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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:20-hydroxy steroid
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Accession:CHEBI:36854 term browser browse the term
Definition:Any hydroxy steroid that in which the steroid skeleton contains a hydroxy substituent at position 20.
Synonyms:related_synonym: 20-hydroxy steroids


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(20R)-17,20-dihydroxypregn-4-en-3-one term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor multiple interactions ISO 17 alpha,20 beta-dihydroxypregn-4-en-3-one inhibits the reaction [Metribolone results in increased activity of AR protein] CTD PMID:18324785 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
(20S)-20-hydroxypregn-4-en-3-one term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1c2 aldo-keto reductase family 1, member C2 increases chemical synthesis ISO AKR1C2 protein results in increased chemical synthesis of 20-alpha-Dihydroprogesterone CTD PMID:11158055 NCBI chr17:65,759,778...65,808,013
Ensembl chr17:65,759,788...65,775,764 		JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 multiple interactions
increases chemical synthesis		 ISO
EXP		 [AKR1C3 protein results in increased metabolism of Progesterone] which results in increased chemical synthesis of 20-alpha-Dihydroprogesterone; [AKR1C3 protein results in increased reduction of Progesterone] which results in increased chemical synthesis of 20-alpha-Dihydroprogesterone
AKR1C18 protein results in increased chemical synthesis of 20-alpha-Dihydroprogesterone
AKR1C3 protein results in increased chemical synthesis of 20-alpha-Dihydroprogesterone		 CTD PMID:8172618 PMID:19010312 PMID:20036328 PMID:25463305 NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873 		JBrowse link
G Mal mal, T-cell differentiation protein multiple interactions EXP 20-alpha-Dihydroprogesterone inhibits the reaction [docetaxel results in decreased expression of MAL mRNA] CTD PMID:19335538 NCBI chr 3:114,864,378...114,888,136
Ensembl chr 3:114,864,378...114,888,136 		JBrowse link
G Mbp myelin basic protein multiple interactions EXP 20-alpha-Dihydroprogesterone inhibits the reaction [docetaxel results in decreased expression of MBP mRNA]; 20-alpha-Dihydroprogesterone inhibits the reaction [Streptozocin results in decreased expression of MBP mRNA] CTD PMID:19335538 PMID:20349157 NCBI chr18:75,855,878...75,966,404
Ensembl chr18:75,855,878...75,966,404 		JBrowse link
G Mpz myelin protein zero increases expression
multiple interactions		 EXP 20-alpha-Dihydroprogesterone results in increased expression of MPZ mRNA
20-alpha-Dihydroprogesterone inhibits the reaction [Docetaxel results in decreased expression of MPZ mRNA]; 20-alpha-Dihydroprogesterone inhibits the reaction [Streptozocin results in decreased expression of MPZ mRNA]		 CTD PMID:16787508 PMID:17187935 PMID:19335538 NCBI chr13:83,570,811...83,576,680
Ensembl chr13:83,570,811...83,576,679 		JBrowse link
G Pmp22 peripheral myelin protein 22 multiple interactions EXP 20-alpha-Dihydroprogesterone inhibits the reaction [docetaxel results in decreased expression of PMP22 mRNA] CTD PMID:19335538 NCBI chr10:47,795,709...47,825,715
Ensembl chr10:47,795,709...47,825,714 		JBrowse link
G Pomc proopiomelanocortin multiple interactions
increases secretion		 ISO Cadmium Chloride inhibits the reaction [POMC protein results in increased secretion of 20-alpha-Dihydroprogesterone] CTD PMID:8299002 NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664 		JBrowse link
(20S)-ginsenoside Rh2 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation ISO ginsenoside Rh2 results in decreased phosphorylation of AKT1 protein CTD PMID:32762018 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO ginsenoside Rh2 results in increased expression of BAX protein CTD PMID:26482938 PMID:32762018 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO ginsenoside Rh2 results in decreased expression of BCL2 protein CTD PMID:26482938 PMID:32762018 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Casp3 caspase 3 increases cleavage
decreases expression		 ISO ginsenoside Rh2 results in increased cleavage of CASP3 protein
ginsenoside Rh2 results in decreased expression of CASP3 protein		 CTD PMID:26482938 PMID:32762018 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp9 caspase 9 decreases expression ISO ginsenoside Rh2 results in decreased expression of CASP9 protein CTD PMID:32762018 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO ginsenoside Rh2 results in decreased expression of CCND1 protein CTD PMID:26482938 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Hdac1 histone deacetylase 1 decreases expression ISO ginsenoside Rh2 results in decreased expression of HDAC1 protein CTD PMID:26482938 NCBI chr 5:141,853,992...141,881,057
Ensembl chr 5:141,853,989...141,881,111 		JBrowse link
