Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:20-hydroxypregn-4-en-3-one
go back to main search page
Accession:CHEBI:36728 term browser browse the term
Definition:A C21-steroid that is pregnane which contains a double bond between positions 4 and 5 and is substituted by an oxo group at position 3 and a hydroxy group at position 20.
Synonyms:related_synonym: 20-dihydroprogesterone;   20-hydroxy-4-pregnen-3-one;   Formula=C21H32O2;   InChI=1S/C21H32O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h12-13,16-19,22H,4-11H2,1-3H3/t13?,16-,17+,18-,19-,20-,21+/m0/s1;   InChIKey=RWBRUCCWZPSBFC-HWSYHKBZSA-N;   SMILES=[H][C@@]1(CC[C@@]2([H])[C@]3([H])CCC4=CC(=O)CC[C@]4(C)[C@@]3([H])CC[C@]12C)C(C)O
 xref: Beilstein:2335964;   KEGG:C03965
 xref_mesh: MESH:C052610
 xref: Reaxys:2335964



show annotations for term's descendants           Sort by:
 
20-hydroxypregn-4-en-3-one term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1c3 aldo-keto reductase family 1, member C3 increases chemical synthesis ISO AKR1C3 protein results in increased chemical synthesis of 3-hydroxypregn-4-en-20-one CTD PMID:25463305 NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO 3-hydroxypregn-4-en-20-one results in increased expression of BAX mRNA CTD PMID:19931389 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions
ISO 3-hydroxypregn-4-en-20-one results in decreased expression of BCL2 mRNA
3-hydroxypregn-4-en-20-one inhibits the reaction [5-alpha-Dihydroprogesterone results in increased expression of BCL2 mRNA]
CTD PMID:19931389 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO 3-hydroxypregn-4-en-20-one results in increased expression of CDKN1A mRNA CTD PMID:19931389 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
(20S)-20-hydroxypregn-4-en-3-one term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1c2 aldo-keto reductase family 1, member C2 increases chemical synthesis ISO AKR1C2 protein results in increased chemical synthesis of 20-alpha-Dihydroprogesterone CTD PMID:11158055 NCBI chr17:65,759,778...65,808,013
Ensembl chr17:65,759,788...65,775,764
JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 multiple interactions
increases chemical synthesis
ISO
EXP
[AKR1C3 protein results in increased metabolism of Progesterone] which results in increased chemical synthesis of 20-alpha-Dihydroprogesterone; [AKR1C3 protein results in increased reduction of Progesterone] which results in increased chemical synthesis of 20-alpha-Dihydroprogesterone
AKR1C18 protein results in increased chemical synthesis of 20-alpha-Dihydroprogesterone
AKR1C3 protein results in increased chemical synthesis of 20-alpha-Dihydroprogesterone
CTD PMID:8172618 PMID:19010312 PMID:20036328 PMID:25463305 NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873
JBrowse link
G Mal mal, T-cell differentiation protein multiple interactions EXP 20-alpha-Dihydroprogesterone inhibits the reaction [docetaxel results in decreased expression of MAL mRNA] CTD PMID:19335538 NCBI chr 3:114,864,378...114,888,136
Ensembl chr 3:114,864,378...114,888,136
JBrowse link
G Mbp myelin basic protein multiple interactions EXP 20-alpha-Dihydroprogesterone inhibits the reaction [docetaxel results in decreased expression of MBP mRNA]; 20-alpha-Dihydroprogesterone inhibits the reaction [Streptozocin results in decreased expression of MBP mRNA] CTD PMID:19335538 PMID:20349157 NCBI chr18:75,855,878...75,966,404
Ensembl chr18:75,855,878...75,966,404
JBrowse link
G Mpz myelin protein zero increases expression
multiple interactions
EXP 20-alpha-Dihydroprogesterone results in increased expression of MPZ mRNA
20-alpha-Dihydroprogesterone inhibits the reaction [Docetaxel results in decreased expression of MPZ mRNA]; 20-alpha-Dihydroprogesterone inhibits the reaction [Streptozocin results in decreased expression of MPZ mRNA]
CTD PMID:16787508 PMID:17187935 PMID:19335538 NCBI chr13:83,570,811...83,576,680
Ensembl chr13:83,570,811...83,576,679
JBrowse link
G Pmp22 peripheral myelin protein 22 multiple interactions EXP 20-alpha-Dihydroprogesterone inhibits the reaction [docetaxel results in decreased expression of PMP22 mRNA] CTD PMID:19335538 NCBI chr10:47,795,709...47,825,715
Ensembl chr10:47,795,709...47,825,714
JBrowse link
G Pomc proopiomelanocortin multiple interactions
increases secretion
ISO Cadmium Chloride inhibits the reaction [POMC protein results in increased secretion of 20-alpha-Dihydroprogesterone] CTD PMID:8299002 NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20059
    chemical entity 20058
      group 19984
        organic group 18943
          3-oxo-Delta(4)-steroid group 9126
            3-oxo-Delta(4) steroid 9126
              20-hydroxypregn-4-en-3-one 10
                (20R)-20-hydroxypregn-4-en-3-one 0
                (20S)-20-hydroxypregn-4-en-3-one 7
Path 2
Term Annotations click to browse term
  CHEBI ontology 20059
    subatomic particle 20056
      composite particle 20056
        hadron 20056
          baryon 20056
            nucleon 20056
              atomic nucleus 20056
                atom 20056
                  main group element atom 19956
                    p-block element atom 19956
                      carbon group element atom 19882
                        carbon atom 19873
                          organic molecular entity 19873
                            organic group 18943
                              organic divalent group 18928
                                organodiyl group 18928
                                  carbonyl group 18877
                                    carbonyl compound 18877
                                      ketone 17090
                                        oxo steroid 10296
                                          3-oxo steroid 9892
                                            3-oxo-Delta(4) steroid 9126
                                              20-hydroxypregn-4-en-3-one 10
                                                (20R)-20-hydroxypregn-4-en-3-one 0
                                                (20S)-20-hydroxypregn-4-en-3-one 7
paths to the root