptoxanthins] which results in increased chemical synthesis of apocarotenal; [BCO2 protein results in increased metabolism of Lutein] which results in increased chemical synthesis of apocarotenal metabolite; [BCO2 protein results in increased metabolism of Zeaxanthins] which results in increased chemical synthesis of apocarotenal metabolite CTD PMID:21106934 NCBI chr 8:50,882,174...50,907,676 JBrowse link
G Casp8ap2 caspase 8 associated protein 2 increases expression ISO apocarotenal results in increased expression of CASP8AP2 mRNA CTD PMID:17034753 NCBI chr 5:47,014,501...47,052,276 JBrowse link
G Cdh1 cadherin 1 increases expression ISO apocarotenal results in increased expression of CDH1 mRNA CTD PMID:17034753 NCBI chr19:34,492,371...34,561,775 JBrowse link
G Cldn10 claudin 10 increases expression ISO apocarotenal results in increased expression of CLDN10 mRNA CTD PMID:17034753 NCBI chr15:95,862,785...95,954,526 JBrowse link
G Cldn18 claudin 18 increases expression ISO apocarotenal results in increased expression of CLDN18 mRNA CTD PMID:17034753 NCBI chr 8:100,246,499...100,265,797 JBrowse link
G Col1a1 collagen type I alpha 1 chain decreases expression ISO apocarotenal results in decreased expression of COL1A1 mRNA CTD PMID:17034753 NCBI chr10:79,883,622...79,900,625 JBrowse link
G Col4a1 collagen type IV alpha 1 chain decreases expression ISO apocarotenal results in decreased expression of COL4A1 mRNA CTD PMID:17034753 NCBI chr16:78,183,533...78,294,412 JBrowse link
G Col4a2 collagen type IV alpha 2 chain decreases expression ISO apocarotenal results in decreased expression of COL4A2 mRNA CTD PMID:17034753 NCBI chr16:78,047,591...78,183,360 JBrowse link
G Crabp2 cellular retinoic acid binding protein 2 decreases expression ISO apocarotenal results in decreased expression of CRABP2 mRNA CTD PMID:17034753 NCBI chr 2:173,417,004...173,421,352 JBrowse link
G Ctsb cathepsin B decreases expression ISO apocarotenal results in decreased expression of CTSB mRNA CTD PMID:17034753 NCBI chr15:37,389,636...37,410,508 JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 increases expression ISO apocarotenal results in increased expression of CXCL12 mRNA CTD PMID:17034753 NCBI chr 4:150,388,326...150,401,173 JBrowse link
G Cxcl6 C-X-C motif chemokine ligand 6 increases expression ISO apocarotenal results in increased expression of CXCL6 mRNA CTD PMID:17034753 NCBI chr14:17,310,089...17,312,303 JBrowse link
G Cxcl9 C-X-C motif chemokine ligand 9 increases expression ISO apocarotenal results in increased expression of CXCL9 mRNA CTD PMID:17034753 NCBI chr14:15,722,868...15,727,779 JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 increases expression ISO apocarotenal results in increased expression of CXCR4 mRNA CTD PMID:17034753 NCBI chr13:40,077,976...40,081,883 JBrowse link
G Dlx2 distal-less homeobox 2 increases expression ISO apocarotenal results in increased expression of DLX2 mRNA CTD PMID:17034753 NCBI chr 3:56,371,347...56,373,230 JBrowse link
G Dlx4 distal-less homeobox 4 increases expression ISO apocarotenal results in increased expression of DLX4 mRNA CTD PMID:17034753 NCBI chr10:80,085,037...80,090,434 JBrowse link
G Ercc2 ERCC excision repair 2, TFIIH core complex helicase subunit decreases expression ISO apocarotenal results in decreased expression of ERCC2 mRNA CTD PMID:17034753 NCBI chr 1:79,033,342...79,047,102 JBrowse link
G Ets1 ETS proto-oncogene 1, transcription factor decreases expression ISO apocarotenal results in decreased expression of ETS1 mRNA CTD PMID:17034753 NCBI chr 8:31,045,909...31,168,010 JBrowse link
G Fas Fas cell surface death receptor increases expression ISO apocarotenal results in increased expression of FAS mRNA CTD PMID:17034753 NCBI chr 1:231,798,963...231,832,591 JBrowse link
G Fasn fatty acid synthase decreases expression ISO apocarotenal results in decreased expression of FASN mRNA CTD PMID:17034753 NCBI chr10:106,072,093...106,090,259 JBrowse link
G Gata6 GATA binding protein 6 increases expression ISO apocarotenal results in increased expression of GATA6 mRNA CTD PMID:17034753 NCBI chr18:2,188,121...2,219,532 JBrowse link
G Gbp1 guanylate binding protein 1 increases expression ISO apocarotenal results in increased expression of GBP1 mRNA CTD PMID:17034753 NCBI chr 2:231,398,136...231,432,773 JBrowse link
G Gstk1 glutathione S-transferase kappa 1 decreases expression ISO apocarotenal results in decreased expression of GSTK1 mRNA CTD PMID:17034753 NCBI chr 4:71,118,979...71,123,298 JBrowse link
G Gstm2 glutathione S-transferase mu 2 decreases expression ISO apocarotenal results in decreased expression of GSTM2 mRNA CTD PMID:17034753 NCBI chr 2:195,624,015...195,628,774 JBrowse link
G Gstm3l glutathione S-transferase mu 3-like increases expression ISO apocarotenal results in increased expression of GSTM5 mRNA CTD PMID:17034753 NCBI chr 2:195,590,450...195,612,578 JBrowse link
G Gstm4 glutathione S-transferase mu 4 decreases expression ISO apocarotenal results in decreased expression of GSTM4 mRNA CTD PMID:17034753 NCBI chr 2:195,667,940...195,685,315 JBrowse link
G Gstz1 glutathione S-transferase zeta 1 decreases expression ISO apocarotenal results in decreased expression of GSTZ1 mRNA CTD PMID:17034753 NCBI chr 6:106,794,594...106,805,284 JBrowse link
G Hoxa7 homeobox A7 increases expression ISO apocarotenal results in increased expression of HOXA7 mRNA CTD PMID:17034753 NCBI chr 4:81,315,730...81,317,629 JBrowse link
G Hoxb6 homeo box B6 increases expression ISO apocarotenal results in increased expression of HOXB6 mRNA CTD PMID:17034753 NCBI chr10:81,258,726...81,267,458 JBrowse link
G Hoxc10 homeo box C10 increases expression ISO apocarotenal results in increased expression of HOXC10 mRNA CTD PMID:17034753 NCBI chr 7:134,103,741...134,108,966 JBrowse link
G Irf8 interferon regulatory factor 8 increases expression ISO apocarotenal results in increased expression of IRF8 mRNA CTD PMID:17034753 NCBI chr19:48,790,483...48,812,363 JBrowse link
G Irx4 iroquois homeobox 4 decreases expression ISO apocarotenal results in decreased expression of IRX4 mRNA CTD PMID:17034753 NCBI chr 1:30,030,561...30,039,549 JBrowse link
G Itgb4 integrin subunit beta 4 decreases expression ISO apocarotenal results in decreased expression of ITGB4 mRNA CTD PMID:17034753 NCBI chr10:101,206,657...101,243,012 JBrowse link
G Ivl involucrin increases expression ISO apocarotenal results in increased expression of IVL mRNA CTD PMID:17034753 NCBI chr 2:178,146,694...178,160,807 JBrowse link
G Krt17 keratin 17 decreases expression ISO apocarotenal results in decreased expression of KRT17 mRNA CTD PMID:17034753 NCBI chr10:85,178,673...85,183,392 JBrowse link
G Krt2 keratin 2 increases expression ISO apocarotenal results in increased expression of KRT2 mRNA CTD PMID:17034753 NCBI chr 7:132,941,275...132,947,963 JBrowse link
G Krt7 keratin 7 affects expression ISO apocarotenal affects the expression of KRT7 mRNA CTD PMID:17034753 NCBI chr 7:132,528,863...132,545,052 JBrowse link
G Lhx3 LIM homeobox 3 increases expression ISO apocarotenal results in increased expression of LHX3 mRNA CTD PMID:17034753 NCBI chr 3:9,026,432...9,035,122 JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member affects expression ISO apocarotenal affects the expression of MCL1 mRNA CTD PMID:17034753 NCBI chr 2:183,219,137...183,235,676 JBrowse link
G Meis2 Meis homeobox 2 increases expression ISO apocarotenal results in increased expression of MEIS2 mRNA CTD PMID:17034753 NCBI chr 3:102,742,905...102,944,833 JBrowse link
G Meox1 mesenchyme homeobox 1 increases expression ISO apocarotenal results in increased expression of MEOX1 mRNA CTD PMID:17034753 NCBI chr10:86,818,450...86,837,563 JBrowse link
G Mnx1 motor neuron and pancreas homeobox 1 increases expression ISO apocarotenal results in increased expression of MNX1 mRNA CTD PMID:17034753 NCBI chr 4:5,866,506...5,871,465 JBrowse link
G Msh5 mutS homolog 5 increases expression ISO apocarotenal results in increased expression of MSH5 mRNA CTD PMID:17034753 NCBI chr20:3,773,867...3,793,337 JBrowse link
G Muc5ac mucin 5AC, oligomeric mucus/gel-forming increases expression ISO apocarotenal results in increased expression of MUC5AC mRNA CTD PMID:17034753 NCBI chr 1:196,864,375...196,896,475 JBrowse link
G Nos1 nitric oxide synthase 1 increases expression ISO apocarotenal results in increased expression of NOS1 mRNA CTD PMID:17034753 NCBI chr12:38,615,111...38,795,492 JBrowse link
G Olr1 oxidized low density lipoprotein receptor 1 increases expression ISO apocarotenal results in increased expression of OLR1 mRNA CTD PMID:17034753 NCBI chr 4:162,926,436...162,949,057 JBrowse link
G Pcdhgc3 protocadherin gamma subfamily C, 3 increases expression ISO apocarotenal results in increased expression of PCDHGC3 mRNA CTD PMID:17034753 NCBI chr18:29,633,016...29,667,865 JBrowse link
G Plscr1 phospholipid scramblase 1 increases expression ISO apocarotenal results in increased expression of PLSCR1 mRNA CTD PMID:17034753 NCBI chr 8:92,784,279...92,804,698 JBrowse link
G Plscr3 phospholipid scramblase 3 increases expression ISO apocarotenal results in increased expression of PLSCR3 mRNA CTD PMID:17034753 NCBI chr10:54,566,556...54,573,240 JBrowse link
G Plscr4 phospholipid scramblase 4 increases expression ISO apocarotenal results in increased expression of PLSCR4 mRNA CTD PMID:17034753 NCBI chr 8:92,987,290...93,026,056 JBrowse link
G Rad51ap1 RAD51 associated protein 1 increases expression ISO apocarotenal results in increased expression of RAD51AP1 mRNA CTD PMID:17034753 NCBI chr 4:159,759,454...159,772,524 JBrowse link
G Rad51d RAD51 paralog D increases expression ISO apocarotenal results in increased expression of RAD51D mRNA CTD PMID:17034753 NCBI chr10:67,805,720...67,824,452 JBrowse link
G Rara retinoic acid receptor, alpha decreases expression ISO apocarotenal results in decreased expression of RARA mRNA CTD PMID:17034753 NCBI chr10:83,883,490...83,928,932 JBrowse link
G Rarb retinoic acid receptor, beta increases expression ISO apocarotenal results in increased expression of RARB mRNA CTD PMID:17034753 NCBI chr15:8,700,533...9,051,288 JBrowse link
G Rarres1 retinoic acid receptor responder 1 increases expression ISO apocarotenal results in increased expression of RARRES1 mRNA CTD PMID:17034753 NCBI chr 2:151,749,715...151,783,975 JBrowse link
G Six6 SIX homeobox 6 increases expression ISO apocarotenal results in increased expression of SIX6 mRNA CTD PMID:17034753 NCBI chr 6:91,634,568...91,639,548 JBrowse link
G Sod1 superoxide dismutase 1 decreases expression ISO apocarotenal results in decreased expression of SOD1 mRNA CTD PMID:17034753 NCBI chr11:29,456,673...29,462,249 JBrowse link
G Sptlc2 serine palmitoyltransferase, long chain base subunit 2 affects expression ISO apocarotenal affects the expression of SPTLC2 mRNA CTD PMID:17034753 NCBI chr 6:106,948,681...107,031,584 JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 increases expression ISO apocarotenal results in increased expression of SREBF1 mRNA CTD PMID:17034753 NCBI chr10:45,007,637...45,029,650 JBrowse link
G Tgm4 transglutaminase 4 increases expression ISO apocarotenal results in increased expression of TGM4 mRNA CTD PMID:17034753 NCBI chr 8:122,689,429...122,726,463 JBrowse link
G Tnfrsf9 TNF receptor superfamily member 9 increases expression ISO apocarotenal results in increased expression of TNFRSF9 mRNA CTD PMID:17034753 NCBI chr 5:161,381,662...161,408,003 JBrowse link
G Tnfsf10 TNF superfamily member 10 increases expression ISO apocarotenal results in increased expression of TNFSF10 mRNA CTD PMID:17034753 NCBI chr 2:110,199,835...110,227,239 JBrowse link
G Txndc9 thioredoxin domain containing 9 increases expression ISO apocarotenal results in increased expression of TXNDC9 mRNA CTD PMID:17034753 NCBI chr 9:40,211,818...40,221,953 JBrowse link
G Xrcc3 X-ray repair cross complementing 3 increases expression ISO apocarotenal results in increased expression of XRCC3 mRNA CTD PMID:17034753 NCBI chr 6:130,863,405...130,873,765 JBrowse link
Actein term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2m alpha-2-macroglobulin increases expression EXP actein results in increased expression of A2M mRNA; actein results in increased expression of A2M protein CTD PMID:19527300 PMID:29969672 NCBI chr 4:154,897,770...154,947,787 JBrowse link
G Acox1 acyl-CoA oxidase 1 decreases expression EXP actein results in decreased expression of ACOX1 mRNA CTD PMID:19527300 NCBI chr10:101,406,197...101,431,242 JBrowse link
G Acox2 acyl-CoA oxidase 2 increases expression EXP actein results in increased expression of ACOX2 protein CTD PMID:29969672 NCBI chr15:16,660,584...16,692,160 JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions ISO actein inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of AHR protein] CTD PMID:28836330 NCBI chr 6:52,234,089...52,271,568 JBrowse link
G Ahrr aryl-hydrocarbon receptor repressor multiple interactions ISO actein inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of AHRR protein] CTD PMID:28836330 NCBI chr 1:28,993,634...29,088,673 JBrowse link
G Alox15 arachidonate 15-lipoxygenase increases expression EXP actein results in increased expression of ALOX15 protein CTD PMID:29969672 NCBI chr10:55,060,169...55,068,885 JBrowse link
G Alpl alkaline phosphatase, biomineralization associated multiple interactions ISO actein inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of ALPL mRNA]; actein inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of ALPL protein] CTD PMID:28836330 NCBI chr 5:149,951,397...150,006,424 JBrowse link
G Apcs amyloid P component, serum decreases expression EXP actein results in decreased expression of APCS mRNA CTD PMID:19527300 NCBI chr13:85,373,338...85,374,134 JBrowse link
G Ascl1 achaete-scute family bHLH transcription factor 1 decreases expression EXP actein results in decreased expression of ASCL1 protein CTD PMID:29969672 NCBI chr 7:21,904,153...21,906,003 JBrowse link
G Atp5me ATP synthase membrane subunit e decreases expression EXP actein results in decreased expression of ATP5ME mRNA CTD PMID:19527300 NCBI chr14:1,319,868...1,320,996 JBrowse link
G C4bpa complement component 4 binding protein, alpha increases expression EXP actein results in increased expression of C4BPA mRNA CTD PMID:19527300 NCBI chr13:42,075,715...42,111,205 JBrowse link
G C4bpb complement component 4 binding protein, beta increases expression EXP actein results in increased expression of C4BPB mRNA CTD PMID:19527300 NCBI chr13:42,120,798...42,131,515 JBrowse link
G C5 complement C5 increases expression EXP actein results in increased expression of C5 mRNA CTD PMID:19527300 NCBI chr 3:18,270,696...18,361,994 JBrowse link
G Ca3 carbonic anhydrase 3 increases expression EXP actein results in increased expression of CA3 protein CTD PMID:29969672 NCBI chr 2:86,770,418...86,780,011 JBrowse link
G Ccnd1 cyclin D1 affects expression
decreases expression
EXP
ISO
actein affects the expression of CCND1 mRNA
actein results in decreased expression of CCND1 protein
actein results in decreased expression of CCND1 mRNA; actein results in decreased expression of CCND1 protein
CTD PMID:14758092 PMID:19527300 PMID:29969672 NCBI chr 1:200,089,002...200,098,524 JBrowse link
G Cd44 CD44 molecule (Indian blood group) increases expression EXP actein results in increased expression of CD44 mRNA CTD PMID:19527300 NCBI chr 3:89,155,850...89,244,615 JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases expression ISO actein results in decreased expression of CDK4 protein CTD PMID:14758092 NCBI chr 7:62,885,647...62,889,562 JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO actein results in increased expression of CDKN1A protein CTD PMID:14758092 NCBI chr20:7,149,177...7,159,727 JBrowse link
G Ces1d carboxylesterase 1D decreases expression EXP actein results in decreased expression of CES1 protein CTD PMID:29969672 NCBI chr19:13,873,490...13,912,035 JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 increases expression EXP actein results in increased expression of CXCL1 mRNA CTD PMID:19527300 NCBI chr14:17,193,364...17,195,143 JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 increases expression EXP actein results in increased expression of CXCL2 protein CTD PMID:29969672 NCBI chr14:17,181,030...17,183,075 JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO actein inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein] CTD PMID:28836330 NCBI chr 8:58,096,021...58,102,130 JBrowse link
G Cyp2c22 cytochrome P450, family 2, subfamily c, polypeptide 22 decreases expression EXP actein results in decreased expression of CYP2C22 mRNA CTD PMID:19527300 NCBI chr 1:238,991,698...239,031,323 JBrowse link
G Cyp2j4 cytochrome P450, family 2, subfamily j, polypeptide 4 decreases expression EXP actein results in decreased expression of CYP2J9 protein CTD PMID:29969672 NCBI chr 5:111,179,981...111,207,490 JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 increases expression EXP actein results in increased expression of CYP7A1 mRNA CTD PMID:19527300 NCBI chr 5:19,376,979...19,386,676 JBrowse link
G Dipk1c divergent protein kinase domain 1C decreases expression EXP actein results in decreased expression of DIPK1C protein CTD PMID:29969672 NCBI chr18:78,087,972...78,109,910 JBrowse link
G Epo erythropoietin decreases expression EXP actein results in decreased expression of EPO mRNA CTD PMID:19527300 NCBI chr12:19,204,258...19,207,948 JBrowse link
G Fas Fas cell surface death receptor increases expression EXP actein results in increased expression of FAS mRNA CTD PMID:19527300 NCBI chr 1:231,798,963...231,832,591 JBrowse link
G Fdps farnesyl diphosphate synthase increases expression EXP actein results in increased expression of FDPS mRNA CTD PMID:19527300 NCBI chr 2:174,497,402...174,507,031 JBrowse link
G Flt1 Fms related receptor tyrosine kinase 1 increases expression EXP actein results in increased expression of FLT1 mRNA CTD PMID:19527300 NCBI chr12:7,296,899...7,468,626 JBrowse link
G Fmo1 flavin containing dimethylaniline monoxygenase 1 increases expression EXP actein results in increased expression of FMO1 protein CTD PMID:29969672 NCBI chr13:75,182,184...75,214,439 JBrowse link