G Hdac2 histone deacetylase 2 decreases expression ISO ginsenoside Rh2 results in decreased expression of HDAC2 protein CTD PMID:26482938 NCBI chr20:40,548,244...40,571,609
Ensembl chr20:40,548,250...40,571,609 		JBrowse link
G Hdac6 histone deacetylase 6 decreases expression ISO ginsenoside Rh2 results in decreased expression of HDAC6 protein CTD PMID:26482938 NCBI chr  X:14,550,645...14,572,445
Ensembl chr  X:14,551,044...14,572,441 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO ginsenoside Rh2 inhibits the reaction [Galactose results in increased secretion of IL6 protein] CTD PMID:29412148 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation
increases phosphorylation		 ISO ginsenoside Rh2 results in decreased phosphorylation of MAPK1 protein
ginsenoside Rh2 results in increased phosphorylation of MAPK1 protein		 CTD PMID:26482938 PMID:32762018 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation
increases phosphorylation		 ISO ginsenoside Rh2 results in decreased phosphorylation of MAPK3 protein
ginsenoside Rh2 results in increased phosphorylation of MAPK3 protein		 CTD PMID:26482938 PMID:32762018 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mtor mechanistic target of rapamycin kinase decreases phosphorylation ISO ginsenoside Rh2 results in decreased phosphorylation of MTOR protein CTD PMID:32762018 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Nfkbia NFKB inhibitor alpha increases expression ISO ginsenoside Rh2 results in increased expression of NFKBIA protein CTD PMID:32762018 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO ginsenoside Rh2 results in increased expression of and results in decreased phosphorylation of RELA protein CTD PMID:32762018 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
20-hydroxycholesterol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 multiple interactions ISO [NR5A1 protein co-treated with 20-hydroxycholesterol co-treated with Tretinoin co-treated with 8-Bromo Cyclic Adenosine Monophosphate] results in increased expression of CYP11A1 mRNA CTD PMID:21610156 NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338 		JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 increases metabolic processing EXP
ISO		 CYP7A1 protein results in increased metabolism of 20-hydroxycholesterol CTD PMID:10882719 NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688 		JBrowse link
G Hsd17b10 hydroxysteroid (17-beta) dehydrogenase 10 multiple interactions ISO [20-hydroxycholesterol co-treated with NAD] binds to HSD17B10 protein CTD PMID:25526675 NCBI chr  X:21,089,142...21,091,603
Ensembl chr  X:21,089,122...21,109,488 		JBrowse link
G Mc2r melanocortin 2 receptor multiple interactions ISO [20-hydroxycholesterol co-treated with Tretinoin co-treated with 8-Bromo Cyclic Adenosine Monophosphate] promotes the reaction [NR5A1 protein binds to MC2R promoter] CTD PMID:21610156 NCBI chr18:62,001,980...62,015,567
Ensembl chr18:62,004,948...62,015,488 		JBrowse link
G Nr5a1 nuclear receptor subfamily 5, group A, member 1 multiple interactions ISO [20-hydroxycholesterol co-treated with Tretinoin co-treated with 8-Bromo Cyclic Adenosine Monophosphate] promotes the reaction [NR5A1 protein binds to MC2R promoter]; [NR5A1 protein co-treated with 20-hydroxycholesterol co-treated with Tretinoin co-treated with 8-Bromo Cyclic Adenosine Monophosphate] results in increased abundance of Progesterone; [NR5A1 protein co-treated with 20-hydroxycholesterol co-treated with Tretinoin co-treated with 8-Bromo Cyclic Adenosine Monophosphate] results in increased expression of CYP11A1 mRNA CTD PMID:21610156 NCBI chr 3:22,464,786...22,486,328
Ensembl chr 3:22,465,502...22,486,328 		JBrowse link
20-hydroxyecdysone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ecdysterone promotes the reaction [1-Methyl-4-phenylpyridinium results in increased activity of AKT1 protein]]; Ecdysterone promotes the reaction [1-Methyl-4-phenylpyridinium results in increased activity of AKT1 protein] CTD PMID:26048653 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO Ecdysterone results in increased expression of BAX protein CTD PMID:33878320 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator affects expression ISO Ecdysterone affects the expression of BCL2 protein CTD PMID:33878320 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Casp3 caspase 3 increases activity
increases cleavage		 ISO Ecdysterone results in increased activity of CASP3 protein
Ecdysterone results in increased cleavage of CASP3 protein		 CTD PMID:29126784 PMID:33878320 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ecdysterone inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased phosphorylation of and results in decreased activity of GSK3B protein]]; Ecdysterone inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased phosphorylation of and results in decreased activity of GSK3B protein] CTD PMID:26048653 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ecdysterone promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HMOX1 protein]]; Ecdysterone promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HMOX1 mRNA]; Ecdysterone promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HMOX1 protein] CTD PMID:26048653 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 decreases expression
