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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:20-hydroxypregn-4-en-3-one
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Accession:CHEBI:36728 term browser browse the term
Definition:A C21-steroid that is pregnane which contains a double bond between positions 4 and 5 and is substituted by an oxo group at position 3 and a hydroxy group at position 20.
Synonyms:related_synonym: 20-dihydroprogesterone;   20-hydroxy-4-pregnen-3-one;   Formula=C21H32O2;   InChI=1S/C21H32O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h12-13,16-19,22H,4-11H2,1-3H3/t13?,16-,17+,18-,19-,20-,21+/m0/s1;   InChIKey=RWBRUCCWZPSBFC-HWSYHKBZSA-N;   SMILES=[H][C@@]1(CC[C@@]2([H])[C@]3([H])CCC4=CC(=O)CC[C@]4(C)[C@@]3([H])CC[C@]12C)C(C)O
 xref: Beilstein:2335964;   KEGG:C03965
 xref_mesh: MESH:C052610
 xref: Reaxys:2335964


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20-hydroxypregn-4-en-3-one term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1c3 aldo-keto reductase family 1, member C3 increases chemical synthesis ISO AKR1C3 protein results in increased chemical synthesis of 3-hydroxypregn-4-en-20-one CTD PMID:25463305 NCBI chr17:69,761,126...69,778,021
Ensembl chr17:69,761,118...69,778,021
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO 3-hydroxypregn-4-en-20-one results in increased expression of BAX mRNA CTD PMID:19931389 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions
ISO 3-hydroxypregn-4-en-20-one results in decreased expression of BCL2 mRNA
3-hydroxypregn-4-en-20-one inhibits the reaction [5-alpha-Dihydroprogesterone results in increased expression of BCL2 mRNA]
CTD PMID:19931389 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO 3-hydroxypregn-4-en-20-one results in increased expression of CDKN1A mRNA CTD PMID:19931389 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
(20S)-20-hydroxypregn-4-en-3-one term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1c1 aldo-keto reductase family 1, member C1 increases chemical synthesis ISO AKR1C4 protein results in increased chemical synthesis of 20-alpha-Dihydroprogesterone CTD PMID:11158055 NCBI chr17:69,441,253...69,460,334
Ensembl chr17:69,441,223...69,460,321
JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 increases chemical synthesis ISO AKR1C2 protein results in increased chemical synthesis of 20-alpha-Dihydroprogesterone CTD PMID:11158055 NCBI chr17:69,388,337...69,435,160
Ensembl chr17:69,388,335...69,404,341
JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 multiple interactions
increases chemical synthesis
ISO
EXP
[AKR1C3 protein results in increased metabolism of Progesterone] which results in increased chemical synthesis of 20-alpha-Dihydroprogesterone; [AKR1C3 protein results in increased reduction of Progesterone] which results in increased chemical synthesis of 20-alpha-Dihydroprogesterone
AKR1C18 protein results in increased chemical synthesis of 20-alpha-Dihydroprogesterone
AKR1C3 protein results in increased chemical synthesis of 20-alpha-Dihydroprogesterone
CTD PMID:8172618 PMID:19010312 PMID:20036328 PMID:25463305 NCBI chr17:69,761,126...69,778,021
Ensembl chr17:69,761,118...69,778,021
JBrowse link
G Mal mal, T-cell differentiation protein multiple interactions EXP 20-alpha-Dihydroprogesterone inhibits the reaction [docetaxel results in decreased expression of MAL mRNA] CTD PMID:19335538 NCBI chr 3:120,209,647...120,233,655
Ensembl chr 3:120,209,647...120,233,655
JBrowse link
G Mbp myelin basic protein multiple interactions EXP 20-alpha-Dihydroprogesterone inhibits the reaction [docetaxel results in decreased expression of MBP mRNA]; 20-alpha-Dihydroprogesterone inhibits the reaction [Streptozocin results in decreased expression of MBP mRNA] CTD PMID:19335538 PMID:20349157 NCBI chr18:79,326,738...79,437,310
Ensembl chr18:79,326,738...79,437,310
JBrowse link
G Mpz myelin protein zero increases expression
multiple interactions
EXP 20-alpha-Dihydroprogesterone results in increased expression of MPZ mRNA
20-alpha-Dihydroprogesterone inhibits the reaction [Docetaxel results in decreased expression of MPZ mRNA]; 20-alpha-Dihydroprogesterone inhibits the reaction [Streptozocin results in decreased expression of MPZ mRNA]
CTD PMID:16787508 PMID:17187935 PMID:19335538 NCBI chr13:89,524,204...89,530,070
Ensembl chr13:89,524,329...89,530,068
JBrowse link
G Pmp22 peripheral myelin protein 22 multiple interactions EXP 20-alpha-Dihydroprogesterone inhibits the reaction [docetaxel results in decreased expression of PMP22 mRNA] CTD PMID:19335538 NCBI chr10:49,538,588...49,568,583
Ensembl chr10:49,538,588...49,568,583
JBrowse link
G Pomc proopiomelanocortin multiple interactions
increases secretion
ISO Cadmium Chloride inhibits the reaction [POMC protein results in increased secretion of 20-alpha-Dihydroprogesterone] CTD PMID:8299002 NCBI chr 6:28,382,937...28,388,771
Ensembl chr 6:28,382,962...28,388,967
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19771
    chemical entity 19771
      group 19689
        organic group 18599
          3-oxo-Delta(4)-steroid group 8425
            3-oxo-Delta(4) steroid 8425
              20-hydroxypregn-4-en-3-one 11
                (20R)-20-hydroxypregn-4-en-3-one 0
                (20S)-20-hydroxypregn-4-en-3-one 8
Path 2
Term Annotations click to browse term
  CHEBI ontology 19771
    subatomic particle 19770
      composite particle 19770
        hadron 19770
          baryon 19770
            nucleon 19770
              atomic nucleus 19770
                atom 19770
                  main group element atom 19658
                    p-block element atom 19658
                      carbon group element atom 19574
                        carbon atom 19564
                          organic molecular entity 19564
                            organic group 18599
                              organic divalent group 18590
                                organodiyl group 18590
                                  carbonyl group 18505
                                    carbonyl compound 18505
                                      ketone 16829
                                        oxo steroid 9722
                                          3-oxo steroid 9283
                                            3-oxo-Delta(4) steroid 8425
                                              20-hydroxypregn-4-en-3-one 11
                                                (20R)-20-hydroxypregn-4-en-3-one 0
                                                (20S)-20-hydroxypregn-4-en-3-one 8
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