G Gpd2 glycerol-3-phosphate dehydrogenase 2 decreases expression EXP actein results in decreased expression of GPD2 mRNA CTD PMID:19527300 NCBI chr 3:41,800,552...41,937,729 JBrowse link
G Hamp hepcidin antimicrobial peptide decreases expression EXP actein results in decreased expression of HAMP protein CTD PMID:29969672 NCBI chr 1:86,170,926...86,172,865 JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase affects expression EXP actein affects the expression of HMGCR mRNA CTD PMID:19527300 NCBI chr 2:27,997,523...28,018,983 JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 affects expression
increases expression
EXP actein affects the expression of HMGCS1 mRNA
actein results in increased expression of HMGCS1 mRNA
CTD PMID:19527300 NCBI chr 2:51,649,368...51,667,100 JBrowse link
G Hsd17b7 hydroxysteroid (17-beta) dehydrogenase 7 affects expression EXP actein affects the expression of HSD17B7 mRNA CTD PMID:19527300 NCBI chr13:82,170,079...82,190,018 JBrowse link
G Ibsp integrin-binding sialoprotein multiple interactions ISO actein inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of IBSP mRNA] CTD PMID:28836330 NCBI chr14:5,439,825...5,452,570 JBrowse link
G Id1 inhibitor of DNA binding 1, HLH protein decreases expression EXP actein results in decreased expression of ID1 protein CTD PMID:29969672 NCBI chr 3:141,210,666...141,212,420 JBrowse link
G Id3 inhibitor of DNA binding 3, HLH protein affects expression EXP actein affects the expression of ID3 mRNA CTD PMID:19527300 NCBI chr 5:148,372,784...148,374,353 JBrowse link
G Idi1 isopentenyl-diphosphate delta isomerase 1 increases expression EXP actein results in increased expression of IDI1 protein CTD PMID:29969672 NCBI chr17:61,629,592...61,637,357 JBrowse link
G Isg15 ISG15 ubiquitin-like modifier increases expression EXP actein results in increased expression of ISG15 protein CTD PMID:29969672 NCBI chr 5:166,784,148...166,785,435 JBrowse link
G Lcn2 lipocalin 2 increases expression EXP actein results in increased expression of LCN2 protein CTD PMID:29969672 NCBI chr 3:15,680,688...15,684,033 JBrowse link
G Lgalsl galectin-like decreases expression EXP actein results in decreased expression of LGALSL protein CTD PMID:29969672 NCBI chr14:94,996,991...95,004,499 JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO actein inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of MAPK3 mRNA] CTD PMID:28836330 NCBI chr 1:181,366,646...181,372,863 JBrowse link
G Me1 malic enzyme 1 decreases expression EXP actein results in decreased expression of ME1 mRNA CTD PMID:19527300 NCBI chr 8:87,549,043...87,660,251 JBrowse link
G Mx1 MX dynamin like GTPase 1 increases expression EXP actein results in increased expression of MX1 protein CTD PMID:29969672 NCBI chr11:36,799,659...36,825,209 JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO actein inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of NFKB1 mRNA] CTD PMID:28836330 NCBI chr 2:224,016,214...224,132,135 JBrowse link
G Noct nocturnin decreases expression EXP actein results in decreased expression of NOCT protein CTD PMID:29969672 NCBI chr 2:135,271,189...135,291,407 JBrowse link
G Npas2 neuronal PAS domain protein 2 decreases expression EXP actein results in decreased expression of NPAS2 protein CTD PMID:29969672 NCBI chr 9:41,463,361...41,642,322 JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 affects expression
increases expression
EXP actein affects the expression of NQO1 mRNA
actein results in increased expression of NQO1 mRNA
CTD PMID:19527300 NCBI chr19:35,295,633...35,310,528 JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 decreases expression EXP actein results in decreased expression of NR0B2 protein CTD PMID:29969672 NCBI chr 5:145,779,294...145,782,609 JBrowse link
G Oas1a 2'-5' oligoadenylate synthetase 1A increases expression EXP actein results in increased expression of OAS1 protein CTD PMID:29969672 NCBI chr12:35,669,798...35,680,505 JBrowse link
G Oasl 2'-5'-oligoadenylate synthetase-like increases expression EXP actein results in increased expression of OASL protein CTD PMID:29969672 NCBI chr12:41,682,900...41,695,641 JBrowse link
G Pcsk9 proprotein convertase subtilisin/kexin type 9 increases expression EXP actein results in increased expression of PCSK9 protein CTD PMID:29969672 NCBI chr 5:121,211,278...121,233,688 JBrowse link
G Psmb10 proteasome 20S subunit beta 10 increases expression EXP actein results in increased expression of PSMB10 mRNA CTD PMID:19527300 NCBI chr19:33,830,958...33,833,442 JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases expression ISO actein results in decreased expression of RB1 protein CTD PMID:14758092 NCBI chr15:48,371,295...48,502,473 JBrowse link
G Rgs5 regulator of G-protein signaling 5 increases expression EXP actein results in increased expression of RGS5 protein CTD PMID:29969672 NCBI chr13:81,848,254...81,885,053 JBrowse link
G S100a8 S100 calcium binding protein A8 increases expression EXP actein results in increased expression of S100A8 protein CTD PMID:29969672 NCBI chr 2:176,166,517...176,167,645 JBrowse link
G S100a9 S100 calcium binding protein A9 increases expression
affects expression
EXP actein results in increased expression of S100A9 mRNA; actein results in increased expression of S100A9 protein
actein affects the expression of S100A9 mRNA
CTD PMID:19527300 PMID:29969672 NCBI chr 2:176,190,361...176,193,182 JBrowse link
G Scd stearoyl-CoA desaturase decreases expression EXP actein results in decreased expression of SCD protein; actein results in decreased expression of SCD1 mRNA CTD PMID:19527300 PMID:29969672 NCBI chr 1:243,269,745...243,282,878 JBrowse link
G Sdf2l1 stromal cell-derived factor 2-like 1 increases expression EXP actein results in increased expression of SDF2L1 protein CTD PMID:29969672 NCBI chr11:83,872,659...83,874,902 JBrowse link
G Slc25a30 solute carrier family 25, member 30 decreases expression EXP actein results in decreased expression of SLC25A30 protein CTD PMID:29969672 NCBI chr15:51,076,998...51,099,613 JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions ISO actein inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of SOD2 mRNA] CTD PMID:28836330 NCBI chr 1:47,638,318...47,645,163 JBrowse link
G Sod3 superoxide dismutase 3 multiple interactions ISO actein inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of SOD3 mRNA] CTD PMID:28836330 NCBI chr14:58,610,104...58,615,845 JBrowse link
G Sp7 Sp7 transcription factor multiple interactions ISO actein inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of SP7 mRNA] CTD PMID:28836330 NCBI chr 7:133,484,609...133,494,788 JBrowse link
G Sqle squalene epoxidase increases expression EXP actein results in increased expression of SQLE protein CTD PMID:29969672 NCBI chr 7:90,867,973...90,883,623 JBrowse link
G Tfrc transferrin receptor increases expression EXP actein results in increased expression of TFRC mRNA CTD PMID:19527300 NCBI chr11:68,163,413...68,185,257 JBrowse link
G Tsku tsukushi, small leucine rich proteoglycan decreases expression EXP actein results in decreased expression of TSKU protein CTD PMID:29969672 NCBI chr 1:152,660,259...152,671,682 JBrowse link
G Tspo translocator protein increases expression EXP actein results in increased expression of TSPO mRNA CTD PMID:19527300 NCBI chr 7:114,720,188...114,730,450 JBrowse link
G Usp18 ubiquitin specific peptidase 18 increases expression EXP actein results in increased expression of USP18 protein CTD PMID:29969672 NCBI chr 4:154,471,634...154,499,154 JBrowse link
G Usp2 ubiquitin specific peptidase 2 decreases expression EXP actein results in decreased expression of USP2 protein CTD PMID:29969672 NCBI chr 8:44,411,457...44,439,668 JBrowse link
G Zfp354a zinc finger protein 354A decreases expression EXP actein results in decreased expression of ZNF354A protein CTD PMID:29969672 NCBI chr10:35,396,242...35,408,065 JBrowse link
alpha-amyrin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tacr1 tachykinin receptor 1 multiple interactions ISO [alpha-amyrin co-treated with beta-amyrin] inhibits the reaction [Cyclophosphamide results in increased expression of TACR1 protein] CTD PMID:18210232 NCBI chr 4:114,920,844...115,089,733 JBrowse link
arjunolic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bad BCL2-associated agonist of cell death multiple interactions ISO
EXP
arjunolic acid inhibits the reaction [Cadmium Chloride results in increased expression of BAD protein]
arjunolic acid inhibits the reaction [Streptozocin results in increased expression of BAD protein]
CTD PMID:19682444 PMID:21420465 NCBI chr 1:204,133,502...204,142,829 JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP
ISO
arjunolic acid inhibits the reaction [Streptozocin results in increased expression of BCL2 protein]
arjunolic acid inhibits the reaction [Cadmium Chloride results in decreased expression of BCL2 protein]
CTD PMID:19682444 PMID:21420465 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions EXP arjunolic acid inhibits the reaction [Streptozocin results in increased expression of BCL2L1 protein] CTD PMID:19682444 NCBI chr 3:141,253,508...141,304,582 JBrowse link
G Bid BH3 interacting domain death agonist multiple interactions ISO arjunolic acid inhibits the reaction [Cadmium Chloride results in increased expression of BID protein] CTD PMID:21420465 NCBI chr 4:154,113,198...154,136,353 JBrowse link
G Casp3 caspase 3 multiple interactions EXP
ISO
arjunolic acid inhibits the reaction [Acetaminophen results in increased cleavage of and results in increased activity of CASP3 protein]; arjunolic acid inhibits the reaction [Streptozocin results in increased activity of CASP3 protein]
arjunolic acid inhibits the reaction [Cadmium Chloride results in increased cleavage of CASP3 protein]
CTD PMID:19133311 PMID:19682444 PMID:19922764 PMID:20053369 PMID:21420465 NCBI chr16:45,662,910...45,681,171 JBrowse link
G Casp8 caspase 8 multiple interactions ISO arjunolic acid inhibits the reaction [Cadmium Chloride results in increased expression of CASP8 protein] CTD PMID:21420465 NCBI chr 9:60,263,863...60,312,542 JBrowse link
G Casp9 caspase 9 multiple interactions ISO arjunolic acid inhibits the reaction [Cadmium Chloride results in increased activity of CASP9 protein] CTD PMID:21420465 NCBI chr 5:154,108,872...154,126,628 JBrowse link
G Cat catalase multiple interactions ISO
EXP
arjunolic acid inhibits the reaction [Cadmium Chloride results in decreased activity of CAT protein]; arjunolic acid inhibits the reaction [sodium arsenite affects the activity of CAT protein]; arjunolic acid inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]
arjunolic acid inhibits the reaction [Streptozocin results in decreased activity of CAT protein]
CTD PMID:18273903 PMID:18434106 PMID:19133311 PMID:19682444 PMID:20053369 PMID:21420465 NCBI chr 3:89,842,393...89,874,577 JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex multiple interactions ISO arjunolic acid inhibits the reaction [Cadmium Chloride results in increased phosphorylation of CHUK protein] CTD PMID:21420465 NCBI chr 1:242,959,539...242,995,066 JBrowse link
G Cycs cytochrome c, somatic multiple interactions EXP arjunolic acid inhibits the reaction [Streptozocin affects the localization of CYCS protein] CTD PMID:19682444 NCBI chr 4:79,651,894...79,653,994 JBrowse link
G Fas Fas cell surface death receptor multiple interactions ISO arjunolic acid inhibits the reaction [Cadmium Chloride results in increased expression of FAS protein] CTD PMID:21420465 NCBI chr 1:231,798,963...231,832,591 JBrowse link
G G6pd glucose-6-phosphate dehydrogenase multiple interactions EXP arjunolic acid inhibits the reaction [Streptozocin results in decreased activity of G6PD protein] CTD PMID:19133311 PMID:19682444 NCBI chr  X:152,201,081...152,220,863 JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions ISO
EXP
arjunolic acid inhibits the reaction [Cadmium Chloride results in decreased activity of GSR protein]; arjunolic acid inhibits the reaction [sodium arsenite affects the activity of GSR protein]; arjunolic acid inhibits the reaction [sodium arsenite results in decreased activity of GSR protein]
arjunolic acid inhibits the reaction [Streptozocin results in decreased activity of GSR protein]
CTD PMID:18273903 PMID:18434106 PMID:19682444 PMID:20053369 PMID:21420465 NCBI chr16:58,482,209...58,525,256 JBrowse link
G Ifng interferon gamma multiple interactions EXP arjunolic acid inhibits the reaction [Streptozocin results in decreased expression of IFNG protein] CTD PMID:20053369 NCBI chr 7:53,903,339...53,907,375 JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta multiple interactions ISO arjunolic acid inhibits the reaction [Cadmium Chloride results in increased phosphorylation of IKBKB protein] CTD PMID:21420465 NCBI chr16:69,319,487...69,373,251 JBrowse link
G Il2 interleukin 2 multiple interactions EXP arjunolic acid inhibits the reaction [Streptozocin results in decreased expression of IL2 protein] CTD PMID:20053369 NCBI chr 2:120,004,862...120,009,566 JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions EXP arjunolic acid inhibits the reaction [Streptozocin results in increased phosphorylation of and results in increased activity of MAPK1 protein]; arjunolic acid inhibits the reaction [Streptozocin results in increased phosphorylation of MAPK1 protein] CTD PMID:19133311 PMID:19682444 PMID:20053369 NCBI chr11:83,957,813...84,023,629 JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions EXP arjunolic acid inhibits the reaction [Streptozocin results in increased phosphorylation of and results in increased activity of MAPK3 protein]; arjunolic acid inhibits the reaction [Streptozocin results in increased phosphorylation of MAPK3 protein] CTD PMID:19133311 PMID:19682444 PMID:20053369 NCBI chr 1:181,366,646...181,372,863 JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO
EXP
arjunolic acid inhibits the reaction [Cadmium Chloride results in increased degradation of and results in decreased expression of NFKBIA protein]
arjunolic acid inhibits the reaction [Streptozocin results in decreased expression of NFKBIA protein]; arjunolic acid inhibits the reaction [Streptozocin results in increased phosphorylation of NFKBIA protein]
CTD PMID:20053369 PMID:21420465 NCBI chr 6:72,858,713...72,861,941 JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP arjunolic acid inhibits the reaction [Acetaminophen results in increased expression of NOS2 protein]; arjunolic acid inhibits the reaction [Cisplatin results in increased expression of NOS2] CTD PMID:19922764 PMID:25130312 NCBI chr10:63,815,308...63,851,208 JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 increases expression EXP arjunolic acid increases expression of Nr1h4 mRNA in steatotic liver RGD PMID:30257410 RGD:15090799 NCBI chr 7:23,846,122...23,942,085 JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO arjunolic acid inhibits the reaction [Cadmium Chloride results in increased cleavage of PARP1 protein] CTD PMID:21420465 NCBI chr13:92,307,593...92,339,406 JBrowse link
G Prkcd protein kinase C, delta multiple interactions EXP arjunolic acid inhibits the reaction [Streptozocin results in increased expression of PRKCD protein] CTD PMID:19682444 NCBI chr16:5,769,226...5,807,214 JBrowse link
G Prkce protein kinase C, epsilon multiple interactions EXP arjunolic acid inhibits the reaction [Streptozocin results in increased expression of PRKCE protein] CTD PMID:19682444 NCBI chr 6:7,965,048...8,451,966 JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO
EXP
arjunolic acid inhibits the reaction [Cadmium Chloride results in increased expression of RELA protein]
arjunolic acid inhibits the reaction [Streptozocin results in increased expression of RELA protein]; arjunolic acid inhibits the reaction [Streptozocin results in increased phosphorylation of RELA protein]
CTD PMID:19133311 PMID:19682444 PMID:20053369 PMID:21420465 NCBI chr 1:202,925,001...202,935,484 JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions EXP arjunolic acid inhibits the reaction [Streptozocin results in decreased activity of SOD1 protein] CTD PMID:20053369 NCBI chr11:29,456,673...29,462,249 JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions EXP arjunolic acid inhibits the reaction [Streptozocin results in decreased activity of SOD2 protein] CTD PMID:20053369 NCBI chr 1:47,638,318...47,645,163 JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP arjunolic acid inhibits the reaction [Acetaminophen results in increased expression of TNF protein]; arjunolic acid inhibits the reaction [Cisplatin results in increased expression of TNF]; arjunolic acid inhibits the reaction [Streptozocin results in increased expression of TNF protein] CTD PMID:19682444 PMID:19922764 PMID:20053369 PMID:25130312 NCBI chr20:3,622,011...3,624,629 JBrowse link
asiatic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP
ISO
asiatic acid inhibits the reaction [1,2-Dimethylhydrazine results in decreased expression of BAX protein]
[Carnosine co-treated with asiatic acid] inhibits the reaction [Glucose results in increased expression of BAX mRNA]; asiatic acid inhibits the reaction [Glucose results in increased expression of BAX mRNA]
CTD PMID:29108773 PMID:30802477 NCBI chr 1:95,940,001...95,945,407 JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP
ISO
asiatic acid inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of BCL2 protein]
asiatic acid inhibits the reaction [Glucose results in decreased expression of BCL2 mRNA]; asiatic acid promotes the reaction [Carnosine inhibits the reaction [Glucose results in decreased expression of BCL2 mRNA]]; Carnosine promotes the reaction [asiatic acid inhibits the reaction [Glucose results in decreased expression of BCL2 mRNA]]
CTD PMID:29108773 PMID:30802477 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Casp3 caspase 3 multiple interactions EXP
ISO
asiatic acid inhibits the reaction [1,2-Dimethylhydrazine results in decreased expression of CASP3 protein]
[Carnosine co-treated with asiatic acid] inhibits the reaction [Glucose results in increased activity of CASP3 protein]; asiatic acid inhibits the reaction [Glucose results in increased activity of CASP3 protein]
CTD PMID:29108773 PMID:30802477 NCBI chr16:45,662,910...45,681,171 JBrowse link