increases expression		 ISO Ecdysterone results in decreased expression of HSPA5 protein
Ecdysterone results in increased expression of HSPA5 mRNA		 CTD PMID:29126784 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891 		JBrowse link
G Mtor mechanistic target of rapamycin kinase affects expression ISO Ecdysterone affects the expression of MTOR protein CTD PMID:33878320 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions
increases response to substance		 EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ecdysterone promotes the reaction [1-Methyl-4-phenylpyridinium affects the localization of NFE2L2 protein]]; Ecdysterone promotes the reaction [1-Methyl-4-phenylpyridinium affects the localization of NFE2L2 protein]
NFE2L2 results in increased susceptibility to Ecdysterone		 CTD PMID:26048653 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO Ecdysterone results in increased cleavage of PARP1 protein CTD PMID:33878320 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Sqstm1 sequestosome 1 affects expression ISO Ecdysterone affects the expression of SQSTM1 protein CTD PMID:33878320 NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673 		JBrowse link
20-hydroxypregn-4-en-3-one term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1c3 aldo-keto reductase family 1, member C3 increases chemical synthesis ISO AKR1C3 protein results in increased chemical synthesis of 3-hydroxypregn-4-en-20-one CTD PMID:25463305 NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO 3-hydroxypregn-4-en-20-one results in increased expression of BAX mRNA CTD PMID:19931389 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions		 ISO 3-hydroxypregn-4-en-20-one results in decreased expression of BCL2 mRNA
3-hydroxypregn-4-en-20-one inhibits the reaction [5-alpha-Dihydroprogesterone results in increased expression of BCL2 mRNA]		 CTD PMID:19931389 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO 3-hydroxypregn-4-en-20-one results in increased expression of CDKN1A mRNA CTD PMID:19931389 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
ginsenoside Rf term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apoa1 apolipoprotein A1 multiple interactions
decreases expression		 ISO ginsenoside Rf inhibits the reaction [pirinixic acid results in decreased expression of APOA1 mRNA]; ginsenoside Rf inhibits the reaction [pirinixic acid results in decreased expression of APOA1 protein]; PPARA protein affects the reaction [ginsenoside Rf inhibits the reaction [pirinixic acid results in decreased expression of APOA1 mRNA]]
ginsenoside Rf results in decreased expression of APOA1 protein		 CTD PMID:16297877 NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035 		JBrowse link
G Apoc3 apolipoprotein C3 multiple interactions
decreases expression
increases expression		 ISO ginsenoside Rf inhibits the reaction [pirinixic acid results in decreased expression of APOC3 mRNA]; ginsenoside Rf inhibits the reaction [pirinixic acid results in decreased expression of APOC3 protein]; PPARA protein affects the reaction [ginsenoside Rf inhibits the reaction [pirinixic acid results in decreased expression of APOC3 mRNA]]; PPARA protein affects the reaction [ginsenoside Rf results in increased expression of APOC3 mRNA]
ginsenoside Rf results in decreased expression of APOC3 protein		 CTD PMID:16297877 NCBI chr 8:46,531,478...46,533,658
Ensembl chr 8:46,531,478...46,533,583 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 affects activity ISO ginsenoside Rf affects the activity of KCNH2 protein CTD PMID:15842772 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions
decreases expression		 ISO ginsenoside Rf binds to and results in decreased activity of PPARA protein; ginsenoside Rf inhibits the reaction [pirinixic acid results in increased activity of PPARA protein]; ginsenoside Rf inhibits the reaction [pirinixic acid results in increased expression of PPARA mRNA]; PPARA protein affects the reaction [ginsenoside Rf inhibits the reaction [pirinixic acid results in decreased expression of APOA1 mRNA]]; PPARA protein affects the reaction [ginsenoside Rf inhibits the reaction [pirinixic acid results in decreased expression of APOC3 mRNA]]; PPARA protein affects the reaction [ginsenoside Rf results in increased expression of APOC3 mRNA]
ginsenoside Rf results in decreased expression of PPARA mRNA		 CTD PMID:16297877 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346 		JBrowse link
