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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:ponasterone A
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Accession:CHEBI:28135 term browser browse the term
Definition:A 2beta-hydroxy steroid that has formula C27H44O6.
Synonyms:exact_synonym: (22R)-2beta,3beta,14,20,22-pentahydroxy-5beta-cholest-7-en-6-one
 related_synonym: 25-Deoxycedysterone;   Formula=C27H44O6;   InChI=1S/C27H44O6/c1-15(2)6-7-23(31)26(5,32)22-9-11-27(33)17-12-19(28)18-13-20(29)21(30)14-24(18,3)16(17)8-10-25(22,27)4/h12,15-16,18,20-23,29-33H,6-11,13-14H2,1-5H3/t16-,18-,20+,21-,22-,23+,24+,25+,26+,27+/m0/s1;   InChIKey=PJYYBCXMCWDUAZ-JJJZTNILSA-N;   SMILES=[H][C@]12CC[C@]3(C)[C@]([H])(CC[C@@]3(O)C1=CC(=O)[C@]1([H])C[C@@H](O)[C@@H](O)C[C@]21C)[C@@](C)(O)[C@H](O)CCC(C)C
 alt_id: CHEBI:26210;   CHEBI:8331
 xref: Beilstein:2422988;   CAS:13408-56-5;   KEGG:C08835;   KNApSAcK:C00003667
 xref_mesh: MESH:C008999
 xref: PDBeChem:P1A

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ponasterone A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 decreases activity
multiple interactions
EXP ponasterone A results in decreased activity of CASP3 protein
L-161982 inhibits the reaction [ponasterone A results in decreased activity of CASP3 protein]
CTD PMID:16396944 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Fhit fragile histidine triad diadenosine triphosphatase affects expression ISO ponasterone A affects the expression of FHIT protein CTD PMID:17019711 NCBI chr15:13,935,029...15,442,620
Ensembl chr15:13,934,995...15,442,340
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases expression
EXP L-161982 inhibits the reaction [ponasterone A results in increased expression of PTGS2 protein] CTD PMID:16396944 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases expression ISO ponasterone A results in increased expression of UGT1A3 protein CTD PMID:17058234 NCBI chr 9:88,791,216...88,808,465 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19812
    chemical entity 19812
      molecular entity 19811
        polyatomic entity 19732
          heteroatomic molecular entity 19673
            hydroxides 19175
              organic hydroxy compound 18668
                hydroxy steroid 12657
                  20-hydroxy steroid 51
                    ponasterone A 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19708
                    p-block element atom 19708
                      carbon group element atom 19630
                        carbon atom 19620
                          organic molecular entity 19620
                            organic group 18728
                              organic divalent group 18719
                                organodiyl group 18719
                                  carbonyl group 18667
                                    carbonyl compound 18667
                                      ketone 16924
                                        oxo steroid 9718
                                          6-oxo steroid 23
                                            ponasterone A 4
paths to the root