G Casp9 caspase 9 multiple interactions EXP asiatic acid inhibits the reaction [1,2-Dimethylhydrazine results in decreased expression of CASP9 protein] CTD PMID:29108773 NCBI chr 5:154,108,872...154,126,628 JBrowse link
G Ccnd1 cyclin D1 multiple interactions EXP asiatic acid inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of CCND1 protein] CTD PMID:29108773 NCBI chr 1:200,089,002...200,098,524 JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions EXP asiatic acid inhibits the reaction [1,2-Dimethylhydrazine results in increased activity of CYP2E1 protein] CTD PMID:29108773 NCBI chr 1:195,840,330...195,850,728 JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO asiatic acid inhibits the reaction [Streptozocin results in increased expression of IL1B protein]; asiatic acid promotes the reaction [Carnosine inhibits the reaction [Streptozocin results in increased expression of IL1B protein]]
[Carnosine co-treated with asiatic acid] inhibits the reaction [Glucose results in increased secretion of IL1B protein]; asiatic acid inhibits the reaction [Glucose results in increased secretion of IL1B protein]
CTD PMID:30802477 NCBI chr 3:116,577,005...116,583,386 JBrowse link
G Il6 interleukin 6 multiple interactions ISO asiatic acid inhibits the reaction [Streptozocin results in increased expression of IL6 protein]; asiatic acid promotes the reaction [Carnosine inhibits the reaction [Streptozocin results in increased expression of IL6 protein]]; Carnosine promotes the reaction [asiatic acid inhibits the reaction [Streptozocin results in increased expression of IL6 protein]]
[Carnosine co-treated with asiatic acid] inhibits the reaction [Glucose results in increased secretion of IL6 protein]; asiatic acid inhibits the reaction [Glucose results in increased secretion of IL6 protein]
CTD PMID:30802477 NCBI chr 4:5,214,602...5,219,178 JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO [Carnosine co-treated with asiatic acid] inhibits the reaction [Streptozocin results in increased phosphorylation of MAPK8 protein]; asiatic acid inhibits the reaction [Streptozocin results in increased phosphorylation of MAPK8 protein] CTD PMID:30802477 NCBI chr16:8,638,897...8,721,960 JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions EXP asiatic acid inhibits the reaction [1,2-Dimethylhydrazine results in decreased activity of NQO1 protein] CTD PMID:29108773 NCBI chr19:35,295,633...35,310,528 JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions EXP asiatic acid inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of PCNA protein] CTD PMID:29108773 NCBI chr 3:119,499,039...119,502,911 JBrowse link
G Por cytochrome p450 oxidoreductase multiple interactions EXP asiatic acid inhibits the reaction [1,2-Dimethylhydrazine results in increased activity of POR protein] CTD PMID:29108773 NCBI chr12:20,951,058...20,999,198 JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions ISO [Glutamic Acid co-treated with asiatic acid] results in increased expression of PPARGC1A protein CTD PMID:22447225 NCBI chr14:58,860,752...59,516,525 JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO asiatic acid inhibits the reaction [Streptozocin results in increased activity of PTGS2 protein]; asiatic acid promotes the reaction [Carnosine inhibits the reaction [Streptozocin results in increased activity of PTGS2 protein]]; Carnosine promotes the reaction [asiatic acid inhibits the reaction [Streptozocin results in increased activity of PTGS2 protein]] CTD PMID:30802477 NCBI chr13:62,164,080...62,169,770 JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO asiatic acid inhibits the reaction [Streptozocin results in increased expression of RELA protein]; Carnosine promotes the reaction [asiatic acid inhibits the reaction [Streptozocin results in increased expression of RELA protein]] CTD PMID:30802477 NCBI chr 1:202,925,001...202,935,484 JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO asiatic acid inhibits the reaction [Glucose results in increased secretion of TNF protein]; asiatic acid promotes the reaction [Carnosine inhibits the reaction [Glucose results in increased secretion of TNF protein]]; Carnosine promotes the reaction [asiatic acid inhibits the reaction [Glucose results in increased secretion of TNF protein]]
asiatic acid inhibits the reaction [Streptozocin results in increased expression of TNF protein]; asiatic acid promotes the reaction [Carnosine inhibits the reaction [Streptozocin results in increased expression of TNF protein]]; Carnosine promotes the reaction [asiatic acid inhibits the reaction [Streptozocin results in increased expression of TNF protein]]
CTD PMID:30802477 NCBI chr20:3,622,011...3,624,629 JBrowse link
G Vdac1 voltage-dependent anion channel 1 multiple interactions ISO asiatic acid inhibits the reaction [Hydrogen Peroxide results in increased expression of VDAC1 mRNA]; asiatic acid inhibits the reaction [Rotenone results in increased expression of VDAC1 mRNA]; asiatic acid inhibits the reaction [Rotenone results in increased expression of VDAC1 protein] CTD PMID:18802751 NCBI chr10:36,532,306...36,559,642 JBrowse link
astragaloside IV term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 multiple interactions EXP astragaloside A inhibits the reaction [Isoproterenol results in decreased expression of and results in decreased activity of ATP2A2 protein]; astragaloside A inhibits the reaction [Isoproterenol results in decreased expression of ATP2A2 mRNA] CTD PMID:17509559 NCBI chr12:34,072,710...34,122,142 JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO astragaloside A inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BAX protein]; astragaloside A inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of BAX protein] CTD PMID:22278385 PMID:33285147 NCBI chr 1:95,940,001...95,945,407 JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO astragaloside A inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in decreased expression of BCL2 protein] CTD PMID:33285147 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bcs1l BCS1 homolog, ubiquinol-cytochrome c reductase complex chaperone multiple interactions ISO astragaloside A inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of BCS1L protein] CTD PMID:22278385 NCBI chr 9:76,164,925...76,168,940 JBrowse link
G Cacna1c calcium voltage-gated channel subunit alpha1 C multiple interactions ISO astragaloside A inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of CACNA1C protein] CTD PMID:33285147 NCBI chr 4:151,764,138...152,379,454 JBrowse link
G Casp3 caspase 3 multiple interactions ISO
EXP
astragaloside A inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased cleavage of CASP3 protein]; astragaloside A inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of and results in increased cleavage of CASP3 protein]
astragaloside A inhibits the reaction [Cisplatin results in increased expression of CASP3 protein]
CTD PMID:22278385 PMID:30842369 PMID:33285147 NCBI chr16:45,662,910...45,681,171 JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex multiple interactions ISO astragaloside A inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased phosphorylation of CHUK protein] CTD PMID:33285147 NCBI chr 1:242,959,539...242,995,066 JBrowse link
G Fth1 ferritin heavy chain 1 multiple interactions ISO astragaloside A inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of FTH1 protein] CTD PMID:33285147 NCBI chr 1:206,627,142...206,629,430 JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP astragaloside A inhibits the reaction [Cisplatin results in increased expression of GPT protein] CTD PMID:30842369 NCBI chr 7:108,416,646...108,419,495 JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression
ISO [astragaloside A co-treated with ginsenoside Rg1 co-treated with ginsenoside Rb1 co-treated with notoginsenoside R1] results in increased expression of HMOX1 mRNA; [astragaloside A co-treated with ginsenoside Rg1 co-treated with ginsenoside Rb1 co-treated with notoginsenoside R1] results in increased expression of HMOX1 protein
astragaloside A results in increased expression of HMOX1 mRNA; astragaloside A results in increased expression of HMOX1 protein
CTD PMID:25422538 NCBI chr19:13,466,287...13,474,082 JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP astragaloside A inhibits the reaction [Cisplatin results in increased expression of IL1B protein]; astragaloside A inhibits the reaction [Taurocholic Acid results in increased expression of IL1B mRNA]; astragaloside A inhibits the reaction [Taurocholic Acid results in increased expression of IL1B protein] CTD PMID:25604657 PMID:30842369 NCBI chr 3:116,577,005...116,583,386 JBrowse link
G Il6 interleukin 6 multiple interactions EXP
ISO
astragaloside A inhibits the reaction [Taurocholic Acid results in increased expression of IL6 mRNA]; astragaloside A inhibits the reaction [Taurocholic Acid results in increased expression of IL6 protein]
astragaloside A inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of IL6 protein]
CTD PMID:25604657 PMID:33285147 NCBI chr 4:5,214,602...5,219,178 JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO astragaloside A inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased phosphorylation of MAPK1 protein] CTD PMID:33285147 NCBI chr11:83,957,813...84,023,629 JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO astragaloside A inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased phosphorylation of MAPK3 protein] CTD PMID:33285147 NCBI chr 1:181,366,646...181,372,863 JBrowse link
G Mpo myeloperoxidase multiple interactions EXP astragaloside A inhibits the reaction [Taurocholic Acid results in increased activity of MPO protein] CTD PMID:25604657 NCBI chr10:72,594,458...72,608,862 JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions
affects localization
ISO [astragaloside A co-treated with ginsenoside Rg1 co-treated with ginsenoside Rb1 co-treated with notoginsenoside R1] affects the localization of NFE2L2 protein
astragaloside A affects the localization of NFE2L2 protein
CTD PMID:25422538 NCBI chr 3:60,594,239...60,621,785 JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions EXP
ISO
astragaloside A inhibits the reaction [Taurocholic Acid results in decreased expression of NFKBIA mRNA]; astragaloside A inhibits the reaction [Taurocholic Acid results in decreased expression of NFKBIA protein]
astragaloside A inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased phosphorylation of NFKBIA protein]
CTD PMID:25604657 PMID:33285147 NCBI chr 6:72,858,713...72,861,941 JBrowse link
G Nfkbib NFKB inhibitor beta multiple interactions EXP astragaloside A inhibits the reaction [Taurocholic Acid results in decreased expression of NFKBIB mRNA]; astragaloside A inhibits the reaction [Taurocholic Acid results in decreased expression of NFKBIB protein] CTD PMID:25604657 NCBI chr 1:84,046,292...84,053,862 JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions EXP astragaloside A inhibits the reaction [Cisplatin results in increased expression of NLRP3 protein] CTD PMID:30842369 NCBI chr10:44,326,770...44,353,814 JBrowse link
G Pln phospholamban multiple interactions EXP astragaloside A inhibits the reaction [Isoproterenol results in decreased phosphorylation of PLN protein] CTD PMID:17509559 NCBI chr20:32,629,537...32,639,559 JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP
ISO
astragaloside A inhibits the reaction [Taurocholic Acid affects the localization of RELA protein]
astragaloside A inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which affects the localization of RELA protein]
CTD PMID:25604657 PMID:33285147 NCBI chr 1:202,925,001...202,935,484 JBrowse link
G Rho rhodopsin multiple interactions ISO astragaloside A inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in decreased expression of RHO mRNA] CTD PMID:33285147 NCBI chr 4:148,975,597...148,988,693 JBrowse link
G Rpe65 retinoid isomerohydrolase RPE65 multiple interactions ISO astragaloside A inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in decreased expression of RPE65 mRNA] CTD PMID:33285147 NCBI chr 2:248,766,497...248,798,403 JBrowse link
G Slc11a2 solute carrier family 11 member 2 multiple interactions ISO astragaloside A inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of SLC11A2 protein] CTD PMID:33285147 NCBI chr 7:131,503,076...131,540,246 JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions EXP astragaloside A inhibits the reaction [Taurocholic Acid results in decreased expression of SOD1 mRNA]; astragaloside A inhibits the reaction [Taurocholic Acid results in decreased expression of SOD1 protein] CTD PMID:25604657 NCBI chr11:29,456,673...29,462,249 JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions EXP astragaloside A promotes the reaction [Taurocholic Acid results in decreased expression of SOD2 protein]; astragaloside A promotes the reaction [Taurocholic Acid results in increased expression of SOD2 mRNA] CTD PMID:25604657 NCBI chr 1:47,638,318...47,645,163 JBrowse link
G Sqstm1 sequestosome 1 multiple interactions EXP astragaloside A inhibits the reaction [Cisplatin results in increased expression of SQSTM1 protein] CTD PMID:30842369 NCBI chr10:34,525,517...34,536,685 JBrowse link
G Tfrc transferrin receptor multiple interactions ISO astragaloside A inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of TFRC protein] CTD PMID:33285147 NCBI chr11:68,163,413...68,185,257 JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP
ISO
astragaloside A inhibits the reaction [Taurocholic Acid results in increased expression of TNF mRNA]; astragaloside A inhibits the reaction [Taurocholic Acid results in increased expression of TNF protein]
astragaloside A inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of TNF protein]
CTD PMID:25604657 PMID:33285147 NCBI chr20:3,622,011...3,624,629 JBrowse link
azadirachtin A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acp5 acid phosphatase 5, tartrate resistant decreases expression
multiple interactions
ISO azadirachtin results in decreased expression of ACP5 mRNA
azadirachtin inhibits the reaction [Estrogens deficiency results in increased expression of ACP5 mRNA]
CTD PMID:31225646 NCBI chr 8:20,663,984...20,670,604 JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 increases expression ISO azadirachtin results in increased expression of APAF1 protein CTD PMID:20429769 NCBI chr 7:25,494,143...25,579,540 JBrowse link
G Bad BCL2-associated agonist of cell death increases expression ISO azadirachtin results in increased expression of BAD mRNA CTD PMID:20429769 NCBI chr 1:204,133,502...204,142,829 JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO azadirachtin results in increased expression of BAX mRNA CTD PMID:20429769 NCBI chr 1:95,940,001...95,945,407 JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO azadirachtin results in decreased expression of BCL2 mRNA; azadirachtin results in decreased expression of BCL2 protein CTD PMID:20429769 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression ISO azadirachtin results in decreased expression of BCL2L1 mRNA CTD PMID:20429769 NCBI chr 3:141,253,508...141,304,582 JBrowse link
G Bglap bone gamma-carboxyglutamate protein multiple interactions ISO azadirachtin inhibits the reaction [Estrogens deficiency results in increased expression of BGLAP protein] CTD PMID:31225646 NCBI chr 2:173,838,518...173,839,495 JBrowse link
G Bid BH3 interacting domain death agonist increases expression ISO azadirachtin results in increased expression of BID mRNA CTD PMID:20429769 NCBI chr 4:154,113,198...154,136,353 JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 decreases expression ISO azadirachtin results in decreased expression of BIRC5 protein CTD PMID:20429769 NCBI chr10:103,072,530...103,081,382 JBrowse link
G Bmp2 bone morphogenetic protein 2 increases expression ISO azadirachtin results in increased expression of BMP2 mRNA; azadirachtin results in increased expression of BMP2 protein CTD PMID:31225646 NCBI chr 3:120,812,660...120,822,579 JBrowse link
G Casp3 caspase 3 increases expression ISO azadirachtin results in increased expression of CASP3 mRNA; azadirachtin results in increased expression of CASP3 protein CTD PMID:20429769 NCBI chr16:45,662,910...45,681,171 JBrowse link
G Casp6 caspase 6 increases expression ISO azadirachtin results in increased expression of CASP6 protein CTD PMID:20429769 NCBI chr 2:218,466,063...218,478,503 JBrowse link
G Casp8 caspase 8 increases expression ISO azadirachtin results in increased expression of CASP8 protein CTD PMID:20429769 NCBI chr 9:60,263,863...60,312,542 JBrowse link
G Casp9 caspase 9 increases expression ISO azadirachtin results in increased expression of CASP9 mRNA; azadirachtin results in increased expression of CASP9 protein CTD PMID:20429769 NCBI chr 5:154,108,872...154,126,628 JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO azadirachtin results in decreased expression of CCND1 mRNA CTD PMID:20429769 NCBI chr 1:200,089,002...200,098,524 JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO azadirachtin results in increased expression of CDKN1A mRNA; azadirachtin results in increased expression of CDKN1A protein CTD PMID:20429769 NCBI chr20:7,149,177...7,159,727 JBrowse link
G Cycs cytochrome c, somatic increases expression
affects localization
ISO azadirachtin results in increased expression of CYCS mRNA
azadirachtin affects the localization of CYCS protein
CTD PMID:20429769 NCBI chr 4:79,651,894...79,653,994 JBrowse link
G Esr1 estrogen receptor 1 increases expression
multiple interactions
affects binding
ISO azadirachtin results in increased expression of ESR1 mRNA; azadirachtin results in increased expression of ESR1 protein
1,3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole inhibits the reaction [azadirachtin results in increased expression of ESR1 mRNA]; 1,3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole inhibits the reaction [azadirachtin results in increased expression of ESR1 protein]; azadirachtin inhibits the reaction [Estrogens deficiency results in decreased expression of ESR1 mRNA]; ESR1 protein promotes the reaction [azadirachtin results in increased expression of RUNX2 mRNA]; ESR1 protein promotes the reaction [azadirachtin results in increased expression of RUNX2 protein]