ginsenoside Rg2 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc2 ATP binding cassette subfamily C member 2 increases expression EXP ginsenoside Rg2 results in increased expression of ABCC2 mRNA CTD PMID:23835644 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ginsenoside Rg2 inhibits the reaction [APP protein modified form results in decreased phosphorylation of AKT1 protein]]; ginsenoside Rg2 inhibits the reaction [APP protein modified form results in decreased phosphorylation of AKT1 protein] CTD PMID:28756148 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G App amyloid beta precursor protein multiple interactions EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ginsenoside Rg2 inhibits the reaction [APP protein modified form results in decreased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ginsenoside Rg2 inhibits the reaction [APP protein modified form results in increased activity of CASP3 protein]]; ginsenoside Rg2 inhibits the reaction [APP protein modified form results in decreased expression of BCL2 protein]; ginsenoside Rg2 inhibits the reaction [APP protein modified form results in decreased phosphorylation of AKT1 protein]; ginsenoside Rg2 inhibits the reaction [APP protein modified form results in increased activity of and results in increased cleavage of CASP3 protein]; ginsenoside Rg2 inhibits the reaction [APP protein modified form results in increased expression of BAX protein] CTD PMID:28756148 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP ginsenoside Rg2 inhibits the reaction [APP protein modified form results in increased expression of BAX protein] CTD PMID:28756148 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP ginsenoside Rg2 inhibits the reaction [APP protein modified form results in decreased expression of BCL2 protein] CTD PMID:28756148 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Becn2 beclin 2 multiple interactions ISO ginsenoside Rg2 inhibits the reaction [BECN2 protein binds to GPRASP1 protein] CTD PMID:27305347 NCBI chr13:87,842,980...87,892,410
Ensembl chr13:87,844,531...87,845,787 		JBrowse link
G Casp3 caspase 3 multiple interactions EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ginsenoside Rg2 inhibits the reaction [APP protein modified form results in increased activity of CASP3 protein]]; ginsenoside Rg2 inhibits the reaction [APP protein modified form results in increased activity of and results in increased cleavage of CASP3 protein] CTD PMID:28756148 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Crtc2 CREB regulated transcription coactivator 2 multiple interactions ISO [ginsenoside Rg2 results in increased activity of NR0B2 protein] which results in decreased activity of CRTC2 protein CTD PMID:22062806 NCBI chr 2:175,709,603...175,719,768
Ensembl chr 2:175,709,644...175,719,763 		JBrowse link
G G6pc3 glucose 6 phosphatase catalytic subunit 3 decreases expression
multiple interactions		 ISO ginsenoside Rg2 results in decreased expression of G6PC3 mRNA
dorsomorphin inhibits the reaction [ginsenoside Rg2 results in decreased expression of G6PC3 mRNA]		 CTD PMID:22062806 NCBI chr10:87,146,987...87,151,223
Ensembl chr10:87,146,901...87,151,221 		JBrowse link
G Gprasp1 G protein-coupled receptor associated sorting protein 1 multiple interactions ISO ginsenoside Rg2 inhibits the reaction [BECN2 protein binds to GPRASP1 protein] CTD PMID:27305347 NCBI chr  X:98,764,853...98,772,685
Ensembl chr  X:98,709,841...98,772,851 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta increases phosphorylation
multiple interactions		 ISO ginsenoside Rg2 results in increased phosphorylation of GSK3B protein
[[ginsenoside Rg2 results in increased phosphorylation of GSK3B protein] co-treated with [ginsenoside Rg2 results in increased expression of NR0B2 mRNA]] results in decreased chemical synthesis of Glucose; dorsomorphin inhibits the reaction [ginsenoside Rg2 results in increased phosphorylation of GSK3B protein]		 CTD PMID:22062806 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions
increases expression		 ISO bafilomycin A1 promotes the reaction [ginsenoside Rg2 results in increased expression of MAP1LC3B protein modified form] CTD PMID:27305347 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690 		JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 multiple interactions
increases activity
increases expression		 ISO [[ginsenoside Rg2 results in increased phosphorylation of GSK3B protein] co-treated with [ginsenoside Rg2 results in increased expression of NR0B2 mRNA]] results in decreased chemical synthesis of Glucose; [ginsenoside Rg2 results in increased activity of NR0B2 protein] which results in decreased activity of CRTC2 protein CTD PMID:22062806 NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609 		JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 multiple interactions
decreases expression		 ISO dorsomorphin inhibits the reaction [ginsenoside Rg2 results in decreased expression of PCK1 mRNA] CTD PMID:22062806 NCBI chr 3:161,930,256...161,936,205
