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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:(20S)-ginsenoside Rh2
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Accession:CHEBI:77147 term browser browse the term
Definition:A ginsenoside found in Panax species that is dammarane which is substituted by hydroxy groups at the 3beta, 12beta and 20 pro-S positions, in which the hydroxy group at position 3 has been converted to the corresponding beta-D-glucopyranoside, and in which a double bond has been introduced at the 24-25 position.
Synonyms:exact_synonym: (3beta,12beta)-12,20-dihydroxydammar-24-en-3-yl beta-D-glucopyranoside
 related_synonym: 3beta-(beta-D-glucopyranosyloxy)dammar-24-ene-3beta,20beta-diol;   Formula=C36H62O8;   InChI=1S/C36H62O8/c1-20(2)10-9-14-36(8,42)21-11-16-35(7)27(21)22(38)18-25-33(5)15-13-26(32(3,4)24(33)12-17-34(25,35)6)44-31-30(41)29(40)28(39)23(19-37)43-31/h10,21-31,37-42H,9,11-19H2,1-8H3/t21-,22+,23+,24-,25+,26-,27-,28+,29-,30+,31-,33-,34+,35+,36-/m0/s1;   InChIKey=CKUVNOCSBYYHIS-IRFFNABBSA-N;   SMILES=CC(C)=CCC[C@](C)(O)[C@H]1CC[C@]2(C)[C@@H]1[C@H](O)C[C@@H]1[C@@]3(C)CC[C@H](O[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)C(C)(C)[C@@H]3CC[C@@]21C
 xref: CAS:78214-33-2
 xref_mesh: MESH:C055305
 xref: MetaCyc:CPD-12104;   PMID:16204963;   PMID:17268094;   PMID:19428246;   PMID:22007558;   PMID:23125868;   PMID:23892274;   Reaxys:4895638


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(20S)-ginsenoside Rh2 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation ISO ginsenoside Rh2 results in decreased phosphorylation of AKT1 protein CTD PMID:32762018 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO ginsenoside Rh2 results in increased expression of BAX protein CTD PMID:26482938 PMID:32762018 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO ginsenoside Rh2 results in decreased expression of BCL2 protein CTD PMID:26482938 PMID:32762018 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Casp3 caspase 3 increases cleavage
decreases expression		 ISO ginsenoside Rh2 results in increased cleavage of CASP3 protein
ginsenoside Rh2 results in decreased expression of CASP3 protein		 CTD PMID:26482938 PMID:32762018 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp9 caspase 9 decreases expression ISO ginsenoside Rh2 results in decreased expression of CASP9 protein CTD PMID:32762018 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO ginsenoside Rh2 results in decreased expression of CCND1 protein CTD PMID:26482938 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Hdac1 histone deacetylase 1 decreases expression ISO ginsenoside Rh2 results in decreased expression of HDAC1 protein CTD PMID:26482938 NCBI chr 5:141,853,992...141,881,057
Ensembl chr 5:141,853,989...141,881,111 		JBrowse link
G Hdac2 histone deacetylase 2 decreases expression ISO ginsenoside Rh2 results in decreased expression of HDAC2 protein CTD PMID:26482938 NCBI chr20:40,548,250...40,571,609
Ensembl chr20:40,548,250...40,571,609 		JBrowse link
G Hdac6 histone deacetylase 6 decreases expression ISO ginsenoside Rh2 results in decreased expression of HDAC6 protein CTD PMID:26482938 NCBI chr  X:14,550,645...14,572,445
Ensembl chr  X:14,551,044...14,572,441 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO ginsenoside Rh2 inhibits the reaction [Galactose results in increased secretion of IL6 protein] CTD PMID:29412148 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation
increases phosphorylation		 ISO ginsenoside Rh2 results in decreased phosphorylation of MAPK1 protein
ginsenoside Rh2 results in increased phosphorylation of MAPK1 protein		 CTD PMID:26482938 PMID:32762018 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation
increases phosphorylation		 ISO ginsenoside Rh2 results in decreased phosphorylation of MAPK3 protein
ginsenoside Rh2 results in increased phosphorylation of MAPK3 protein		 CTD PMID:26482938 PMID:32762018 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mtor mechanistic target of rapamycin kinase decreases phosphorylation ISO ginsenoside Rh2 results in decreased phosphorylation of MTOR protein CTD PMID:32762018 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Nfkbia NFKB inhibitor alpha increases expression ISO ginsenoside Rh2 results in increased expression of NFKBIA protein CTD PMID:32762018 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO ginsenoside Rh2 results in increased expression of and results in decreased phosphorylation of RELA protein CTD PMID:32762018 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
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  CHEBI ontology 19812
    role 19784
      biological role 19782
        biochemical role 19495
          apoptosis inducer 13497
            (20S)-ginsenoside Rh2 15
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19810
      composite particle 19810
        hadron 19810
          baryon 19810
            nucleon 19810
              atomic nucleus 19810
                atom 19810
                  main group element atom 19755
                    p-block element atom 19755
                      carbon group element atom 19698
                        carbon atom 19693
                          organic molecular entity 19693
                            heteroorganic entity 19450
                              organochalcogen compound 19236
                                organooxygen compound 19149
                                  carbohydrates and carbohydrate derivatives 14948
                                    carbohydrate 14948
                                      monosaccharide 4405
                                        aldose 2758
                                          aldohexose 2400
                                            glucose 2359
                                              D-glucose 2359
                                                D-glucopyranose 1793
                                                  beta-D-glucose 1642
                                                    beta-D-glucoside 1444
                                                      (20S)-ginsenoside Rh2 15
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