azadirachtin binds to ESR1 protein
CTD PMID:31225646 NCBI chr 1:41,106,335...41,499,104 JBrowse link
G Esr2 estrogen receptor 2 multiple interactions
affects binding
increases expression
ISO azadirachtin inhibits the reaction [Estrogens deficiency results in decreased expression of ESR2 mRNA]
azadirachtin binds to ESR2 protein
azadirachtin results in increased expression of ESR2 mRNA; azadirachtin results in increased expression of ESR2 protein
CTD PMID:31225646 NCBI chr 6:94,858,438...94,909,630 JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta decreases expression ISO azadirachtin results in decreased expression of IKBKB protein CTD PMID:20429769 NCBI chr16:69,319,487...69,373,251 JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation ISO azadirachtin results in increased phosphorylation of MAPK1 protein CTD PMID:31225646 NCBI chr11:83,957,813...84,023,629 JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation ISO azadirachtin results in increased phosphorylation of MAPK3 protein CTD PMID:31225646 NCBI chr 1:181,366,646...181,372,863 JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 decreases expression ISO azadirachtin results in decreased expression of NFKB1 protein CTD PMID:20429769 NCBI chr 2:224,016,214...224,132,135 JBrowse link
G Nfkbia NFKB inhibitor alpha decreases expression ISO azadirachtin results in decreased expression of NFKBIA protein modified form CTD PMID:20429769 NCBI chr 6:72,858,713...72,861,941 JBrowse link
G Pcna proliferating cell nuclear antigen decreases expression ISO azadirachtin results in decreased expression of PCNA mRNA; azadirachtin results in decreased expression of PCNA protein CTD PMID:20429769 NCBI chr 3:119,499,039...119,502,911 JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit decreases expression ISO azadirachtin results in decreased expression of RELA protein CTD PMID:20429769 NCBI chr 1:202,925,001...202,935,484 JBrowse link
G Runx2 RUNX family transcription factor 2 increases expression
multiple interactions
ISO azadirachtin results in increased expression of RUNX2 mRNA; azadirachtin results in increased expression of RUNX2 protein
ESR1 protein promotes the reaction [azadirachtin results in increased expression of RUNX2 mRNA]; ESR1 protein promotes the reaction [azadirachtin results in increased expression of RUNX2 protein]
CTD PMID:31225646 NCBI chr 9:16,167,504...16,492,826 JBrowse link
G Smad1 SMAD family member 1 increases expression ISO azadirachtin results in increased expression of SMAD1 protein modified form CTD PMID:31225646 NCBI chr19:28,513,130...28,573,665 JBrowse link
G Tnf tumor necrosis factor decreases expression ISO azadirachtin results in decreased expression of TNF mRNA CTD PMID:31225646 NCBI chr20:3,622,011...3,624,629 JBrowse link
G Tnfrsf11a TNF receptor superfamily member 11A multiple interactions
decreases expression
ISO azadirachtin inhibits the reaction [Estrogens deficiency results in increased expression of TNFRSF11A mRNA]
azadirachtin results in decreased expression of TNFRSF11A mRNA
CTD PMID:31225646 NCBI chr13:21,928,370...21,986,719 JBrowse link
G Tp53 tumor protein p53 increases expression ISO azadirachtin results in increased expression of TP53 mRNA; azadirachtin results in increased expression of TP53 protein CTD PMID:20429769 NCBI chr10:54,300,070...54,311,525 JBrowse link
azadiradione term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 increases activity ISO azadiradione results in increased activity of CASP3 protein CTD PMID:21381696 NCBI chr16:45,662,910...45,681,171 JBrowse link
G Casp8 caspase 8 increases activity ISO azadiradione results in increased activity of CASP8 protein CTD PMID:21381696 NCBI chr 9:60,263,863...60,312,542 JBrowse link
G Casp9 caspase 9 increases activity ISO azadiradione results in increased activity of CASP9 protein CTD PMID:21381696 NCBI chr 5:154,108,872...154,126,628 JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A increases expression ISO azadiradione results in increased expression of HSPA1A mRNA CTD PMID:30309986
beta-amyrin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arg1 arginase 1 multiple interactions ISO beta-amyrin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in decreased expression of ARG1 mRNA] CTD PMID:29501766 NCBI chr 1:20,475,878...20,488,422 JBrowse link
G Ifng interferon gamma multiple interactions ISO beta-amyrin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in decreased expression of ARG1 mRNA]; beta-amyrin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of IL1B mRNA]; beta-amyrin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of IL1B protein]; beta-amyrin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of IL6 mRNA]; beta-amyrin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of IL6 protein]; beta-amyrin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; beta-amyrin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of PTGS2 mRNA]; beta-amyrin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of TNF mRNA]; beta-amyrin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of TNF protein] CTD PMID:29501766 NCBI chr 7:53,903,339...53,907,375 JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO beta-amyrin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of IL1B mRNA]; beta-amyrin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of IL1B protein] CTD PMID:29501766 NCBI chr 3:116,577,005...116,583,386 JBrowse link
G Il6 interleukin 6 multiple interactions ISO beta-amyrin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of IL6 mRNA]; beta-amyrin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of IL6 protein] CTD PMID:29501766 NCBI chr 4:5,214,602...5,219,178 JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO beta-amyrin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 mRNA] CTD PMID:29501766 NCBI chr10:63,815,308...63,851,208 JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO beta-amyrin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of PTGS2 mRNA] CTD PMID:29501766 NCBI chr13:62,164,080...62,169,770 JBrowse link
G Tacr1 tachykinin receptor 1 multiple interactions ISO [alpha-amyrin co-treated with beta-amyrin] inhibits the reaction [Cyclophosphamide results in increased expression of TACR1 protein] CTD PMID:18210232 NCBI chr 4:114,920,844...115,089,733 JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO beta-amyrin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of TNF mRNA]; beta-amyrin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of TNF protein] CTD PMID:29501766 NCBI chr20:3,622,011...3,624,629 JBrowse link
betulin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle multiple interactions EXP betulin inhibits the reaction [Ethanol results in increased expression of ACTA2 protein] CTD PMID:21172400 NCBI chr 1:231,746,527...231,759,307 JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases phosphorylation ISO betulin results in increased phosphorylation of AKT1 protein CTD PMID:32190974 NCBI chr 6:131,713,716...131,735,319 JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO betulin results in increased expression of BAX protein CTD PMID:33181113 NCBI chr 1:95,940,001...95,945,407 JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO [betulin co-treated with Oxygen deficiency] results in decreased expression of BCL2 protein CTD PMID:33181113 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 multiple interactions
decreases expression
ISO betulin analog promotes the reaction [Oxygen deficiency results in decreased expression of BIRC5 protein]
betulin analog results in decreased expression of BIRC5 protein
CTD PMID:26540049 NCBI chr10:103,072,530...103,081,382 JBrowse link
G Braf B-Raf proto-oncogene, serine/threonine kinase multiple interactions ISO betulin affects the reaction [BRAF protein affects the reaction [Vemurafenib results in decreased cleavage of SREBF1 protein]]; betulin affects the reaction [BRAF protein affects the susceptibility to [dabrafenib co-treated with trametinib]]; betulin affects the reaction [BRAF protein affects the susceptibility to Vemurafenib] CTD PMID:29950559 NCBI chr 4:68,375,484...68,510,652 JBrowse link
G Ca9 carbonic anhydrase 9 multiple interactions ISO betulin analog inhibits the reaction [Oxygen deficiency results in increased expression of CA9 protein] CTD PMID:26540049 NCBI chr 5:57,763,234...57,769,838 JBrowse link
G Casp3 caspase 3 increases cleavage
multiple interactions
ISO betulin results in increased cleavage of CASP3 protein
Chloroquine inhibits the reaction [betulin results in increased cleavage of CASP3 protein]
CTD PMID:32190974 NCBI chr16:45,662,910...45,681,171 JBrowse link
G Casp8 caspase 8 increases cleavage ISO betulin results in increased cleavage of CASP8 protein CTD PMID:32190974 NCBI chr 9:60,263,863...60,312,542 JBrowse link
G Casp9 caspase 9 increases cleavage ISO betulin results in increased cleavage of CASP9 protein CTD PMID:32190974 NCBI chr 5:154,108,872...154,126,628 JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions ISO [betulin co-treated with Oxygen deficiency] results in decreased expression of CTNNB1 protein CTD PMID:33181113 NCBI chr 8:120,640,008...120,667,110 JBrowse link
G Egfr epidermal growth factor receptor multiple interactions
decreases phosphorylation
ISO [Gefitinib co-treated with betulin] results in decreased expression of and results in decreased phosphorylation of EGFR protein
betulin results in decreased phosphorylation of EGFR protein
CTD PMID:27447558 NCBI chr14:91,176,931...91,349,722 JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 decreases phosphorylation ISO betulin results in decreased phosphorylation of EIF4EBP1 protein CTD PMID:32190974 NCBI chr16:64,792,595...64,805,984 JBrowse link
G Fasn fatty acid synthase decreases expression ISO betulin results in decreased expression of FASN mRNA; betulin results in decreased expression of FASN protein CTD PMID:27378817 PMID:27447558 NCBI chr10:106,072,093...106,090,259 JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions ISO [betulin co-treated with Oxygen deficiency] affects the phosphorylation of GSK3B protein CTD PMID:33181113 NCBI chr11:62,498,997...62,648,665 JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha decreases expression
multiple interactions
ISO betulin analog results in decreased expression of HIF1A protein; betulin results in decreased expression of HIF1A protein
betulin analog inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein]
CTD PMID:26540049 PMID:33181113 NCBI chr 6:92,624,059...92,669,262 JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase decreases expression ISO betulin results in decreased expression of HMGCR mRNA; betulin results in decreased expression of HMGCR protein CTD PMID:27378817 PMID:27447558 NCBI chr 2:27,997,523...28,018,983 JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 decreases expression ISO betulin results in decreased expression of HMGCS1 mRNA CTD PMID:27378817 NCBI chr 2:51,649,368...51,667,100 JBrowse link
G Ifng interferon gamma increases secretion ISO betulin results in increased secretion of IFNG protein CTD PMID:25756279 NCBI chr 7:53,903,339...53,907,375 JBrowse link
G Il12a interleukin 12A multiple interactions
increases expression
ISO betulin results in increased secretion of [IL12A protein binds to IL12B protein]
betulin results in increased expression of IL12A mRNA
CTD PMID:25756279 NCBI chr 2:152,965,769...152,973,035 JBrowse link
G Il12b interleukin 12B multiple interactions ISO betulin results in increased secretion of [IL12A protein binds to IL12B protein] CTD PMID:25756279 NCBI chr10:28,888,832...28,903,796 JBrowse link
G Il2 interleukin 2 increases secretion ISO betulin results in increased secretion of IL2 protein CTD PMID:25756279 NCBI chr 2:120,004,862...120,009,566 JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation
ISO [betulin co-treated with Oxygen deficiency] results in increased phosphorylation of MAPK1 protein
betulin results in increased phosphorylation of MAPK1 protein
CTD PMID:33181113 NCBI chr11:83,957,813...84,023,629 JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation
multiple interactions
ISO betulin results in increased phosphorylation of MAPK3 protein
[betulin co-treated with Oxygen deficiency] results in increased phosphorylation of MAPK3 protein
CTD PMID:33181113 NCBI chr 1:181,366,646...181,372,863 JBrowse link
G Marveld1 MARVEL domain containing 1 decreases expression ISO betulin results in decreased expression of MARVELD1 mRNA CTD PMID:27447558 NCBI chr 1:240,954,452...240,958,384 JBrowse link
G Mki67 marker of proliferation Ki-67 multiple interactions ISO [Gefitinib co-treated with betulin] results in decreased expression of MKI67 protein CTD PMID:27447558 NCBI chr 1:190,496,319...190,522,983 JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions EXP betulin inhibits the reaction [Ethanol results in increased expression of MMP2 protein] CTD PMID:21172400 NCBI chr19:14,154,657...14,182,870 JBrowse link
G Mtor mechanistic target of rapamycin kinase decreases phosphorylation ISO betulin results in decreased phosphorylation of MTOR protein CTD PMID:32190974 NCBI chr 5:158,884,856...158,994,311 JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions ISO [betulin co-treated with Oxygen deficiency] results in decreased expression of MYC protein CTD PMID:33181113 NCBI chr 7:93,593,705...93,598,633 JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases cleavage
ISO [betulin co-treated with Oxygen] results in increased cleavage of PARP1 protein; betulin analog promotes the reaction [Oxygen deficiency results in increased expression of PARP1 protein modified form]; Chloroquine inhibits the reaction [betulin results in increased cleavage of PARP1 protein] CTD PMID:26540049 PMID:32190974 PMID:33181113 NCBI chr13:92,307,593...92,339,406 JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP betulin inhibits the reaction [Ethanol results in increased phosphorylation of RELA protein] CTD PMID:21172400 NCBI chr 1:202,925,001...202,935,484 JBrowse link
G Scd stearoyl-CoA desaturase decreases expression ISO betulin results in decreased expression of SCD mRNA; betulin results in decreased expression of SCD protein CTD PMID:27378817 PMID:27447558 NCBI chr 1:243,269,745...243,282,878 JBrowse link
G Smad3 SMAD family member 3 multiple interactions EXP betulin inhibits the reaction [Ethanol results in increased phosphorylation of SMAD3 protein] CTD PMID:21172400 NCBI chr 8:64,126,829...64,236,960 JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 decreases cleavage
multiple interactions
decreases expression
ISO betulin results in decreased cleavage of SREBF1 protein
[Gefitinib co-treated with betulin] results in decreased expression of SREBF1 protein; betulin affects the reaction [BRAF protein affects the reaction [Vemurafenib results in decreased cleavage of SREBF1 protein]]
betulin results in decreased expression of SREBF1 protein
CTD PMID:27447558 PMID:29950559 NCBI chr10:45,007,637...45,029,650 JBrowse link
G Sult2a1 sulfotransferase family 2A member 1 increases sulfation ISO SULT2A1 protein results in increased sulfation of betulin CTD PMID:30776358 NCBI chr 1:75,451,178...75,508,142 JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP betulin inhibits the reaction [Ethanol results in increased expression of TGFB1 protein] CTD PMID:21172400 NCBI chr 1:81,196,532...81,212,848 JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions EXP betulin inhibits the reaction [Ethanol results in increased expression of TIMP1 protein] CTD PMID:21172400 NCBI chr  X:1,212,969...1,217,714 JBrowse link
G Timp2 TIMP metallopeptidase inhibitor 2 multiple interactions EXP betulin inhibits the reaction [Ethanol results in increased expression of TIMP2 protein] CTD PMID:21172400 NCBI chr10:103,541,199...103,590,611 JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases glucuronidation ISO UGT1A3 protein results in increased glucuronidation of betulin CTD PMID:30776358 NCBI chr 9:88,791,216...88,808,465 JBrowse link
G Ugt1a5 UDP glucuronosyltransferase family 1 member A5 increases glucuronidation ISO UGT1A4 protein results in increased glucuronidation of betulin CTD PMID:30776358 NCBI chr 9:88,762,250...88,808,465 JBrowse link
betulinic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle multiple interactions EXP betulinic acid inhibits the reaction [Ethanol results in increased expression of ACTA2 protein]; betulinic acid inhibits the reaction [Thioacetamide results in increased expression of ACTA2] CTD PMID:21172400 PMID:22285267 NCBI chr 1:231,746,527...231,759,307 JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
increases phosphorylation
ISO 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [betulinic acid results in increased phosphorylation of AKT1 protein] CTD PMID:16077934 NCBI chr 6:131,713,716...131,735,319 JBrowse link
G Bak1 BCL2-antagonist/killer 1 increases expression
multiple interactions
ISO betulinic acid results in increased expression of BAK1 protein
[betulinic acid co-treated with Oxygen deficiency] results in increased expression of BAK1 protein
CTD PMID:33181113 NCBI chr20:5,100,480...5,109,669 JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO [2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine co-treated with betulinic acid analog] results in increased activity of BAX protein; CA 074 methyl ester inhibits the reaction [[2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine co-treated with betulinic acid analog] results in increased activity of BAX protein] CTD PMID:23000516 NCBI chr 1:95,940,001...95,945,407 JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions
ISO betulinic acid results in decreased expression of BCL2 protein
[betulinic acid co-treated with Oxygen deficiency] results in decreased expression of BCL2 protein
CTD PMID:30136359 PMID:33181113 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 increases expression
decreases expression
decreases response to substance
multiple interactions
ISO betulinic acid results in increased expression of BIRC5
betulinic acid results in decreased expression of BIRC5 protein