Ensembl chr 3:161,930,256...161,936,191 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions
decreases expression		 ISO dorsomorphin inhibits the reaction [ginsenoside Rg2 results in decreased expression of PPARGC1A mRNA] CTD PMID:22062806 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656 		JBrowse link
G Sqstm1 sequestosome 1 multiple interactions
decreases expression		 ISO bafilomycin A1 promotes the reaction [ginsenoside Rg2 results in decreased expression of SQSTM1 protein] CTD PMID:27305347 NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673 		JBrowse link
G Stk11 serine/threonine kinase 11 increases phosphorylation
multiple interactions		 ISO ginsenoside Rg2 results in increased phosphorylation of STK11 protein
dorsomorphin inhibits the reaction [ginsenoside Rg2 results in increased phosphorylation of STK11 protein]		 CTD PMID:22062806 NCBI chr 7:9,574,553...9,591,315
Ensembl chr 7:9,575,269...9,591,315 		JBrowse link
ponasterone A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 decreases activity
multiple interactions		 EXP ponasterone A results in decreased activity of CASP3 protein
L-161982 inhibits the reaction [ponasterone A results in decreased activity of CASP3 protein]		 CTD PMID:16396944 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Dnm1l dynamin 1-like multiple interactions EXP [ponasterone A results in increased expression of PINK1 protein] which results in decreased expression of DNM1L protein CTD PMID:20164189 NCBI chr11:84,581,216...84,632,382
Ensembl chr11:84,581,216...84,631,482 		JBrowse link
G Fhit fragile histidine triad diadenosine triphosphatase affects expression ISO ponasterone A affects the expression of FHIT protein CTD PMID:17019711 NCBI chr15:13,935,029...15,442,620
Ensembl chr15:13,934,995...15,442,340 		JBrowse link
G Fis1 fission, mitochondrial 1 multiple interactions EXP [ponasterone A results in increased expression of PINK1 protein] which results in decreased expression of FIS1 protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[ponasterone A results in increased expression of PINK1 protein] which results in decreased expression of FIS1 protein] CTD PMID:20164189 NCBI chr12:19,708,560...19,723,392
Ensembl chr12:19,708,558...19,723,377 		JBrowse link
G Mfn2 mitofusin 2 increases expression EXP [ponasterone A results in increased expression of PINK1 protein] which results in increased expression of MFN2 protein CTD PMID:20164189 NCBI chr 5:158,304,285...158,335,502
Ensembl chr 5:158,304,287...158,335,342 		JBrowse link
G Pink1 PTEN induced kinase 1 multiple interactions
increases expression		 EXP [ponasterone A results in increased expression of PINK1 protein] which results in decreased expression of DNM1L protein; [ponasterone A results in increased expression of PINK1 protein] which results in decreased expression of FIS1 protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[ponasterone A results in increased expression of PINK1 protein] which results in decreased expression of FIS1 protein]
[ponasterone A results in increased expression of PINK1 protein] which results in increased expression of MFN2 protein; ponasterone A results in increased expression of PINK1 protein		 CTD PMID:20164189 NCBI chr 5:150,530,523...150,542,635
Ensembl chr 5:150,530,523...150,542,635 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases expression		 EXP L-161982 inhibits the reaction [ponasterone A results in increased expression of PTGS2 protein] CTD PMID:16396944 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases expression ISO ponasterone A results in increased expression of UGT1A3 protein CTD PMID:17058234 NCBI chr 9:88,791,216...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19848
    chemical entity 19846
      molecular entity 19846
        polyatomic entity 19803
          heteroatomic molecular entity 19760
            hydroxides 19334
              organic hydroxy compound 18967
                hydroxy steroid 14435
                  20-hydroxy steroid 57
                    (20R)-17alpha,20-dihydroxycholesterol 0
                    (20R,22R)-20,22-dihydroxycholesterol 0
                    (20S)-17alpha,20-dihydroxycholesterol 0
                    (20S)-ginsenoside Rh2 15
                    (24R)-11alpha,20,24-trihydroxyecdysone 0
                    (25R)-11alpha,20,26-trihydroxyecdysone 0
                    (25S)-11alpha,20,26-trihydroxyecdysone 0
                    17,20-dihydroxypregn-4-en-3-one + 1
                    17alpha-hydroxywithanolide D 0
                    20,26-dihydroxyecdysone 0
                    20-hydroxy-3-oxopregn-4-en-21-al 0
                    20-hydroxycholesterol 5
                    20-hydroxyecdysone 11
                    20-hydroxypregn-4-en-3-one + 10
                    20-hydroxytubocapsanolide A 0
                    20alpha-dihydroprednisolone 0
                    20alpha-dihydroprednisone 0
                    20beta-dihydrocorticosterone 0