BIRC5 protein results in decreased susceptibility to betulinic acid
4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [betulinic acid results in increased expression of BIRC5]; betulinic acid promotes the reaction [Oxygen deficiency results in decreased expression of BIRC5 protein]; Erlotinib Hydrochloride inhibits the reaction [betulinic acid results in decreased expression of BIRC5 protein]
CTD PMID:16077934 PMID:26540049 PMID:30136359 NCBI chr10:103,072,530...103,081,382 JBrowse link
G Ca9 carbonic anhydrase 9 multiple interactions
decreases activity
ISO betulinic acid inhibits the reaction [Oxygen deficiency results in increased expression of CA9 protein]
betulinic acid analog results in decreased activity of CA9 protein
CTD PMID:26540049 PMID:29454615 NCBI chr 5:57,763,234...57,769,838 JBrowse link
G Casp3 caspase 3 increases cleavage
multiple interactions
increases activity
ISO betulinic acid analog results in increased cleavage of CASP3 protein; betulinic acid results in increased cleavage of CASP3 protein
betulinic acid inhibits the reaction [[Chloroquine co-treated with Bortezomib] results in increased cleavage of CASP3 protein]; betulinic acid inhibits the reaction [Bortezomib results in increased cleavage of CASP3 protein]
betulinic acid analog results in increased activity of CASP3 protein; betulinic acid results in increased activity of CASP3 protein
2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine promotes the reaction [betulinic acid analog results in increased cleavage of CASP3 protein]; betulinic acid inhibits the reaction [[Chloroquine co-treated with Bortezomib] results in increased cleavage of CASP3 protein]; betulinic acid inhibits the reaction [Bortezomib results in increased cleavage of CASP3 protein]; CA 074 methyl ester inhibits the reaction [2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine promotes the reaction [betulinic acid analog results in increased cleavage of CASP3 protein]]; VDAC1 protein inhibits the reaction [betulinic acid results in increased expression of CASP3 protein modified form]
CTD PMID:22260869 PMID:23000516 PMID:26772157 PMID:28578903 PMID:29454615 PMID:30136359 PMID:30482226 NCBI chr16:45,662,910...45,681,171 JBrowse link
G Casp7 caspase 7 increases activity
multiple interactions
ISO betulinic acid results in increased activity of CASP7 protein
VDAC1 protein inhibits the reaction [betulinic acid results in increased expression of CASP7 protein modified form]
CTD PMID:22260869 PMID:30136359 NCBI chr 1:255,437,195...255,476,737 JBrowse link
G Casp8 caspase 8 increases activity ISO betulinic acid results in increased activity of CASP8 protein CTD PMID:26772157 PMID:29454615 NCBI chr 9:60,263,863...60,312,542 JBrowse link
G Casp9 caspase 9 increases activity ISO betulinic acid analog results in increased activity of CASP9 protein; betulinic acid results in increased activity of CASP9 protein CTD PMID:26772157 PMID:29454615 NCBI chr 5:154,108,872...154,126,628 JBrowse link
G Ccnb1 cyclin B1 decreases expression ISO betulinic acid results in decreased expression of CCNB1 protein CTD PMID:33181113 NCBI chr 2:31,912,190...31,921,163 JBrowse link
G Ccnd1 cyclin D1 decreases expression
multiple interactions
ISO betulinic acid analog results in decreased expression of CCND1 protein; betulinic acid results in decreased expression of CCND1 protein
[betulinic acid co-treated with Oxygen deficiency] results in decreased expression of CCND1 protein
CTD PMID:28254521 PMID:33181113 NCBI chr 1:200,089,002...200,098,524 JBrowse link
G Cdk6 cyclin-dependent kinase 6 multiple interactions ISO betulinic acid promotes the reaction [Erlotinib Hydrochloride results in decreased expression of CDK6 protein]; betulinic acid promotes the reaction [Gefitinib results in decreased expression of CDK6 protein] CTD PMID:30136359 NCBI chr 4:30,637,650...30,829,688 JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO betulinic acid analog results in increased expression of CDKN1A protein CTD PMID:28254521 NCBI chr20:7,149,177...7,159,727 JBrowse link
G Cebpb CCAAT/enhancer binding protein beta multiple interactions
decreases expression
ISO betulinic acid inhibits the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of CEBPB protein alternative form]; betulinic acid inhibits the reaction [Bortezomib results in increased expression of CEBPB protein alternative form]
betulinic acid results in decreased expression of CEBPB protein modified form
CTD PMID:30482226 NCBI chr 3:156,398,035...156,399,466 JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions
decreases expression
ISO [betulinic acid co-treated with Erlotinib Hydrochloride] results in decreased expression of CTNNB1 protein; [betulinic acid co-treated with Oxygen deficiency] results in decreased expression of CTNNB1 protein
betulinic acid results in decreased expression of CTNNB1 protein
CTD PMID:30136359 PMID:33181113 NCBI chr 8:120,640,008...120,667,110 JBrowse link
G Ctsk cathepsin K multiple interactions ISO betulinic acid inhibits the reaction [TNFSF11 protein results in increased secretion of CTSK protein] CTD PMID:24463094 NCBI chr 2:183,058,586...183,069,551 JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions ISO betulinic acid inhibits the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of DDIT3 protein]; betulinic acid inhibits the reaction [Bortezomib results in increased expression of DDIT3 protein] CTD PMID:30482226 NCBI chr 7:63,115,645...63,121,203 JBrowse link
G Egfr epidermal growth factor receptor multiple interactions
increases phosphorylation
ISO 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [betulinic acid results in increased phosphorylation of EGFR protein]; betulinic acid promotes the reaction [Gefitinib results in decreased expression of EGFR protein modified form] CTD PMID:16077934 PMID:30136359 NCBI chr14:91,176,931...91,349,722 JBrowse link
G Gsk3b glycogen synthase kinase 3 beta increases phosphorylation
multiple interactions
ISO betulinic acid results in increased phosphorylation of GSK3B protein
[betulinic acid co-treated with Oxygen deficiency] results in increased phosphorylation of GSK3B protein
CTD PMID:33181113 NCBI chr11:62,498,997...62,648,665 JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha decreases expression
multiple interactions
ISO betulinic acid results in decreased expression of HIF1A protein
[betulinic acid co-treated with Oxygen deficiency] affects the expression of HIF1A protein
CTD PMID:26540049 PMID:33181113 NCBI chr 6:92,624,059...92,669,262 JBrowse link
G Hk2 hexokinase 2 multiple interactions ISO [VDAC1 protein results in decreased susceptibility to betulinic acid] which results in increased expression of HK2 protein CTD PMID:30136359 NCBI chr 4:115,234,509...115,283,530 JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions
increases expression
ISO Erlotinib Hydrochloride promotes the reaction [betulinic acid results in increased expression of MAP1LC3B protein modified form] CTD PMID:30136359 NCBI chr19:49,665,795...49,673,655 JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation
ISO 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [betulinic acid results in increased phosphorylation of MAPK1 protein]; [betulinic acid co-treated with Oxygen deficiency] results in increased phosphorylation of MAPK1 protein CTD PMID:16077934 PMID:33181113 NCBI chr11:83,957,813...84,023,629 JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation
ISO 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [betulinic acid results in increased phosphorylation of MAPK3 protein]; [betulinic acid co-treated with Oxygen deficiency] results in increased phosphorylation of MAPK3 protein CTD PMID:16077934 PMID:33181113 NCBI chr 1:181,366,646...181,372,863 JBrowse link
G Mir24-2 microRNA 24-2 affects response to substance
multiple interactions
ISO MIR24-2 mRNA affects the susceptibility to betulinic acid
MIR24-2 mRNA affects the susceptibility to [betulinic acid co-treated with gemcitabine]
CTD PMID:25841339 NCBI chr19:23,954,683...23,954,790 JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions EXP
ISO
betulinic acid inhibits the reaction [Ethanol results in increased expression of MMP2 protein]
betulinic acid affects the reaction [TGFB1 protein affects the expression of and affects the secretion of MMP2 protein]
betulinic acid inhibits the reaction [TNFSF11 protein results in increased secretion of MMP2 protein]
CTD PMID:21172400 PMID:24463094 PMID:28578903 NCBI chr19:14,154,657...14,182,870 JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO betulinic acid inhibits the reaction [TNFSF11 protein results in increased secretion of MMP9 protein] CTD PMID:24463094 NCBI chr 3:153,684,158...153,692,118 JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions ISO [betulinic acid co-treated with Oxygen deficiency] results in decreased expression of MYC protein CTD PMID:33181113 NCBI chr 7:93,593,705...93,598,633 JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions EXP betulinic acid inhibits the reaction [Ethanol results in increased phosphorylation of NFKBIA protein] CTD PMID:21172400 NCBI chr 6:72,858,713...72,861,941 JBrowse link
G Nos1 nitric oxide synthase 1 multiple interactions ISO betulinic acid inhibits the reaction [Bortezomib results in increased expression of NOS1 protein] CTD PMID:30482226 NCBI chr12:38,615,111...38,795,492 JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases expression
multiple interactions
increases cleavage
ISO betulinic acid results in increased expression of PARP1 protein modified form
[betulinic acid co-treated with Oxygen] results in increased cleavage of PARP1 protein; betulinic acid promotes the reaction [Gefitinib results in increased cleavage of PARP1 protein]
betulinic acid results in increased cleavage of PARP1 protein
CTD PMID:26540049 PMID:30136359 PMID:33181113 NCBI chr13:92,307,593...92,339,406 JBrowse link
G Pcna proliferating cell nuclear antigen decreases expression ISO betulinic acid analog results in decreased expression of PCNA protein CTD PMID:28254521 NCBI chr 3:119,499,039...119,502,911 JBrowse link
G Pla2g2a phospholipase A2 group IIA affects binding ISO betulinic acid binds to PLA2G2A protein CTD PMID:29391000 NCBI chr 5:151,076,442...151,079,019 JBrowse link
G Pthlh parathyroid hormone-like hormone multiple interactions
decreases response to substance
decreases expression
decreases secretion
ISO betulinic acid inhibits the reaction [PTHLH protein results in increased expression of TNFSF11 protein]
betulinic acid results in decreased susceptibility to PTHLH protein
betulinic acid results in decreased expression of PTHLH mRNA
betulinic acid results in decreased secretion of PTHLH protein
CTD PMID:24463094 NCBI chr 4:180,188,792...180,199,847 JBrowse link
G Rb1 RB transcriptional corepressor 1 multiple interactions
decreases expression
ISO betulinic acid promotes the reaction [Erlotinib Hydrochloride results in decreased expression of RB1 protein modified form]; betulinic acid promotes the reaction [Gefitinib results in decreased expression of RB1 protein modified form]; Erlotinib Hydrochloride promotes the reaction [betulinic acid results in decreased expression of RB1 protein modified form]; Gefitinib promotes the reaction [betulinic acid results in decreased expression of RB1 protein modified form] CTD PMID:30136359 NCBI chr15:48,371,295...48,502,473 JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP betulinic acid inhibits the reaction [Ethanol results in increased phosphorylation of RELA protein] CTD PMID:21172400 NCBI chr 1:202,925,001...202,935,484 JBrowse link
G Smad3 SMAD family member 3 multiple interactions EXP betulinic acid inhibits the reaction [Ethanol results in increased phosphorylation of SMAD3 protein] CTD PMID:21172400 NCBI chr 8:64,126,829...64,236,960 JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO [betulinic acid co-treated with Erlotinib Hydrochloride] results in decreased expression of STAT3 protein modified form CTD PMID:30136359 NCBI chr10:85,811,206...85,863,057 JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP
ISO
betulinic acid inhibits the reaction [Ethanol results in increased expression of TGFB1 protein]
betulinic acid affects the reaction [TGFB1 protein affects the expression of and affects the secretion of MMP2 protein]
CTD PMID:21172400 PMID:28578903 NCBI chr 1:81,196,532...81,212,848 JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions EXP betulinic acid inhibits the reaction [Ethanol results in increased expression of TIMP1 protein] CTD PMID:21172400 NCBI chr  X:1,212,969...1,217,714 JBrowse link
G Timp2 TIMP metallopeptidase inhibitor 2 multiple interactions EXP betulinic acid inhibits the reaction [Ethanol results in increased expression of TIMP2 protein] CTD PMID:21172400 NCBI chr10:103,541,199...103,590,611 JBrowse link
G Tnfsf11 TNF superfamily member 11 multiple interactions
decreases response to substance
ISO betulinic acid inhibits the reaction [PTHLH protein results in increased expression of TNFSF11 protein]
betulinic acid results in decreased susceptibility to TNFSF11 protein
betulinic acid inhibits the reaction [TNFSF11 protein results in increased secretion of CTSK protein]; betulinic acid inhibits the reaction [TNFSF11 protein results in increased secretion of MMP2 protein]; betulinic acid inhibits the reaction [TNFSF11 protein results in increased secretion of MMP9 protein]
CTD PMID:24463094 NCBI chr15:53,674,990...53,705,171 JBrowse link
G Top1 DNA topoisomerase I decreases activity ISO betulinic acid results in decreased activity of TOP1 protein CTD PMID:10860928 NCBI chr 3:149,293,658...149,375,405 JBrowse link
G Top2a DNA topoisomerase II alpha decreases activity ISO betulinic acid results in decreased activity of TOP2A protein CTD PMID:10860928 NCBI chr10:83,946,186...83,975,694 JBrowse link
G Tp53 tumor protein p53 increases expression
multiple interactions
ISO betulinic acid results in increased expression of TP53 protein
[betulinic acid co-treated with Oxygen deficiency] results in increased expression of TP53 protein
CTD PMID:33181113 NCBI chr10:54,300,070...54,311,525 JBrowse link
G Trib3 tribbles pseudokinase 3 multiple interactions ISO betulinic acid inhibits the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of TRIB3 protein]; betulinic acid inhibits the reaction [Bortezomib results in increased expression of TRIB3 protein] CTD PMID:30482226 NCBI chr 3:140,809,634...140,815,230 JBrowse link
G Tyms thymidylate synthetase decreases expression
multiple interactions
ISO betulinic acid results in decreased expression of TYMS protein
betulinic acid promotes the reaction [Erlotinib Hydrochloride results in decreased expression of TYMS protein]; betulinic acid promotes the reaction [Gefitinib results in decreased expression of TYMS protein]; Erlotinib Hydrochloride promotes the reaction [betulinic acid results in decreased expression of TYMS protein]; Gefitinib promotes the reaction [betulinic acid results in decreased expression of TYMS protein]
CTD PMID:30136359 NCBI chr 9:113,313,454...113,329,551 JBrowse link
G Vdac1 voltage-dependent anion channel 1 decreases response to substance
multiple interactions
increases expression
ISO VDAC1 protein results in decreased susceptibility to betulinic acid
[VDAC1 protein results in decreased susceptibility to betulinic acid] which results in increased expression of HK2 protein; VDAC1 protein inhibits the reaction [betulinic acid results in increased expression of CASP3 protein modified form]; VDAC1 protein inhibits the reaction [betulinic acid results in increased expression of CASP7 protein modified form]
betulinic acid results in increased expression of VDAC1 protein
CTD PMID:30136359 NCBI chr10:36,532,306...36,559,642 JBrowse link
Brusatol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bak1 BCL2-antagonist/killer 1 increases expression ISO brusatol results in increased expression of BAK1 protein CTD PMID:33465425 NCBI chr20:5,100,480...5,109,669 JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO brusatol results in increased expression of BAX protein CTD PMID:33465425 NCBI chr 1:95,940,001...95,945,407 JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO brusatol results in decreased expression of BCL2 protein CTD PMID:33465425 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression ISO brusatol results in decreased expression of BCL2L1 protein CTD PMID:33465425 NCBI chr 3:141,253,508...141,304,582 JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage
ISO brusatol promotes the reaction [T-2 Toxin results in increased activity of CASP3 protein]
brusatol results in increased cleavage of CASP3 protein
CTD PMID:29432840 PMID:33465425 NCBI chr16:45,662,910...45,681,171 JBrowse link
G Casp8 caspase 8 increases cleavage ISO brusatol results in increased cleavage of CASP8 protein CTD PMID:33465425 NCBI chr 9:60,263,863...60,312,542 JBrowse link
G Casp9 caspase 9 multiple interactions ISO brusatol promotes the reaction [T-2 Toxin results in increased activity of CASP9 protein] CTD PMID:29432840 NCBI chr 5:154,108,872...154,126,628 JBrowse link
G Cat catalase multiple interactions ISO brusatol inhibits the reaction [Saponins inhibits the reaction [Hydrogen Peroxide results in decreased expression of CAT mRNA]] CTD PMID:29274434 NCBI chr 3:89,842,393...89,874,577 JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit decreases expression ISO brusatol results in decreased expression of GCLC protein CTD PMID:27639429 NCBI chr 8:78,629,899...78,668,547 JBrowse link
G Hmox1 heme oxygenase 1 decreases expression
multiple interactions
ISO brusatol results in decreased expression of HMOX1 protein
brusatol inhibits the reaction [2-tert-butylhydroquinone results in increased expression of HMOX1 protein]
CTD PMID:33465425 NCBI chr19:13,466,287...13,474,082 JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO brusatol inhibits the reaction [Saponins inhibits the reaction [Hydrogen Peroxide results in increased expression of IL1B mRNA]] CTD PMID:29274434 NCBI chr 3:116,577,005...116,583,386 JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 multiple interactions ISO [KEAP1 protein results in decreased expression of NFE2L2 protein] which results in decreased susceptibility to brusatol; brusatol inhibits the reaction [KEAP1 gene mutant form results in increased expression of NFE2L2 protein]; brusatol inhibits the reaction [KEAP1 gene mutant form results in increased expression of SOX9 protein] CTD PMID:21205897 PMID:32682831 NCBI chr 8:19,768,375...19,777,862 JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions
decreases expression
ISO [brusatol results in increased ubiquitination of and results in increased degradation of NFE2L2 protein] which results in increased susceptibility to Cisplatin; [KEAP1 protein results in decreased expression of NFE2L2 protein] which results in decreased susceptibility to brusatol; brusatol inhibits the reaction [2-tert-butylhydroquinone results in increased expression of NFE2L2 protein]; brusatol inhibits the reaction [KEAP1 gene mutant form results in increased expression of NFE2L2 protein]; brusatol inhibits the reaction [Saponins inhibits the reaction [Hydrogen Peroxide results in decreased expression of NFE2L2 protein]]; brusatol results in increased ubiquitination of and results in increased degradation of NFE2L2 protein
brusatol results in decreased expression of NFE2L2 protein
CTD PMID:21205897 PMID:27639429 PMID:29274434 PMID:32682831 PMID:33465425 NCBI chr 3:60,594,239...60,621,785 JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO brusatol results in increased cleavage of PARP1 protein CTD PMID:33465425 NCBI chr13:92,307,593...92,339,406 JBrowse link
G Sesn1 sestrin 1 multiple interactions ISO brusatol inhibits the reaction [Saponins inhibits the reaction [Hydrogen Peroxide results in decreased expression of SESN1 mRNA]] CTD PMID:29274434 NCBI chr20:45,294,876...45,387,698 JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions ISO brusatol inhibits the reaction [Saponins inhibits the reaction [Hydrogen Peroxide results in decreased expression of SOD1 mRNA]] CTD PMID:29274434 NCBI chr11:29,456,673...29,462,249 JBrowse link
G Sox9 SRY-box transcription factor 9 multiple interactions
decreases expression
ISO brusatol inhibits the reaction [KEAP1 gene mutant form results in increased expression of SOX9 protein]
brusatol results in decreased expression of SOX9 mRNA
CTD PMID:32682831 NCBI chr10:97,806,485...97,811,994 JBrowse link
G Xiap X-linked inhibitor of apoptosis decreases expression ISO brusatol results in decreased expression of XIAP protein CTD PMID:33465425 NCBI chr  X:120,890,537...120,938,413 JBrowse link
CARBENOXOLONE term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 affects expression ISO Carbenoxolone affects the expression of AKT1 mRNA CTD PMID:23678415 NCBI chr 6:131,713,716...131,735,319 JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP [[lead acetate results in increased abundance of Lead] which co-treated with Carbenoxolone] results in increased expression of BAX protein CTD PMID:33242459 NCBI chr 1:95,940,001...95,945,407 JBrowse link
G Bcl2 BCL2, apoptosis regulator affects expression
multiple interactions
ISO
EXP
Carbenoxolone affects the expression of BCL2 mRNA
[[lead acetate results in increased abundance of Lead] which co-treated with Carbenoxolone] results in decreased expression of BCL2 protein
CTD PMID:23678415 PMID:33242459 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Casp3 caspase 3 multiple interactions EXP Carbenoxolone promotes the reaction [[lead acetate results in increased abundance of Lead] which results in increased cleavage of CASP3 protein] CTD PMID:33242459 NCBI chr16:45,662,910...45,681,171 JBrowse link
G Casp9 caspase 9 multiple interactions EXP Carbenoxolone promotes the reaction [[lead acetate results in increased abundance of Lead] which results in increased cleavage of CASP9 protein] CTD PMID:33242459 NCBI chr 5:154,108,872...154,126,628 JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO Carbenoxolone inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA] CTD PMID:27523796 NCBI chr10:67,005,424...67,007,222 JBrowse link
G Cycs cytochrome c, somatic affects expression ISO Carbenoxolone affects the expression of CYCS mRNA CTD PMID:23678415 NCBI chr 4:79,651,894...79,653,994 JBrowse link
G Dhrs11 dehydrogenase/reductase 11 decreases activity ISO Carbenoxolone results in decreased activity of DHRS11 protein CTD PMID:30926317 NCBI chr10:69,698,214...69,708,294 JBrowse link
G Gja1 gap junction protein, alpha 1 multiple interactions EXP GJA1 protein inhibits the reaction [Carbenoxolone results in decreased uptake of lead acetate] CTD PMID:26926986 NCBI chr20:35,756,007...35,768,481 JBrowse link
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 decreases activity
multiple interactions
ISO
EXP
Carbenoxolone results in decreased activity of HSD11B1 protein
Carbenoxolone inhibits the reaction [Lipopolysaccharides results in increased expression of HSD11B1 mRNA]
CTD PMID:23814014 PMID:24135201 PMID:27523796 NCBI chr13:104,728,539...104,798,884 JBrowse link
G Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 decreases activity ISO
EXP
Carbenoxolone results in decreased activity of HSD11B2 protein CTD PMID:16857225 PMID:23814014 PMID:24135201 NCBI chr19:33,397,656...33,402,899 JBrowse link
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 multiple interactions ISO [Carbenoxolone co-treated with NADP] binds to HSD3B1 protein CTD PMID:25526675 NCBI chr 2:186,169,864...186,175,984 JBrowse link
G Il6 interleukin 6 multiple interactions ISO Carbenoxolone inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA] CTD PMID:27523796 NCBI chr 4:5,214,602...5,219,178 JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO Carbenoxolone inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein] CTD PMID:27523796 NCBI chr11:83,957,813...84,023,629 JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO Carbenoxolone inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein] CTD PMID:27523796 NCBI chr 1:181,366,646...181,372,863 JBrowse link
G Mpo myeloperoxidase multiple interactions ISO Carbenoxolone inhibits the reaction [[Ethanol co-treated with Hydrochloric Acid] results in increased activity of MPO protein]; Carbenoxolone inhibits the reaction [[Ethanol co-treated with Hydrochloric Acid] results in increased expression of MPO protein] CTD PMID:32006539 PMID:32531310 NCBI chr10:72,594,458...72,608,862 JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO Carbenoxolone inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] CTD PMID:27523796 NCBI chr10:63,815,308...63,851,208 JBrowse link
G Panx1 Pannexin 1 multiple interactions
decreases activity
ISO Carbenoxolone inhibits the reaction [PANX1 protein results in increased export of Adenosine Triphosphate]
Carbenoxolone results in decreased activity of PANX1 protein
CTD PMID:19023039 PMID:19213873 NCBI chr 8:11,851,176...11,889,774 JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Carbenoxolone inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein] CTD PMID:27523796 NCBI chr 1:202,925,001...202,935,484 JBrowse link
G Sgk1 serum/glucocorticoid regulated kinase 1 multiple interactions
decreases activity
EXP Carbenoxolone inhibits the reaction [11-dehydrocorticosterone results in increased expression of SGK1 mRNA]
Carbenoxolone results in decreased activity of SGK1 protein
CTD PMID:16533503 NCBI chr 1:22,980,257...23,098,122 JBrowse link
G Slc2a4 solute carrier family 2 member 4 multiple interactions EXP Carbenoxolone affects the reaction [Sodium Glutamate affects the expression of SLC2A4 mRNA]; Carbenoxolone affects the reaction [Sodium Glutamate affects the expression of SLC2A4 protein] CTD PMID:31077719 NCBI chr10:54,666,015...54,671,581 JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions
affects activity
EXP Carbenoxolone affects the reaction [Sodium Glutamate affects the expression of SREBF1 mRNA]
Carbenoxolone affects the activity of SREBF1 protein
CTD PMID:31077719 NCBI chr10:45,007,637...45,029,650 JBrowse link
G Stat1 signal transducer and activator of transcription 1 affects expression ISO Carbenoxolone affects the expression of STAT1 mRNA CTD PMID:23678415 NCBI chr 9:49,419,561...49,459,969 JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Carbenoxolone inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA] CTD PMID:27523796 NCBI chr20:3,622,011...3,624,629 JBrowse link
G Tp53 tumor protein p53 affects expression ISO Carbenoxolone affects the expression of TP53 mRNA CTD PMID:23678415 NCBI chr10:54,300,070...54,311,525 JBrowse link
G Ube2i ubiquitin-conjugating enzyme E2I multiple interactions EXP Carbenoxolone inhibits the reaction [Sodium Glutamate results in decreased expression of UBE2I protein] CTD PMID:31077719 NCBI chr10:14,277,749...14,294,681 JBrowse link
celastrol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle multiple interactions ISO celastrol inhibits the reaction [Bleomycin results in increased expression of ACTA2 protein]; celastrol inhibits the reaction [Folic Acid results in increased expression of ACTA2 protein]; SR 144528 inhibits the reaction [celastrol inhibits the reaction [Folic Acid results in increased expression of ACTA2 protein]]
celastrol inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]
CTD PMID:29789558 PMID:31901889 NCBI chr 1:231,746,527...231,759,307 JBrowse link
G Adgre1 adhesion G protein-coupled receptor E1 multiple interactions ISO [celastrol co-treated with coomassie Brilliant Blue] inhibits the reaction [Acetaminophen results in increased expression of ADGRE1 protein]; celastrol inhibits the reaction [Acetaminophen results in increased expression of ADGRE1 protein] CTD PMID:28435131 NCBI chr 9:2,242,476...2,398,000 JBrowse link
G Ahsa1 activator of Hsp90 ATPase activity 1 increases expression ISO celastrol results in increased expression of AHSA1 mRNA CTD PMID:17010675 NCBI chr 6:106,913,296...106,921,347 JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 increases expression ISO celastrol results in increased expression of AKR1C2 mRNA CTD PMID:17010675 NCBI chr17:65,759,778...65,808,013 JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation
multiple interactions
increases phosphorylation
ISO
EXP
celastrol results in decreased phosphorylation of AKT1 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [celastrol results in decreased phosphorylation of AKT1 protein]
celastrol results in increased phosphorylation of AKT1 protein
celastrol inhibits the reaction [Cadmium Chloride results in increased phosphorylation of AKT1 protein]; PTEN protein promotes the reaction [celastrol inhibits the reaction [Cadmium Chloride results in increased phosphorylation of AKT1 protein]]
CTD PMID:21466843 PMID:24111524 PMID:25903958 PMID:31715269 NCBI chr 6:131,713,716...131,735,319 JBrowse link
G Apc APC regulator of WNT signaling pathway multiple interactions ISO celastrol affects the reaction [APC protein mutant form affects the expression of CCND1 mRNA]; celastrol affects the reaction [APC protein mutant form affects the expression of CCND1 protein]; celastrol affects the reaction [APC protein mutant form affects the expression of CTNNB1 protein]; celastrol affects the reaction [APC protein mutant form affects the expression of MYC mRNA]; celastrol affects the reaction [APC protein mutant form affects the expression of MYC protein]; celastrol affects the reaction [APC protein mutant form affects the phosphorylation of GSK3B protein] CTD PMID:31715269 NCBI chr18:25,828,558...25,925,511 JBrowse link
G Ar androgen receptor multiple interactions
decreases expression
increases degradation
ISO calpain inhibitor 2 inhibits the reaction [celastrol results in increased degradation of AR protein]; CAST inhibits the reaction [celastrol results in increased degradation of AR protein]
celastrol results in decreased expression of AR protein
CTD PMID:17010675 PMID:18726991 NCBI chr  X:63,104,771...63,273,934 JBrowse link
G Arid5b AT-rich interaction domain 5B decreases expression ISO celastrol results in decreased expression of ARID5B mRNA CTD PMID:17010675 NCBI chr20:20,307,731...20,490,746 JBrowse link
G Arrb2 arrestin, beta 2 multiple interactions ISO [celastrol co-treated with CNR2 protein] affects the localization of ARRB2 protein CTD PMID:31901889 NCBI chr10:55,146,887...55,154,854 JBrowse link
G Atf3 activating transcription factor 3 increases expression ISO celastrol results in increased expression of ATF3 mRNA CTD PMID:17010675 NCBI chr13:102,751,278...102,800,520 JBrowse link
G Axin2 axin 2 multiple interactions ISO celastrol inhibits the reaction [[Dextran Sulfate co-treated with Azoxymethane] results in increased expression of AXIN2 mRNA]; celastrol inhibits the reaction [[Dextran Sulfate co-treated with Azoxymethane] results in increased expression of AXIN2 protein] CTD PMID:31715269 NCBI chr10:93,893,830...93,927,042 JBrowse link
G Bag3 BAG cochaperone 3 increases expression ISO celastrol results in increased expression of BAG3 mRNA CTD PMID:17010675 NCBI chr 1:183,103,038...183,126,862 JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions
ISO celastrol results in increased expression of BAX mRNA; celastrol results in increased expression of BAX protein
Uridine inhibits the reaction [celastrol results in increased expression of BAX protein]
[celastrol co-treated with coomassie Brilliant Blue] inhibits the reaction [Acetaminophen results in increased expression of BAX protein]; celastrol inhibits the reaction [Acetaminophen results in increased expression of BAX protein]; celastrol inhibits the reaction [Plant Preparations results in increased expression of BAX mRNA]; celastrol inhibits the reaction [Plant Preparations results in increased expression of BAX protein]
CTD PMID:21466843 PMID:27374097 PMID:28435131 PMID:29643811 NCBI chr 1:95,940,001...95,945,407 JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions
increases expression
ISO celastrol results in decreased expression of BCL2 protein
celastrol inhibits the reaction [Plant Preparations results in decreased expression of BCL2 protein]
celastrol results in increased expression of BCL2 mRNA
CTD PMID:21466843 PMID:29643811 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Becn1 beclin 1 increases expression EXP celastrol results in increased expression of BECN1 protein CTD PMID:32470352 NCBI chr10:86,231,387...86,246,742 JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 decreases expression ISO celastrol results in decreased expression of BIRC5 mRNA CTD PMID:17010675 NCBI chr10:103,072,530...103,081,382 JBrowse link
G Btg1 BTG anti-proliferation factor 1 decreases expression ISO celastrol results in decreased expression of BTG1 mRNA CTD PMID:17010675 NCBI chr 7:31,341,391...31,343,649 JBrowse link
G Cacybp calcyclin binding protein increases expression ISO celastrol results in increased expression of CACYBP mRNA CTD PMID:17010675 NCBI chr13:72,437,485...72,447,810 JBrowse link
G Casp1 caspase 1 multiple interactions EXP celastrol inhibits the reaction [Dextran Sulfate results in increased expression of CASP1 protein]; MCC-950 promotes the reaction [celastrol inhibits the reaction [Dextran Sulfate results in increased expression of CASP1 protein]] CTD PMID:32470352 NCBI chr 8:2,587,812...2,597,403 JBrowse link
G Casp3 caspase 3 increases cleavage
multiple interactions
increases expression
ISO
EXP
celastrol results in increased cleavage of CASP3 protein
celastrol inhibits the reaction [Plant Preparations results in increased expression of CASP3 mRNA]; celastrol inhibits the reaction [Plant Preparations results in increased expression of CASP3 protein]
celastrol results in increased expression of CASP3 mRNA
celastrol inhibits the reaction [Cadmium Chloride results in increased cleavage of CASP3 protein]; JUN mutant form promotes the reaction [celastrol inhibits the reaction [Cadmium Chloride results in increased cleavage of CASP3 protein]]; PTEN protein promotes the reaction [celastrol inhibits the reaction [Cadmium Chloride results in increased cleavage of CASP3 protein]]; pyrazolanthrone promotes the reaction [celastrol inhibits the reaction [Cadmium Chloride results in increased cleavage of CASP3 protein]]
[TNFSF10 protein co-treated with celastrol] results in increased cleavage of CASP3 protein; Uridine inhibits the reaction [celastrol results in increased cleavage of CASP3 protein]
CTD PMID:20605676 PMID:21466843 PMID:24111524 PMID:27374097 PMID:29643811 NCBI chr16:45,662,910...45,681,171 JBrowse link
G Casp8 caspase 8 increases cleavage
decreases expression
ISO celastrol results in increased cleavage of CASP8 protein
celastrol results in decreased expression of CASP8 mRNA
CTD PMID:21466843 PMID:27374097 NCBI chr 9:60,263,863...60,312,542 JBrowse link
G Casp9 caspase 9 increases cleavage
increases expression
multiple interactions
ISO celastrol results in increased cleavage of CASP9 protein
celastrol results in increased expression of CASP9 mRNA
Uridine inhibits the reaction [celastrol results in increased cleavage of CASP9 protein]
CTD PMID:21466843 PMID:27374097 NCBI chr 5:154,108,872...154,126,628 JBrowse link
G Cast calpastatin multiple interactions ISO CAST inhibits the reaction [celastrol results in increased degradation of AR protein] CTD PMID:18726991 NCBI chr 2:3,973,112...4,082,658 JBrowse link
G Cat catalase multiple interactions EXP celastrol inhibits the reaction [Bleomycin results in decreased activity of CAT protein] CTD PMID:26768587 NCBI chr 3:89,842,393...89,874,577 JBrowse link
G Cbr3 carbonyl reductase 3 increases expression ISO celastrol results in increased expression of CBR3 mRNA CTD PMID:17010675 NCBI chr11:33,008,615...33,016,877 JBrowse link
G Ccl3 C-C motif chemokine ligand 3 increases expression ISO celastrol results in increased expression of CCL3 mRNA CTD PMID:25477506 NCBI chr10:68,451,388...68,452,938 JBrowse link
G Ccnd1 cyclin D1 multiple interactions
decreases expression
ISO celastrol affects the reaction [APC protein mutant form affects the expression of CCND1 mRNA]; celastrol affects the reaction [APC protein mutant form affects the expression of CCND1 protein]; celastrol inhibits the reaction [[Dextran Sulfate co-treated with Azoxymethane] results in increased expression of CCND1 mRNA]; celastrol inhibits the reaction [[Dextran Sulfate co-treated with Azoxymethane] results in increased expression of CCND1 protein]
celastrol results in decreased expression of CCND1 mRNA; celastrol results in decreased expression of CCND1 protein