                    20beta-dihydrocortisol 0
                    20beta-dihydroprednisolone 0
                    20beta-dihydroprednisone 0
                    20beta-hydroxycortisone 0
                    22-deoxy-20,21-dihydroxyecdysone 0
                    23,24-dimethylcholest-16(17)-E-en-3beta,5alpha,6beta,20(S)-tetrol 0
                    4-pregnen-20,21-diol-3-one 0
                    4-pregnen-3beta,20alpha-diol 0
                    5alpha-cholesta-24-en-3beta,20beta-diol-23-one 0
                    5alpha-cholesta-9(11)-en-3beta, 20beta-diol 0
                    5alpha-pregan-20beta-ol-3-one 0
                    5beta-pregnan-20alpha-ol-3-one 0
                    NCS172285 0
                    ajugalactone 0
                    cyasterone 0
                    ginsenoside Rf 4
                    ginsenoside Rg2 17
                    inokosterone 0
                    makisterone B 0
                    podecdysone B 0
                    polypodine B 0
                    ponasterone A 8
                    shidasterone 0
                    stachsterol 0
                    withanolide D + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19848
    subatomic particle 19846
      composite particle 19846
        hadron 19846
          baryon 19846
            nucleon 19846
              atomic nucleus 19846
                atom 19846
                  main group element atom 19796
                    p-block element atom 19796
                      carbon group element atom 19741
                        carbon atom 19737
                          organic molecular entity 19737
                            organic molecule 19690
                              organic cyclic compound 19501
                                organic polycyclic compound 17247
                                  steroid 14689
                                    hydroxy steroid 14435
                                      20-hydroxy steroid 57
                                        (20R)-17alpha,20-dihydroxycholesterol 0
                                        (20R,22R)-20,22-dihydroxycholesterol 0
                                        (20S)-17alpha,20-dihydroxycholesterol 0
                                        (20S)-ginsenoside Rh2 15
                                        (24R)-11alpha,20,24-trihydroxyecdysone 0
                                        (25R)-11alpha,20,26-trihydroxyecdysone 0
                                        (25S)-11alpha,20,26-trihydroxyecdysone 0
                                        17,20-dihydroxypregn-4-en-3-one + 1
                                        17alpha-hydroxywithanolide D 0
                                        20,26-dihydroxyecdysone 0
                                        20-hydroxy-3-oxopregn-4-en-21-al 0
                                        20-hydroxycholesterol 5
                                        20-hydroxyecdysone 11
                                        20-hydroxypregn-4-en-3-one + 10
                                        20-hydroxytubocapsanolide A 0
                                        20alpha-dihydroprednisolone 0
                                        20alpha-dihydroprednisone 0
                                        20beta-dihydrocorticosterone 0
                                        20beta-dihydrocortisol 0
                                        20beta-dihydroprednisolone 0
                                        20beta-dihydroprednisone 0
                                        20beta-hydroxycortisone 0
                                        22-deoxy-20,21-dihydroxyecdysone 0
                                        23,24-dimethylcholest-16(17)-E-en-3beta,5alpha,6beta,20(S)-tetrol 0
                                        4-pregnen-20,21-diol-3-one 0
                                        4-pregnen-3beta,20alpha-diol 0
                                        5alpha-cholesta-24-en-3beta,20beta-diol-23-one 0
                                        5alpha-cholesta-9(11)-en-3beta, 20beta-diol 0
                                        5alpha-pregan-20beta-ol-3-one 0
                                        5beta-pregnan-20alpha-ol-3-one 0
                                        NCS172285 0
                                        ajugalactone 0
                                        cyasterone 0
                                        ginsenoside Rf 4
                                        ginsenoside Rg2 17
                                        inokosterone 0
                                        makisterone B 0
                                        podecdysone B 0
                                        polypodine B 0
                                        ponasterone A 8
                                        shidasterone 0
                                        stachsterol 0
                                        withanolide D + 0
paths to the root