CTD PMID:31715269 NCBI chr 1:200,089,002...200,098,524 JBrowse link
G Cda cytidine deaminase increases expression ISO celastrol results in increased expression of CDA mRNA CTD PMID:27374097 NCBI chr 5:150,556,615...150,583,231 JBrowse link
G Cdc7 cell division cycle 7 decreases expression ISO celastrol results in decreased expression of CDC7 mRNA CTD PMID:17010675 NCBI chr14:2,804,660...2,824,796 JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases expression ISO celastrol results in decreased expression of CDK2 mRNA CTD PMID:17010675 NCBI chr 7:1,129,878...1,137,431 JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha affects expression ISO celastrol affects the expression of CEBPA mRNA; celastrol affects the expression of CEBPA protein CTD PMID:27085773 NCBI chr 1:87,759,631...87,762,303 JBrowse link
G Chordc1 cysteine and histidine rich domain containing 1 increases expression ISO celastrol results in increased expression of CHORDC1 mRNA CTD PMID:17010675 NCBI chr 8:15,374,356...15,398,436 JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex multiple interactions EXP celastrol inhibits the reaction [Doxorubicin results in increased phosphorylation of CHUK protein] CTD PMID:30588110 NCBI chr 1:242,959,539...242,995,066 JBrowse link
G Cited2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 decreases expression ISO celastrol results in decreased expression of CITED2 mRNA CTD PMID:17010675 NCBI chr 1:12,312,426...12,314,869 JBrowse link
G Ckb creatine kinase B multiple interactions EXP celastrol inhibits the reaction [Doxorubicin results in increased secretion of [CKM protein binds to CKB protein]] CTD PMID:30588110 NCBI chr 6:130,729,420...130,732,301 JBrowse link
G Ckm creatine kinase, M-type multiple interactions EXP celastrol inhibits the reaction [Doxorubicin results in increased secretion of [CKM protein binds to CKB protein]] CTD PMID:30588110 NCBI chr 1:79,061,390...79,071,721 JBrowse link
G Cnr2 cannabinoid receptor 2 multiple interactions ISO [celastrol co-treated with CNR2 protein] affects the localization of ARRB2 protein; celastrol inhibits the reaction [TGFB1 protein results in decreased expression of CNR2 protein]
6,7-dimethyl-2-(2E)-3-(1-methyl-2-phenyl-1H-pyrrolo(2,3-b)pyridin-3-yl-prop-2-enoyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride inhibits the reaction [celastrol inhibits the reaction [Folic Acid results in decreased expression of CNR2 protein]]; celastrol inhibits the reaction [Folic Acid results in decreased expression of CNR2 protein]
CTD PMID:29789558 PMID:31901889 NCBI chr 5:148,125,222...148,151,548 JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions EXP celastrol inhibits the reaction [Doxorubicin results in increased expression of COL1A1 mRNA] CTD PMID:30588110 NCBI chr10:79,883,622...79,900,625 JBrowse link
G Cryab crystallin, alpha B increases expression ISO celastrol results in increased expression of CRYAB mRNA CTD PMID:25477506 NCBI chr 8:51,093,441...51,099,161 JBrowse link
G Ctnnb1 catenin beta 1 decreases expression
multiple interactions
ISO celastrol results in decreased expression of CTNNB1 protein
celastrol affects the reaction [APC protein mutant form affects the expression of CTNNB1 protein]; celastrol inhibits the reaction [[Dextran Sulfate co-treated with Azoxymethane] results in increased expression of CTNNB1 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [celastrol results in decreased expression of CTNNB1 protein]; Chir 99021 inhibits the reaction [celastrol results in decreased expression of CTNNB1 protein]; GSK3B protein affects the reaction [celastrol results in decreased expression of CTNNB1 protein]; Lithium Chloride inhibits the reaction [celastrol results in decreased expression of CTNNB1 protein]; SB 216763 inhibits the reaction [celastrol results in decreased expression of CTNNB1 protein]
CTD PMID:31715269 NCBI chr 8:120,640,008...120,667,110 JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 increases expression
multiple interactions
ISO celastrol results in increased expression of CXCL10 mRNA
celastrol inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL10 mRNA]
CTD PMID:25477506 PMID:31901889 NCBI chr14:15,704,772...15,706,969 JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases expression ISO celastrol results in decreased expression of CYP1A1 mRNA CTD PMID:17010675 NCBI chr 8:58,096,021...58,102,130 JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO celastrol results in increased expression of DDIT3 mRNA CTD PMID:17010675 NCBI chr 7:63,115,645...63,121,203 JBrowse link
G Ddit4 DNA-damage-inducible transcript 4 increases expression ISO celastrol results in increased expression of DDIT4 mRNA CTD PMID:17010675 NCBI chr20:27,891,989...27,894,088 JBrowse link
G Dhodh dihydroorotate dehydrogenase (quinone) decreases expression ISO celastrol results in decreased expression of DHODH mRNA; celastrol results in decreased expression of DHODH protein CTD PMID:27374097 NCBI chr19:37,551,858...37,573,327 JBrowse link
G Dkk2 dickkopf WNT signaling pathway inhibitor 2 multiple interactions ISO celastrol inhibits the reaction [[Dextran Sulfate co-treated with Azoxymethane] results in increased expression of DKK2 mRNA] CTD PMID:31715269 NCBI chr 2:220,568,338...220,660,225 JBrowse link
G Dnaja1 DnaJ heat shock protein family (Hsp40) member A1 increases expression ISO celastrol results in increased expression of DNAJA1 mRNA CTD PMID:17010675 NCBI chr 5:55,842,414...55,853,326 JBrowse link
G Dnajb4 DnaJ heat shock protein family (Hsp40) member B4 increases expression ISO celastrol results in increased expression of DNAJB4 mRNA CTD PMID:17010675 NCBI chr 2:241,129,346...241,159,272 JBrowse link
G Efnb2 ephrin B2 decreases expression ISO celastrol results in decreased expression of EFNB2 mRNA CTD PMID:17010675 NCBI chr16:80,783,389...80,827,420 JBrowse link
G Egfr epidermal growth factor receptor multiple interactions
decreases expression
ISO [Sulfasalazine co-treated with celastrol] affects the expression of EGFR protein; [Sulfasalazine co-treated with celastrol] results in decreased expression of EGFR protein
celastrol results in decreased expression of EGFR protein
CTD PMID:17010675 PMID:20007406 NCBI chr14:91,176,931...91,349,722 JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 multiple interactions EXP celastrol inhibits the reaction [Cadmium Chloride results in increased phosphorylation of EIF4EBP1 protein] CTD PMID:24111524 NCBI chr16:64,792,595...64,805,984 JBrowse link
G Fabp4 fatty acid binding protein 4 affects expression ISO celastrol affects the expression of FABP4 mRNA CTD PMID:27085773 NCBI chr 2:91,580,858...91,585,578 JBrowse link
G Fas Fas cell surface death receptor increases expression ISO celastrol results in increased expression of FAS protein CTD PMID:21466843 NCBI chr 1:231,798,963...231,832,591 JBrowse link
G Faslg Fas ligand increases expression ISO celastrol results in increased expression of FASLG protein CTD PMID:21466843 NCBI chr13:74,151,519...74,172,760 JBrowse link
G Fbxo32 F-box protein 32 multiple interactions
decreases expression
EXP HSPA1A protein affects the reaction [celastrol results in decreased expression of FBXO32 protein] CTD PMID:25903958 NCBI chr 7:89,731,626...89,764,761 JBrowse link
G Ficd FIC domain protein adenylyltransferase increases expression ISO celastrol results in increased expression of FICD mRNA CTD PMID:17010675 NCBI chr12:42,889,195...42,894,090 JBrowse link
G Flt3 Fms related receptor tyrosine kinase 3 decreases expression ISO celastrol results in decreased expression of FLT3 protein CTD PMID:17010675 NCBI chr12:7,623,658...7,699,474 JBrowse link
G Fn1 fibronectin 1 multiple interactions ISO
EXP
celastrol inhibits the reaction [TGFB1 protein results in increased expression of FN1 protein]
celastrol inhibits the reaction [Doxorubicin results in increased expression of FN1 mRNA]
celastrol inhibits the reaction [Folic Acid results in increased expression of FN1 protein]; SR 144528 inhibits the reaction [celastrol inhibits the reaction [Folic Acid results in increased expression of FN1 protein]]
CTD PMID:29789558 PMID:30588110 NCBI chr 9:73,196,044...73,264,695 JBrowse link
G Foxo3 forkhead box O3 increases phosphorylation EXP celastrol results in increased phosphorylation of FOXO3 protein CTD PMID:25903958 NCBI chr20:45,669,708...45,764,606 JBrowse link
G Gatd3a glutamine amidotransferase class 1 domain containing 3A decreases expression ISO celastrol results in decreased expression of GATD3 mRNA CTD PMID:17010675 NCBI chr20:10,514,793...10,522,894 JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions EXP celastrol inhibits the reaction [Doxorubicin results in decreased expression of GCLC mRNA]; celastrol inhibits the reaction [Doxorubicin results in decreased expression of GCLC protein] CTD PMID:30588110 NCBI chr 8:78,629,899...78,668,547 JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression
multiple interactions
ISO
EXP
celastrol results in increased expression of GCLM mRNA
celastrol inhibits the reaction [Doxorubicin results in decreased expression of GCLM mRNA]
CTD PMID:17010675 PMID:30588110 NCBI chr 2:210,347,482...210,367,537 JBrowse link
G Gdf15 growth differentiation factor 15 increases expression ISO celastrol results in increased expression of GDF15 mRNA CTD PMID:17010675 NCBI chr16:18,805,312...18,807,893 JBrowse link
G Gpd1 glycerol-3-phosphate dehydrogenase 1 affects activity ISO celastrol affects the activity of GPD1 protein CTD PMID:27085773 NCBI chr 7:130,842,526...130,851,530 JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO [coomassie Brilliant Blue co-treated with celastrol] inhibits the reaction [Acetaminophen results in increased activity of GPT protein]; celastrol inhibits the reaction [Acetaminophen results in increased activity of GPT protein] CTD PMID:28435131 NCBI chr 7:108,416,646...108,419,495 JBrowse link
G Gsk3b glycogen synthase kinase 3 beta decreases phosphorylation
multiple interactions
ISO celastrol results in decreased phosphorylation of GSK3B protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [celastrol results in decreased phosphorylation of GSK3B protein]; GSK3B protein affects the reaction [celastrol results in decreased expression of CTNNB1 protein]; Lithium Chloride inhibits the reaction [celastrol results in decreased phosphorylation of GSK3B protein]
celastrol affects the reaction [APC protein mutant form affects the phosphorylation of GSK3B protein]
CTD PMID:31715269 NCBI chr11:62,498,997...62,648,665 JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions EXP celastrol inhibits the reaction [Bleomycin results in decreased activity of GSR protein] CTD PMID:26768587 NCBI chr16:58,482,209...58,525,256 JBrowse link
G Gtpbp2 GTP binding protein 2 increases expression ISO celastrol results in increased expression of GTPBP2 mRNA CTD PMID:17010675 NCBI chr 9:14,813,964...14,823,419 JBrowse link
G Hilpda hypoxia inducible lipid droplet-associated decreases expression ISO celastrol results in decreased expression of HILPDA mRNA CTD PMID:17010675 NCBI chr 4:57,871,076...57,875,206 JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 increases expression ISO celastrol results in increased expression of HMGCS1 mRNA CTD PMID:17010675 NCBI chr 2:51,649,368...51,667,100 JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions
ISO
EXP
celastrol results in increased expression of HMOX1 mRNA
celastrol inhibits the reaction [Plant Preparations results in decreased expression of HMOX1 mRNA]; celastrol inhibits the reaction [Plant Preparations results in decreased expression of HMOX1 protein]
celastrol results in increased expression of HMOX1 protein
celastrol inhibits the reaction [Bleomycin results in decreased expression of HMOX1 protein]; celastrol inhibits the reaction [Doxorubicin results in decreased expression of HMOX1 mRNA]; celastrol inhibits the reaction [Doxorubicin results in decreased expression of HMOX1 protein]
CTD PMID:17010675 PMID:23942037 PMID:26768587 PMID:29643811 PMID:30588110 NCBI chr19:13,466,287...13,474,082 JBrowse link
G Hsf1 heat shock transcription factor 1 multiple interactions EXP celastrol results in increased phosphorylation of and affects the localization of HSF1 protein CTD PMID:25903958 NCBI chr 7:108,196,040...108,223,011 JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 decreases activity
multiple interactions
ISO
EXP
celastrol results in decreased activity of HSP90AA1 protein
celastrol inhibits the reaction [Dextran Sulfate results in increased expression of HSP90AA1 mRNA]
CTD PMID:17010675 PMID:32470352 NCBI chr 6:129,702,376...129,707,907 JBrowse link
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 multiple interactions EXP celastrol inhibits the reaction [Dextran Sulfate results in increased expression of HSP90AB1 protein] CTD PMID:32470352 NCBI chr 9:15,432,986...15,438,358 JBrowse link
G Hspa13 heat shock protein family A (Hsp70) member 13 increases expression ISO celastrol results in increased expression of STCH mRNA CTD PMID:17010675 NCBI chr11:14,375,669...14,389,853 JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A increases expression
multiple interactions
ISO
EXP
celastrol results in increased expression of HSPA1A mRNA
HSPA1A protein affects the reaction [celastrol results in decreased expression of FBXO32 protein]
CTD PMID:17010675 PMID:25477506 PMID:25903958
G Hspa1b heat shock protein family A (Hsp70) member 1B increases expression ISO celastrol results in increased expression of HSPA1B mRNA CTD PMID:17010675 NCBI chr20:3,855,104...3,859,148 JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression ISO celastrol results in increased expression of HSPA5 mRNA CTD PMID:17010675 NCBI chr 3:18,055,507...18,059,969 JBrowse link
G Hsph1 heat shock protein family H (Hsp110) member 1 increases expression ISO celastrol results in increased expression of HSPH1 mRNA CTD PMID:17010675 NCBI chr12:5,390,916...5,410,224 JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO celastrol inhibits the reaction [IFNG protein results in increased expression of ICAM1 protein]; celastrol inhibits the reaction [IL1B protein results in increased expression of ICAM1 protein]; celastrol inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; celastrol inhibits the reaction [TNF protein results in increased expression of ICAM1 protein] CTD PMID:16769766 NCBI chr 8:19,553,063...19,565,438 JBrowse link
G Ifng interferon gamma multiple interactions ISO celastrol inhibits the reaction [IFNG protein results in increased expression of ICAM1 protein]; celastrol inhibits the reaction [IFNG protein results in increased expression of VCAM1 protein]
celastrol inhibits the reaction [Dextran Sulfate results in increased expression of IFNG protein]
CTD PMID:16769766 PMID:24384223 NCBI chr 7:53,903,339...53,907,375 JBrowse link
G Il10 interleukin 10 multiple interactions ISO [celastrol co-treated with coomassie Brilliant Blue] inhibits the reaction [Acetaminophen results in increased expression of IL10 protein]; celastrol inhibits the reaction [Dextran Sulfate results in decreased expression of IL10 protein] CTD PMID:24384223 PMID:28435131 NCBI chr13:42,472,625...42,477,308 JBrowse link
G Il17a interleukin 17A multiple interactions ISO [celastrol co-treated with coomassie Brilliant Blue] inhibits the reaction [Acetaminophen results in increased expression of IL17A protein]; celastrol inhibits the reaction [Dextran Sulfate results in increased expression of IL17A protein] CTD PMID:24384223 PMID:28435131 NCBI chr 9:23,144,402...23,147,889 JBrowse link
G Il18 interleukin 18 multiple interactions EXP celastrol inhibits the reaction [Dextran Sulfate results in increased expression of IL18 protein]; celastrol promotes the reaction [MCC-950 inhibits the reaction [Dextran Sulfate results in increased expression of IL18 protein]]; MCC-950 promotes the reaction [celastrol inhibits the reaction [Dextran Sulfate results in increased expression of IL18 protein]] CTD PMID:32470352 NCBI chr 8:50,904,630...50,932,887 JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases expression
ISO
EXP
celastrol inhibits the reaction [IL1B protein results in increased expression of ICAM1 protein]; celastrol inhibits the reaction [IL1B protein results in increased expression of SELE protein]; celastrol inhibits the reaction [IL1B protein results in increased expression of VCAM1 protein]
celastrol inhibits the reaction [Dextran Sulfate results in increased expression of IL1B protein]; celastrol promotes the reaction [MCC-950 inhibits the reaction [Dextran Sulfate results in increased expression of IL1B protein]]
celastrol results in increased expression of IL1B mRNA
celastrol inhibits the reaction [Dextran Sulfate results in increased expression of IL1B protein]; celastrol inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; celastrol inhibits the reaction [Plant Preparations results in increased expression of IL1B protein]
CTD PMID:16769766 PMID:24384223 PMID:25477506 PMID:29643811 PMID:31715269 PMID:31901889 PMID:32470352 NCBI chr 3:116,577,005...116,583,386 JBrowse link
G Il1rn interleukin 1 receptor antagonist decreases expression ISO celastrol results in decreased expression of IL1RN mRNA CTD PMID:17010675 NCBI chr 3:7,111,567...7,127,451 JBrowse link
G Il23a interleukin 23 subunit alpha multiple interactions ISO [celastrol co-treated with coomassie Brilliant Blue] inhibits the reaction [Acetaminophen results in increased expression of IL23A protein]; celastrol inhibits the reaction [Dextran Sulfate results in increased expression of IL23A protein] CTD PMID:24384223 PMID:28435131 NCBI chr 7:721,809...723,923 JBrowse link
G Il6 interleukin 6 increases expression
multiple interactions
ISO
EXP
celastrol results in increased expression of IL6 mRNA
celastrol inhibits the reaction [Dextran Sulfate results in increased expression of IL6 protein]; celastrol inhibits the reaction [Plant Preparations results in increased expression of IL6 protein]
celastrol inhibits the reaction [Dextran Sulfate results in increased expression of IL6 protein]; celastrol inhibits the reaction [Doxorubicin results in increased expression of IL6 protein]; celastrol promotes the reaction [MCC-950 inhibits the reaction [Dextran Sulfate results in increased expression of IL6 protein]]
CTD PMID:25477506 PMID:29643811 PMID:30588110 PMID:31715269 PMID:32470352 NCBI chr 4:5,214,602...5,219,178 JBrowse link
G Insig1 insulin induced gene 1 increases expression ISO celastrol results in increased expression of INSIG1 mRNA CTD PMID:17010675 NCBI chr 4:7,315,494...7,323,972 JBrowse link
G Jag1 jagged canonical Notch ligand 1 decreases expression ISO celastrol results in decreased expression of JAG1 mRNA CTD PMID:17010675 NCBI chr 3:124,406,794...124,442,220 JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP celastrol inhibits the reaction [Cadmium Chloride results in increased expression of and results in increased phosphorylation of JUN protein]; JUN mutant form promotes the reaction [celastrol inhibits the reaction [Cadmium Chloride results in increased cleavage of CASP3 protein]]; pyrazolanthrone promotes the reaction [celastrol inhibits the reaction [Cadmium Chloride results in increased expression of and results in increased phosphorylation of JUN protein]] CTD PMID:24111524 NCBI chr 5:109,894,175...109,897,268 JBrowse link
G Kcnn2 potassium calcium-activated channel subfamily N member 2 decreases expression ISO celastrol results in decreased expression of KCNN2 mRNA CTD PMID:17010675 NCBI chr18:37,817,966...38,258,347 JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 multiple interactions EXP celastrol inhibits the reaction [Bleomycin results in decreased expression of KEAP1 protein] CTD PMID:26768587 NCBI chr 8:19,768,375...19,777,862 JBrowse link
G Ldlr low density lipoprotein receptor increases expression ISO celastrol results in increased expression of LDLR mRNA CTD PMID:17010675 NCBI chr 8:20,270,020...20,292,981 JBrowse link
G Lef1 lymphoid enhancer binding factor 1 multiple interactions ISO celastrol inhibits the reaction [[Dextran Sulfate co-treated with Azoxymethane] results in increased expression of LEF1 mRNA]; celastrol inhibits the reaction [[Dextran Sulfate co-treated with Azoxymethane] results in increased expression of LEF1 protein] CTD PMID:31715269 NCBI chr 2:219,666,549...219,779,815 JBrowse link
G LOC686035 similar to heat shock 70kDa protein 6 (HSP70B) increases expression ISO celastrol results in increased expression of HSPA6 mRNA CTD PMID:25477506 NCBI chr13:83,271,340...83,275,267 JBrowse link
G Lpin1 lipin 1 increases expression ISO celastrol results in increased expression of LPIN1 mRNA CTD PMID:17010675 NCBI chr 6:39,309,198...39,417,034 JBrowse link
G Lrp5 LDL receptor related protein 5 multiple interactions ISO celastrol inhibits the reaction [[Dextran Sulfate co-treated with Azoxymethane] results in increased expression of LRP5 mRNA] CTD PMID:31715269 NCBI chr 1:200,814,247...200,917,581 JBrowse link
G Ltn1 listerin E3 ubiquitin protein ligase 1 decreases expression ISO celastrol results in decreased expression of LTN1 mRNA CTD PMID:17010675 NCBI chr11:26,603,903...26,660,871 JBrowse link
G Mafb MAF bZIP transcription factor B decreases expression ISO celastrol results in decreased expression of MAFB mRNA CTD PMID:17010675 NCBI chr 3:148,998,111...149,000,031 JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation
EXP celastrol promotes the reaction [Cadmium Chloride results in increased phosphorylation of MAPK1 protein]
celastrol results in increased phosphorylation of MAPK1 protein
CTD PMID:24111524 PMID:25903958 NCBI chr11:83,957,813...84,023,629 JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation
EXP celastrol promotes the reaction [Cadmium Chloride results in increased phosphorylation of MAPK3 protein]
celastrol results in increased phosphorylation of MAPK3 protein
CTD PMID:24111524 PMID:25903958 NCBI chr 1:181,366,646...181,372,863 JBrowse link
G Mdh2 malate dehydrogenase 2 decreases expression ISO celastrol results in decreased expression of MDH2 mRNA CTD PMID:17010675 NCBI chr12:20,894,269...20,907,225 JBrowse link
G Me1 malic enzyme 1 increases expression ISO celastrol results in increased expression of ME1 mRNA CTD PMID:17010675 NCBI chr 8:87,549,043...87,660,251 JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions EXP celastrol inhibits the reaction [Bleomycin results in increased expression of MMP2 protein]; celastrol inhibits the reaction [Doxorubicin results in increased expression of MMP2 mRNA]; celastrol inhibits the reaction [Doxorubicin results in increased expression of MMP2 protein] CTD PMID:26768587 PMID:30588110 NCBI chr19:14,154,657...14,182,870 JBrowse link
G Mmp7 matrix metallopeptidase 7 multiple interactions ISO celastrol inhibits the reaction [[Dextran Sulfate co-treated with Azoxymethane] results in increased expression of MMP7 mRNA] CTD PMID:31715269 NCBI chr 8:4,848,186...4,855,908 JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions EXP celastrol inhibits the reaction [Bleomycin results in increased expression of MMP9 protein]; celastrol inhibits the reaction [Doxorubicin results in increased expression of MMP9 mRNA]; celastrol inhibits the reaction [Doxorubicin results in increased expression of MMP9 protein] CTD PMID:26768587 PMID:30588110 NCBI chr 3:153,684,158...153,692,118 JBrowse link
G Mnt MAX network transcriptional repressor increases expression ISO celastrol results in increased expression of MNT mRNA CTD PMID:17010675 NCBI chr10:59,699,208...59,714,848 JBrowse link
G Mpo myeloperoxidase multiple interactions ISO
EXP
[celastrol co-treated with coomassie Brilliant Blue] inhibits the reaction [Acetaminophen results in increased activity of MPO protein]; celastrol inhibits the reaction [Acetaminophen results in increased activity of MPO protein]; celastrol inhibits the reaction [Dextran Sulfate results in increased activity of MPO protein]
celastrol inhibits the reaction [Dextran Sulfate results in increased expression of MPO protein]
CTD PMID:24384223 PMID:28435131 PMID:32470352 NCBI chr10:72,594,458...72,608,862 JBrowse link
G Mrpl18 mitochondrial ribosomal protein L18 increases expression ISO celastrol results in increased expression of MRPL18 mRNA CTD PMID:17010675 NCBI chr 1:47,837,169...47,841,987 JBrowse link
G Msh6 mutS homolog 6 decreases expression ISO celastrol results in decreased expression of MSH6 mRNA CTD PMID:17010675 NCBI chr 6:6,562,631...6,579,995 JBrowse link
G Msmo1 methylsterol monooxygenase 1 increases expression ISO celastrol results in increased expression of MSMO1 mRNA CTD PMID:17010675 NCBI chr16:24,980,680...24,997,927 JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions EXP [MCC-950 co-treated with celastrol] results in decreased expression of MTOR protein modified form; celastrol inhibits the reaction [Dextran Sulfate results in increased expression of MTOR protein modified form] CTD PMID:32470352 NCBI chr 5:158,884,856...158,994,311 JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor decreases expression
multiple interactions
ISO celastrol results in decreased expression of MYC mRNA; celastrol results in decreased expression of MYC protein
celastrol affects the reaction [APC protein mutant form affects the expression of MYC mRNA]; celastrol affects the reaction [APC protein mutant form affects the expression of MYC protein]; celastrol inhibits the reaction [[Dextran Sulfate co-treated with Azoxymethane] results in increased expression of MYC mRNA]; celastrol inhibits the reaction [[Dextran Sulfate co-treated with Azoxymethane] results in increased expression of MYC protein]
CTD PMID:26474287 PMID:31715269 NCBI chr 7:93,593,705...93,598,633 JBrowse link
G Mycbp2 MYC binding protein 2 decreases expression ISO celastrol results in decreased expression of MYCBP2 mRNA CTD PMID:17010675 NCBI chr15:79,937,354...80,175,432 JBrowse link
G Mynn myoneurin decreases expression ISO celastrol results in decreased expression of MYNN mRNA CTD PMID:17010675 NCBI chr 2:112,779,654...112,797,188 JBrowse link
G Nbn nibrin decreases expression ISO celastrol results in decreased expression of NBN mRNA CTD PMID:17010675 NCBI chr 5:29,459,574...29,494,152 JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 increases expression
increases activity
multiple interactions
EXP
ISO
celastrol results in increased expression of NFE2L2 protein
celastrol results in increased expression of NFE2L2 mRNA
celastrol results in increased activity of NFE2L2 protein
celastrol inhibits the reaction [Bleomycin results in decreased expression of NFE2L2 protein]; celastrol inhibits the reaction [Doxorubicin results in decreased expression of and affects the localization of and results in decreased activity of NFE2L2 protein]; celastrol inhibits the reaction [Doxorubicin results in decreased expression of NFE2L2 mRNA]
CTD PMID:26768587 PMID:29643811 PMID:30588110 NCBI chr 3:60,594,239...60,621,785 JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions EXP celastrol inhibits the reaction [Doxorubicin results in increased expression of NFKBIA protein modified form] CTD PMID:30588110 NCBI chr 6:72,858,713...72,861,941 JBrowse link
G Nkd1 NKD inhibitor of WNT signaling pathway 1 multiple interactions ISO celastrol inhibits the reaction [[Dextran Sulfate co-treated with Azoxymethane] results in increased expression of NKD1 mRNA] CTD PMID:31715269 NCBI chr19:18,476,344...18,549,380 JBrowse link
G Nkx3-1 NK3 homeobox 1 decreases expression ISO celastrol results in decreased expression of NKX3-1 mRNA CTD PMID:17010675 NCBI chr15:44,473,851...44,476,443 JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions EXP celastrol inhibits the reaction [Dextran Sulfate results in increased expression of NLRP3 mRNA]; MCC-950 promotes the reaction [celastrol inhibits the reaction [Dextran Sulfate results in increased expression of NLRP3 mRNA]] CTD PMID:32470352 NCBI chr10:44,326,770...44,353,814 JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO celastrol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA] CTD PMID:31901889 NCBI chr10:63,815,308...63,851,208 JBrowse link
G Notum NOTUM, palmitoleoyl-protein carboxylesterase multiple interactions ISO celastrol inhibits the reaction [[Dextran Sulfate co-treated with Azoxymethane] results in increased expression of NOTUM mRNA] CTD PMID:31715269 NCBI chr10:105,933,245...105,940,315 JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions EXP celastrol inhibits the reaction [Bleomycin results in decreased activity of NQO1 protein]; celastrol inhibits the reaction [Doxorubicin results in decreased expression of NQO1 mRNA]; celastrol inhibits the reaction [Doxorubicin results in decreased expression of NQO1 protein] CTD PMID:26768587 PMID:30588110 NCBI chr19:35,295,633...35,310,528 JBrowse link
G Nrep neuronal regeneration related protein decreases expression ISO celastrol results in decreased expression of NREP mRNA CTD PMID:17010675 NCBI chr18:25,017,069...25,046,564 JBrowse link
G Oprk1 opioid receptor, kappa 1 decreases expression ISO celastrol results in decreased expression of OPRK1 mRNA CTD PMID:17010675 NCBI chr 5:13,860,016...13,877,823 JBrowse link
G Oser1 oxidative stress responsive serine-rich 1 increases expression ISO celastrol results in increased expression of OSER1 mRNA CTD PMID:17010675 NCBI chr 3:152,066,975...152,085,180 JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases cleavage
ISO [TNFSF10 protein co-treated with celastrol] results in increased cleavage of PARP1 protein; TNFRSF10A protein promotes the reaction [[TNFSF10 protein co-treated with celastrol] results in increased cleavage of PARP1 protein]; TNFRSF10B protein promotes the reaction [[TNFSF10 protein co-treated with celastrol] results in increased cleavage of PARP1 protein]
celastrol results in increased cleavage of PARP1 protein
CTD PMID:20605676 PMID:31715269 NCBI chr13:92,307,593...92,339,406 JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions ISO celastrol promotes the reaction [[coomassie Brilliant Blue co-treated with Acetaminophen] results in increased expression of PCNA protein] CTD PMID:28435131 NCBI chr 3:119,499,039...119,502,911 JBrowse link
G Pde9a phosphodiesterase 9A decreases expression ISO celastrol results in decreased expression of PDE9A mRNA CTD PMID:17010675 NCBI chr20:9,469,809...9,562,949 JBrowse link
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta decreases expression ISO celastrol results in decreased expression of PIK3CD mRNA CTD PMID:17010675 NCBI chr 5:160,094,952...160,142,962 JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 decreases expression ISO celastrol results in decreased expression of PIK3R1 mRNA CTD PMID:17010675 NCBI chr 2:32,878,942...32,963,611 JBrowse link
G Plin1 perilipin 1 affects expression ISO celastrol affects the expression of PLIN1 mRNA CTD PMID:27085773 NCBI chr 1:133,664,294...133,676,854 JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma affects expression ISO celastrol affects the expression of PPARG mRNA; celastrol affects the expression of PPARG protein CTD PMID:27085773 NCBI chr 4:148,423,102...148,548,471 JBrowse link
G Ppif peptidylprolyl isomerase F decreases expression ISO celastrol results in decreased expression of PPIF mRNA CTD PMID:17010675 NCBI chr16:1,257,197...1,263,919 JBrowse link
G Pten phosphatase and tensin homolog multiple interactions EXP celastrol inhibits the reaction [Cadmium Chloride results in decreased expression of PTEN protein]; PTEN protein promotes the reaction [celastrol inhibits the reaction [Cadmium Chloride results in increased cleavage of CASP3 protein]]; PTEN protein promotes the reaction [celastrol inhibits the reaction [Cadmium Chloride results in increased phosphorylation of AKT1 protein]]; PTEN protein promotes the reaction [celastrol inhibits the reaction [Cadmium Chloride results in increased phosphorylation of RPS6KB1 protein]] CTD PMID:24111524 NCBI chr 1:230,631,303...230,696,754 JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 increases expression ISO celastrol results in increased expression of PTGS1 mRNA CTD PMID:25477506 NCBI chr 3:19,584,015...19,605,589 JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression ISO celastrol results in decreased expression of PTGS2 mRNA; celastrol results in decreased expression of PTGS2 protein CTD PMID:31715269 NCBI chr13:62,164,080...62,169,770 JBrowse link
G Pura purine rich element binding protein A decreases expression ISO celastrol results in decreased expression of PURA mRNA CTD PMID:17010675
G Rac3 Rac family small GTPase 3 multiple interactions ISO celastrol inhibits the reaction [[Dextran Sulfate co-treated with Azoxymethane] results in increased expression of RAC3 mRNA] CTD PMID:31715269 NCBI chr10:106,002,808...106,005,244 JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO
EXP
celastrol inhibits the reaction [TNF protein affects the localization of and results in increased activity of RELA protein]
celastrol inhibits the reaction [Plant Preparations results in increased expression of RELA protein]
celastrol inhibits the reaction [Doxorubicin results in increased expression of and results in increased phosphorylation of and results in increased activity of RELA protein]
CTD PMID:16769766 PMID:29643811 PMID:30588110 NCBI chr 1:202,925,001...202,935,484 JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 multiple interactions EXP celastrol inhibits the reaction [Cadmium Chloride results in increased phosphorylation of RPS6KB1 protein]; PTEN protein promotes the reaction [celastrol inhibits the reaction [Cadmium Chloride results in increased phosphorylation of RPS6KB1 protein]] CTD PMID:24111524 NCBI chr10:71,323,777...71,367,908 JBrowse link
G Rrm2 ribonucleotide reductase regulatory subunit M2 decreases expression ISO celastrol results in decreased expression of RRM2 mRNA CTD PMID:17010675 NCBI chr 6:41,339,858...41,346,774 JBrowse link
G Sele selectin E multiple interactions ISO celastrol inhibits the reaction [IL1B protein results in increased expression of SELE protein]; celastrol inhibits the reaction [TNF protein results in increased expression of SELE mRNA]; celastrol inhibits the reaction [TNF protein results in increased expression of SELE protein] CTD PMID:16769766 NCBI chr13:76,402,841...76,412,741 JBrowse link
G Serp1 stress-associated endoplasmic reticulum protein 1 increases expression ISO celastrol results in increased expression of SERP1 mRNA CTD PMID:17010675 NCBI chr 2:142,757,254...142,761,243 JBrowse link
G Sesn1 sestrin 1 decreases expression ISO celastrol results in decreased expression of SESN1 mRNA CTD PMID:17010675 NCBI chr20:45,294,876...45,387,698 JBrowse link
G Slc3a2 solute carrier family 3 member 2 increases expression ISO celastrol results in increased expression of SLC3A2 mRNA CTD PMID:17010675 NCBI chr 1:205,604,468...205,618,931 JBrowse link
G Slc7a11 solute carrier family 7 member 11 decreases response to substance
increases expression
ISO SLC7A11 protein results in decreased susceptibility to celastrol
celastrol results in increased expression of SLC7A11 mRNA
CTD PMID:17010675 PMID:20007406 NCBI chr 2:134,382,002...134,517,622 JBrowse link
G Sltm SAFB-like, transcription modulator decreases expression ISO celastrol results in decreased expression of SLTM mRNA CTD PMID:17010675 NCBI chr 8:71,215,995...71,261,821 JBrowse link
G Smad3 SMAD family member 3 multiple interactions ISO celastrol inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein] CTD PMID:29789558 NCBI chr 8:64,126,829...64,236,960 JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions EXP celastrol inhibits the reaction [Bleomycin results in decreased activity of SOD2 protein] CTD PMID:26768587 NCBI chr 1:47,638,318...47,645,163 JBrowse link
G Sox4 SRY-box transcription factor 4 decreases expression ISO celastrol results in decreased expression of SOX4 mRNA CTD PMID:17010675 NCBI chr17:35,667,809...35,672,515 JBrowse link
G Sqstm1 sequestosome 1 decreases expression
multiple interactions
EXP celastrol results in decreased expression of SQSTM1 protein
MCC-950 promotes the reaction [celastrol results in decreased expression of SQSTM1 protein]
CTD PMID:32470352 NCBI chr10:34,525,517...34,536,685 JBrowse link
G Stip1 stress-induced phosphoprotein 1 increases expression ISO celastrol results in increased expression of STIP1 mRNA CTD PMID:17010675 NCBI chr 1:204,209,434...204,228,452 JBrowse link
G